ME-31-RM40_0.01uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.01uM, (E)-3-[4-[(2-carbazol-9-ylethylamino)methyl]phenyl]-N-hydroxyprop-2-enamide, Histone Deacetylase (HDAC) Inhibitors targeting HDAC9, HDAC5, HDAC7, HDAC8, HDAC11, HDAC10 (Novartis, 11058122)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/11058122
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Genes

37 genes differentially expressed following the ME-31-RM40_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 1.19981
HBA2 hemoglobin, alpha 2 1.00912
TIMP1 TIMP metallopeptidase inhibitor 1 0.608164
MT1E metallothionein 1E 0.451082
SYTL3 synaptotagmin-like 3 0.397523
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 0.325273
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.318302
CCDC85B coiled-coil domain containing 85B 0.299269
RPL28 ribosomal protein L28 0.285743
ATP5MC3 ATP synthase membrane subunit c locus 3 0.285743
FRMD6 FERM domain containing 6 0.264046
SYP synaptophysin 0.264046
BABAM2 BRISC and BRCA1 A complex member 2 0.259935
RPL41 ribosomal protein L41 0.242259
KRTAP2-3 keratin associated protein 2-3 0.240307
OTOP2 otopetrin 2 0.224536
BOLA2B bolA family member 2B 0.217167
MRPL41 mitochondrial ribosomal protein L41 0.212981
SYT5 synaptotagmin V 0.207502
VGF VGF nerve growth factor inducible 0.205806
IL18 interleukin 18 0.204852
IER3 immediate early response 3 0.204465

decreased expression

Symbol Name Standardized Value
SMIM29 small integral membrane protein 29 -0.996389
HDGF hepatoma-derived growth factor -0.816583
TNNT2 troponin T type 2 (cardiac) -0.669097
GPC1 glypican 1 -0.586374
AP1M2 adaptor-related protein complex 1, mu 2 subunit -0.451082
EPS8L2 EPS8-like 2 -0.325273
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -0.303495
COL1A1 collagen, type I, alpha 1 -0.299269
GNAS GNAS complex locus -0.259935
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.237037
CHD4 chromodomain helicase DNA binding protein 4 -0.235347
GLS2 glutaminase 2 (liver, mitochondrial) -0.230471
SDC2 syndecan 2 -0.226926
ADI1 acireductone dioxygenase 1 -0.201037
MDK midkine (neurite growth-promoting factor 2) -0.201037