| Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
| External Link | http://www.broadinstitute.org/gsea/msigdb/cards/MEL18_DN.V1_UP |
| Similar Terms | |
| Downloads & Tools |
289 genes differentially expressed following the MEL18_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
| Symbol | Name |
|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
| ABLIM3 | actin binding LIM protein family, member 3 |
| ADAM12 | ADAM metallopeptidase domain 12 |
| ADAM19 | ADAM metallopeptidase domain 19 |
| ADGRE5 | adhesion G protein-coupled receptor E5 |
| ADM | adrenomedullin |
| AGRN | agrin |
| ARL4C | ADP-ribosylation factor-like 4C |
| ASPH | aspartate beta-hydroxylase |
| ATP13A2 | ATPase type 13A2 |
| BDKRB2 | bradykinin receptor B2 |
| C2CD2 | C2 calcium-dependent domain containing 2 |
| C2CD2L | C2CD2-like |
| C3AR1 | complement component 3a receptor 1 |
| C3ORF52 | chromosome 3 open reading frame 52 |
| CA12 | carbonic anhydrase XII |
| CACNG4 | calcium channel, voltage-dependent, gamma subunit 4 |
| CCND1 | cyclin D1 |
| CD83 | CD83 molecule |
| CDCP1 | CUB domain containing protein 1 |
| CDH13 | cadherin 13 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 |
| CLDN1 | claudin 1 |
| CLSPN | claspin |
| COL13A1 | collagen, type XIII, alpha 1 |
| COL16A1 | collagen, type XVI, alpha 1 |
| COL7A1 | collagen, type VII, alpha 1 |
| CPA4 | carboxypeptidase A4 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 |
| CSF1 | colony stimulating factor 1 (macrophage) |
| CSF2 | colony stimulating factor 2 (granulocyte-macrophage) |
| CSPG4 | chondroitin sulfate proteoglycan 4 |
| CTSS | cathepsin S |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| DDIT4 | DNA-damage-inducible transcript 4 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 |
| ECM1 | extracellular matrix protein 1 |
| EDN1 | endothelin 1 |
| ENTPD6 | ectonucleoside triphosphate diphosphohydrolase 6 (putative) |
| EPHA2 | EPH receptor A2 |
| ERO1L | ERO1-like (S. cerevisiae) |
| F3 | coagulation factor III (thromboplastin, tissue factor) |
| FADS3 | fatty acid desaturase 3 |
| FAP | fibroblast activation protein, alpha |
| FGF21 | fibroblast growth factor 21 |
| FJX1 | four jointed box 1 (Drosophila) |
| FOSL1 | FOS-like antigen 1 |
| FURIN | furin (paired basic amino acid cleaving enzyme) |
| FZD6 | frizzled class receptor 6 |
| GAL | galanin/GMAP prepropeptide |
| GDF5 | growth differentiation factor 5 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 |
| GNB3 | guanine nucleotide binding protein (G protein), beta polypeptide 3 |
| GPR3 | G protein-coupled receptor 3 |
| GREM1 | gremlin 1, DAN family BMP antagonist |
| HAS2 | hyaluronan synthase 2 |
| HBEGF | heparin-binding EGF-like growth factor |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
| IL7R | interleukin 7 receptor |
| INHBA | inhibin, beta A |
| INHBE | inhibin, beta E |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
| ITGB8 | integrin, beta 8 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 |
| JAG1 | jagged 1 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 |
| KCNN3 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 |
| KIF21B | kinesin family member 21B |
| KMT2A | lysine (K)-specific methyltransferase 2A |
| LAMB3 | laminin, beta 3 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 |
| LIF | leukemia inhibitory factor |
| LPL | lipoprotein lipase |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 |
| LTBP4 | latent transforming growth factor beta binding protein 4 |
| MEOX1 | mesenchyme homeobox 1 |
| MICA | MHC class I polypeptide-related sequence A |
| MICB | MHC class I polypeptide-related sequence B |
| MMP15 | matrix metallopeptidase 15 (membrane-inserted) |
| MMP7 | matrix metallopeptidase 7 |
| MT1F | metallothionein 1F |
| NRP1 | neuropilin 1 |
| NRP2 | neuropilin 2 |
| NT5E | 5'-nucleotidase, ecto (CD73) |
| NTM | neurotrimin |
| P2RX5 | purinergic receptor P2X, ligand gated ion channel, 5 |
| P3H3 | prolyl 3-hydroxylase 3 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 |
| PDCD1LG2 | programmed cell death 1 ligand 2 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 |
