MEK1 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase kinase 1|The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5604)
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Genes

100 substrates of the kinase MEK1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
DCLRE1C DNA cross-link repair 1C
MYOM1 myomesin 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
ACIN1 apoptotic chromatin condensation inducer 1
CHGB chromogranin B
TTN titin
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
CASP9 caspase 9, apoptosis-related cysteine peptidase
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
FAM46D family with sequence similarity 46, member D
CCDC88A coiled-coil domain containing 88A
ALYREF Aly/REF export factor
UFC1 ubiquitin-fold modifier conjugating enzyme 1
RBMX RNA binding motif protein, X-linked
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
THSD1 thrombospondin, type I, domain containing 1
SPEN spen family transcriptional repressor
GAPDH glyceraldehyde-3-phosphate dehydrogenase
PPAP2A phosphatidic acid phosphatase type 2A
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SDCBP syndecan binding protein (syntenin)
PSIP1 PC4 and SFRS1 interacting protein 1
SCAF1 SR-related CTD-associated factor 1
RBM7 RNA binding motif protein 7
GCLM glutamate-cysteine ligase, modifier subunit
SELPLG selectin P ligand
WIPF2 WAS/WASL interacting protein family, member 2
RAI14 retinoic acid induced 14
STYX serine/threonine/tyrosine interacting protein
HNF1B HNF1 homeobox B
IQGAP3 IQ motif containing GTPase activating protein 3
NADK NAD kinase
NCKIPSD NCK interacting protein with SH3 domain
HTATSF1 HIV-1 Tat specific factor 1
SUCLG1 succinate-CoA ligase, alpha subunit
ALDOA aldolase A, fructose-bisphosphate
DLC1 DLC1 Rho GTPase activating protein
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
PLEKHA6 pleckstrin homology domain containing, family A member 6
AIP aryl hydrocarbon receptor interacting protein
ZNF780B zinc finger protein 780B
KLF10 Kruppel-like factor 10
ZNF174 zinc finger protein 174
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
UNG uracil-DNA glycosylase
PARK2 parkin RBR E3 ubiquitin protein ligase
MEOX2 mesenchyme homeobox 2
GPATCH8 G patch domain containing 8
SPATS2 spermatogenesis associated, serine-rich 2
RAD9A RAD9 homolog A (S. pombe)
PGK1 phosphoglycerate kinase 1
CD99L2 CD99 molecule-like 2
DVL3 dishevelled segment polarity protein 3
TBC1D10C TBC1 domain family, member 10C
MAT2B methionine adenosyltransferase II, beta
TUBB tubulin, beta class I
SYNM synemin, intermediate filament protein
MALT1 MALT1 paracaspase
RBMXL1 RNA binding motif protein, X-linked-like 1
APP amyloid beta (A4) precursor protein
PGK2 phosphoglycerate kinase 2
CBX3 chromobox homolog 3
STAMBP STAM binding protein
MB myoglobin
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
PHF3 PHD finger protein 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
CDR2L cerebellar degeneration-related protein 2-like
HVCN1 hydrogen voltage gated channel 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
PARD3B par-3 family cell polarity regulator beta
PPP6R2 protein phosphatase 6, regulatory subunit 2
TCF12 transcription factor 12
ZNF395 zinc finger protein 395
RBM15B RNA binding motif protein 15B
STAG2 stromal antigen 2
SETD2 SET domain containing 2
FAM161A family with sequence similarity 161, member A
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
ANXA2 annexin A2
CDC25B cell division cycle 25B
GRAP2 GRB2-related adaptor protein 2
CCM2 cerebral cavernous malformation 2
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
RAI1 retinoic acid induced 1
CCDC6 coiled-coil domain containing 6
CCDC9 coiled-coil domain containing 9
KRT19 keratin 19, type I
BMP2K BMP2 inducible kinase
BLVRA biliverdin reductase A
CEP170 centrosomal protein 170kDa
C12ORF10 chromosome 12 open reading frame 10
SSH2 slingshot protein phosphatase 2