MEK5 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase kinase 5|The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011] (NCBI Entrez Gene Database, 5607)
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100 substrates of the kinase MEK5 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
IRS1 insulin receptor substrate 1
RAB1A RAB1A, member RAS oncogene family
RAB1B RAB1B, member RAS oncogene family
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
EGFR epidermal growth factor receptor
BAHD1 bromo adjacent homology domain containing 1
GCLM glutamate-cysteine ligase, modifier subunit
AIP aryl hydrocarbon receptor interacting protein
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
TAOK1 TAO kinase 1
RAB10 RAB10, member RAS oncogene family
NCF4 neutrophil cytosolic factor 4, 40kDa
CASP9 caspase 9, apoptosis-related cysteine peptidase
ALYREF Aly/REF export factor
MYOM1 myomesin 1
CCDC85C coiled-coil domain containing 85C
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
TTN titin
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
TAOK2 TAO kinase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
RAI14 retinoic acid induced 14
FRMD4B FERM domain containing 4B
RAB35 RAB35, member RAS oncogene family
ANO6 anoctamin 6
CREBBP CREB binding protein
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
TRPC1 transient receptor potential cation channel, subfamily C, member 1
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
NADK NAD kinase
FRK fyn-related Src family tyrosine kinase
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EXPH5 exophilin 5
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
S1PR1 sphingosine-1-phosphate receptor 1
PRKCD protein kinase C, delta
RPL15 ribosomal protein L15
GPATCH8 G patch domain containing 8
SYK spleen tyrosine kinase
SNRK SNF related kinase
STK26 serine/threonine protein kinase 26
GIPC1 GIPC PDZ domain containing family, member 1
LPAR1 lysophosphatidic acid receptor 1
BAIAP2L1 BAI1-associated protein 2-like 1
HNRNPF heterogeneous nuclear ribonucleoprotein F
RPL4 ribosomal protein L4
KLF4 Kruppel-like factor 4 (gut)
KLF2 Kruppel-like factor 2
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
DAPK3 death-associated protein kinase 3
HDAC4 histone deacetylase 4
MAP3K11 mitogen-activated protein kinase kinase kinase 11
SYNM synemin, intermediate filament protein
PGK1 phosphoglycerate kinase 1
PGK2 phosphoglycerate kinase 2
CBX3 chromobox homolog 3
ITCH itchy E3 ubiquitin protein ligase
DFNA5 deafness, autosomal dominant 5
RASA1 RAS p21 protein activator (GTPase activating protein) 1
SLK STE20-like kinase
TPD52L2 tumor protein D52-like 2
CYTH2 cytohesin 2
FGG fibrinogen gamma chain
PCM1 pericentriolar material 1
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
PNP purine nucleoside phosphorylase
CDR2L cerebellar degeneration-related protein 2-like
DCLRE1C DNA cross-link repair 1C
P4HB prolyl 4-hydroxylase, beta polypeptide
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
IL2RA interleukin 2 receptor, alpha
TBC1D4 TBC1 domain family, member 4
LARP1 La ribonucleoprotein domain family, member 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
WIBG within bgcn homolog (Drosophila)
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
RBM15B RNA binding motif protein 15B
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
ARHGAP21 Rho GTPase activating protein 21
MYOD1 myogenic differentiation 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
KRT18 keratin 18, type I
CLK2 CDC-like kinase 2
RAB8B RAB8B, member RAS oncogene family
RAB8A RAB8A, member RAS oncogene family
BLVRA biliverdin reductase A
BRAF B-Raf proto-oncogene, serine/threonine kinase
SETD1A SET domain containing 1A
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3