MEK_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MEK_UP.V1_UP
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Genes

392 genes differentially expressed following the MEK_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRL2 adhesion G protein-coupled receptor L2
ADM adrenomedullin
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ANGPTL4 angiopoietin-like 4
ANOS1 anosmin 1
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL4C ADP-ribosylation factor-like 4C
ARRB1 arrestin, beta 1
ASPH aspartate beta-hydroxylase
ATXN1 ataxin 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BACE2 beta-site APP-cleaving enzyme 2
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL3 B-cell CLL/lymphoma 3
BMP7 bone morphogenetic protein 7
C11ORF95 chromosome 11 open reading frame 95
C1ORF106 chromosome 1 open reading frame 106
C1ORF115 chromosome 1 open reading frame 115
CADPS2 Ca++-dependent secretion activator 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN2 calpain 2, (m/II) large subunit
CAPN5 calpain 5
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNJL cyclin J-like
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CHKA choline kinase alpha
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLDN4 claudin 4
CLDN9 claudin 9
CLMN calmin (calponin-like, transmembrane)
COL5A2 collagen, type V, alpha 2
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CRAT carnitine O-acetyltransferase
CRLF1 cytokine receptor-like factor 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CUEDC1 CUE domain containing 1
CXADR coxsackie virus and adenovirus receptor
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2
DUSP4 dual specificity phosphatase 4
EDN1 endothelin 1
EFHD2 EF-hand domain family, member D2
EGLN3 egl-9 family hypoxia-inducible factor 3
EHBP1L1 EH domain binding protein 1-like 1
ELL2 elongation factor, RNA polymerase II, 2
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EPHA1 EPH receptor A1
EPHA2 EPH receptor A2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERO1L ERO1-like (S. cerevisiae)
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADS2 fatty acid desaturase 2
FAM105A family with sequence similarity 105, member A
FERMT2 fermitin family member 2
FGB fibrinogen beta chain
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOSL1 FOS-like antigen 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAL galanin/GMAP prepropeptide
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GDF15 growth differentiation factor 15
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GOLM1 golgi membrane protein 1
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GRAMD3 GRAM domain containing 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL4R interleukin 4 receptor
ITGB4 integrin, beta 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF4 Kruppel-like factor 4 (gut)
KRT7 keratin 7, type II
KRT81 keratin 81, type II
L1CAM L1 cell adhesion molecule
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALSL lectin, galactoside-binding-like
LHFP lipoma HMGIC fusion partner
LIMCH1 LIM and calponin homology domains 1
LOXL1 lysyl oxidase-like 1
LRP5 low density lipoprotein receptor-related protein 5
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MALL mal, T-cell differentiation protein-like
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MEF2C myocyte enhancer factor 2C
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MPZL2 myelin protein zero-like 2
MXRA7 matrix-remodelling associated 7
MYO1D myosin ID
MYO5A myosin VA (heavy chain 12, myoxin)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPC2 Niemann-Pick disease, type C2
NT5C2 5'-nucleotidase, cytosolic II
NT5DC2 5'-nucleotidase domain containing 2
NUMB numb homolog (Drosophila)
OPN3 opsin 3
PACS1 phosphofurin acidic cluster sorting protein 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PARM1 prostate androgen-regulated mucin-like protein 1
PCDH1 protocadherin 1
PCDH9 protocadherin 9
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM7 PDZ and LIM domain 7 (enigma)
PEG10 paternally expressed 10
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLAU plasminogen activator, urokinase
POR P450 (cytochrome) oxidoreductase
PPAP2A phosphatidic acid phosphatase type 2A
PPARG peroxisome proliferator-activated receptor gamma
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRKCH protein kinase C, eta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTK7 protein tyrosine kinase 7 (inactive)
PTMS parathymosin
PTOV1 prostate tumor overexpressed 1
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRU protein tyrosine phosphatase, receptor type, U
RAB5C RAB5C, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
RAI14 retinoic acid induced 14
RAI2 retinoic acid induced 2
RFTN1 raftlin, lipid raft linker 1
S100A6 S100 calcium binding protein A6
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SCAMP4 secretory carrier membrane protein 4
SCCPDH saccharopine dehydrogenase (putative)
SDCBP syndecan binding protein (syntenin)
SEPT10 septin 10
SGCE sarcoglycan, epsilon
SGPP1 sphingosine-1-phosphate phosphatase 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIX2 SIX homeobox 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG1 sperm associated antigen 1
SPTBN2 spectrin, beta, non-erythrocytic 2
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STRN4 striatin, calmodulin binding protein 4
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBI transforming growth factor, beta-induced, 68kDa
THEM6 thioesterase superfamily member 6
TIMP2 TIMP metallopeptidase inhibitor 2
TMPRSS4 transmembrane protease, serine 4
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNS3 tensin 3
TP53I11 tumor protein p53 inducible protein 11
TRIM29 tripartite motif containing 29
TTC9 tetratricopeptide repeat domain 9
TUBB2A tubulin, beta 2A class IIa
ULBP2 UL16 binding protein 2
UPK1A uroplakin 1A
UPK2 uroplakin 2
UPK3B uroplakin 3B
VASP vasodilator-stimulated phosphoprotein
VWA1 von Willebrand factor A domain containing 1
WNT11 wingless-type MMTV integration site family, member 11

