MECOM Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description MDS1 and EVI1 complex locus|The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] (NCBI Entrez Gene Database, 2122)
Similar Terms
Downloads & Tools

Genes

336 genes differentially expressed following the MECOM gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RS1 retinoschisin 1 2.28401
PDYN prodynorphin 2.28401
SSTR1 somatostatin receptor 1 2.28401
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.28401
OSGIN1 oxidative stress induced growth inhibitor 1 2.28401
KRT20 keratin 20, type I 2.28401
KRT23 keratin 23, type I 2.28401
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.28401
ECEL1 endothelin converting enzyme-like 1 2.28401
CXORF65 chromosome X open reading frame 65 2.28401
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.28401
MUC1 mucin 1, cell surface associated 2.28401
SLC16A11 solute carrier family 16, member 11 2.28401
IGFL3 IGF-like family member 3 2.28401
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.28401
HNF4A hepatocyte nuclear factor 4, alpha 2.28401
PLVAP plasmalemma vesicle associated protein 2.28401
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 2.28401
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.28401
LURAP1L leucine rich adaptor protein 1-like 2.28401
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 2.28401
ADGRE5 adhesion G protein-coupled receptor E5 2.28401
SCN2B sodium channel, voltage gated, type II beta subunit 2.28401
LRRTM2 leucine rich repeat transmembrane neuronal 2 2.28401
PAX4 paired box 4 2.28401
CSMD3 CUB and Sushi multiple domains 3 2.28401
ACVRL1 activin A receptor type II-like 1 2.28401
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.28401
HBM hemoglobin, mu 2.28401
OXT oxytocin/neurophysin I prepropeptide 2.28401
MMP20 matrix metallopeptidase 20 2.28401
CDK19 cyclin-dependent kinase 19 2.28401
ATOH8 atonal homolog 8 (Drosophila) 2.28401
PRDM12 PR domain containing 12 2.28401
HMX1 H6 family homeobox 1 2.28401
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.28401
LCN15 lipocalin 15 2.28401
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.28401
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.28401
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 2.28401
ASB12 ankyrin repeat and SOCS box containing 12 2.28401
RSPO2 R-spondin 2 2.28401
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.28401
SNX4 sorting nexin 4 2.28401
GPR22 G protein-coupled receptor 22 2.28401
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.28401
SLC23A3 solute carrier family 23, member 3 2.28401
TRIM74 tripartite motif containing 74 2.28401
GCKR glucokinase (hexokinase 4) regulator 2.28401
RNF39 ring finger protein 39 2.28401
KLHL30 kelch-like family member 30 2.28401
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.28401
CFAP65 cilia and flagella associated protein 65 2.28401
SQOR sulfide quinone oxidoreductase 2.28401
SEPTIN14 septin 14 2.28401
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.28401
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 2.28401
TCERG1L transcription elongation regulator 1-like 2.28401
FRG2C FSHD region gene 2 family, member C 2.28401
TBC1D3L TBC1 domain family, member 3L 2.28401
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 2.28401
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.28401
ZNRD2 zinc ribbon domain containing 2 2.28401
DIPK2B divergent protein kinase domain 2B 2.28401
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.28401
SPATA31G1 SPATA31 subfamily G member 1 2.28401
CIMAP2 ciliary microtubule associated protein 2 2.28401
EPCIP exosomal polycystin 1 interacting protein 2.28401
PNMA6F PNMA family member 6F 2.28401
CPNE8-AS1 CPNE8 antisense RNA 1 2.28401
ANKRD42-DT ANKRD42 divergent transcript 2.28401
H3C13 H3 clustered histone 13 2.28401
RHEX regulator of hemoglobinization and erythroid cell expansion 2.28401
AKAIN1 A-kinase anchor inhibitor 1 2.28401
CFAP107 cilia and flagella associated protein 107 2.28401
RPS27A ribosomal protein S27a 2.28401
