MELK Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description maternal embryonic leucine zipper kinase| (NCBI Entrez Gene Database, 9833)
External Link https://ncbi.nlm.nih.gov/gene/9833
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Genes

500 genes differentially expressed following the MELK gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.00938297
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00911842
BAMBI BMP and activin membrane-bound inhibitor 0.00791813
S100P S100 calcium binding protein P 0.0077947
CXCL8 chemokine (C-X-C motif) ligand 8 0.00726477
RGCC regulator of cell cycle 0.00710529
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.00692267
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.00658411
MSLN mesothelin 0.00618701
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.00611575
TGFA transforming growth factor, alpha 0.00602573
BIK BCL2-interacting killer (apoptosis-inducing) 0.00588475
PLK2 polo-like kinase 2 0.00584584
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.00579506
PCNA proliferating cell nuclear antigen 0.00579369
CD9 CD9 molecule 0.00577382
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.00568819
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.00568046
LIMCH1 LIM and calponin homology domains 1 0.00565233
COPS7A COP9 signalosome subunit 7A 0.00563536
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.0055639
LBH limb bud and heart development 0.0055582
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00546441
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 0.00545457
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 0.00516815
RHOB ras homolog family member B 0.00510639
S100A12 S100 calcium binding protein A12 0.00508213
RBPMS RNA binding protein with multiple splicing 0.00502926
SAT1 spermidine/spermine N1-acetyltransferase 1 0.00501098
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0049637
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.00495878
BCL2A1 BCL2-related protein A1 0.00495013
SIK1 salt-inducible kinase 1 0.00481509
FABP4 fatty acid binding protein 4, adipocyte 0.00480111
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.00476912
BHLHE41 basic helix-loop-helix family, member e41 0.00473134
CAST calpastatin 0.00471319
PODXL podocalyxin-like 0.00465599
KRT7 keratin 7, type II 0.00465396
PLAT plasminogen activator, tissue 0.00465029
MME membrane metallo-endopeptidase 0.00463449
ZBED2 zinc finger, BED-type containing 2 0.00461175
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.00460054
ZNF395 zinc finger protein 395 0.00453743
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.00448424
SH3TC1 SH3 domain and tetratricopeptide repeats 1 0.00445944
LGALS13 lectin, galactoside-binding, soluble, 13 0.00445699
OPHN1 oligophrenin 1 0.00443728
PTGES prostaglandin E synthase 0.00441739
CLDN8 claudin 8 0.00441223
TMEM100 transmembrane protein 100 0.00439846
KRT23 keratin 23, type I 0.00438231
KRT13 keratin 13, type I 0.00434652
HBEGF heparin-binding EGF-like growth factor 0.00431745
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.00429224
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.00429097
PDZK1IP1 PDZK1 interacting protein 1 0.00426365
PMEPA1 prostate transmembrane protein, androgen induced 1 0.00426158
MCOLN1 mucolipin 1 0.00425642
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.00425065
PDE4A phosphodiesterase 4A, cAMP-specific 0.00421471
TBX3 T-box 3 0.00421248
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.00417998
ADGRE5 adhesion G protein-coupled receptor E5 0.00417286
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.00416627
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.00416269
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.00415331
MMP7 matrix metallopeptidase 7 0.00412435
CCL20 chemokine (C-C motif) ligand 20 0.00411139
CLIC5 chloride intracellular channel 5 0.00411081
OLFM4 olfactomedin 4 0.00408819
JAG1 jagged 1 0.00408439
PLBD1 phospholipase B domain containing 1 0.004072
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.00405142
TRIB2 tribbles pseudokinase 2 0.00404853
ABLIM1 actin binding LIM protein 1 0.00402402
CXCL5 chemokine (C-X-C motif) ligand 5 0.00402308
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.00401784
TMEM87A transmembrane protein 87A 0.00401316
MGAM maltase-glucoamylase 0.00401273
SPRY2 sprouty homolog 2 (Drosophila) 0.00399419
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.00397065
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.00395704
