MEKK2 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase kinase kinase 2|The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10746)
Similar Terms
Downloads & Tools

Genes

100 substrates of the kinase MEKK2 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
STK4 serine/threonine kinase 4
EPS8L1 EPS8-like 1
EPS8L2 EPS8-like 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
PLEC plectin
GCLM glutamate-cysteine ligase, modifier subunit
SELPLG selectin P ligand
PTMA prothymosin, alpha
SRSF1 serine/arginine-rich splicing factor 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
PKP4 plakophilin 4
C11ORF52 chromosome 11 open reading frame 52
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
EPS8 epidermal growth factor receptor pathway substrate 8
CCDC85C coiled-coil domain containing 85C
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
ARHGAP32 Rho GTPase activating protein 32
TTN titin
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
LUC7L2 LUC7-like 2 (S. cerevisiae)
ZBTB48 zinc finger and BTB domain containing 48
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
SCAMP4 secretory carrier membrane protein 4
ZMYM3 zinc finger, MYM-type 3
ATRIP ATR interacting protein
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYH1 myosin, heavy chain 1, skeletal muscle, adult
MYH9 myosin, heavy chain 9, non-muscle
PRRC2B proline-rich coiled-coil 2B
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
FRMD4B FERM domain containing 4B
METAP2 methionyl aminopeptidase 2
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
CDK1 cyclin-dependent kinase 1
SNRK SNF related kinase
ANLN anillin, actin binding protein
MYH13 myosin, heavy chain 13, skeletal muscle
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
STK26 serine/threonine protein kinase 26
MTSS1 metastasis suppressor 1
GMPS guanine monphosphate synthase
TTC7A tetratricopeptide repeat domain 7A
GIPC1 GIPC PDZ domain containing family, member 1
UFD1L ubiquitin fusion degradation 1 like (yeast)
DSP desmoplakin
NOSIP nitric oxide synthase interacting protein
PGK2 phosphoglycerate kinase 2
PGK1 phosphoglycerate kinase 1
RPL4 ribosomal protein L4
DKC1 dyskeratosis congenita 1, dyskerin
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
SYNM synemin, intermediate filament protein
PNP purine nucleoside phosphorylase
MET MET proto-oncogene, receptor tyrosine kinase
DST dystonin
RICTOR RPTOR independent companion of MTOR, complex 2
DYNLT1 dynein, light chain, Tctex-type 1
CLINT1 clathrin interactor 1
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
RASA1 RAS p21 protein activator (GTPase activating protein) 1
ABLIM1 actin binding LIM protein 1
MARK2 MAP/microtubule affinity-regulating kinase 2
TPD52L2 tumor protein D52-like 2
C8ORF33 chromosome 8 open reading frame 33
CYTH2 cytohesin 2
CALCOCO2 calcium binding and coiled-coil domain 2
FERMT3 fermitin family member 3
RASGEF1A RasGEF domain family, member 1A
HSPB1 heat shock 27kDa protein 1
WAC WW domain containing adaptor with coiled-coil
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
CDK16 cyclin-dependent kinase 16
CDK17 cyclin-dependent kinase 17
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
WIBG within bgcn homolog (Drosophila)
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8
FXYD1 FXYD domain containing ion transport regulator 1
RBM15B RNA binding motif protein 15B
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
PDCD11 programmed cell death 11
CARD9 caspase recruitment domain family, member 9
CTNND1 catenin (cadherin-associated protein), delta 1
CGN cingulin
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
TGM1 transglutaminase 1
RBM8A RNA binding motif protein 8A
BRAF B-Raf proto-oncogene, serine/threonine kinase
TARDBP TAR DNA binding protein
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
STK3 serine/threonine kinase 3