PRDM7 PR domain containing 7 2.28401
CCR3 chemokine (C-C motif) receptor 3 2.28401
SPDYC speedy/RINGO cell cycle regulator family member C 2.28401
MIP major intrinsic protein of lens fiber 2.28401
IAPP islet amyloid polypeptide 2.28401
ZIC5 Zic family member 5 2.28401
ULBP1 UL16 binding protein 1 2.28401
NR1I2 nuclear receptor subfamily 1, group I, member 2 2.28401
DAO D-amino-acid oxidase 2.28401
MAGEB3 melanoma antigen family B3 2.28401
CCDC13 coiled-coil domain containing 13 2.28401
S100G S100 calcium binding protein G 2.28401
PGLYRP2 peptidoglycan recognition protein 2 2.28401
LRRC3C leucine rich repeat containing 3C 2.28401
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.28401
FBXO21 F-box protein 21 2.28401
HNF1B HNF1 homeobox B 2.28401
SMCP sperm mitochondria-associated cysteine-rich protein 2.28401
ACE2 angiotensin I converting enzyme 2 2.28401
GDF9 growth differentiation factor 9 2.28401
GPR83 G protein-coupled receptor 83 2.28401
PNPLA1 patatin-like phospholipase domain containing 1 2.28401
SAMD11 sterile alpha motif domain containing 11 2.28401
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.28401
PCDHB10 protocadherin beta 10 2.28401
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.28401
TCF21 transcription factor 21 2.28401
TIGD3 tigger transposable element derived 3 2.28401
TMEM202 transmembrane protein 202 2.28401
CPA5 carboxypeptidase A5 2.28401
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 2.28401
TRIM50 tripartite motif containing 50 2.28401
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.28401
DRD2 dopamine receptor D2 2.28401
DSC1 desmocollin 1 2.28401
KLK11 kallikrein-related peptidase 11 2.28401
CDHR5 cadherin-related family member 5 2.28401
CLRN2 clarin 2 2.28401
KLHL1 kelch-like family member 1 2.28401
MAGEA11 melanoma antigen family A11 2.28401
LRCOL1 leucine rich colipase-like 1 2.28401
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.28401
CLIC3 chloride intracellular channel 3 2.28401
TCEA2 transcription elongation factor A (SII), 2 2.28401
LCT lactase 2.28401
ZBP1 Z-DNA binding protein 1 2.28401
EFCAB9 EF-hand calcium binding domain 9 2.28401
EHF ets homologous factor 2.28401
EGR2 early growth response 2 2.28401
LRRC19 leucine rich repeat containing 19 2.28401
SAMD5 sterile alpha motif domain containing 5 2.28401
RBBP8NL RBBP8 N-terminal like 2.28401
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.28401
FAM204A family with sequence similarity 204, member A 2.28401
TYR tyrosinase 2.28401
CNGB1 cyclic nucleotide gated channel beta 1 2.28401
ADRA2A adrenoceptor alpha 2A 2.28401
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.28401
GOLGA8N golgin A8 family, member N 2.28401
FOXS1 forkhead box S1 2.28401
NXF2B nuclear RNA export factor 2B 2.28401
LHX2 LIM homeobox 2 2.28401
CTSF cathepsin F 2.28401
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 2.28401
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.28401
PRR35 proline rich 35 2.28401
ZC3H12D zinc finger CCCH-type containing 12D 2.28401
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 2.28401
DLX5 distal-less homeobox 5 2.28401
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.28401
PENK proenkephalin 2.28401
TAGAP T-cell activation RhoGTPase activating protein 2.28401
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 2.28401
DMTN dematin actin binding protein 2.28401
NLRP8 NLR family, pyrin domain containing 8 2.28401
IL10RA interleukin 10 receptor, alpha 2.28401
DMRTC1 DMRT-like family C1 2.28401
IRX1 iroquois homeobox 1 2.28401
GRAP2 GRB2-related adaptor protein 2 2.28401
ALLC allantoicase 2.28401
PITX2 paired-like homeodomain 2 2.28401
CD86 CD86 molecule 2.28401
MMRN1 multimerin 1 2.28401
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.28401
NYX nyctalopin 2.28401
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.28401
DNAH1 dynein, axonemal, heavy chain 1 2.28401
TMEM215 transmembrane protein 215 2.28401
NSFL1C NSFL1 (p97) cofactor (p47) 2.28401
TGM3 transglutaminase 3 2.28401
NEUROD2 neuronal differentiation 2 2.28401
TMPRSS13 transmembrane protease, serine 13 2.28401
