MDM2 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description MDM2 proto-oncogene, E3 ubiquitin protein ligase|This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013] (NCBI Entrez Gene Database, 4193)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_MDM2
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Genes

281 co-expressed genes for MDM2 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ADAM20 ADAM metallopeptidase domain 20
ADAMTSL3 ADAMTS-like 3
ADCY3 adenylate cyclase 3
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
AKAP3 A kinase (PRKA) anchor protein 3
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
AOC4P amine oxidase, copper containing 4, pseudogene
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
AQP7 aquaporin 7
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARL3 ADP-ribosylation factor-like 3
ATF2 activating transcription factor 2
ATF6B activating transcription factor 6 beta
ATP10B ATPase, class V, type 10B
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP4B ATPase, H+/K+ exchanging, beta polypeptide
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATXN3 ataxin 3
BARX2 BARX homeobox 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BMP10 bone morphogenetic protein 10
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
BRCA1 breast cancer 1, early onset
BRD4 bromodomain containing 4
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C1ORF216 chromosome 1 open reading frame 216
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CADM4 cell adhesion molecule 4
CALN1 calneuron 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL16 chemokine (C-C motif) ligand 16
CCR3 chemokine (C-C motif) receptor 3
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CDC73 cell division cycle 73
CDKL5 cyclin-dependent kinase-like 5
CDR1 cerebellar degeneration-related protein 1, 34kDa
CEP162 centrosomal protein 162kDa
CFH complement factor H
CLCN3 chloride channel, voltage-sensitive 3
CLOCK clock circadian regulator
CNTN6 contactin 6
COL14A1 collagen, type XIV, alpha 1
COL19A1 collagen, type XIX, alpha 1
COL8A1 collagen, type VIII, alpha 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPB2 carboxypeptidase B2 (plasma)
CPEB3 cytoplasmic polyadenylation element binding protein 3
CRHR1 corticotropin releasing hormone receptor 1
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CTRL chymotrypsin-like
CTSB cathepsin B
CXCL5 chemokine (C-X-C motif) ligand 5
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DBT dihydrolipoamide branched chain transacylase E2
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DKFZP434C153 DKFZP434C153 protein
DMD dystrophin
DMPK dystrophia myotonica-protein kinase
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DPT dermatopontin
DRD1 dopamine receptor D1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EDIL3 EGF-like repeats and discoidin I-like domains 3
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ELOVL6 ELOVL fatty acid elongase 6
EPHB2 EPH receptor B2
ERC1 ELKS/RAB6-interacting/CAST family member 1
ERCC4 excision repair cross-complementation group 4
EXOC4 exocyst complex component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM153B family with sequence similarity 153, member B
FAM63B family with sequence similarity 63, member B
FAS Fas cell surface death receptor
FBXL4 F-box and leucine-rich repeat protein 4
FGF18 fibroblast growth factor 18
FGF2 fibroblast growth factor 2 (basic)
FLJ16124
FLT1 fms-related tyrosine kinase 1
FNTB farnesyltransferase, CAAX box, beta
FOSL1 FOS-like antigen 1
FSHR follicle stimulating hormone receptor
FZD5 frizzled class receptor 5
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GCA grancalcin, EF-hand calcium binding protein
GCM1 glial cells missing homolog 1 (Drosophila)
GJB5 gap junction protein, beta 5, 31.1kDa
GLE1 GLE1 RNA export mediator
GLRA3 glycine receptor, alpha 3
GMPR guanosine monophosphate reductase
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR1 G protein-coupled receptor 1
GPR15 G protein-coupled receptor 15
GPR171 G protein-coupled receptor 171
GPR18 G protein-coupled receptor 18
GPR19 G protein-coupled receptor 19
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIK5 glutamate receptor, ionotropic, kainate 5
GUCY2C guanylate cyclase 2C
GUCY2F guanylate cyclase 2F, retinal
HCG8 HLA complex group 8
HCRTR2 hypocretin (orexin) receptor 2
HIST1H3E histone cluster 1, H3e
HNF1A HNF1 homeobox A
HOXC11 homeobox C11
HOXD4 homeobox D4
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFNA1 interferon, alpha 1
IFNA14 interferon, alpha 14
IFNW1 interferon, omega 1
IGKV7-3 immunoglobulin kappa variable 7-3 (pseudogene)
IL11RA interleukin 11 receptor, alpha
IL16 interleukin 16
IL4 interleukin 4
IL5 interleukin 5
IL7 interleukin 7
IPO9 importin 9
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
IVL involucrin
JADE3 jade family PHD finger 3
JRKL JRK-like
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KLRC4 killer cell lectin-like receptor subfamily C, member 4
KNG1 kininogen 1
