MDM2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description MDM2 proto-oncogene, E3 ubiquitin protein ligase|This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013] (NCBI Entrez Gene Database, 4193)
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Genes

201 genes differentially expressed following the MDM2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FIRRM FIGNL1 interacting regulator of recombination and mitosis 2.13754
ITPKB inositol-trisphosphate 3-kinase B 2.13754
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.13754
JADE2 jade family PHD finger 2 2.13754
TPRG1L tumor protein p63 regulated 1-like 2.13754
ZNF630 zinc finger protein 630 2.13754
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.13754
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.12602
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) 2.12602
F8A1 coagulation factor VIII-associated 1 2.12602
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.12602
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.12602
KLHL28 kelch-like family member 28 2.12602
HSPA2 heat shock 70kDa protein 2 2.12602
DIO2 deiodinase, iodothyronine, type II 2.12602
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 2.12602
A4GALT alpha 1,4-galactosyltransferase 2.12602
SLC26A5 solute carrier family 26 (anion exchanger), member 5 2.12602
WASHC3 WASH complex subunit 3 2.12602
ARID1B AT rich interactive domain 1B (SWI1-like) 2.12602
CC2D1A coiled-coil and C2 domain containing 1A 2.12602
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 2.12602
RECQL5 RecQ protein-like 5 2.12602
HSF2BP heat shock transcription factor 2 binding protein 2.12602
ADGRB2 adhesion G protein-coupled receptor B2 2.12602
ZNF776 zinc finger protein 776 2.12602
CD44 CD44 molecule (Indian blood group) 2.12602
SNX21 sorting nexin family member 21 2.12602
CYB5RL cytochrome b5 reductase-like 2.12602
ADH6 alcohol dehydrogenase 6 (class V) 2.12602
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.12602
TRIM21 tripartite motif containing 21 2.12602
PPP1R3D protein phosphatase 1, regulatory subunit 3D 2.12602
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.12602
ARFRP1 ADP-ribosylation factor related protein 1 2.12602
AGRN agrin 2.12602
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 2.12602
NGFR nerve growth factor receptor 2.12602
NBPF3 neuroblastoma breakpoint family, member 3 2.12602
ZNF337 zinc finger protein 337 2.12602
MAP3K15 mitogen-activated protein kinase kinase kinase 15 2.12602
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 2.12602
SAYSD1 SAYSVFN motif domain containing 1 2.12602
HBEGF heparin-binding EGF-like growth factor 2.12602
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 2.12602
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.12602
AARS2 alanyl-tRNA synthetase 2, mitochondrial 2.12602
ANO7 anoctamin 7 2.03603
NPTXR neuronal pentraxin receptor 2.03603
CREBRF CREB3 regulatory factor 2.03603
CDPF1 cysteine-rich, DPF motif domain containing 1 2.03603
FAM193A family with sequence similarity 193, member A 2.03603
ZNF276 zinc finger protein 276 2.03603
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 2.03603
TCEAL5 transcription elongation factor A (SII)-like 5 2.03603
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.03603
SLC44A2 solute carrier family 44 (choline transporter), member 2 2.03603
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 2.03603
CA12 carbonic anhydrase XII 2.03603
RBP7 retinol binding protein 7, cellular 2.03603
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2.03603
NXF1 nuclear RNA export factor 1 2.03603
NOL6 nucleolar protein 6 (RNA-associated) 2.03603
ZBED3 zinc finger, BED-type containing 3 2.03603
TTC19 tetratricopeptide repeat domain 19 2.03603
RUNDC1 RUN domain containing 1 2.03603
ZNFX1 zinc finger, NFX1-type containing 1 2.03603
CFAP96 cilia and flagella associated protein 96 2.03603
RBM47 RNA binding motif protein 47 2.01566

