MEK2 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase kinase 2|The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5605)
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100 substrates of the kinase MEK2 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase
MICALL2 MICAL-like 2
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
PKP3 plakophilin 3
PKP2 plakophilin 2
DCBLD2 discoidin, CUB and LCCL domain containing 2
FAM46D family with sequence similarity 46, member D
ACTG1 actin gamma 1
PASK PAS domain containing serine/threonine kinase
TMF1 TATA element modulatory factor 1
OSBPL3 oxysterol binding protein-like 3
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8
PPAP2A phosphatidic acid phosphatase type 2A
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
RBM7 RNA binding motif protein 7
UFC1 ubiquitin-fold modifier conjugating enzyme 1
MYOM1 myomesin 1
CCDC85C coiled-coil domain containing 85C
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2
TTN titin
EGFR epidermal growth factor receptor
ECT2 epithelial cell transforming 2
ADAR adenosine deaminase, RNA-specific
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
CHEK2 checkpoint kinase 2
IGF1R insulin-like growth factor 1 receptor
PBRM1 polybromo 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
RAI14 retinoic acid induced 14
MAPK7 mitogen-activated protein kinase 7
ANO6 anoctamin 6
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ACTA1 actin, alpha 1, skeletal muscle
UBAP1 ubiquitin associated protein 1
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
SELPLG selectin P ligand
BCAR3 breast cancer anti-estrogen resistance 3
AIP aryl hydrocarbon receptor interacting protein
NDRG1 N-myc downstream regulated 1
TAOK2 TAO kinase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
AHNAK AHNAK nucleoprotein
KLF10 Kruppel-like factor 10
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
SPATS2 spermatogenesis associated, serine-rich 2
ABI1 abl-interactor 1
BAIAP2L1 BAI1-associated protein 2-like 1
CTBP2 C-terminal binding protein 2
SPANXN2 SPANX family, member N2
ACTC1 actin, alpha, cardiac muscle 1
TP53BP1 tumor protein p53 binding protein 1
PRKCSH protein kinase C substrate 80K-H
TUBB tubulin, beta class I
HDAC4 histone deacetylase 4
HDAC7 histone deacetylase 7
SYNM synemin, intermediate filament protein
PGK1 phosphoglycerate kinase 1
PGK2 phosphoglycerate kinase 2
CBX3 chromobox homolog 3
ACTN2 actinin, alpha 2
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
AGMO alkylglycerol monooxygenase
CALCOCO2 calcium binding and coiled-coil domain 2
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SAMD9 sterile alpha motif domain containing 9
CDR2L cerebellar degeneration-related protein 2-like
CCM2 cerebral cavernous malformation 2
C12ORF10 chromosome 12 open reading frame 10
CDC25B cell division cycle 25B
BRAF B-Raf proto-oncogene, serine/threonine kinase
SETD2 SET domain containing 2
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
CENPU centromere protein U
CENPT centromere protein T
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
STK38 serine/threonine kinase 38
PLK4 polo-like kinase 4
TRPM7 transient receptor potential cation channel, subfamily M, member 7
ACTB actin, beta
POTEE POTE ankyrin domain family, member E
INSR insulin receptor
TRIP6 thyroid hormone receptor interactor 6
CCDC6 coiled-coil domain containing 6
BANK1 B-cell scaffold protein with ankyrin repeats 1
CLK1 CDC-like kinase 1
CLK4 CDC-like kinase 4
BMP2K BMP2 inducible kinase
POTEJ POTE ankyrin domain family, member J
POTEI POTE ankyrin domain family, member I
POTEF POTE ankyrin domain family, member F
NQO1 NAD(P)H dehydrogenase, quinone 1