| PLAT | plasminogen activator, tissue |
| PLAUR | plasminogen activator, urokinase receptor |
| PLXNA1 | plexin A1 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 |
| PTHLH | parathyroid hormone-like hormone |
| PYGB | phosphorylase, glycogen; brain |
| SIK1 | salt-inducible kinase 1 |
| SLC16A6 | solute carrier family 16, member 6 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 |
| SLC29A1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 |
| SLCO2A1 | solute carrier organic anion transporter family, member 2A1 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 |
| SND1-IT1 | SND1 intronic transcript 1 |
| SPP1 | secreted phosphoprotein 1 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 |
| STC2 | stanniocalcin 2 |
| STEAP3 | STEAP family member 3, metalloreductase |
| STX1A | syntaxin 1A (brain) |
| SUN2 | Sad1 and UNC84 domain containing 2 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
| TEK | TEK tyrosine kinase, endothelial |
| TFEC | transcription factor EC |
| TGFB2 | transforming growth factor, beta 2 |
| TGFBR3 | transforming growth factor, beta receptor III |
| TIE1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 |
| TMEM51 | transmembrane protein 51 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 |
| TNFRSF8 | tumor necrosis factor receptor superfamily, member 8 |
| TNFRSF9 | tumor necrosis factor receptor superfamily, member 9 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 |
| TYRO3 | TYRO3 protein tyrosine kinase |
| VEGFA | vascular endothelial growth factor A |
| VEGFC | vascular endothelial growth factor C |
| VLDLR | very low density lipoprotein receptor |
| VNN1 | vanin 1 |
| WISP1 | WNT1 inducible signaling pathway protein 1 |
| WNT5B | wingless-type MMTV integration site family, member 5B |
| ZC3H12A | zinc finger CCCH-type containing 12A |
| Symbol | Name |
|---|---|
| A2M | alpha-2-macroglobulin |
| AK1 | adenylate kinase 1 |
| ALDH6A1 | aldehyde dehydrogenase 6 family, member A1 |
| APOE | apolipoprotein E |
| AQP3 | aquaporin 3 (Gill blood group) |
| ASIC2 | acid sensing (proton gated) ion channel 2 |
| ATXN3 | ataxin 3 |
| B3GAT1 | beta-1,3-glucuronyltransferase 1 |
| BAALC | brain and acute leukemia, cytoplasmic |
| BAG3 | BCL2-associated athanogene 3 |
| BLNK | B-cell linker |
| BST2 | bone marrow stromal cell antigen 2 |
| C1ORF54 | chromosome 1 open reading frame 54 |
| CA2 | carbonic anhydrase II |
| CCKAR | cholecystokinin A receptor |
| CDH10 | cadherin 10, type 2 (T2-cadherin) |
| CDH22 | cadherin 22, type 2 |
| CFAP20 | cilia and flagella associated protein 20 |
| CHN2 | chimerin 2 |
| CLIP3 | CAP-GLY domain containing linker protein 3 |
| COL14A1 | collagen, type XIV, alpha 1 |
| COL9A3 | collagen, type IX, alpha 3 |
| CRABP1 | cellular retinoic acid binding protein 1 |
| CRABP2 | cellular retinoic acid binding protein 2 |
| CREM | cAMP responsive element modulator |
| CRIP1 | cysteine-rich protein 1 (intestinal) |
| CUX2 | cut-like homeobox 2 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 |
| DDC | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 |
| DIO2 | deiodinase, iodothyronine, type II |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 |
| DLK1 | delta-like 1 homolog (Drosophila) |
| DMD | dystrophin |
| DOK5 | docking protein 5 |
| DPYD | dihydropyrimidine dehydrogenase |
| DUSP2 | dual specificity phosphatase 2 |
| EBF2 | early B-cell factor 2 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 |
| EFHD1 | EF-hand domain family, member D1 |
| EGFL6 | EGF-like-domain, multiple 6 |
| EGR1 | early growth response 1 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 |
| EPHA3 | EPH receptor A3 |
| ESRP1 | epithelial splicing regulatory protein 1 |
| EYA4 | EYA transcriptional coactivator and phosphatase 4 |
| FAM46A | family with sequence similarity 46, member A |
| FANCF | Fanconi anemia, complementation group F |
| FOS | FBJ murine osteosarcoma viral oncogene homolog |
| FRMD4B | FERM domain containing 4B |
| GAS2 | growth arrest-specific 2 |
| GAS7 | growth arrest-specific 7 |
| GLS2 | glutaminase 2 (liver, mitochondrial) |