MICU2 mitochondrial calcium uptake 2 2.28401
CHAT choline O-acetyltransferase 2.28401
NR2F1 nuclear receptor subfamily 2, group F, member 1 2.28401
PRSS21 protease, serine, 21 (testisin) 2.28401
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 2.28401
PTGDR prostaglandin D2 receptor (DP) 2.28401
KRTAP5-2 keratin associated protein 5-2 2.28401
TBC1D28 TBC1 domain family, member 28 2.28401
SUN5 Sad1 and UNC84 domain containing 5 2.28401
EPX eosinophil peroxidase 2.28401
CARNS1 carnosine synthase 1 2.28401
ALOX15B arachidonate 15-lipoxygenase, type B 2.28401
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.28401
CLCF1 cardiotrophin-like cytokine factor 1 2.28401
AQP1 aquaporin 1 (Colton blood group) 2.28401
ZNF730 zinc finger protein 730 2.28401
PRSS22 protease, serine, 22 2.28401
POTEJ POTE ankyrin domain family, member J 2.28401
TFG TRK-fused gene 2.27547
MRPS16 mitochondrial ribosomal protein S16 2.27511
ODC1 ornithine decarboxylase 1 2.26995
PCSK7 proprotein convertase subtilisin/kexin type 7 2.23626
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 2.23544
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 2.23529
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 2.17986
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.17505
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 2.17235
TMEM67 transmembrane protein 67 2.1715
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 2.16103
ALK anaplastic lymphoma receptor tyrosine kinase 2.16103
MTNR1A melatonin receptor 1A 2.16103
SERTM1 serine-rich and transmembrane domain containing 1 2.16103
S1PR1 sphingosine-1-phosphate receptor 1 2.16103
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 2.15066
ANKRD17 ankyrin repeat domain 17 2.13809
DUSP16 dual specificity phosphatase 16 2.13585
NFRKB nuclear factor related to kappaB binding protein 2.13233
EVL Enah/Vasp-like 2.12632
SPPL2B signal peptide peptidase like 2B 2.11532
SLC4A11 solute carrier family 4, sodium borate transporter, member 11 2.11319
AQP5 aquaporin 5 2.10734
PALM paralemmin 2.10392
SMDT1 single-pass membrane protein with aspartate-rich tail 1 2.10237
GMIP GEM interacting protein 2.10028
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 2.06829
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 2.0598
ARL2BP ADP-ribosylation factor-like 2 binding protein 2.04702
VKORC1 vitamin K epoxide reductase complex, subunit 1 2.04149
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 2.04064
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 2.02745
GOLGB1 golgin B1 2.00148
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2.00076

decreased expression

Symbol Name Standardized Value
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase -2.28401
HCRTR2 hypocretin (orexin) receptor 2 -2.28401
CIITA class II, major histocompatibility complex, transactivator -2.28401
TUBB1 tubulin, beta 1 class VI -2.28401
TNNI1 troponin I type 1 (skeletal, slow) -2.28401
CELF1 CUGBP, Elav-like family member 1 -2.28401
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta -2.28401
PROKR1 prokineticin receptor 1 -2.28401
KDM3A lysine (K)-specific demethylase 3A -2.28401
ZNF98 zinc finger protein 98 -2.28401
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -2.28401
PRSS35 protease, serine, 35 -2.28401
XPO7 exportin 7 -2.28401
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 -2.28401
ZNF563 zinc finger protein 563 -2.28401
EMCN endomucin -2.28401
NWD1 NACHT and WD repeat domain containing 1 -2.28401
CFAP54 cilia and flagella associated 54 -2.28401
CLCN1 chloride channel, voltage-sensitive 1 -2.28401
CCDC39 coiled-coil domain containing 39 -2.28401
ATP8B4 ATPase, class I, type 8B, member 4 -2.28401
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -2.28401
PTPRQ protein tyrosine phosphatase, receptor type, Q -2.28401
AMBP alpha-1-microglobulin/bikunin precursor -2.28401
PLCZ1 phospholipase C, zeta 1 -2.28401
MLN motilin -2.28401
GPR34 G protein-coupled receptor 34 -2.28401
UNC93A unc-93 homolog A (C. elegans) -2.28401
SGF29 SAGA complex associated factor 29 -2.28401
