MEF2D Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description myocyte enhancer factor 2D|This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] (NCBI Entrez Gene Database, 4209)
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Genes

337 genes differentially expressed following the MEF2D gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FGF21 fibroblast growth factor 21 3.8383
UPB1 ureidopropionase, beta 3.8383
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.8383
WT1 Wilms tumor 1 3.8383
MTTP microsomal triglyceride transfer protein 3.8383
BMP8B bone morphogenetic protein 8b 3.8383
LRG1 leucine-rich alpha-2-glycoprotein 1 3.8383
ASPA aspartoacylase 3.8383
SFXN3 sideroflexin 3 3.8383
MFAP5 microfibrillar associated protein 5 3.8383
GPR20 G protein-coupled receptor 20 3.8383
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.8383
HGD homogentisate 1,2-dioxygenase 3.8383
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3.8383
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.8383
CARD18 caspase recruitment domain family, member 18 3.8383
NPAP1 nuclear pore associated protein 1 3.8383
WDR87 WD repeat domain 87 3.8383
LIPH lipase, member H 3.8383
ADGRE3 adhesion G protein-coupled receptor E3 3.8383
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.8383
HEATR9 HEAT repeat containing 9 3.8383
CD160 CD160 molecule 3.8383
MYOM3 myomesin 3 3.8383
GIMAP4 GTPase, IMAP family member 4 3.8383
GALR3 galanin receptor 3 3.8383
GYS2 glycogen synthase 2 (liver) 3.8383
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.8383
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 3.8383
PRR29 proline rich 29 3.8383
PRDM1 PR domain containing 1, with ZNF domain 3.8383
CFAP53 cilia and flagella associated protein 53 3.8383
GRIFIN galectin-related inter-fiber protein 3.8383
FAM9B family with sequence similarity 9, member B 3.8383
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 3.8383
AVP arginine vasopressin 3.8383
MPZ myelin protein zero 3.8383
ZNF792 zinc finger protein 792 3.8383
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 3.8383
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.8383
SMIM5 small integral membrane protein 5 3.8383
CLEC5A C-type lectin domain family 5, member A 3.8383
PLK5 polo-like kinase 5 3.8383
GNRH2 gonadotropin-releasing hormone 2 3.8383
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.8383
CORO6 coronin 6 3.8383
ADH6 alcohol dehydrogenase 6 (class V) 3.8383
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.8383
SPATA31H1 SPATA31 subfamily H member 1 3.8383
PCDHGA9 protocadherin gamma subfamily A, 9 3.8383
ZAR1 zygote arrest 1 3.8383
OPRM1 opioid receptor, mu 1 3.8383
ALX4 ALX homeobox 4 3.8383
TRPC7 transient receptor potential cation channel, subfamily C, member 7 3.8383
SIM1 single-minded family bHLH transcription factor 1 3.8383
GOLGA6L10 golgin A6 family-like 10 3.8383
FRG2C FSHD region gene 2 family, member C 3.8383
TMPRSS7 transmembrane protease, serine 7 3.8383
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.8383
MT3 metallothionein 3 3.8383
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 3.8383
TEX53 testis expressed 53 3.8383
CSP2 CS pseudogene 2 3.8383
H4C15 H4 clustered histone 15 3.8383
CBY2 chibby family member 2 3.8383
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.8383
JAML junction adhesion molecule like 3.8383
PLPP4 phospholipid phosphatase 4 3.8383
GK3 glycerol kinase 3 3.8383
H1-6 H1.6 linker histone, cluster member 3.8383
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.8383
PROC protein C (inactivator of coagulation factors Va and VIIIa) 3.8383
ZNF441 zinc finger protein 441 3.8383
TFEC transcription factor EC 3.8383
CKM creatine kinase, muscle 3.8383
C3ORF80 chromosome 3 open reading frame 80 3.8383
CAPN14 calpain 14 3.8383
ATP13A4 ATPase type 13A4 3.8383
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.8383
WEE2 WEE1 homolog 2 (S. pombe) 3.8383
LOX lysyl oxidase 3.8383
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 3.8383
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 3.8383
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.8383
