MECP2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description methyl CpG binding protein 2|DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq, Jul 2009] (NCBI Entrez Gene Database, 4204)
Similar Terms
Downloads & Tools

Genes

316 genes differentially expressed following the MECP2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LGI1 leucine-rich, glioma inactivated 1 3.608
CLDN5 claudin 5 3.608
CRX cone-rod homeobox 3.608
LCN12 lipocalin 12 3.608
EFCAB9 EF-hand calcium binding domain 9 3.608
HLX H2.0-like homeobox 3.608
GOLGA6L4 golgin A6 family-like 4 3.608
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.608
S100B S100 calcium binding protein B 3.608
RERGL RERG/RAS-like 3.608
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.608
FGF10 fibroblast growth factor 10 3.608
OCSTAMP osteoclast stimulatory transmembrane protein 3.608
CCL27 chemokine (C-C motif) ligand 27 3.608
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.608
ASB15 ankyrin repeat and SOCS box containing 15 3.608
SLC39A12 solute carrier family 39 (zinc transporter), member 12 3.608
GK3 glycerol kinase 3 3.608
NECTIN4 nectin cell adhesion molecule 4 3.608
TAS2R13 taste receptor, type 2, member 13 3.608
ASGR2 asialoglycoprotein receptor 2 3.608
TMEM100 transmembrane protein 100 3.602
XCL1 chemokine (C motif) ligand 1 3.602
LIPN lipase, family member N 3.602
DSG3 desmoglein 3 3.602
FFAR4 free fatty acid receptor 4 3.602
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.602
NANOS3 nanos homolog 3 (Drosophila) 3.602
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 3.602
GSTM5 glutathione S-transferase mu 5 3.602
OSR2 odd-skipped related transciption factor 2 3.602
RNF133 ring finger protein 133 3.602
OLFM4 olfactomedin 4 3.602
SSTR3 somatostatin receptor 3 3.602
TMEM71 transmembrane protein 71 3.602
APOBR apolipoprotein B receptor 3.602
ACVRL1 activin A receptor type II-like 1 3.602
PODN podocan 3.602
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.602
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.602
SLC10A5 solute carrier family 10, member 5 3.602
TECTB tectorin beta 3.602
ZNF556 zinc finger protein 556 3.602
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 3.602
ADAD2 adenosine deaminase domain containing 2 3.602
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.602
ARSF arylsulfatase F 3.602
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.602
OR12D3 olfactory receptor, family 12, subfamily D, member 3 3.602
DEFB106B defensin, beta 106B 3.602
AVPR2 arginine vasopressin receptor 2 3.602
ADAMTSL5 ADAMTS-like 5 3.602
PCDHGA11 protocadherin gamma subfamily A, 11 3.602
CD6 CD6 molecule 3.602
LITAFD LITAF domain containing 3.602
MYH1 myosin, heavy chain 1, skeletal muscle, adult 3.602
NEURL3 neuralized E3 ubiquitin protein ligase 3 3.602
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 3.602
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.602
VSIG8 V-set and immunoglobulin domain containing 8 3.602
GATA6 GATA binding protein 6 3.602
KL klotho 3.602
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.602
ALX4 ALX homeobox 4 3.602
ADPRHL1 ADP-ribosylhydrolase like 1 3.602
SEPTIN14 septin 14 3.602
DEFB109B defensin beta 109B 3.602
PVALEF parvalbumin like EF-hand containing 3.602
H4C14 H4 clustered histone 14 3.602
EZHIP EZH inhibitory protein 3.602
GSG1L2 GSG1 like 2 3.602
CFAP107 cilia and flagella associated protein 107 3.602
TENT5D terminal nucleotidyltransferase 5D 3.602
AJM1 apical junction component 1 homolog 3.602
ACE2 angiotensin I converting enzyme 2 3.602
TMEM119 transmembrane protein 119 3.602
OOSP1 oocyte secreted protein 1, pseudogene 3.602
TBC1D3I TBC1 domain family member 3I 3.602
OR7C1 olfactory receptor, family 7, subfamily C, member 1 3.602
