MEK162 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/10288191
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Genes

198 proteins with high or low expression in MEK162 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ALPP alkaline phosphatase, placental 2.91
ARID5B AT rich interactive domain 5B (MRF1-like) 2.72
CLIC3 chloride intracellular channel 3 2.6
KLHDC8B kelch domain containing 8B 2.33
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 2.32
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.28
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.23
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 2.1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.03
IRF9 interferon regulatory factor 9 1.98
TACSTD2 tumor-associated calcium signal transducer 2 1.93
PPL periplakin 1.91
LAMB2 laminin, beta 2 (laminin S) 1.89
ABAT 4-aminobutyrate aminotransferase 1.84
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 1.74
CLU clusterin 1.68
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 1.66
TJP3 tight junction protein 3 1.62
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 1.53
AHNAK2 AHNAK nucleoprotein 2 1.49
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 1.43
DTX3L deltex 3 like, E3 ubiquitin ligase 1.41
DPP4 dipeptidyl-peptidase 4 1.4
RBL2 retinoblastoma-like 2 1.4
ITGB8 integrin, beta 8 1.39
PARP9 poly (ADP-ribose) polymerase family, member 9 1.38
ARG2 arginase 2 1.37
CCDC102A coiled-coil domain containing 102A 1.35
VWA5A von Willebrand factor A domain containing 5A 1.35
TM7SF2 transmembrane 7 superfamily member 2 1.32
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.3
SYBU syntabulin (syntaxin-interacting) 1.29
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.28
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 1.25
CDA cytidine deaminase 1.23
HMOX1 heme oxygenase 1 1.18
AMACR alpha-methylacyl-CoA racemase 1.18
RBM47 RNA binding motif protein 47 1.18
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 1.18
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 1.17
BCAM basal cell adhesion molecule (Lutheran blood group) 1.17
EPN3 epsin 3 1.15
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.15
CRIP2 cysteine-rich protein 2 1.15
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.13
MAP2 microtubule-associated protein 2 1.13
GPC1 glypican 1 1.12
PLD1 phospholipase D1, phosphatidylcholine-specific 1.11
HID1 HID1 domain containing 1.1
MSRB2 methionine sulfoxide reductase B2 1.1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 1.1
OPTN optineurin 1.09
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.08
L1CAM L1 cell adhesion molecule 1.07
OASL 2'-5'-oligoadenylate synthetase-like 1.07
SAMD9 sterile alpha motif domain containing 9 1.06
APOL2 apolipoprotein L, 2 1.06
SLC44A2 solute carrier family 44 (choline transporter), member 2 1.06
NIPSNAP3A nipsnap homolog 3A (C. elegans) 1.05
MSLN mesothelin 1.05
TNS3 tensin 3 1.04
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.04
ALPK3 alpha-kinase 3 1.04
GSDME gasdermin E 1.04
PALM3 paralemmin 3 1.03
TSC22D4 TSC22 domain family, member 4 1.02
TLL2 tolloid-like 2 1.02
PGM2L1 phosphoglucomutase 2-like 1 1.01
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 1.01
NPTXR neuronal pentraxin receptor 1.01
CGN cingulin 1.01
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 1.0
SYTL1 synaptotagmin-like 1 1.0
AASS aminoadipate-semialdehyde synthase 1.0
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 0.99
MTUS1 microtubule associated tumor suppressor 1 0.98
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 0.98
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 0.97
UNC13D unc-13 homolog D (C. elegans) 0.97
NEU1 sialidase 1 (lysosomal sialidase) 0.96
WDTC1 WD and tetratricopeptide repeats 1 0.96
ELMO3 engulfment and cell motility 3 0.96
TUFT1 tuftelin 1 0.96
CRABP2 cellular retinoic acid binding protein 2 0.96
FTH1 ferritin, heavy polypeptide 1 0.96
BDH2 3-hydroxybutyrate dehydrogenase, type 2 0.95
PHLDB1 pleckstrin homology-like domain, family B, member 1 0.95
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.95
PLCD1 phospholipase C, delta 1 0.95
FBXL8 F-box and leucine-rich repeat protein 8 0.95
MRAS muscle RAS oncogene homolog 0.94
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.94
C6ORF132 chromosome 6 open reading frame 132 0.94
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.94
CAPN5 calpain 5 0.93
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 0.93
KLK7 kallikrein-related peptidase 7 0.92
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.92

