MELK Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description maternal embryonic leucine zipper kinase| (NCBI Entrez Gene Database, 9833)
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Genes

349 genes differentially expressed following the MELK gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TLE6 transducin-like enhancer of split 6 2.56256
MAP3K7CL MAP3K7 C-terminal like 2.56256
SCG2 secretogranin II 2.56256
RXFP1 relaxin/insulin-like family peptide receptor 1 2.56256
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.56256
NANOS3 nanos homolog 3 (Drosophila) 2.56256
TMEM176B transmembrane protein 176B 2.56256
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.56256
PGAM2 phosphoglycerate mutase 2 (muscle) 2.56256
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.56256
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.56256
GFRA3 GDNF family receptor alpha 3 2.56256
PARP3 poly (ADP-ribose) polymerase family, member 3 2.56256
CLEC12A C-type lectin domain family 12, member A 2.56256
RNF17 ring finger protein 17 2.56256
GGT5 gamma-glutamyltransferase 5 2.56256
GGT1 gamma-glutamyltransferase 1 2.56256
PCDHA7 protocadherin alpha 7 2.56256
FOXD1 forkhead box D1 2.56256
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.56256
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.56256
FAM3D family with sequence similarity 3, member D 2.56256
SYCP2 synaptonemal complex protein 2 2.56256
SRL sarcalumenin 2.56256
FER1L6 fer-1-like family member 6 2.56256
SIX6 SIX homeobox 6 2.56256
RIMBP2 RIMS binding protein 2 2.56256
CCNB3 cyclin B3 2.56256
SH2D7 SH2 domain containing 7 2.56256
TDRD9 tudor domain containing 9 2.56256
ZSCAN21 zinc finger and SCAN domain containing 21 2.56256
UBA7 ubiquitin-like modifier activating enzyme 7 2.56256
CIC capicua transcriptional repressor 2.56256
OR6A2 olfactory receptor, family 6, subfamily A, member 2 2.56256
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.56256
LRRIQ1 leucine-rich repeats and IQ motif containing 1 2.56256
NPIPA2 nuclear pore complex interacting protein family, member A2 2.56256
PTK6 protein tyrosine kinase 6 2.56256
JCHAIN joining chain of multimeric IgA and IgM 2.56256
TSHZ1 teashirt zinc finger homeobox 1 2.56256
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 2.56256
ECHDC1 ethylmalonyl-CoA decarboxylase 1 2.56256
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.56256
CSTL1 cystatin-like 1 2.56256
XCL1 chemokine (C motif) ligand 1 2.56256
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.56256
ASPA aspartoacylase 2.56256
TAS2R1 taste receptor, type 2, member 1 2.56256
PBOV1 prostate and breast cancer overexpressed 1 2.56256
GFI1 growth factor independent 1 transcription repressor 2.56256
C11ORF87 chromosome 11 open reading frame 87 2.56256
BIRC3 baculoviral IAP repeat containing 3 2.56256
PTGFR prostaglandin F receptor (FP) 2.56256
THRSP thyroid hormone responsive 2.56256
VCX variable charge, X-linked 2.56256
LGALS7B lectin, galactoside-binding, soluble, 7B 2.56256
SPATA31G1 SPATA31 subfamily G member 1 2.56256
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.56256
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.56256
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.56256
RHCG Rh family, C glycoprotein 2.56256
RD3 retinal degeneration 3 2.56256
FOXN4 forkhead box N4 2.56256
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.56256
TRIM31 tripartite motif containing 31 2.56256
TEDDM1 transmembrane epididymal protein 1 2.56256
BDKRB2 bradykinin receptor B2 2.56256
MYEOV myeloma overexpressed 2.56256
GBP3 guanylate binding protein 3 2.56256
PHF24 PHD finger protein 24 2.56256
CFAP65 cilia and flagella associated protein 65 2.56256
SPMIP11 sperm microtubule inner protein 11 2.56256
CHLSN cholesin 2.56256
SPEGNB SPEG neighbor 2.56256
LRRC8C-DT LRRC8C divergent transcript 2.56256
LINC02560 long intergenic non-protein coding RNA 2560 2.56256
SPAAR small regulatory polypeptide of amino acid response 2.56256
IQCN IQ motif containing N 2.56256
GARIN1A golgi associated RAB2 interactor 1A 2.56256
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.56256
RTL5 retrotransposon Gag like 5 2.56256
CALHM5 calcium homeostasis modulator family member 5 2.56256
MYPN myopalladin 2.56256
SPATA22 spermatogenesis associated 22 2.56256
FAM228A family with sequence similarity 228, member A 2.56256