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.602
TEX101 testis expressed 101 3.602
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.602
FPR2 formyl peptide receptor 2 3.602
KBTBD13 kelch repeat and BTB (POZ) domain containing 13 3.602
PRLHR prolactin releasing hormone receptor 3.602
ANXA10 annexin A10 3.602
ZNF575 zinc finger protein 575 3.602
BHLHA9 basic helix-loop-helix family, member a9 3.602
OPN5 opsin 5 3.602
C9 complement component 9 3.602
S100G S100 calcium binding protein G 3.602
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 3.602
SPDYC speedy/RINGO cell cycle regulator family member C 3.602
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 3.602
SLAMF7 SLAM family member 7 3.602
GDF10 growth differentiation factor 10 3.602
TSSK4 testis-specific serine kinase 4 3.602
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.602
NUTM2B NUT family member 2B 3.602
PCDHGB1 protocadherin gamma subfamily B, 1 3.602
KCNK9 potassium channel, two pore domain subfamily K, member 9 3.602
NXNL1 nucleoredoxin-like 1 3.602
ADORA3 adenosine A3 receptor 3.602
PCP2 Purkinje cell protein 2 3.602
GOLGA6D golgin A6 family, member D 3.602
MEFV Mediterranean fever 3.602
APOC4 apolipoprotein C-IV 3.602
APOD apolipoprotein D 3.602
ESAM endothelial cell adhesion molecule 3.602
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.602
LIMS3 LIM and senescent cell antigen-like domains 3 3.602
SHOX short stature homeobox 3.602
IL12B interleukin 12B 3.602
OR9I1 olfactory receptor, family 9, subfamily I, member 1 3.602
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.602
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 3.602
FCN1 ficolin (collagen/fibrinogen domain containing) 1 3.602
IFNL4 interferon, lambda 4 (gene/pseudogene) 3.602
WNT7B wingless-type MMTV integration site family, member 7B 3.602
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.602
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.602
PRSS38 protease, serine, 38 3.602
HMGB4 high mobility group box 4 3.602
LDLRAD1 low density lipoprotein receptor class A domain containing 1 3.602
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.602
IL26 interleukin 26 3.602
FOXN1 forkhead box N1 3.602
HOXA10 homeobox A10 3.602
DMRT2 doublesex and mab-3 related transcription factor 2 3.602
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.602
TAT tyrosine aminotransferase 3.602
IL19 interleukin 19 3.602
GPR62 G protein-coupled receptor 62 3.602
RAB40AL RAB40A, member RAS oncogene family-like 3.602
COL6A5 collagen, type VI, alpha 5 3.602
EGR2 early growth response 2 3.602
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.602
TBX1 T-box 1 3.602
PHOX2A paired-like homeobox 2a 3.602
NLRP6 NLR family, pyrin domain containing 6 3.602
AMIGO3 adhesion molecule with Ig-like domain 3 3.602
FOXP3 forkhead box P3 3.602
CIB4 calcium and integrin binding family member 4 3.602
NNMT nicotinamide N-methyltransferase 3.602
TEX36 testis expressed 36 3.602
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.602
IRX4 iroquois homeobox 4 3.602
OR10G3 olfactory receptor, family 10, subfamily G, member 3 3.602
ZPLD1 zona pellucida-like domain containing 1 3.602
GHRH growth hormone releasing hormone 3.602
HEPACAM hepatic and glial cell adhesion molecule 3.602
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.602
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 3.602
STOML3 stomatin (EPB72)-like 3 3.602
C5ORF46 chromosome 5 open reading frame 46 3.602
AQP1 aquaporin 1 (Colton blood group) 3.602
CLCA2 chloride channel accessory 2 3.602
OR4E1 olfactory receptor, family 4, subfamily E, member 1 (gene/pseudogene) 3.602
MMP3 matrix metallopeptidase 3 3.602
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.602