F3 coagulation factor III (thromboplastin, tissue factor) 0.0039501
RGS10 regulator of G-protein signaling 10 0.00392152
PELO pelota homolog (Drosophila) 0.00392095
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.00390546
PRR7 proline rich 7 (synaptic) 0.00388724
NOP10 NOP10 ribonucleoprotein 0.00385118
FYB1 FYN binding protein 1 0.00381891
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.00381176
AKAP1 A kinase (PRKA) anchor protein 1 0.00379801
EREG epiregulin 0.0037831
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.00377827
ATF3 activating transcription factor 3 0.0037642
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0037625
C8ORF4 chromosome 8 open reading frame 4 0.00375304
STC1 stanniocalcin 1 0.00373595
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.00372583
RRAGD Ras-related GTP binding D 0.00371361
JCHAIN joining chain of multimeric IgA and IgM 0.00370867
ORC1 origin recognition complex, subunit 1 0.00370684
CHPT1 choline phosphotransferase 1 0.00370344
CEMIP cell migration inducing protein, hyaluronan binding 0.00367851
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.00367705
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.00367443
CKAP4 cytoskeleton-associated protein 4 0.00365695
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00363867
MUC4 mucin 4, cell surface associated 0.00363147
PFN1 profilin 1 0.00360882
NAV2 neuron navigator 2 0.00360035
CXCL13 chemokine (C-X-C motif) ligand 13 0.00359908
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.0035957
ZMYM2 zinc finger, MYM-type 2 0.00359421
HSPH1 heat shock 105kDa/110kDa protein 1 0.00358654
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 0.00358654
RND3 Rho family GTPase 3 0.00358049
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.00357531
DEFB1 defensin, beta 1 0.00355484
CD1E CD1e molecule 0.00355458
DUSP1 dual specificity phosphatase 1 0.0035436
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00350397
MLPH melanophilin 0.0034934
NEBL nebulette 0.00348543
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.00348088
ADORA2B adenosine A2b receptor 0.00347015
NCF4 neutrophil cytosolic factor 4, 40kDa 0.00346497
OXTR oxytocin receptor 0.00346337
SMAD7 SMAD family member 7 0.00346248
NPTN neuroplastin 0.0034565
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.0034556
DRAM1 DNA-damage regulated autophagy modulator 1 0.00345459
RPS27L ribosomal protein S27-like 0.00343991
POLR1D polymerase (RNA) I polypeptide D, 16kDa 0.00343471
CD59 CD59 molecule, complement regulatory protein 0.00339545
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 0.0033868
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 0.00337173
WFDC2 WAP four-disulfide core domain 2 0.00337118
DUT deoxyuridine triphosphatase 0.00337016
FGF13 fibroblast growth factor 13 0.00337001
ODAM odontogenic, ameloblast asssociated 0.00336499
SFRP1 secreted frizzled-related protein 1 0.00336371
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.00335415
GRK5 G protein-coupled receptor kinase 5 0.0033486
TSPAN1 tetraspanin 1 0.00331916
TRIM29 tripartite motif containing 29 0.00331554
ANXA3 annexin A3 0.00331483
IER5 immediate early response 5 0.00331291
ELF1 E74-like factor 1 (ets domain transcription factor) 0.00330696
TMEM127 transmembrane protein 127 0.00330205
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.00329928
TGM2 transglutaminase 2 0.00329505
TOR1A torsin family 1, member A (torsin A) 0.0032913
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.003291
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 0.00325232
SPRR3 small proline-rich protein 3 0.0032423
TACC2 transforming, acidic coiled-coil containing protein 2 0.00324213
SERINC3 serine incorporator 3 0.00323515
CXCL3 chemokine (C-X-C motif) ligand 3 0.00323164
MMP10 matrix metallopeptidase 10 0.00323131
RAB11FIP2 RAB11 family interacting protein 2 (class I) 0.00322974
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 0.0032207
XCL1 chemokine (C motif) ligand 1 0.00322065
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.00320647
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.00318274
YBX3 Y box binding protein 3 0.00317624
TARBP1 TAR (HIV-1) RNA binding protein 1 0.00317148
HK2 hexokinase 2 0.00316738
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00316068
TCL1A T-cell leukemia/lymphoma 1A 0.00315905
CAVIN1 caveolae associated protein 1 0.00315563
FOSL2 FOS-like antigen 2 0.00315214
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.00314621