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.56256
MIA melanoma inhibitory activity 2.56256
TLR8 toll-like receptor 8 2.56256
IL6 interleukin 6 2.56256
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.56256
CXCL14 chemokine (C-X-C motif) ligand 14 2.56256
UROC1 urocanate hydratase 1 2.56256
C10ORF67 chromosome 10 open reading frame 67 2.56256
C3ORF80 chromosome 3 open reading frame 80 2.56256
AXDND1 axonemal dynein light chain domain containing 1 2.56256
IL31RA interleukin 31 receptor A 2.56256
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.56256
C1QTNF7 C1q and tumor necrosis factor related protein 7 2.56256
NPFF neuropeptide FF-amide peptide precursor 2.56256
DYNLRB1 dynein, light chain, roadblock-type 1 2.56256
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.56256
SYT15 synaptotagmin XV 2.56256
LTF lactotransferrin 2.56256
LTB lymphotoxin beta (TNF superfamily, member 3) 2.56256
TMEM119 transmembrane protein 119 2.56256
PLEK2 pleckstrin 2 2.56256
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.56256
FGFBP2 fibroblast growth factor binding protein 2 2.56256
XRN1 5'-3' exoribonuclease 1 2.56256
CCR3 chemokine (C-C motif) receptor 3 2.56256
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.56256
ASGR2 asialoglycoprotein receptor 2 2.56256
C9ORF57 chromosome 9 open reading frame 57 2.56256
RAD51AP2 RAD51 associated protein 2 2.56256
AQP3 aquaporin 3 (Gill blood group) 2.56256
DEFB107B defensin, beta 107B 2.56256
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 2.56256
NOX1 NADPH oxidase 1 2.56256
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 2.56256
GOLGA6C golgin A6 family, member C 2.56256
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) 2.56256
HKDC1 hexokinase domain containing 1 2.56256
CPA2 carboxypeptidase A2 (pancreatic) 2.56256
SNX31 sorting nexin 31 2.56256
CLDN34 claudin 34 2.56256
EXTL1 exostosin-like glycosyltransferase 1 2.56256
TBC1D28 TBC1 domain family, member 28 2.56256
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 2.56256
ACSM4 acyl-CoA synthetase medium-chain family member 4 2.56256
ANKRD62 ankyrin repeat domain 62 2.56256
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.56256
NBPF8 neuroblastoma breakpoint family, member 8 2.56256
CPZ carboxypeptidase Z 2.56256
HGFAC HGF activator 2.56256
APOB apolipoprotein B 2.56256
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.56256
CT55 cancer/testis antigen 55 2.56256
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.56256
VWA3B von Willebrand factor A domain containing 3B 2.56256
GPR61 G protein-coupled receptor 61 2.56256
OR4D1 olfactory receptor, family 4, subfamily D, member 1 2.56256
TCAP titin-cap 2.56256
MYADML2 myeloid-associated differentiation marker-like 2 2.56256
GPR146 G protein-coupled receptor 146 2.56256
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 2.56256
CCDC70 coiled-coil domain containing 70 2.56256
SYT5 synaptotagmin V 2.56256
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.56256
CFP complement factor properdin 2.56256
ART1 ADP-ribosyltransferase 1 2.56256
INSM1 insulinoma-associated 1 2.56256
NT5C1B 5'-nucleotidase, cytosolic IB 2.56256
DHH desert hedgehog 2.56256
SCARF1 scavenger receptor class F, member 1 2.56256
COL6A5 collagen, type VI, alpha 5 2.56256
TEX12 testis expressed 12 2.56256
FAM168B family with sequence similarity 168, member B 2.56256
ZNF843 zinc finger protein 843 2.56256
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) 2.56256
ITGA10 integrin, alpha 10 2.56256
LY96 lymphocyte antigen 96 2.56256
ZC3H12D zinc finger CCCH-type containing 12D 2.56256
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.56256
NTSR2 neurotensin receptor 2 2.56256
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.56256
FGF7 fibroblast growth factor 7 2.56256
AHSG alpha-2-HS-glycoprotein 2.56256
TAS2R42 taste receptor, type 2, member 42 2.56256
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.56256
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.56256
TGM6 transglutaminase 6 2.56256
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.56256
SPAG8 sperm associated antigen 8 2.56256
CIB4 calcium and integrin binding family member 4 2.56256
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.56256
ZNF648 zinc finger protein 648 2.56256
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.56256
ERAP2 endoplasmic reticulum aminopeptidase 2 2.56256