MISP3 MISP family member 3 -2.28401
TENT2 terminal nucleotidyltransferase 2 -2.28401
HJV hemojuvelin BMP co-receptor -2.28401
INSYN2B inhibitory synaptic factor family member 2B -2.28401
NGEF neuronal guanine nucleotide exchange factor -2.28401
POU2F1 POU class 2 homeobox 1 -2.28401
ZSWIM6 zinc finger, SWIM-type containing 6 -2.28401
HMCN2 hemicentin 2 -2.28401
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 -2.28401
GDF11 growth differentiation factor 11 -2.28401
SPDYE16 speedy/RINGO cell cycle regulator family member E16 -2.28401
ACP7 acid phosphatase 7, tartrate resistant (putative) -2.28401
GCFC2 GC-rich sequence DNA-binding factor 2 -2.28401
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.28401
LTF lactotransferrin -2.28401
SPDYE21 speedy/RINGO cell cycle regulator family member E21 -2.28401
IZUMO3 IZUMO family member 3 -2.28401
ABHD1 abhydrolase domain containing 1 -2.28401
CD177 CD177 molecule -2.28401
IFT43 intraflagellar transport 43 -2.28401
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -2.28401
PPID peptidylprolyl isomerase D -2.28401
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.28401
UTS2B urotensin 2B -2.28401
NBPF9 neuroblastoma breakpoint family, member 9 -2.28401
MEMO1 mediator of cell motility 1 -2.28401
CYS1 cystin 1 -2.28401
GAL3ST2 galactose-3-O-sulfotransferase 2 -2.28401
CTCFL CCCTC-binding factor (zinc finger protein)-like -2.28401
DGCR6 DiGeorge syndrome critical region gene 6 -2.28401
TMEM61 transmembrane protein 61 -2.28401
TMIGD2 transmembrane and immunoglobulin domain containing 2 -2.28401
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -2.28401
GGN gametogenetin -2.28401
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 -2.28401
MEIS2 Meis homeobox 2 -2.28401
IGSF10 immunoglobulin superfamily, member 10 -2.28401
AHSP alpha hemoglobin stabilizing protein -2.28401
SDSL serine dehydratase-like -2.28401
SYNRG synergin, gamma -2.28401
NIPAL3 NIPA-like domain containing 3 -2.28401
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -2.28401
LGALS14 lectin, galactoside-binding, soluble, 14 -2.28401
DAPL1 death associated protein-like 1 -2.28401
GCK glucokinase (hexokinase 4) -2.27853
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -2.27477
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -2.26845
NDC1 NDC1 transmembrane nucleoporin -2.26845
SPOPL speckle-type POZ protein-like -2.25781
SSH2 slingshot protein phosphatase 2 -2.23626
NFIA nuclear factor I/A -2.23626
CCDC30 coiled-coil domain containing 30 -2.23453
NOP58 NOP58 ribonucleoprotein -2.16103
C1ORF122 chromosome 1 open reading frame 122 -2.16103
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.14818
EPHA5 EPH receptor A5 -2.14643
ACSBG2 acyl-CoA synthetase bubblegum family member 2 -2.14643
TTC23 tetratricopeptide repeat domain 23 -2.13638
SLC44A5 solute carrier family 44, member 5 -2.13103
POR P450 (cytochrome) oxidoreductase -2.13103
LCLAT1 lysocardiolipin acyltransferase 1 -2.12634
MLH1 mutL homolog 1 -2.10734
WDR53 WD repeat domain 53 -2.10734
FBXO11 F-box protein 11 -2.10638
H2AC11 H2A clustered histone 11 -2.10237
TMEM263 transmembrane protein 263 -2.10218
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -2.10028
NUTF2 nuclear transport factor 2 -2.10028
GOLGA2 golgin A2 -2.10028
DPY30 dpy-30 homolog (C. elegans) -2.10028
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -2.081
MACO1 macoilin 1 -2.07988
MTCP1 mature T-cell proliferation 1 -2.07988
COMMD3 COMM domain containing 3 -2.0733
DVL1 dishevelled segment polarity protein 1 -2.06526
DAZL deleted in azoospermia-like -2.0605
ATXN7L1 ataxin 7-like 1 -2.05837
SELENOI selenoprotein I -2.04901
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -2.04901
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial -2.04064
APLF aprataxin and PNKP like factor -2.03414
KIF1B kinesin family member 1B -2.02745
TFDP1 transcription factor Dp-1 -2.02059
H4C6 H4 clustered histone 6 -2.02059
RRP1 ribosomal RNA processing 1 -2.02059
DTWD2 DTW domain containing 2 -2.02039
RPN2 ribophorin II -2.01818