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
KRT1 keratin 1, type II
KRT2 keratin 2, type II
KRT33A keratin 33A, type I
KRT33B keratin 33B, type I
KRT34 keratin 34, type I
KRT86 keratin 86, type II
LECT2 leukocyte cell-derived chemotaxin 2
LGI1 leucine-rich, glioma inactivated 1
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC48 leucine rich repeat containing 48
MAGEA8 melanoma antigen family A8
MAGEA9 melanoma antigen family A9
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP2 microtubule-associated protein 2
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MC5R melanocortin 5 receptor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFN1 mitofusin 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MON2 MON2 homolog (S. cerevisiae)
MPZL1 myelin protein zero-like 1
MPZL2 myelin protein zero-like 2
MSH3 mutS homolog 3
MSL3 male-specific lethal 3 homolog (Drosophila)
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYOZ3 myozenin 3
MYT1 myelin transcription factor 1
NCKIPSD NCK interacting protein with SH3 domain
NEB nebulin
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NHEJ1 nonhomologous end-joining factor 1
NOS2 nitric oxide synthase 2, inducible
NOVA1 neuro-oncological ventral antigen 1
NPAS2 neuronal PAS domain protein 2
NPFF neuropeptide FF-amide peptide precursor
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C2 nuclear receptor subfamily 3, group C, member 2
NTNG2 netrin G2
NXPE3 neurexophilin and PC-esterase domain family, member 3
OR2B6 olfactory receptor, family 2, subfamily B, member 6
P2RY10 purinergic receptor P2Y, G-protein coupled, 10
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PAX6 paired box 6
PAX7 paired box 7
PAX9 paired box 9
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCM1 pericentriolar material 1
PDE10A phosphodiesterase 10A
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PGM3 phosphoglucomutase 3
PHF10 PHD finger protein 10
PHLDB1 pleckstrin homology-like domain, family B, member 1
PHOX2B paired-like homeobox 2b
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
POU6F1 POU class 6 homeobox 1
POU6F2 POU class 6 homeobox 2
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRKCA protein kinase C, alpha
PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1
PSD pleckstrin and Sec7 domain containing
PSG1 pregnancy specific beta-1-glycoprotein 1
PTPRB protein tyrosine phosphatase, receptor type, B
PTPRR protein tyrosine phosphatase, receptor type, R
PTPRS protein tyrosine phosphatase, receptor type, S
PVR poliovirus receptor
R3HCC1L R3H domain and coiled-coil containing 1-like
RAD51D RAD51 paralog D
RB1CC1 RB1-inducible coiled-coil 1
RBBP7 retinoblastoma binding protein 7
RBMS3 RNA binding motif, single stranded interacting protein 3
RBMXL1 RNA binding motif protein, X-linked-like 1
RNF24 ring finger protein 24
ROR2 receptor tyrosine kinase-like orphan receptor 2
RORB RAR-related orphan receptor B
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RREB1 ras responsive element binding protein 1
RSC1A1 regulatory solute carrier protein, family 1, member 1
RXRG retinoid X receptor, gamma
RYR3 ryanodine receptor 3
S100A5 S100 calcium binding protein A5
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SIM2 single-minded family bHLH transcription factor 2
SIX6 SIX homeobox 6
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC17A1 solute carrier family 17 (organic anion transporter), member 1
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC46A3 solute carrier family 46, member 3
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SOAT2 sterol O-acyltransferase 2
SPA17 sperm autoantigenic protein 17
SPAG11B sperm associated antigen 11B
SRPK3 SRSF protein kinase 3
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STAC SH3 and cysteine rich domain
STAG1 stromal antigen 1
SULT4A1 sulfotransferase family 4A, member 1
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SYT5 synaptotagmin V
T T, brachyury homolog (mouse)
TACC2 transforming, acidic coiled-coil containing protein 2
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBX19 T-box 19
TBX5 T-box 5
TENM4 teneurin transmembrane protein 4
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMEM26 transmembrane protein 26
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNK1 tyrosine kinase, non-receptor, 1
TRIM24 tripartite motif containing 24
TRIO trio Rho guanine nucleotide exchange factor
TSPAN2 tetraspanin 2
TSSK2 testis-specific serine kinase 2
TTTY1 testis-specific transcript, Y-linked 1 (non-protein coding)
UBE4B ubiquitination factor E4B
ULK2 unc-51 like autophagy activating kinase 2
VKORC1 vitamin K epoxide reductase complex, subunit 1
WBP4 WW domain binding protein 4
ZBTB14 zinc finger and BTB domain containing 14
ZBTB40 zinc finger and BTB domain containing 40
ZNF132 zinc finger protein 132
ZNF134 zinc finger protein 134
ZNF141 zinc finger protein 141
ZNF157 zinc finger protein 157
ZNF200 zinc finger protein 200
ZNF202 zinc finger protein 202
ZNF266 zinc finger protein 266
ZSCAN26 zinc finger and SCAN domain containing 26