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.602
ADRA2A adrenoceptor alpha 2A 3.54289
VCX variable charge, X-linked 3.54289
NLRP10 NLR family, pyrin domain containing 10 3.54289
LYRM2 LYR motif containing 2 3.19434
FREM1 FRAS1 related extracellular matrix 1 3.15634
PIF1 PIF1 5'-to-3' DNA helicase 3.12061
POU5F1 POU class 5 homeobox 1 3.0127
PEX19 peroxisomal biogenesis factor 19 2.94447
CCDC9 coiled-coil domain containing 9 2.87961
KLHL3 kelch-like family member 3 2.85636
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.81549
HAX1 HCLS1 associated protein X-1 2.72618
GLI2 GLI family zinc finger 2 2.71437
MBLAC2 metallo-beta-lactamase domain containing 2 2.66329
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 2.64085
NIBAN3 niban apoptosis regulator 3 2.63411
ULK3 unc-51 like kinase 3 2.59303
PITPNB phosphatidylinositol transfer protein, beta 2.49601
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 2.44658
TBC1D3L TBC1 domain family, member 3L 2.44406
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.44406
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.44406
ZNF285 zinc finger protein 285 2.44406
FETUB fetuin B 2.44406
EFCAB12 EF-hand calcium binding domain 12 2.44406
ASXL3 additional sex combs like transcriptional regulator 3 2.44406
SNF8 SNF8, ESCRT-II complex subunit 2.43424
RBBP6 retinoblastoma binding protein 6 2.42689
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.42412
CD48 CD48 molecule 2.3982
NBPF9 neuroblastoma breakpoint family, member 9 2.38239
SPACA6 sperm acrosome associated 6 2.35706
SMIM10 small integral membrane protein 10 2.3509
ANKRD26 ankyrin repeat domain 26 2.32887
ZNF844 zinc finger protein 844 2.30812
ST18 suppression of tumorigenicity 18, zinc finger 2.30812
FGF18 fibroblast growth factor 18 2.30812
PCDHB10 protocadherin beta 10 2.30812
PURA purine-rich element binding protein A 2.29845
PHTF1 putative homeodomain transcription factor 1 2.28358
PDHB pyruvate dehydrogenase (lipoamide) beta 2.27646
LYST lysosomal trafficking regulator 2.25132
OLIG1 oligodendrocyte transcription factor 1 2.24771
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 2.24771
FNDC1 fibronectin type III domain containing 1 2.24771
NPFF neuropeptide FF-amide peptide precursor 2.24771
ZCCHC12 zinc finger, CCHC domain containing 12 2.24771
CRYBG3 beta-gamma crystallin domain containing 3 2.24179
BMP3 bone morphogenetic protein 3 2.2332
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.2332
BMAL1 basic helix-loop-helix ARNT like 1 2.22086
IL17RE interleukin 17 receptor E 2.21431
CD163L1 CD163 molecule-like 1 2.18727
PLS1 plastin 1 2.17771
ZNF223 zinc finger protein 223 2.13633
CDK11B cyclin-dependent kinase 11B 2.13125
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 2.13125
BBIP1 BBSome interacting protein 1 2.11247
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 2.10926
POMZP3 POM121 and ZP3 fusion 2.10926
ZNF460 zinc finger protein 460 2.10926
PEPD peptidase D 2.099
NSD3 nuclear receptor binding SET domain protein 3 2.09075
SPATA6L spermatogenesis associated 6-like 2.09075
FOSL2 FOS-like antigen 2 2.09075
NLGN4X neuroligin 4, X-linked 2.09075
IGFBP6 insulin-like growth factor binding protein 6 2.08801
ANKRD45 ankyrin repeat domain 45 2.06316
TBL1X transducin (beta)-like 1X-linked 2.03659
JPH2 junctophilin 2 2.02482
MATN3 matrilin 3 2.02312
RINT1 RAD50 interactor 1 2.02312
MPPED1 metallophosphoesterase domain containing 1 2.01327
DYNC2I2 dynein 2 intermediate chain 2 2.00491

decreased expression

Symbol Name Standardized Value
ALAS2 5'-aminolevulinate synthase 2 -3.608
SH2D6 SH2 domain containing 6 -3.608
POSTN periostin, osteoblast specific factor -3.602
TSPAN1 tetraspanin 1 -3.602
CLEC6A C-type lectin domain family 6, member A -3.602
PRR4 proline rich 4 (lacrimal) -3.602
