MECP2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description methyl CpG binding protein 2|DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq, Jul 2009] (NCBI Entrez Gene Database, 4204)
External Link http://www.ncbi.nlm.nih.gov/gene/4204
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Genes

53 interacting proteins for MECP2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
CAT catalase
CBX1 chromobox homolog 1
CBX3 chromobox homolog 3
CBX5 chromobox homolog 5
CCND1 cyclin D1
CDKL5 cyclin-dependent kinase-like 5
CXCL10 chemokine (C-X-C motif) ligand 10
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ELAVL1 ELAV like RNA binding protein 1
ESR1 estrogen receptor 1
GTF2B general transcription factor IIB
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
HIPK2 homeodomain interacting protein kinase 2
HIST1H4F histone cluster 1, H4f
HIST2H2AC histone cluster 2, H2ac
HIST2H2BE histone cluster 2, H2be
HIST2H3A histone cluster 2, H3a
HMGB1 high mobility group box 1
HPDL 4-hydroxyphenylpyruvate dioxygenase-like
LBR lamin B receptor
NCOR1 nuclear receptor corepressor 1
NRF1 nuclear respiratory factor 1
PPARG peroxisome proliferator-activated receptor gamma
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RCOR1 REST corepressor 1
SIN3A SIN3 transcription regulator family member A
SIN3B SIN3 transcription regulator family member B
SKI SKI proto-oncogene
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SMC3 structural maintenance of chromosomes 3
SOX18 SRY (sex determining region Y)-box 18
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPI1 Spi-1 proto-oncogene
SUMO2 small ubiquitin-like modifier 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TERF2 telomeric repeat binding factor 2
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
UBC ubiquitin C
WHSC1 Wolf-Hirschhorn syndrome candidate 1
XPC xeroderma pigmentosum, complementation group C
YBX1 Y box binding protein 1
YY1 YY1 transcription factor