Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
Category | transcriptomics |
Type | gene perturbation |
Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
External Link | http://www.broadinstitute.org/gsea/msigdb/cards/MEK_UP.V1_UP |
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392 genes differentially expressed following the MEK_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
Symbol | Name |
---|---|
ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
ACSL1 | acyl-CoA synthetase long-chain family member 1 |
ADGRL2 | adhesion G protein-coupled receptor L2 |
ADM | adrenomedullin |
AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 |
AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) |
AKR1C2 | aldo-keto reductase family 1, member C2 |
AKR1C3 | aldo-keto reductase family 1, member C3 |
ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 |
ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 |
ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 |
ANGPTL4 | angiopoietin-like 4 |
ANOS1 | anosmin 1 |
APOD | apolipoprotein D |
AQP3 | aquaporin 3 (Gill blood group) |
AREL1 | apoptosis resistant E3 ubiquitin protein ligase 1 |
ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta |
ARL4C | ADP-ribosylation factor-like 4C |
ARRB1 | arrestin, beta 1 |
ASPH | aspartate beta-hydroxylase |
ATXN1 | ataxin 1 |
B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 |
BACE2 | beta-site APP-cleaving enzyme 2 |
BCAM | basal cell adhesion molecule (Lutheran blood group) |
BCL3 | B-cell CLL/lymphoma 3 |
BMP7 | bone morphogenetic protein 7 |
C11ORF95 | chromosome 11 open reading frame 95 |
C1ORF106 | chromosome 1 open reading frame 106 |
C1ORF115 | chromosome 1 open reading frame 115 |
CADPS2 | Ca++-dependent secretion activator 2 |
CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 |
CAPN2 | calpain 2, (m/II) large subunit |
CAPN5 | calpain 5 |
CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
CCNJL | cyclin J-like |
CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) |
CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 |
CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) |
CEMIP | cell migration inducing protein, hyaluronan binding |
CHKA | choline kinase alpha |
CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 |
CLDN4 | claudin 4 |
CLDN9 | claudin 9 |
CLMN | calmin (calponin-like, transmembrane) |
COL5A2 | collagen, type V, alpha 2 |
CORO1A | coronin, actin binding protein, 1A |
COTL1 | coactosin-like F-actin binding protein 1 |
CRAT | carnitine O-acetyltransferase |
CRLF1 | cytokine receptor-like factor 1 |
CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 |
CUEDC1 | CUE domain containing 1 |
CXADR | coxsackie virus and adenovirus receptor |
CXCR4 | chemokine (C-X-C motif) receptor 4 |
CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 |
CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
DBNDD1 | dysbindin (dystrobrevin binding protein 1) domain containing 1 |
DBNDD2 | dysbindin (dystrobrevin binding protein 1) domain containing 2 |
DUSP4 | dual specificity phosphatase 4 |
EDN1 | endothelin 1 |
EFHD2 | EF-hand domain family, member D2 |
EGLN3 | egl-9 family hypoxia-inducible factor 3 |
EHBP1L1 | EH domain binding protein 1-like 1 |
ELL2 | elongation factor, RNA polymerase II, 2 |
ENO2 | enolase 2 (gamma, neuronal) |
EPAS1 | endothelial PAS domain protein 1 |
EPHA1 | EPH receptor A1 |
EPHA2 | EPH receptor A2 |
EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) |
ERO1L | ERO1-like (S. cerevisiae) |
ETV5 | ets variant 5 |
F2RL1 | coagulation factor II (thrombin) receptor-like 1 |
FADS2 | fatty acid desaturase 2 |
FAM105A | family with sequence similarity 105, member A |
FERMT2 | fermitin family member 2 |
FGB | fibrinogen beta chain |
FGFR3 | fibroblast growth factor receptor 3 |
FHL1 | four and a half LIM domains 1 |
FLVCR2 | feline leukemia virus subgroup C cellular receptor family, member 2 |
FOSL1 | FOS-like antigen 1 |
GABBR2 | gamma-aminobutyric acid (GABA) B receptor, 2 |
GAL | galanin/GMAP prepropeptide |
GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 |
GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 |
GDF15 | growth differentiation factor 15 |
GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
GOLM1 | golgi membrane protein 1 |
GPX2 | glutathione peroxidase 2 |
GPX3 | glutathione peroxidase 3 |
GRAMD3 | GRAM domain containing 3 |
GUCY1B3 | guanylate cyclase 1, soluble, beta 3 |
IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 |
IL4R | interleukin 4 receptor |
ITGB4 | integrin, beta 4 |
KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 |
KLF4 | Kruppel-like factor 4 (gut) |
KRT7 | keratin 7, type II |
KRT81 | keratin 81, type II |
L1CAM | L1 cell adhesion molecule |
LAMC1 | laminin, gamma 1 (formerly LAMB2) |
LGALSL | lectin, galactoside-binding-like |
LHFP | lipoma HMGIC fusion partner |
LIMCH1 | LIM and calponin homology domains 1 |
LOXL1 | lysyl oxidase-like 1 |
LRP5 | low density lipoprotein receptor-related protein 5 |
LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor |
MALL | mal, T-cell differentiation protein-like |
MAN1A1 | mannosidase, alpha, class 1A, member 1 |
MAOA | monoamine oxidase A |
MAP3K9 | mitogen-activated protein kinase kinase kinase 9 |
MEF2C | myocyte enhancer factor 2C |
MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 |
MPZL2 | myelin protein zero-like 2 |
MXRA7 | matrix-remodelling associated 7 |
MYO1D | myosin ID |
MYO5A | myosin VA (heavy chain 12, myoxin) |
NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 |
NME4 | NME/NM23 nucleoside diphosphate kinase 4 |
NPC2 | Niemann-Pick disease, type C2 |
NT5C2 | 5'-nucleotidase, cytosolic II |
NT5DC2 | 5'-nucleotidase domain containing 2 |
NUMB | numb homolog (Drosophila) |
OPN3 | opsin 3 |
PACS1 | phosphofurin acidic cluster sorting protein 1 |
PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 |
PARM1 | prostate androgen-regulated mucin-like protein 1 |
PCDH1 | protocadherin 1 |
PCDH9 | protocadherin 9 |
PDK4 | pyruvate dehydrogenase kinase, isozyme 4 |
PDLIM7 | PDZ and LIM domain 7 (enigma) |
PEG10 | paternally expressed 10 |
PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha |
PLAU | plasminogen activator, urokinase |
POR | P450 (cytochrome) oxidoreductase |
PPAP2A | phosphatidic acid phosphatase type 2A |
PPARG | peroxisome proliferator-activated receptor gamma |
PPP1R13B | protein phosphatase 1, regulatory subunit 13B |
PRKCH | protein kinase C, eta |
PTGER4 | prostaglandin E receptor 4 (subtype EP4) |
PTK7 | protein tyrosine kinase 7 (inactive) |
PTMS | parathymosin |
PTOV1 | prostate tumor overexpressed 1 |
PTPRE | protein tyrosine phosphatase, receptor type, E |
PTPRU | protein tyrosine phosphatase, receptor type, U |
RAB5C | RAB5C, member RAS oncogene family |
RAB8B | RAB8B, member RAS oncogene family |
RAI14 | retinoic acid induced 14 |
RAI2 | retinoic acid induced 2 |
RFTN1 | raftlin, lipid raft linker 1 |
S100A6 | S100 calcium binding protein A6 |
S100P | S100 calcium binding protein P |
SAMD4A | sterile alpha motif domain containing 4A |
SCAMP4 | secretory carrier membrane protein 4 |
SCCPDH | saccharopine dehydrogenase (putative) |
SDCBP | syndecan binding protein (syntenin) |
SEPT10 | septin 10 |
SGCE | sarcoglycan, epsilon |
SGPP1 | sphingosine-1-phosphate phosphatase 1 |
SH3GLB2 | SH3-domain GRB2-like endophilin B2 |
SIX2 | SIX homeobox 2 |
SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 |
SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 |
SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 |
SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
SLC9A6 | solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 |
SORL1 | sortilin-related receptor, L(DLR class) A repeats containing |
SPAG1 | sperm associated antigen 1 |
SPTBN2 | spectrin, beta, non-erythrocytic 2 |
SPTLC2 | serine palmitoyltransferase, long chain base subunit 2 |
ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) |
ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 |
ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
STRN4 | striatin, calmodulin binding protein 4 |
TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) |
TGFB1I1 | transforming growth factor beta 1 induced transcript 1 |
TGFBI | transforming growth factor, beta-induced, 68kDa |
THEM6 | thioesterase superfamily member 6 |
TIMP2 | TIMP metallopeptidase inhibitor 2 |
TMPRSS4 | transmembrane protease, serine 4 |
TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 |
TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b |
TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 |
TNS3 | tensin 3 |
TP53I11 | tumor protein p53 inducible protein 11 |
TRIM29 | tripartite motif containing 29 |
TTC9 | tetratricopeptide repeat domain 9 |
TUBB2A | tubulin, beta 2A class IIa |
ULBP2 | UL16 binding protein 2 |
UPK1A | uroplakin 1A |
UPK2 | uroplakin 2 |