decreased expression

Symbol Name Standardized Value
SHLD1 shieldin complex subunit 1 -2.13754
PRKCE protein kinase C, epsilon -2.13754
FBXO45 F-box protein 45 -2.13754
BTBD1 BTB (POZ) domain containing 1 -2.13754
ATG101 autophagy related 101 -2.13754
LYRM1 LYR motif containing 1 -2.13754
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 -2.13754
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -2.13754
ZNF407 zinc finger protein 407 -2.13754
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 -2.13754
STX10 syntaxin 10 -2.13754
THSD7B thrombospondin, type I, domain containing 7B -2.13754
EXOG endo/exonuclease (5'-3'), endonuclease G-like -2.13754
SPTBN1 spectrin, beta, non-erythrocytic 1 -2.12602
ACBD4 acyl-CoA binding domain containing 4 -2.12602
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -2.12602
ZC3H3 zinc finger CCCH-type containing 3 -2.12602
FSTL5 follistatin-like 5 -2.12602
LPAR4 lysophosphatidic acid receptor 4 -2.12602
FZD4 frizzled class receptor 4 -2.12602
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.12602
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 -2.12602
ATXN7L3 ataxin 7-like 3 -2.12602
NEK10 NIMA-related kinase 10 -2.12602
ANKRD18A ankyrin repeat domain 18A -2.12602
ZNF202 zinc finger protein 202 -2.12602
ELL elongation factor RNA polymerase II -2.12602
AJUBA ajuba LIM protein -2.12602
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein -2.12602
RHOBTB2 Rho-related BTB domain containing 2 -2.12602
TXNDC11 thioredoxin domain containing 11 -2.12602
ZNF563 zinc finger protein 563 -2.12602
EDA2R ectodysplasin A2 receptor -2.12602
ZNF546 zinc finger protein 546 -2.12602
ZCCHC14 zinc finger, CCHC domain containing 14 -2.12602
RDM1 RAD52 motif containing 1 -2.12602
BOK BCL2-related ovarian killer -2.12602
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 -2.12602
MXRA8 matrix-remodelling associated 8 -2.12602
PLAC9 placenta-specific 9 -2.12602
IGSF9B immunoglobulin superfamily, member 9B -2.12602
POU5F1B POU class 5 homeobox 1B -2.12602
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -2.12602
SCHIP1 schwannomin interacting protein 1 -2.12602
FASN fatty acid synthase -2.12602
SYT2 synaptotagmin II -2.12602
RGMB repulsive guidance molecule family member b -2.12602
ZSCAN18 zinc finger and SCAN domain containing 18 -2.12602
C10ORF88 chromosome 10 open reading frame 88 -2.12602
CHID1 chitinase domain containing 1 -2.12602
NIPAL1 NIPA-like domain containing 1 -2.12602
GUCD1 guanylyl cyclase domain containing 1 -2.09059
ENDOG endonuclease G -2.09059
RNF11 ring finger protein 11 -2.04582
POGLUT3 protein O-glucosyltransferase 3 -2.03603
FOXL2 forkhead box L2 -2.03603
GMEB2 glucocorticoid modulatory element binding protein 2 -2.03603
TMEM145 transmembrane protein 145 -2.03603
ZNF780A zinc finger protein 780A -2.03603
WHR1 winged helix repair factor 1 -2.03603
TPBG trophoblast glycoprotein -2.03603
NYAP1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 -2.03603
ALKAL2 ALK and LTK ligand 2 -2.03603
H2AC11 H2A clustered histone 11 -2.03603
DUS3L dihydrouridine synthase 3-like (S. cerevisiae) -2.03603
GPR3 G protein-coupled receptor 3 -2.03603
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 -2.03603
RAB35 RAB35, member RAS oncogene family -2.03603
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.03603
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.03603
LCTL lactase-like -2.03603
FAM185A family with sequence similarity 185, member A -2.03603
NCKIPSD NCK interacting protein with SH3 domain -2.03603
ZNF771 zinc finger protein 771 -2.03603
YPEL2 yippee-like 2 (Drosophila) -2.03603
ZNF778 zinc finger protein 778 -2.03603
SPDYA speedy/RINGO cell cycle regulator family member A -2.03603
MEGF11 multiple EGF-like-domains 11 -2.03603
PSPN persephin -2.03603
CLGN calmegin -2.03603
SRPRA SRP receptor subunit alpha -2.03603
LIPE lipase, hormone-sensitive -2.03603
ZNF174 zinc finger protein 174 -2.03603
SPDYE1 speedy/RINGO cell cycle regulator family member E1 -2.03603
THBS3 thrombospondin 3 -2.03603
RIN2 Ras and Rab interactor 2 -2.03603
EFCAB5 EF-hand calcium binding domain 5 -2.03603
PMM1 phosphomannomutase 1 -2.03603
DPEP3 dipeptidase 3 -2.03603
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -2.03603
SETMAR SET domain and mariner transposase fusion gene -2.03603
TARBP2 TAR (HIV-1) RNA binding protein 2 -2.03603
SCTR secretin receptor -2.03603
PDE8B phosphodiesterase 8B -2.03603
KLHL3 kelch-like family member 3 -2.03603
ISY1 ISY1 splicing factor homolog (S. cerevisiae) -2.03603
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 -2.03603
ZNF418 zinc finger protein 418 -2.03603
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -2.03603
SCRIB scribbled planar cell polarity protein -2.03603
CTSB cathepsin B -2.03603
CHST10 carbohydrate sulfotransferase 10 -2.03603
GDAP2 ganglioside induced differentiation associated protein 2 -2.03603
DDRGK1 DDRGK domain containing 1 -2.03603
SIDT2 SID1 transmembrane family, member 2 -2.03603
ZNF763 zinc finger protein 763 -2.03603
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules -2.03603
GMPPB GDP-mannose pyrophosphorylase B -2.03603
FMN1 formin 1 -2.03603
HEXA hexosaminidase A (alpha polypeptide) -2.03603
SCN5A sodium channel, voltage gated, type V alpha subunit -2.03603
MED11 mediator complex subunit 11 -2.03603
CORT cortistatin -2.03603
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -2.03603
STRIP2 striatin interacting protein 2 -2.03603
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.03603
ACVR1C activin A receptor, type IC -2.03603
ZDHHC8 zinc finger, DHHC-type containing 8 -2.03603
ATF5 activating transcription factor 5 -2.03603
ETNK1 ethanolamine kinase 1 -2.03603
FAM89B family with sequence similarity 89, member B -2.03603
TRIM47 tripartite motif containing 47 -2.03603
STX4 syntaxin 4 -2.03603
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 -2.03603
ROGDI rogdi homolog (Drosophila) -2.03603
PLXNA2 plexin A2 -2.03603
PTCHD4 patched domain containing 4 -2.03603
SAFB scaffold attachment factor B -2.02251
KCTD2 potassium channel tetramerization domain containing 2 -2.01566
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 -2.01566
LGALS1 lectin, galactoside-binding, soluble, 1 -2.01566
GARNL3 GTPase activating Rap/RanGAP domain-like 3 -2.01566