| GNG7 | guanine nucleotide binding protein (G protein), gamma 7 |
| GPD1L | glycerol-3-phosphate dehydrogenase 1-like |
| GPR137B | G protein-coupled receptor 137B |
| GPR88 | G protein-coupled receptor 88 |
| GTF2A1L | general transcription factor IIA, 1-like |
| GTF2I | general transcription factor IIi |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 |
| HIST1H4H | histone cluster 1, H4h |
| HOXB13 | homeobox B13 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein |
| IFI27 | interferon, alpha-inducible protein 27 |
| IFI6 | interferon, alpha-inducible protein 6 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 |
| IFITM1 | interferon induced transmembrane protein 1 |
| IL1R1 | interleukin 1 receptor, type I |
| IRF9 | interferon regulatory factor 9 |
| JUP | junction plakoglobin |
| KANSL3 | KAT8 regulatory NSL complex subunit 3 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 |
| LECT1 | leukocyte cell derived chemotaxin 1 |
| LY6E | lymphocyte antigen 6 complex, locus E |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog |
| MAOB | monoamine oxidase B |
| MAP7 | microtubule-associated protein 7 |
| MCTS1 | malignant T cell amplified sequence 1 |
| MGC2889 | uncharacterized protein MGC2889 |
| MIA | melanoma inhibitory activity |
| MPPED2 | metallophosphoesterase domain containing 2 |
| MVP | major vault protein |
| NDRG2 | NDRG family member 2 |
| NMNAT2 | nicotinamide nucleotide adenylyltransferase 2 |
| NTS | neurotensin |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa |
| OLFM4 | olfactomedin 4 |
| OSBPL10 | oxysterol binding protein-like 10 |
| PCDH8 | protocadherin 8 |
| PCGF2 | polycomb group ring finger 2 |
| PCP4 | Purkinje cell protein 4 |
| PDE4B | phosphodiesterase 4B, cAMP-specific |
| PDE5A | phosphodiesterase 5A, cGMP-specific |
| PDE7B | phosphodiesterase 7B |
| PDLIM5 | PDZ and LIM domain 5 |
| PEG3 | paternally expressed 3 |
| PENK | proenkephalin |
| PHYH | phytanoyl-CoA 2-hydroxylase |
| PID1 | phosphotyrosine interaction domain containing 1 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta |
| PKP2 | plakophilin 2 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 |
| PLGRKT | plasminogen receptor, C-terminal lysine transmembrane protein |
| PLN | phospholamban |
| PNMAL1 | paraneoplastic Ma antigen family-like 1 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
| PROM1 | prominin 1 |
| PRPF6 | pre-mRNA processing factor 6 |
| PTER | phosphotriesterase related |
| RBP4 | retinol binding protein 4, plasma |
| RGS2 | regulator of G-protein signaling 2 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E |
| SEPP1 | selenoprotein P, plasma, 1 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like |
| SIM1 | single-minded family bHLH transcription factor 1 |
| SKAP2 | src kinase associated phosphoprotein 2 |
| SLC16A4 | solute carrier family 16, member 4 |
| SLC17A6 | solute carrier family 17 (vesicular glutamate transporter), member 6 |
| SLPI | secretory leukocyte peptidase inhibitor |
| SMR3B | submaxillary gland androgen regulated protein 3B |
| SNCAIP | synuclein, alpha interacting protein |
| SOCS2 | suppressor of cytokine signaling 2 |
| SOX2 | SRY (sex determining region Y)-box 2 |
| STK17B | serine/threonine kinase 17b |
| STON1 | stonin 1 |
| SULF1 | sulfatase 1 |
| SYT17 | synaptotagmin XVII |
| TCAF1 | TRPM8 channel-associated factor 1 |
| TCEAL2 | transcription elongation factor A (SII)-like 2 |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
| TMEM176A | transmembrane protein 176A |
| TMEM176B | transmembrane protein 176B |
| TMOD1 | tropomodulin 1 |
| TRAPPC6A | trafficking protein particle complex 6A |
| TRIM2 | tripartite motif containing 2 |
| TSFM | Ts translation elongation factor, mitochondrial |
| TSPAN1 | tetraspanin 1 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 |
| UNC5C | unc-5 homolog C (C. elegans) |
| VAV3 | vav 3 guanine nucleotide exchange factor |
| VPS8 | vacuolar protein sorting 8 homolog (S. cerevisiae) |
| WFDC2 | WAP four-disulfide core domain 2 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 |