C1QL3 complement component 1, q subcomponent-like 3 -3.602
FOSB FBJ murine osteosarcoma viral oncogene homolog B -3.602
BCAS1 breast carcinoma amplified sequence 1 -3.602
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 -3.602
TUBB1 tubulin, beta 1 class VI -3.602
F2 coagulation factor II (thrombin) -3.602
GPR26 G protein-coupled receptor 26 -3.602
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -3.602
FIMP1 fertilization-influencing membrane protein 1 -3.602
CFAP276 cilia and flagella associated protein 276 -3.602
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 -3.602
LYPD5 LY6/PLAUR domain containing 5 -3.602
ALDOB aldolase B, fructose-bisphosphate -3.602
TEKT2 tektin 2 (testicular) -3.602
PAGE4 P antigen family, member 4 (prostate associated) -3.602
CLDN34 claudin 34 -3.602
LGALS12 lectin, galactoside-binding, soluble, 12 -3.602
SEZ6L seizure related 6 homolog (mouse)-like -3.602
PEX11G peroxisomal biogenesis factor 11 gamma -3.56151
NCBP2AS2 NCBP2 antisense 2 (head to head) -3.09121
CD164 CD164 molecule, sialomucin -2.90229
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) -2.8718
H2BC8 H2B clustered histone 8 -2.83901
KNOP1 lysine-rich nucleolar protein 1 -2.78612
SCIMP SLP adaptor and CSK interacting membrane protein -2.75849
PRUNE1 prune exopolyphosphatase 1 -2.71437
CLCNKA chloride channel, voltage-sensitive Ka -2.69924
CLIC5 chloride intracellular channel 5 -2.69924
COL4A2 collagen, type IV, alpha 2 -2.66329
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -2.62884
MECP2 methyl CpG binding protein 2 -2.6259
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 -2.48434
AGER advanced glycosylation end product-specific receptor -2.44406
CAPN6 calpain 6 -2.43477
SPA17 sperm autoantigenic protein 17 -2.43183
IFITM2 interferon induced transmembrane protein 2 -2.42908
IPP intracisternal A particle-promoted polypeptide -2.42908
SIX1 SIX homeobox 1 -2.42363
THAP3 THAP domain containing, apoptosis associated protein 3 -2.40206
IGSF21 immunoglobin superfamily, member 21 -2.38739
DTX3 deltex 3, E3 ubiquitin ligase -2.34663
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -2.30812
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 -2.30812
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) -2.29845
HEPHL1 hephaestin-like 1 -2.28492
ZNF396 zinc finger protein 396 -2.28439
KIFAP3 kinesin-associated protein 3 -2.28287
PCSK7 proprotein convertase subtilisin/kexin type 7 -2.27921
TMCC3 transmembrane and coiled-coil domain family 3 -2.27646
TTC5 tetratricopeptide repeat domain 5 -2.27646
LRRC45 leucine rich repeat containing 45 -2.27403
SLC49A3 solute carrier family 49 member 3 -2.26783
NID2 nidogen 2 (osteonidogen) -2.24961
HP1BP3 heterochromatin protein 1, binding protein 3 -2.23361
IL2RB interleukin 2 receptor, beta -2.17771
GSTM4 glutathione S-transferase mu 4 -2.17405
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -2.17405
TTYH3 tweety family member 3 -2.17271
ZNF776 zinc finger protein 776 -2.15768
DOC2B double C2-like domains, beta -2.1486
REEP5 receptor accessory protein 5 -2.13125
SHTN1 shootin 1 -2.1196
RAB11B RAB11B, member RAS oncogene family -2.1196
TNRC6B trinucleotide repeat containing 6B -2.11836
RPL26L1 ribosomal protein L26-like 1 -2.09829
SYNGR3 synaptogyrin 3 -2.0964
XPA xeroderma pigmentosum, complementation group A -2.0964
CDK7 cyclin-dependent kinase 7 -2.05817
C4ORF33 chromosome 4 open reading frame 33 -2.05421
UQCC5 ubiquinol-cytochrome c reductase complex assembly factor 5 -2.03836
GPC3 glypican 3 -2.03722
E2F5 E2F transcription factor 5, p130-binding -2.02482
NCAPD2 non-SMC condensin I complex, subunit D2 -2.02312
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -2.00773
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 -2.00426