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.56256
FAM9B family with sequence similarity 9, member B 2.56256
R3HDML R3H domain containing-like 2.56256
AMPD1 adenosine monophosphate deaminase 1 2.56256
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.56256
IRX1 iroquois homeobox 1 2.56256
BIN2 bridging integrator 2 2.56256
NWD2 NACHT and WD repeat domain containing 2 2.56256
NUTM2A NUT family member 2A 2.56256
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.56256
CHRM1 cholinergic receptor, muscarinic 1 2.56256
SCN3A sodium channel, voltage gated, type III alpha subunit 2.56256
NR2E1 nuclear receptor subfamily 2, group E, member 1 2.56256
ITPKA inositol-trisphosphate 3-kinase A 2.56256
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.56256
PLGLB1 plasminogen-like B1 2.56256
KCNU1 potassium channel, subfamily U, member 1 2.56256
DAND5 DAN domain family member 5, BMP antagonist 2.56256
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.56256
RTN4RL1 reticulon 4 receptor-like 1 2.56256
ZC4H2 zinc finger, C4H2 domain containing 2.56256
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.56256
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.53378
OXA1L oxidase (cytochrome c) assembly 1-like 2.53335
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2.52405
CARHSP1 calcium regulated heat stable protein 1, 24kDa 2.52166
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.47236
C17ORF114 chromosome 17 open reading frame 114 2.41522
IL23A interleukin 23, alpha subunit p19 2.41522
FAM43A family with sequence similarity 43, member A 2.41522
STX4 syntaxin 4 2.40307
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 2.4025
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 2.38674
LENG8 leukocyte receptor cluster (LRC) member 8 2.37774
PTPRS protein tyrosine phosphatase, receptor type, S 2.36627
MANBAL mannosidase, beta A, lysosomal-like 2.34533
RBMS1 RNA binding motif, single stranded interacting protein 1 2.33654
CD22 CD22 molecule 2.29873
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.28737
TMUB1 transmembrane and ubiquitin-like domain containing 1 2.27735
RPL15 ribosomal protein L15 2.27398
TMTC3 transmembrane and tetratricopeptide repeat containing 3 2.27242
SREBF2 sterol regulatory element binding transcription factor 2 2.27242
EHMT2 euchromatic histone-lysine N-methyltransferase 2 2.26918
CAPZB capping protein (actin filament) muscle Z-line, beta 2.2421
CRACR2B calcium release activated channel regulator 2B 2.23691
KARS1 lysyl-tRNA synthetase 1 2.20734
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 2.19726
ZBTB35 zinc finger and BTB domain containing 35 2.18187
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 2.17331
CCNL1 cyclin L1 2.16742
SLC35A4 solute carrier family 35, member A4 2.16337
RTL6 retrotransposon Gag like 6 2.14376
STIL SCL/TAL1 interrupting locus 2.13162
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 2.12596
SPICP3 Spi-C transcription factor pseudogene 3 2.11838
CENPA centromere protein A 2.11432
TCEAL7 transcription elongation factor A (SII)-like 7 2.09077
GPR137C G protein-coupled receptor 137C 2.05882
UBE2F ubiquitin-conjugating enzyme E2F (putative) 2.0413
KIF5A kinesin family member 5A 2.03954
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 2.03563
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 2.0322
GIN1 gypsy retrotransposon integrase 1 2.00759
RNF141 ring finger protein 141 2.00529
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) 2.00529
OPA1 optic atrophy 1 (autosomal dominant) 2.00148
YPEL1 yippee-like 1 (Drosophila) 2.00148
EXOC7 exocyst complex component 7 2.00015

decreased expression

Symbol Name Standardized Value
SMIM45 small integral membrane protein 45 -2.56256
ATXN2L ataxin 2-like -2.56256
NME7 NME/NM23 family member 7 -2.56256
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.56256
PTGES3L prostaglandin E synthase 3 (cytosolic)-like -2.56256
ADAD2 adenosine deaminase domain containing 2 -2.56256
LYNX1 Ly6/neurotoxin 1 -2.56256
PRODH proline dehydrogenase (oxidase) 1 -2.56256
ARRDC2 arrestin domain containing 2 -2.56256
C19ORF25 chromosome 19 open reading frame 25 -2.56256
C12ORF42 chromosome 12 open reading frame 42 -2.56256
SLC25A27 solute carrier family 25, member 27 -2.56256
DTD2 D-tyrosyl-tRNA deacylase 2 (putative) -2.56256
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -2.56256
