MEKK3 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase kinase kinase 3|This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4215)
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Genes

100 substrates of the kinase MEKK3 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
STK3 serine/threonine kinase 3
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
CASP9 caspase 9, apoptosis-related cysteine peptidase
C11ORF52 chromosome 11 open reading frame 52
PKP3 plakophilin 3
ENAH enabled homolog (Drosophila)
GCLM glutamate-cysteine ligase, modifier subunit
SELPLG selectin P ligand
AIP aryl hydrocarbon receptor interacting protein
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
AZI2 5-azacytidine induced 2
DUSP16 dual specificity phosphatase 16
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2
STK4 serine/threonine kinase 4
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13
EPS8 epidermal growth factor receptor pathway substrate 8
SDCBP syndecan binding protein (syntenin)
CCDC85C coiled-coil domain containing 85C
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
EIF5B eukaryotic translation initiation factor 5B
TTN titin
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
FRMD4B FERM domain containing 4B
SCAMP4 secretory carrier membrane protein 4
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
SEC62 SEC62 homolog (S. cerevisiae)
NADK NAD kinase
CAPN1 calpain 1, (mu/I) large subunit
EIF4B eukaryotic translation initiation factor 4B
GIPC1 GIPC PDZ domain containing family, member 1
CASKIN2 CASK interacting protein 2
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
EXPH5 exophilin 5
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
FYB FYN binding protein
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
ZNF638 zinc finger protein 638
PRKCA protein kinase C, alpha
SNRK SNF related kinase
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
STK26 serine/threonine protein kinase 26
RRBP1 ribosome binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
GIPC3 GIPC PDZ domain containing family, member 3
LPAR1 lysophosphatidic acid receptor 1
DST dystonin
ODF2 outer dense fiber of sperm tails 2
CBX3 chromobox homolog 3
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
RPL4 ribosomal protein L4
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
SPIRE1 spire-type actin nucleation factor 1
SYNM synemin, intermediate filament protein
PNP purine nucleoside phosphorylase
CDR2L cerebellar degeneration-related protein 2-like
PPHLN1 periphilin 1
MAP2 microtubule-associated protein 2
DYNLT1 dynein, light chain, Tctex-type 1
EVI2A ecotropic viral integration site 2A
ADCY2 adenylate cyclase 2 (brain)
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
MARK2 MAP/microtubule affinity-regulating kinase 2
TPD52L2 tumor protein D52-like 2
CYTH2 cytohesin 2
FRYL FRY-like
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
FERMT3 fermitin family member 3
ARHGAP21 Rho GTPase activating protein 21
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
RBM15B RNA binding motif protein 15B
FXYD1 FXYD domain containing ion transport regulator 1
WAC WW domain containing adaptor with coiled-coil
DCLRE1C DNA cross-link repair 1C
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
STK38 serine/threonine kinase 38
ATG4B autophagy related 4B, cysteine peptidase
PTK2 protein tyrosine kinase 2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
RHPN2 rhophilin, Rho GTPase binding protein 2
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
TARDBP TAR DNA binding protein
RBM8A RNA binding motif protein 8A
GPATCH2L G patch domain containing 2-like
MET MET proto-oncogene, receptor tyrosine kinase
RASGEF1A RasGEF domain family, member 1A
BLVRA biliverdin reductase A
REEP3 receptor accessory protein 3
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
TKT transketolase
SYNRG synergin, gamma
TGM1 transglutaminase 1
EIF3A eukaryotic translation initiation factor 3, subunit A
WIBG within bgcn homolog (Drosophila)