UPK3B | uroplakin 3B |
VASP | vasodilator-stimulated phosphoprotein |
VWA1 | von Willebrand factor A domain containing 1 |
WNT11 | wingless-type MMTV integration site family, member 11 |
Symbol | Name |
---|---|
ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 |
ABLIM1 | actin binding LIM protein 1 |
ACTR6 | ARP6 actin-related protein 6 homolog (yeast) |
AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase |
AK4P3 | adenylate kinase 4 pseudogene 3 |
ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit |
AMIGO2 | adhesion molecule with Ig-like domain 2 |
ANGEL2 | angel homolog 2 (Drosophila) |
ANXA9 | annexin A9 |
APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 |
AQR | aquarius intron-binding spliceosomal factor |
ARMCX1 | armadillo repeat containing, X-linked 1 |
ARMCX3 | armadillo repeat containing, X-linked 3 |
ARMCX5 | armadillo repeat containing, X-linked 5 |
ASCL1 | achaete-scute family bHLH transcription factor 1 |
ASS1 | argininosuccinate synthase 1 |
ATF1 | activating transcription factor 1 |
ATF3 | activating transcription factor 3 |
ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 |
AUTS2 | autism susceptibility candidate 2 |
BAZ2B | bromodomain adjacent to zinc finger domain, 2B |
BCL2 | B-cell CLL/lymphoma 2 |
BLNK | B-cell linker |
BST2 | bone marrow stromal cell antigen 2 |
C16ORF45 | chromosome 16 open reading frame 45 |
C18ORF8 | chromosome 18 open reading frame 8 |
C9ORF3 | chromosome 9 open reading frame 3 |
CALB2 | calbindin 2 |
CALCR | calcitonin receptor |
CASP8 | caspase 8, apoptosis-related cysteine peptidase |
CBR4 | carbonyl reductase 4 |
CETN3 | centrin, EF-hand protein, 3 |
CHN1 | chimerin 1 |
COL9A3 | collagen, type IX, alpha 3 |
CSTA | cystatin A (stefin A) |
CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 |
DCAF6 | DDB1 and CUL4 associated factor 6 |
DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 |
DLC1 | DLC1 Rho GTPase activating protein |
EGR3 | early growth response 3 |
ELOVL5 | ELOVL fatty acid elongase 5 |
ELOVL6 | ELOVL fatty acid elongase 6 |
F12 | coagulation factor XII (Hageman factor) |
FASTKD1 | FAST kinase domains 1 |
FKTN | fukutin |
FTO | fat mass and obesity associated |
GALC | galactosylceramidase |
GDAP1 | ganglioside induced differentiation associated protein 1 |
GFRA1 | GDNF family receptor alpha 1 |
GNL2 | guanine nucleotide binding protein-like 2 (nucleolar) |
GOLGA4 | golgin A4 |
GOLGA8A | golgin A8 family, member A |
GPER1 | G protein-coupled estrogen receptor 1 |
GREB1 | growth regulation by estrogen in breast cancer 1 |
HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
HIRA | histone cell cycle regulator |
HIST1H1C | histone cluster 1, H1c |
HIST1H2AC | histone cluster 1, H2ac |
HIST1H2AE | histone cluster 1, H2ae |
HIST1H2AG | histone cluster 1, H2ag |
HIST1H2BE | histone cluster 1, H2be |
HIST1H2BF | histone cluster 1, H2bf |
HIST1H2BG | histone cluster 1, H2bg |
HIST1H2BH | histone cluster 1, H2bh |
HIST1H2BI | histone cluster 1, H2bi |
HIST1H3H | histone cluster 1, H3h |
HIST1H4H | histone cluster 1, H4h |
HSPA4L | heat shock 70kDa protein 4-like |
HSPB8 | heat shock 22kDa protein 8 |
IAPP | islet amyloid polypeptide |
ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
IFI27 | interferon, alpha-inducible protein 27 |
IFI35 | interferon-induced protein 35 |
IFI44 | interferon-induced protein 44 |
IFI44L | interferon-induced protein 44-like |
IFI6 | interferon, alpha-inducible protein 6 |
IFIH1 | interferon induced with helicase C domain 1 |
IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 |
IFIT5 | interferon-induced protein with tetratricopeptide repeats 5 |
IFITM1 | interferon induced transmembrane protein 1 |
IFT57 | intraflagellar transport 57 |
IGF1R | insulin-like growth factor 1 receptor |
INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa |
INPP5F | inositol polyphosphate-5-phosphatase F |
INSIG2 | insulin induced gene 2 |
IRF7 | interferon regulatory factor 7 |
IRF9 | interferon regulatory factor 9 |
ISG15 | ISG15 ubiquitin-like modifier |
JAK2 | Janus kinase 2 |
JMJD1C | jumonji domain containing 1C |
KCTD3 | potassium channel tetramerization domain containing 3 |
KIAA0430 | KIAA0430 |
KIAA1324 | KIAA1324 |
KIAA1598 | |
KIF5C | kinesin family member 5C |
LIN7C | lin-7 homolog C (C. elegans) |
LINC00869 | long intergenic non-protein coding RNA 869 |
LPGAT1 | lysophosphatidylglycerol acyltransferase 1 |
LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 |
LSM7 | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
LTN1 | listerin E3 ubiquitin protein ligase 1 |
MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B |
MAN1A2 | mannosidase, alpha, class 1A, member 2 |
METTL3 | methyltransferase like 3 |
MGP | matrix Gla protein |
MINPP1 | multiple inositol-polyphosphate phosphatase 1 |
MOCOS | molybdenum cofactor sulfurase |
MOCS2 | molybdenum cofactor synthesis 2 |
MPDZ | multiple PDZ domain protein |
MSMB | microseminoprotein, beta- |
MTCL1 | microtubule crosslinking factor 1 |
MTIF2 | mitochondrial translational initiation factor 2 |
MYB | v-myb avian myeloblastosis viral oncogene homolog |
MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 |
MYC | v-myc avian myelocytomatosis viral oncogene homolog |
MYLK | myosin light chain kinase |
NDUFAF1 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 |
NGLY1 | N-glycanase 1 |
NMRK1 | nicotinamide riboside kinase 1 |
NOL8 | nucleolar protein 8 |
NPEPPS | aminopeptidase puromycin sensitive |
NPY1R | neuropeptide Y receptor Y1 |
NREP | neuronal regeneration related protein |
NRIP1 | nuclear receptor interacting protein 1 |
OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa |
OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa |
OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa |
OASL | 2'-5'-oligoadenylate synthetase-like |
OXSM | 3-oxoacyl-ACP synthase, mitochondrial |
PCP4 | Purkinje cell protein 4 |
PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
PDZK1 | PDZ domain containing 1 |
PGR | progesterone receptor |
PLBD1 | phospholipase B domain containing 1 |
PMS1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) |
POLI | polymerase (DNA directed) iota |
POT1 | protection of telomeres 1 |
PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta |
PRMT3 | protein arginine methyltransferase 3 |
PRPF38B | pre-mRNA processing factor 38B |
PSPH | phosphoserine phosphatase |
PTBP2 | polypyrimidine tract binding protein 2 |
PTER | phosphotriesterase related |
QPRT | quinolinate phosphoribosyltransferase |
RAB29 | RAB29, member RAS oncogene family |
RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) |
RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) |
RHOBTB3 | Rho-related BTB domain containing 3 |
RMND1 | required for meiotic nuclear division 1 homolog (S. cerevisiae) |
RNF43 | ring finger protein 43 |
RPL29P31 | ribosomal protein L29 pseudogene 31 |
RPRD1A | regulation of nuclear pre-mRNA domain containing 1A |
RSBN1 | round spermatid basic protein 1 |
S100A8 | S100 calcium binding protein A8 |
SAMHD1 | SAM domain and HD domain 1 |
SATB2 | SATB homeobox 2 |
SEC24D | SEC24 family member D |
SGCG | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) |
SLC16A6 | solute carrier family 16, member 6 |
SLC26A2 | solute carrier family 26 (anion exchanger), member 2 |
SLC35A5 | solute carrier family 35, member A5 |
SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 |
SLMO2 | slowmo homolog 2 (Drosophila) |
SMAD7 | SMAD family member 7 |
SMPDL3A | sphingomyelin phosphodiesterase, acid-like 3A |
SNX10 | sorting nexin 10 |
SOX3 | SRY (sex determining region Y)-box 3 |
SP100 | SP100 nuclear antigen |
SP110 | SP110 nuclear body protein |
SSFA2 | sperm specific antigen 2 |
STXBP3 | syntaxin binding protein 3 |
SYCP2 | synaptonemal complex protein 2 |
TAF2 | TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa |
TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
TCF12 | transcription factor 12 |
TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) |
TDRD7 | tudor domain containing 7 |
TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
TFPI2 | tissue factor pathway inhibitor 2 |
TM4SF1 | transmembrane 4 L six family member 1 |
TOP2B | topoisomerase (DNA) II beta 180kDa |
TRIM14 | tripartite motif containing 14 |
TTC39A | tetratricopeptide repeat domain 39A |
UBA3 | ubiquitin-like modifier activating enzyme 3 |
UBE2L6 | ubiquitin-conjugating enzyme E2L 6 |
USP18 | ubiquitin specific peptidase 18 |
UTP14A | UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) |
WIPF1 | WAS/WASL interacting protein family, member 1 |
WISP2 | WNT1 inducible signaling pathway protein 2 |
ZBTB10 | zinc finger and BTB domain containing 10 |
ZNF107 | zinc finger protein 107 |
ZNF140 | zinc finger protein 140 |
ZNF43 | zinc finger protein 43 |
ZNF652 | zinc finger protein 652 |
ZNF84 | zinc finger protein 84 |