MEL18_DN.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MEL18_DN.V1_UP
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Genes

289 genes differentially expressed following the MEL18_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABLIM3 actin binding LIM protein family, member 3
ADAM12 ADAM metallopeptidase domain 12
ADAM19 ADAM metallopeptidase domain 19
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
AGRN agrin
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
ATP13A2 ATPase type 13A2
BDKRB2 bradykinin receptor B2
C2CD2 C2 calcium-dependent domain containing 2
C2CD2L C2CD2-like
C3AR1 complement component 3a receptor 1
C3ORF52 chromosome 3 open reading frame 52
CA12 carbonic anhydrase XII
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CCND1 cyclin D1
CD83 CD83 molecule
CDCP1 CUB domain containing protein 1
CDH13 cadherin 13
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CLDN1 claudin 1
CLSPN claspin
COL13A1 collagen, type XIII, alpha 1
COL16A1 collagen, type XVI, alpha 1
COL7A1 collagen, type VII, alpha 1
CPA4 carboxypeptidase A4
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSPG4 chondroitin sulfate proteoglycan 4
CTSS cathepsin S
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDIT4 DNA-damage-inducible transcript 4
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
ECM1 extracellular matrix protein 1
EDN1 endothelin 1
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
EPHA2 EPH receptor A2
ERO1L ERO1-like (S. cerevisiae)
F3 coagulation factor III (thromboplastin, tissue factor)
FADS3 fatty acid desaturase 3
FAP fibroblast activation protein, alpha
FGF21 fibroblast growth factor 21
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FURIN furin (paired basic amino acid cleaving enzyme)
FZD6 frizzled class receptor 6
GAL galanin/GMAP prepropeptide
GDF5 growth differentiation factor 5
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPR3 G protein-coupled receptor 3
GREM1 gremlin 1, DAN family BMP antagonist
HAS2 hyaluronan synthase 2
HBEGF heparin-binding EGF-like growth factor
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IL7R interleukin 7 receptor
INHBA inhibin, beta A
INHBE inhibin, beta E
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB8 integrin, beta 8
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAG1 jagged 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KIF21B kinesin family member 21B
KMT2A lysine (K)-specific methyltransferase 2A
LAMB3 laminin, beta 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LHFPL2 lipoma HMGIC fusion partner-like 2
LIF leukemia inhibitory factor
LPL lipoprotein lipase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBP4 latent transforming growth factor beta binding protein 4
MEOX1 mesenchyme homeobox 1
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP7 matrix metallopeptidase 7
MT1F metallothionein 1F
NRP1 neuropilin 1
NRP2 neuropilin 2
NT5E 5'-nucleotidase, ecto (CD73)
NTM neurotrimin
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P3H3 prolyl 3-hydroxylase 3
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PDCD1LG2 programmed cell death 1 ligand 2
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLXNA1 plexin A1
PMEPA1 prostate transmembrane protein, androgen induced 1
PTHLH parathyroid hormone-like hormone
PYGB phosphorylase, glycogen; brain
SIK1 salt-inducible kinase 1
SLC16A6 solute carrier family 16, member 6
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SND1-IT1 SND1 intronic transcript 1
SPP1 secreted phosphoprotein 1
SRPX2 sushi-repeat containing protein, X-linked 2
STC2 stanniocalcin 2
STEAP3 STEAP family member 3, metalloreductase
STX1A syntaxin 1A (brain)
SUN2 Sad1 and UNC84 domain containing 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TEK TEK tyrosine kinase, endothelial
TFEC transcription factor EC
TGFB2 transforming growth factor, beta 2
TGFBR3 transforming growth factor, beta receptor III
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TMEM51 transmembrane protein 51
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TYRO3 TYRO3 protein tyrosine kinase
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VLDLR very low density lipoprotein receptor
VNN1 vanin 1
WISP1 WNT1 inducible signaling pathway protein 1
WNT5B wingless-type MMTV integration site family, member 5B
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AK1 adenylate kinase 1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
APOE apolipoprotein E
AQP3 aquaporin 3 (Gill blood group)