IL4I1 interleukin 4 induced 1 -2.56256
TMEM212 transmembrane protein 212 -2.56256
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -2.56256
DNAI3 dynein axonemal intermediate chain 3 -2.56256
CFAP20DC CFAP20 domain containing -2.56256
GIPC2 GIPC PDZ domain containing family, member 2 -2.56256
TPRA1 transmembrane protein, adipocyte asscociated 1 -2.56256
DUSP8 dual specificity phosphatase 8 -2.56256
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) -2.56256
LMNTD1 lamin tail domain containing 1 -2.56256
SPMAP2L sperm microtubule associated protein 2 like -2.56256
GGACT gamma-glutamylamine cyclotransferase -2.56256
BBS9 Bardet-Biedl syndrome 9 -2.56256
PYDC1 PYD (pyrin domain) containing 1 -2.56256
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -2.56256
EFHB EF-hand domain family, member B -2.56256
NIM1K NIM1 serine/threonine protein kinase -2.56256
CD248 CD248 molecule, endosialin -2.56256
CRHR1 corticotropin releasing hormone receptor 1 -2.56256
RUMY3 RUMY family member 3 -2.56256
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B -2.56256
CRYBA4 crystallin, beta A4 -2.56256
FGF1 fibroblast growth factor 1 (acidic) -2.56256
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.56256
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.56256
FANCE Fanconi anemia, complementation group E -2.56256
GPHA2 glycoprotein hormone alpha 2 -2.56256
EFCC1 EF-hand and coiled-coil domain containing 1 -2.56256
NBPF20 neuroblastoma breakpoint family, member 20 -2.56256
FECH ferrochelatase -2.56256
PCSK1 proprotein convertase subtilisin/kexin type 1 -2.56256
GOLGA8R golgin A8 family, member R -2.56256
GCNT7 glucosaminyl (N-acetyl) transferase family member 7 -2.56256
PEBP4 phosphatidylethanolamine-binding protein 4 -2.56256
RAB6A RAB6A, member RAS oncogene family -2.56256
ZNF629 zinc finger protein 629 -2.56256
ADAM8 ADAM metallopeptidase domain 8 -2.56256
ZBED4 zinc finger, BED-type containing 4 -2.56256
SENP6 SUMO1/sentrin specific peptidase 6 -2.55273
MELK maternal embryonic leucine zipper kinase -2.53779
BEGAIN brain-enriched guanylate kinase-associated -2.52691
DENND2D DENN/MADD domain containing 2D -2.52691
TFB1M transcription factor B1, mitochondrial -2.52691
SLK STE20-like kinase -2.47236
NELFA negative elongation factor complex member A -2.42746
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -2.41522
PPP4R4 protein phosphatase 4, regulatory subunit 4 -2.40307
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -2.39401
TAGLN3 transgelin 3 -2.36954
LRRC27 leucine rich repeat containing 27 -2.36954
TGFA transforming growth factor, alpha -2.33962
GAB2 GRB2-associated binding protein 2 -2.29085
SNX2 sorting nexin 2 -2.27735
CBARP CACN subunit beta associated regulatory protein -2.26197
LUZP2 leucine zipper protein 2 -2.26027
EMC2 ER membrane protein complex subunit 2 -2.24627
ACP4 acid phosphatase 4 -2.23828
GRIK3 glutamate receptor, ionotropic, kainate 3 -2.18043
ACP1 acid phosphatase 1, soluble -2.17104
DNAH6 dynein, axonemal, heavy chain 6 -2.16742
C14ORF39 chromosome 14 open reading frame 39 -2.16742
DPYD dihydropyrimidine dehydrogenase -2.16742
RORB RAR-related orphan receptor B -2.16048
PPIF peptidylprolyl isomerase F -2.15525
ADGRB2 adhesion G protein-coupled receptor B2 -2.14356
APLF aprataxin and PNKP like factor -2.13162
VSNL1 visinin-like 1 -2.13162
GYS1 glycogen synthase 1 (muscle) -2.13119
ZDHHC1 zinc finger, DHHC-type containing 1 -2.1264
ARSG arylsulfatase G -2.10949
COG8 component of oligomeric golgi complex 8 -2.09038
FGFBP3 fibroblast growth factor binding protein 3 -2.09038
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa -2.0859
ZSWIM6 zinc finger, SWIM-type containing 6 -2.08086
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) -2.08086
FXR2 fragile X mental retardation, autosomal homolog 2 -2.06115
PXDNL peroxidasin-like -2.05016
NNT nicotinamide nucleotide transhydrogenase -2.04885
TMEM70 transmembrane protein 70 -2.04336
PAK1IP1 PAK1 interacting protein 1 -2.03753
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -2.03563
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 -2.03497
PHF6 PHD finger protein 6 -2.0331
VMAC vimentin-type intermediate filament associated coiled-coil protein -2.0331
TADA2A transcriptional adaptor 2A -2.00951
LYPLAL1 lysophospholipase-like 1 -2.00951
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -2.00951
HTT huntingtin -2.00148