low expression

Symbol Name Standardized Value
NEIL3 nei endonuclease VIII-like 3 (E. coli) -3.4
CCNA2 cyclin A2 -2.74
DUOX1 dual oxidase 1 -2.6
RRM2 ribonucleotide reductase M2 -2.58
DUSP4 dual specificity phosphatase 4 -2.55
ANLN anillin, actin binding protein -2.55
GMNN geminin, DNA replication inhibitor -2.54
CCNB1 cyclin B1 -2.51
CLSPN claspin -2.5
DUSP6 dual specificity phosphatase 6 -2.44
TPX2 TPX2, microtubule-associated -2.4
CCNB2 cyclin B2 -2.4
PCLAF PCNA clamp associated factor -2.38
CCNA1 cyclin A1 -2.36
CDCA5 cell division cycle associated 5 -2.35
PLK1 polo-like kinase 1 -2.34
AURKA aurora kinase A -2.32
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.29
TACC3 transforming, acidic coiled-coil containing protein 3 -2.26
EXO1 exonuclease 1 -2.23
CKAP2 cytoskeleton associated protein 2 -2.21
AURKB aurora kinase B -2.21
PTTG1 pituitary tumor-transforming 1 -2.2
CDCA8 cell division cycle associated 8 -2.17
TK1 thymidine kinase 1, soluble -2.17
TOP2A topoisomerase (DNA) II alpha 170kDa -2.15
TNS4 tensin 4 -2.14
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -2.14
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -2.13
BIRC5 baculoviral IAP repeat containing 5 -2.12
CKAP2L cytoskeleton associated protein 2-like -2.12
PRC1 protein regulator of cytokinesis 1 -2.11
KIF2C kinesin family member 2C -2.11
FOSL1 FOS-like antigen 1 -2.09
INCENP inner centromere protein antigens 135/155kDa -2.08
KIF22 kinesin family member 22 -2.08
AEN apoptosis enhancing nuclease -2.08
GTSE1 G-2 and S-phase expressed 1 -2.07
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.04
CENPF centromere protein F, 350/400kDa -2.0
DONSON downstream neighbor of SON -2.0
UBE2C ubiquitin-conjugating enzyme E2C -2.0
FBXO5 F-box protein 5 -1.99
CDCA2 cell division cycle associated 2 -1.98
KIF20A kinesin family member 20A -1.97
KIF11 kinesin family member 11 -1.96
CDC20 cell division cycle 20 -1.96
PRR11 proline rich 11 -1.93
E2F7 E2F transcription factor 7 -1.93
UBE2S ubiquitin-conjugating enzyme E2S -1.91
SACK1D scaffolding CK1 anchoring protein D -1.89
CENPE centromere protein E, 312kDa -1.89
SGO1 shugoshin 1 -1.88
NUSAP1 nucleolar and spindle associated protein 1 -1.88
CDCA3 cell division cycle associated 3 -1.86
BCORL1 BCL6 corepressor-like 1 -1.85
WDR76 WD repeat domain 76 -1.85
SHCBP1 SHC SH2-domain binding protein 1 -1.84
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -1.82
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -1.82
SLBP stem-loop binding protein -1.81
ZNF367 zinc finger protein 367 -1.8
PSRC1 proline/serine-rich coiled-coil 1 -1.8
CDCA7 cell division cycle associated 7 -1.79
SPRY4 sprouty homolog 4 (Drosophila) -1.79
STIL SCL/TAL1 interrupting locus -1.75
ZWINT ZW10 interacting kinetochore protein -1.73
CDC6 cell division cycle 6 -1.72
USP37 ubiquitin specific peptidase 37 -1.7
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -1.69
MCM10 minichromosome maintenance complex component 10 -1.68
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -1.68
SOX9 SRY (sex determining region Y)-box 9 -1.67
SPDL1 spindle apparatus coiled-coil protein 1 -1.66
EPHA2 EPH receptor A2 -1.66
MIS18BP1 MIS18 binding protein 1 -1.65
ARHGAP11A Rho GTPase activating protein 11A -1.65
KIF18B kinesin family member 18B -1.65
KIF20B kinesin family member 20B -1.64
C5ORF34 chromosome 5 open reading frame 34 -1.64
ORC6 origin recognition complex, subunit 6 -1.64
SASS6 spindle assembly 6 homolog (C. elegans) -1.64
PIMREG PICALM interacting mitotic regulator -1.64
CCNE2 cyclin E2 -1.63
KMT5A lysine methyltransferase 5A -1.63
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -1.63
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -1.62
TTK TTK protein kinase -1.62
CCNF cyclin F -1.61
ATAD2 ATPase family, AAA domain containing 2 -1.59
KIFC1 kinesin family member C1 -1.59
CDC7 cell division cycle 7 -1.59
TROAP trophinin associated protein -1.58
RAD54L RAD54-like (S. cerevisiae) -1.58
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -1.57
RAD51 RAD51 recombinase -1.55
DEPDC1 DEP domain containing 1 -1.54
F3 coagulation factor III (thromboplastin, tissue factor) -1.52
ECT2 epithelial cell transforming 2 -1.52