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 3.8383
IMPG1 interphotoreceptor matrix proteoglycan 1 3.8383
F5 coagulation factor V (proaccelerin, labile factor) 3.8383
GATA4 GATA binding protein 4 3.8383
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 3.8383
PRDM6 PR domain containing 6 3.8383
IL16 interleukin 16 3.8383
ASIC4 acid sensing (proton gated) ion channel family member 4 3.8383
GPR85 G protein-coupled receptor 85 3.8383
LRRC71 leucine rich repeat containing 71 3.8383
PLEK2 pleckstrin 2 3.8383
EGFLAM EGF-like, fibronectin type III and laminin G domains 3.8383
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 3.8383
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.8383
ARR3 arrestin 3, retinal (X-arrestin) 3.8383
CLRN1 clarin 1 3.8383
CYSLTR1 cysteinyl leukotriene receptor 1 3.8383
EMX2 empty spiracles homeobox 2 3.8383
GML glycosylphosphatidylinositol anchored molecule like 3.8383
PKDREJ polycystin (PKD) family receptor for egg jelly 3.8383
CDH19 cadherin 19, type 2 3.8383
RANBP3L RAN binding protein 3-like 3.8383
EMP1 epithelial membrane protein 1 3.8383
THTPA thiamine triphosphatase 3.8383
KLHL1 kelch-like family member 1 3.8383
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 3.8383
KRT17 keratin 17, type I 3.8383
LRRC36 leucine rich repeat containing 36 3.8383
CCDC152 coiled-coil domain containing 152 3.8383
FNDC8 fibronectin type III domain containing 8 3.8383
ZNF132 zinc finger protein 132 3.8383
AKR1B15 aldo-keto reductase family 1, member B15 3.8383
POF1B premature ovarian failure, 1B 3.8383
SV2B synaptic vesicle glycoprotein 2B 3.8383
CGB2 chorionic gonadotropin, beta polypeptide 2 3.8383
TBXA2R thromboxane A2 receptor 3.8383
VAV1 vav 1 guanine nucleotide exchange factor 3.8383
CTSO cathepsin O 3.8383
DAPL1 death associated protein-like 1 3.8383
CSF1R colony stimulating factor 1 receptor 3.8383
OPTC opticin 3.8383
LAMB4 laminin, beta 4 3.8383
FKBP1C FK506 binding protein 1C 3.8383
ZNF835 zinc finger protein 835 3.8383
ZNF831 zinc finger protein 831 3.8383
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.8383
ITGB7 integrin, beta 7 3.8383
NUPR1 nuclear protein, transcriptional regulator, 1 3.8383
ACKR5 atypical chemokine receptor 5 3.8383
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 3.8383
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 3.8383
ISL2 ISL LIM homeobox 2 3.8383
TEKT5 tektin 5 3.8383
CNGB3 cyclic nucleotide gated channel beta 3 3.8383
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 3.8383
IL9R interleukin 9 receptor 3.8383
FNDC9 fibronectin type III domain containing 9 3.8383
TMEM156 transmembrane protein 156 3.8383
TICAM1 toll-like receptor adaptor molecule 1 3.8383
AREG amphiregulin 3.8383
NUTM2D NUT family member 2D 3.8383
NLRP1 NLR family, pyrin domain containing 1 3.8383
SP100 SP100 nuclear antigen 3.8383
POTEJ POTE ankyrin domain family, member J 3.8383
CD8B CD8b molecule 3.8383
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.8383
DRICH1 aspartate-rich 1 3.8383
SGMS2 sphingomyelin synthase 2 3.8383
CHRM1 cholinergic receptor, muscarinic 1 3.8383
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.8383
SUN3 Sad1 and UNC84 domain containing 3 3.8383
ACADL acyl-CoA dehydrogenase, long chain 3.8383
BOLL boule-like RNA-binding protein 3.8383
TTC36 tetratricopeptide repeat domain 36 3.8383
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.8383
A1CF APOBEC1 complementation factor 3.8383
TSSK1B testis-specific serine kinase 1B 3.8383
ITLN1 intelectin 1 (galactofuranose binding) 3.8383
PITX2 paired-like homeodomain 2 3.8383
C17ORF78 chromosome 17 open reading frame 78 3.8383
AGBL4 ATP/GTP binding protein-like 4 3.8383
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 3.8383
CLPSL1 colipase-like 1 3.8383
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 3.68208
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 3.68208
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 3.65824
DVL2 dishevelled segment polarity protein 2 3.1628
SPPL2B signal peptide peptidase like 2B 3.14951
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 3.13591