decreased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABLIM1 actin binding LIM protein 1
ACTR6 ARP6 actin-related protein 6 homolog (yeast)
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AK4P3 adenylate kinase 4 pseudogene 3
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
AMIGO2 adhesion molecule with Ig-like domain 2
ANGEL2 angel homolog 2 (Drosophila)
ANXA9 annexin A9
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQR aquarius intron-binding spliceosomal factor
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX5 armadillo repeat containing, X-linked 5
ASCL1 achaete-scute family bHLH transcription factor 1
ASS1 argininosuccinate synthase 1
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
AUTS2 autism susceptibility candidate 2
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL2 B-cell CLL/lymphoma 2
BLNK B-cell linker
BST2 bone marrow stromal cell antigen 2
C16ORF45 chromosome 16 open reading frame 45
C18ORF8 chromosome 18 open reading frame 8
C9ORF3 chromosome 9 open reading frame 3
CALB2 calbindin 2
CALCR calcitonin receptor
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBR4 carbonyl reductase 4
CETN3 centrin, EF-hand protein, 3
CHN1 chimerin 1
COL9A3 collagen, type IX, alpha 3
CSTA cystatin A (stefin A)
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DCAF6 DDB1 and CUL4 associated factor 6
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DLC1 DLC1 Rho GTPase activating protein
EGR3 early growth response 3
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
F12 coagulation factor XII (Hageman factor)
FASTKD1 FAST kinase domains 1
FKTN fukutin
FTO fat mass and obesity associated
GALC galactosylceramidase
GDAP1 ganglioside induced differentiation associated protein 1
GFRA1 GDNF family receptor alpha 1
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GOLGA4 golgin A4
GOLGA8A golgin A8 family, member A
GPER1 G protein-coupled estrogen receptor 1
GREB1 growth regulation by estrogen in breast cancer 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIRA histone cell cycle regulator
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2AG histone cluster 1, H2ag
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HSPA4L heat shock 70kDa protein 4-like
HSPB8 heat shock 22kDa protein 8
IAPP islet amyloid polypeptide
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFITM1 interferon induced transmembrane protein 1
IFT57 intraflagellar transport 57
IGF1R insulin-like growth factor 1 receptor
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INPP5F inositol polyphosphate-5-phosphatase F
INSIG2 insulin induced gene 2
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JAK2 Janus kinase 2
JMJD1C jumonji domain containing 1C
KCTD3 potassium channel tetramerization domain containing 3
KIAA0430 KIAA0430
KIAA1324 KIAA1324
KIAA1598
KIF5C kinesin family member 5C
LIN7C lin-7 homolog C (C. elegans)
LINC00869 long intergenic non-protein coding RNA 869
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTN1 listerin E3 ubiquitin protein ligase 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A2 mannosidase, alpha, class 1A, member 2
METTL3 methyltransferase like 3
MGP matrix Gla protein
MINPP1 multiple inositol-polyphosphate phosphatase 1
MOCOS molybdenum cofactor sulfurase
MOCS2 molybdenum cofactor synthesis 2
MPDZ multiple PDZ domain protein
MSMB microseminoprotein, beta-
MTCL1 microtubule crosslinking factor 1
MTIF2 mitochondrial translational initiation factor 2
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1
NGLY1 N-glycanase 1
NMRK1 nicotinamide riboside kinase 1
NOL8 nucleolar protein 8
NPEPPS aminopeptidase puromycin sensitive
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PGR progesterone receptor
PLBD1 phospholipase B domain containing 1
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POLI polymerase (DNA directed) iota
POT1 protection of telomeres 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRMT3 protein arginine methyltransferase 3
PRPF38B pre-mRNA processing factor 38B
PSPH phosphoserine phosphatase
PTBP2 polypyrimidine tract binding protein 2
PTER phosphotriesterase related
QPRT quinolinate phosphoribosyltransferase
RAB29 RAB29, member RAS oncogene family
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RHOBTB3 Rho-related BTB domain containing 3
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNF43 ring finger protein 43
RPL29P31 ribosomal protein L29 pseudogene 31
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
RSBN1 round spermatid basic protein 1
S100A8 S100 calcium binding protein A8
SAMHD1 SAM domain and HD domain 1
SATB2 SATB homeobox 2
SEC24D SEC24 family member D
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC16A6 solute carrier family 16, member 6
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35A5 solute carrier family 35, member A5
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLMO2 slowmo homolog 2 (Drosophila)
SMAD7 SMAD family member 7
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNX10 sorting nexin 10
SOX3 SRY (sex determining region Y)-box 3
SP100 SP100 nuclear antigen
SP110 SP110 nuclear body protein
SSFA2 sperm specific antigen 2
STXBP3 syntaxin binding protein 3
SYCP2 synaptonemal complex protein 2
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCF12 transcription factor 12
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDRD7 tudor domain containing 7
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TOP2B topoisomerase (DNA) II beta 180kDa
TRIM14 tripartite motif containing 14
TTC39A tetratricopeptide repeat domain 39A
UBA3 ubiquitin-like modifier activating enzyme 3
UBE2L6 ubiquitin-conjugating enzyme E2L 6
USP18 ubiquitin specific peptidase 18
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WIPF1 WAS/WASL interacting protein family, member 1
WISP2 WNT1 inducible signaling pathway protein 2
ZBTB10 zinc finger and BTB domain containing 10
ZNF107 zinc finger protein 107
ZNF140 zinc finger protein 140
ZNF43 zinc finger protein 43
ZNF652 zinc finger protein 652
ZNF84 zinc finger protein 84