MDM2 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description MDM2 proto-oncogene, E3 ubiquitin protein ligase|This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013] (NCBI Entrez Gene Database, 4193)
External Link http://www.ncbi.nlm.nih.gov/gene/4193
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Genes

193 interacting proteins for hub protein MDM2 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTB actin, beta
ADRBK1 adrenergic, beta, receptor kinase 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALK anaplastic lymphoma receptor tyrosine kinase
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BAIAP2 BAI1-associated protein 2
BANP BTG3 associated nuclear protein
BHLHE40 basic helix-loop-helix family, member e40
CA11 carbonic anhydrase XI
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCAR1 cell division cycle and apoptosis regulator 1
CCNG1 cyclin G1
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHEK2 checkpoint kinase 2
CHRM3 cholinergic receptor, muscarinic 3
CLSTN1 calsyntenin 1
CLU clusterin
COPS5 COP9 signalosome subunit 5
CREBBP CREB binding protein
CSNK1D casein kinase 1, delta
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DAAM2 dishevelled associated activator of morphogenesis 2
DAPK3 death-associated protein kinase 3
DAXX death-domain associated protein
DCD dermcidin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHFR dihydrofolate reductase
E2F1 E2F transcription factor 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1G eukaryotic translation elongation factor 1 gamma
EID1 EP300 interacting inhibitor of differentiation 1
EP300 E1A binding protein p300
EPS15 epidermal growth factor receptor pathway substrate 15
ERICH3 glutamate-rich 3
ESR1 estrogen receptor 1
EZR ezrin
FAM171A1 family with sequence similarity 171, member A1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP3 FK506 binding protein 3, 25kDa
FOXO4 forkhead box O4
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GATA3 GATA binding protein 3
GNAS GNAS complex locus
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
GSTP1 glutathione S-transferase pi 1
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
HDAC1 histone deacetylase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HIST2H2BE histone cluster 2, H2be
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IRF2 interferon regulatory factor 2
JMY junction mediating and regulatory protein, p53 cofactor
JUN jun proto-oncogene
JUND jun D proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
KAT5 K(lysine) acetyltransferase 5
KIF5A kinesin family member 5A
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT2 keratin 2, type II
KRT8 keratin 8, type II
KRT9 keratin 9, type I
MAP2 microtubule-associated protein 2
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARS methionyl-tRNA synthetase
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MEA1 male-enhanced antigen 1
MED1 mediator complex subunit 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MRPS33 mitochondrial ribosomal protein S33
MTBP MDM2 binding protein
NAP1L1 nucleosome assembly protein 1-like 1
NCL nucleolin
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
NEFM neurofilament, medium polypeptide
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
NUMB numb homolog (Drosophila)
PFDN6 prefoldin subunit 6
PIAS1 protein inhibitor of activated STAT, 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIM3 Pim-3 proto-oncogene, serine/threonine kinase
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PLSCR1 phospholipid scramblase 1
PML promyelocytic leukemia
POLE polymerase (DNA directed), epsilon, catalytic subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF6 pre-mRNA processing factor 6
PRRC2C proline-rich coiled-coil 2C
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTK2 protein tyrosine kinase 2
PTPRD protein tyrosine phosphatase, receptor type, D
PYHIN1 pyrin and HIN domain family, member 1
RAD23A RAD23 homolog A (S. cerevisiae)
RANBP2 RAN binding protein 2
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBBP6 retinoblastoma binding protein 6
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPL11 ribosomal protein L11
RPL23 ribosomal protein L23
RPL26 ribosomal protein L26
RPL27A ribosomal protein L27a
RPL5 ribosomal protein L5
RPS20 ribosomal protein S20
RPS27A ribosomal protein S27a
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS7 ribosomal protein S7
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RYBP RING1 and YY1 binding protein
RYR2 ryanodine receptor 2 (cardiac)
SEC63 SEC63 homolog (S. cerevisiae)
SET SET nuclear proto-oncogene
SFN stratifin
SMC3 structural maintenance of chromosomes 3
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRP19 signal recognition particle 19kDa
STX1A syntaxin 1A (brain)
SUMO1 small ubiquitin-like modifier 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAT tyrosine aminotransferase
TBCA tubulin folding cofactor A
TBP TATA box binding protein
TCAP titin-cap
TMEM87A transmembrane protein 87A
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP73 tumor protein p73
TRIM28 tripartite motif containing 28
TSG101 tumor susceptibility 101
TSNAX translin-associated factor X
TUBA1C tubulin, alpha 1c
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
UBB ubiquitin B
UBC ubiquitin C
UBE2A ubiquitin-conjugating enzyme E2A
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2I ubiquitin-conjugating enzyme E2I
UBE2U ubiquitin-conjugating enzyme E2U (putative)
UBE2Z ubiquitin-conjugating enzyme E2Z
UBQLN4 ubiquilin 4
USP2 ubiquitin specific peptidase 2
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VIM vimentin
WDR45 WD repeat domain 45
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YY1 YY1 transcription factor
ZBTB1 zinc finger and BTB domain containing 1
ZNF133 zinc finger protein 133
ZNF326 zinc finger protein 326
ZNF766 zinc finger protein 766
ZNHIT6 zinc finger, HIT-type containing 6