IPMK inositol polyphosphate multikinase 2.96371
PCNX4 pecanex 4 2.91939
IL15RA interleukin 15 receptor, alpha 2.91751
PLEKHA7 pleckstrin homology domain containing, family A member 7 2.7559
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 2.74296
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) 2.72597
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 2.70649
PSD3 pleckstrin and Sec7 domain containing 3 2.68783
DYNLL2 dynein, light chain, LC8-type 2 2.6507
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 2.63296
NT5E 5'-nucleotidase, ecto (CD73) 2.62344
PEBP4 phosphatidylethanolamine-binding protein 4 2.62344
TP53INP2 tumor protein p53 inducible nuclear protein 2 2.62344
ACOT13 acyl-CoA thioesterase 13 2.60041
CEBPZOS CEBPZ opposite strand 2.51795
TGFB2 transforming growth factor, beta 2 2.51795
TSGA10IP testis specific, 10 interacting protein 2.51795
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 2.51206
SPEG SPEG complex locus 2.49776
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 2.48392
CBX4 chromobox homolog 4 2.48392
CCNYL1 cyclin Y-like 1 2.48082
KIF14 kinesin family member 14 2.43409
TMEM179 transmembrane protein 179 2.42803
MAGEF1 melanoma antigen family F1 2.41137
FAM193B family with sequence similarity 193, member B 2.41005
TJAP1 tight junction associated protein 1 (peripheral) 2.40268
ZNF423 zinc finger protein 423 2.39685
AIF1L allograft inflammatory factor 1-like 2.39133
RPL37A ribosomal protein L37a 2.38996
HEXD hexosaminidase D 2.37335
TCL1B T-cell leukemia/lymphoma 1B 2.33699
GAL3ST3 galactose-3-O-sulfotransferase 3 2.32094
RALBP1 ralA binding protein 1 2.29074
ZNF578 zinc finger protein 578 2.27874
ZCCHC2 zinc finger, CCHC domain containing 2 2.27163
MPV17L2 MPV17 mitochondrial membrane protein-like 2 2.27041
PCDHB9 protocadherin beta 9 2.25857
DRC3 dynein regulatory complex subunit 3 2.25857
IKZF2 IKAROS family zinc finger 2 (Helios) 2.25056
TRIM24 tripartite motif containing 24 2.25031
LMCD1 LIM and cysteine-rich domains 1 2.23091
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 2.20853
FDX1 ferredoxin 1 2.17777
COQ4 coenzyme Q4 2.17734
KIF9 kinesin family member 9 2.14128
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 2.11995
SPIN3 spindlin family, member 3 2.0991
ZNF280B zinc finger protein 280B 2.09768
NSMCE3 NSE3 homolog, SMC5-SMC6 complex component 2.07287
PPP1R42 protein phosphatase 1, regulatory subunit 42 2.0659
NAIF1 nuclear apoptosis inducing factor 1 2.0659
ZNF417 zinc finger protein 417 2.05887
PTS 6-pyruvoyltetrahydropterin synthase 2.03945
MLXIP MLX interacting protein 2.03581
DNAAF5 dynein, axonemal, assembly factor 5 2.03382
THBS1 thrombospondin 1 2.03214
MZT2B mitotic spindle organizing protein 2B 2.02935
SLCO4C1 solute carrier organic anion transporter family, member 4C1 2.01042
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 2.01042
NAXE NAD(P)HX epimerase 2.01042

decreased expression

Symbol Name Standardized Value
OAF OAF homolog (Drosophila) -3.8383
SMTNL1 smoothelin-like 1 -3.8383
SMTNL2 smoothelin-like 2 -3.8383
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -3.8383
ZNF879 zinc finger protein 879 -3.8383
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) -3.8383
IL23A interleukin 23, alpha subunit p19 -3.8383
SPDEF SAM pointed domain containing ETS transcription factor -3.8383
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -3.8383
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.8383
ARGFX arginine-fifty homeobox -3.8383
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 -3.8383
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) -3.8383
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -3.8383
FAM229A family with sequence similarity 229, member A -3.8383
BST1 bone marrow stromal cell antigen 1 -3.8383
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -3.8383
TMIE transmembrane inner ear -3.8383
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -3.8383
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 -3.8383
ALG1L2 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 2 -3.8383
CCDC121 coiled-coil domain containing 121 -3.8383
