MEKK1 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase|The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 4214)
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100 substrates of the kinase MEKK1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
RRAS related RAS viral (r-ras) oncogene homolog
MYBPC2 myosin binding protein C, fast type
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
PKP1 plakophilin 1
MADD MAP-kinase activating death domain
TNRC6B trinucleotide repeat containing 6B
RNF219 ring finger protein 219
CSRP2 cysteine and glycine-rich protein 2
CD5 CD5 molecule
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
NF1 neurofibromin 1
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
TUBB8 tubulin, beta 8 class VIII
TUBB6 tubulin, beta 6 class V
TUBB3 tubulin, beta 3 class III
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
TTN titin
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2
REPS1 RALBP1 associated Eps domain containing 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
PTPRA protein tyrosine phosphatase, receptor type, A
GSR glutathione reductase
SOCS6 suppressor of cytokine signaling 6
ARHGAP17 Rho GTPase activating protein 17
FOXK2 forkhead box K2
FOXK1 forkhead box K1
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
UFL1 UFM1-specific ligase 1
PRRC2B proline-rich coiled-coil 2B
GIPC1 GIPC PDZ domain containing family, member 1
TUBB2B tubulin, beta 2B class IIb
TUBB2A tubulin, beta 2A class IIa
STK26 serine/threonine protein kinase 26
IRF5 interferon regulatory factor 5
PTGDR2 prostaglandin D2 receptor 2
ARF3 ADP-ribosylation factor 3
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
UNK unkempt family zinc finger
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
ZNF638 zinc finger protein 638
SYK spleen tyrosine kinase
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
GIPC3 GIPC PDZ domain containing family, member 3
LPAR1 lysophosphatidic acid receptor 1
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRKD2 protein kinase D2
MCTS1 malignant T cell amplified sequence 1
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
POF1B premature ovarian failure, 1B
TUBB tubulin, beta class I
PNP purine nucleoside phosphorylase
CDR2L cerebellar degeneration-related protein 2-like
PKD2 polycystic kidney disease 2 (autosomal dominant)
PRKCDBP protein kinase C, delta binding protein
BAIAP2L1 BAI1-associated protein 2-like 1
NOSIP nitric oxide synthase interacting protein
RPS28 ribosomal protein S28
VPS13B vacuolar protein sorting 13 homolog B (yeast)
ILF3 interleukin enhancer binding factor 3, 90kDa
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
RASA1 RAS p21 protein activator (GTPase activating protein) 1
ABLIM1 actin binding LIM protein 1
DYNLT1 dynein, light chain, Tctex-type 1
ZAK sterile alpha motif and leucine zipper containing kinase AZK
PTDSS1 phosphatidylserine synthase 1
DSP desmoplakin
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
CLASP1 cytoplasmic linker associated protein 1
UPK3BL uroplakin 3B-like
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
MAP3K7 mitogen-activated protein kinase kinase kinase 7
FLOT1 flotillin 1
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
CCDC85C coiled-coil domain containing 85C
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
LMCD1 LIM and cysteine-rich domains 1
FOXO1 forkhead box O1
JPH1 junctophilin 1
BLVRA biliverdin reductase A
JUP junction plakoglobin
TRPM7 transient receptor potential cation channel, subfamily M, member 7
CGN cingulin
FOXO3 forkhead box O3
CAPZB capping protein (actin filament) muscle Z-line, beta
TGM1 transglutaminase 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
CORO1A coronin, actin binding protein, 1A