ASIC2 acid sensing (proton gated) ion channel 2
ATXN3 ataxin 3
B3GAT1 beta-1,3-glucuronyltransferase 1
BAALC brain and acute leukemia, cytoplasmic
BAG3 BCL2-associated athanogene 3
BLNK B-cell linker
BST2 bone marrow stromal cell antigen 2
C1ORF54 chromosome 1 open reading frame 54
CA2 carbonic anhydrase II
CCKAR cholecystokinin A receptor
CDH10 cadherin 10, type 2 (T2-cadherin)
CDH22 cadherin 22, type 2
CFAP20 cilia and flagella associated protein 20
CHN2 chimerin 2
CLIP3 CAP-GLY domain containing linker protein 3
COL14A1 collagen, type XIV, alpha 1
COL9A3 collagen, type IX, alpha 3
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CREM cAMP responsive element modulator
CRIP1 cysteine-rich protein 1 (intestinal)
CUX2 cut-like homeobox 2
CXCL14 chemokine (C-X-C motif) ligand 14
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DIO2 deiodinase, iodothyronine, type II
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
DOK5 docking protein 5
DPYD dihydropyrimidine dehydrogenase
DUSP2 dual specificity phosphatase 2
EBF2 early B-cell factor 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFHD1 EF-hand domain family, member D1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHA3 EPH receptor A3
ESRP1 epithelial splicing regulatory protein 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM46A family with sequence similarity 46, member A
FANCF Fanconi anemia, complementation group F
FOS FBJ murine osteosarcoma viral oncogene homolog
FRMD4B FERM domain containing 4B
GAS2 growth arrest-specific 2
GAS7 growth arrest-specific 7
GLS2 glutaminase 2 (liver, mitochondrial)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPR137B G protein-coupled receptor 137B
GPR88 G protein-coupled receptor 88
GTF2A1L general transcription factor IIA, 1-like
GTF2I general transcription factor IIi
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H4H histone cluster 1, H4h
HOXB13 homeobox B13
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFITM1 interferon induced transmembrane protein 1
IL1R1 interleukin 1 receptor, type I
IRF9 interferon regulatory factor 9
JUP junction plakoglobin
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LECT1 leukocyte cell derived chemotaxin 1
LY6E lymphocyte antigen 6 complex, locus E
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOB monoamine oxidase B
MAP7 microtubule-associated protein 7
MCTS1 malignant T cell amplified sequence 1
MGC2889 uncharacterized protein MGC2889
MIA melanoma inhibitory activity
MPPED2 metallophosphoesterase domain containing 2
MVP major vault protein
NDRG2 NDRG family member 2
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NTS neurotensin
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PCDH8 protocadherin 8
PCGF2 polycomb group ring finger 2
PCP4 Purkinje cell protein 4
PDE4B phosphodiesterase 4B, cAMP-specific
PDE5A phosphodiesterase 5A, cGMP-specific
PDE7B phosphodiesterase 7B
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PENK proenkephalin
PHYH phytanoyl-CoA 2-hydroxylase
PID1 phosphotyrosine interaction domain containing 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKP2 plakophilin 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PLN phospholamban
PNMAL1 paraneoplastic Ma antigen family-like 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PROM1 prominin 1
PRPF6 pre-mRNA processing factor 6
PTER phosphotriesterase related
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIM1 single-minded family bHLH transcription factor 1
SKAP2 src kinase associated phosphoprotein 2
SLC16A4 solute carrier family 16, member 4
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SMR3B submaxillary gland androgen regulated protein 3B
SNCAIP synuclein, alpha interacting protein
SOCS2 suppressor of cytokine signaling 2
SOX2 SRY (sex determining region Y)-box 2
STK17B serine/threonine kinase 17b
STON1 stonin 1
SULF1 sulfatase 1
SYT17 synaptotagmin XVII
TCAF1 TRPM8 channel-associated factor 1
TCEAL2 transcription elongation factor A (SII)-like 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMOD1 tropomodulin 1
TRAPPC6A trafficking protein particle complex 6A
TRIM2 tripartite motif containing 2
TSFM Ts translation elongation factor, mitochondrial
TSPAN1 tetraspanin 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UNC5C unc-5 homolog C (C. elegans)
VAV3 vav 3 guanine nucleotide exchange factor
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae)
WFDC2 WAP four-disulfide core domain 2
ZCCHC24 zinc finger, CCHC domain containing 24