PRG4 proteoglycan 4 -3.8383
CCDC60 coiled-coil domain containing 60 -3.8383
LYNX1 Ly6/neurotoxin 1 -3.8383
CSAG3 CSAG family, member 3 -3.8383
PCDH8 protocadherin 8 -3.8383
AK8 adenylate kinase 8 -3.8383
PRSS50 protease, serine, 50 -3.8383
CAMK2A calcium/calmodulin-dependent protein kinase II alpha -3.8383
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 -3.8383
EBF2 early B-cell factor 2 -3.8383
APOB apolipoprotein B -3.8383
SPEF2 sperm flagellar 2 -3.8383
TMEM278 transmembrane protein 278 -3.8383
OR3A2 olfactory receptor, family 3, subfamily A, member 2 -3.8383
NSG2 neuronal vesicle trafficking associated 2 -3.8383
KMT2C lysine (K)-specific methyltransferase 2C -3.69279
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -3.58657
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -3.52371
NCBP2AS2 NCBP2 antisense 2 (head to head) -3.36572
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) -3.29632
NIPAL2 NIPA-like domain containing 2 -3.29632
KCNK17 potassium channel, two pore domain subfamily K, member 17 -3.29632
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -3.29118
EWSR1 EWS RNA-binding protein 1 -3.13591
SOAT1 sterol O-acyltransferase 1 -3.04114
RAB24 RAB24, member RAS oncogene family -2.99231
ZNF217 zinc finger protein 217 -2.97013
DENND1C DENN/MADD domain containing 1C -2.95115
CRYBG2 crystallin beta-gamma domain containing 2 -2.86395
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -2.82955
SET SET nuclear proto-oncogene -2.82106
IMP3 IMP3, U3 small nucleolar ribonucleoprotein -2.76857
GGT1 gamma-glutamyltransferase 1 -2.7559
TAMALIN trafficking regulator and scaffold protein tamalin -2.7559
TM9SF1 transmembrane 9 superfamily member 1 -2.68927
WASL Wiskott-Aldrich syndrome-like -2.62954
NR1H2 nuclear receptor subfamily 1, group H, member 2 -2.5996
NKAIN1 Na+/K+ transporting ATPase interacting 1 -2.56087
CNR1 cannabinoid receptor 1 (brain) -2.48392
BMP1 bone morphogenetic protein 1 -2.48392
FAM168B family with sequence similarity 168, member B -2.44137
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.43409
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -2.42165
FAM24B family with sequence similarity 24, member B -2.42165
C9ORF153 chromosome 9 open reading frame 153 -2.36384
SLC25A39 solute carrier family 25, member 39 -2.36384
SEC14L6 SEC14-like 6 (S. cerevisiae) -2.36384
CCDC30 coiled-coil domain containing 30 -2.33723
EXOC6 exocyst complex component 6 -2.32323
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -2.32094
SNAP25 synaptosomal-associated protein, 25kDa -2.32094
CDC73 cell division cycle 73 -2.30561
ZNF470 zinc finger protein 470 -2.27163
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) -2.26602
ARHGAP8 Rho GTPase activating protein 8 -2.25857
AKAP12 A kinase (PRKA) anchor protein 12 -2.25857
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 -2.25056
EIF5 eukaryotic translation initiation factor 5 -2.23681
CACNG7 calcium channel, voltage-dependent, gamma subunit 7 -2.21184
KRABD3 KRAB domain containing 3 -2.20917
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 -2.20853
SAP130 Sin3A-associated protein, 130kDa -2.2059
DRG2 developmentally regulated GTP binding protein 2 -2.14094
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -2.13718
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -2.13704
SH2B1 SH2B adaptor protein 1 -2.11207
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -2.10231
LCA5 Leber congenital amaurosis 5 -2.10227
WDR6 WD repeat domain 6 -2.09347
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 -2.08655
ZNF468 zinc finger protein 468 -2.08655
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.07287
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -2.04884
TRIP12 thyroid hormone receptor interactor 12 -2.04544
KIF17 kinesin family member 17 -2.02989
GINS4 GINS complex subunit 4 (Sld5 homolog) -2.02935
NPR1 natriuretic peptide receptor 1 -2.02833
KRT19 keratin 19, type I -2.0261
BBLN bublin coiled coil protein -2.02286
TENT4B terminal nucleotidyltransferase 4B -2.02286
EYA3 EYA transcriptional coactivator and phosphatase 3 -2.01416