PSCA prostate stem cell antigen 0.00314155
RIN2 Ras and Rab interactor 2 0.00314154
PKM pyruvate kinase, muscle 0.00314065
M6PR mannose-6-phosphate receptor (cation dependent) 0.00313958
TXNDC9 thioredoxin domain containing 9 0.00312281
ZBTB16 zinc finger and BTB domain containing 16 0.00312193
CLEC5A C-type lectin domain family 5, member A 0.00311301
C5AR1 complement component 5a receptor 1 0.0031103
TSC22D1 TSC22 domain family, member 1 0.00309805
ACSL1 acyl-CoA synthetase long-chain family member 1 0.00308402
PPARG peroxisome proliferator-activated receptor gamma 0.00308376
CTSC cathepsin C 0.00308091
PROM1 prominin 1 0.00307477
AGTR1 angiotensin II receptor, type 1 0.00307422
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 0.00306981
JUN jun proto-oncogene 0.00306866
RANBP2 RAN binding protein 2 0.00306509
ACP5 acid phosphatase 5, tartrate resistant 0.00306154
SVIL supervillin 0.00305972
BMP2 bone morphogenetic protein 2 0.0030591
NXT1 nuclear transport factor 2-like export factor 1 0.00305734
ADM adrenomedullin 0.00305576
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.00305442
TREM1 triggering receptor expressed on myeloid cells 1 0.00304574
RAB17 RAB17, member RAS oncogene family 0.00304524
KCNK3 potassium channel, two pore domain subfamily K, member 3 0.00304433
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.00304124
PDZD8 PDZ domain containing 8 0.00303538
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.00302295
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.00301514
EMP1 epithelial membrane protein 1 0.00301161
DUSP3 dual specificity phosphatase 3 0.00299485
IVNS1ABP influenza virus NS1A binding protein 0.00298294
FAIM Fas apoptotic inhibitory molecule 0.00298282
RCAN1 regulator of calcineurin 1 0.00297976
KLHL24 kelch-like family member 24 0.00296979
SLC16A6 solute carrier family 16, member 6 0.0029603
RIPOR2 RHO family interacting cell polarization regulator 2 0.00295428
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.00295102
NOP56 NOP56 ribonucleoprotein 0.00293726
CLK4 CDC-like kinase 4 0.00293508
OGFRL1 opioid growth factor receptor-like 1 0.00291923
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.00291704
ERAP2 endoplasmic reticulum aminopeptidase 2 0.00291433
KAZN kazrin, periplakin interacting protein 0.00291143
DSG2 desmoglein 2 0.00290632
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene 0.00290102
LXN latexin 0.00289597
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.00289474
FKBP1A FK506 binding protein 1A, 12kDa 0.00288945
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.00287609
FHOD3 formin homology 2 domain containing 3 0.00287093
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.00287053
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.00286077
TM4SF1 transmembrane 4 L six family member 1 0.00285763
DHCR24 24-dehydrocholesterol reductase 0.00285365
ANO1 anoctamin 1, calcium activated chloride channel 0.00285261
CHRDL1 chordin-like 1 0.00285203
DSTN destrin (actin depolymerizing factor) 0.00285037
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.00284323
GCK glucokinase (hexokinase 4) 0.00284194
ERBB4 erb-b2 receptor tyrosine kinase 4 0.00283093
TBX2 T-box 2 0.00282824
ZNF189 zinc finger protein 189 0.00282538
NCOA4 nuclear receptor coactivator 4 0.00281588
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.00280736
DNMBP dynamin binding protein 0.00280234
PSAP prosaposin 0.00280017
LCK LCK proto-oncogene, Src family tyrosine kinase 0.00279181
L1CAM L1 cell adhesion molecule 0.00278773
TBXA2R thromboxane A2 receptor 0.00278383
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.00278208
HPCAL1 hippocalcin-like 1 0.00278115
PCTP phosphatidylcholine transfer protein 0.00278054
STON1 stonin 1 0.00277286
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.00277206
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0027718

decreased expression

Symbol Name Standardized Value
MELK maternal embryonic leucine zipper kinase -0.0162854
CA2 carbonic anhydrase II -0.00842858
TDO2 tryptophan 2,3-dioxygenase -0.00721878
HOPX HOP homeobox -0.00707792
CFH complement factor H -0.00698232
GJA1 gap junction protein, alpha 1, 43kDa -0.00689845
BCHE butyrylcholinesterase -0.00591763
GRB14 growth factor receptor-bound protein 14 -0.00588222
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -0.00569577
GSTM3 glutathione S-transferase mu 3 (brain) -0.00565151
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.00555191
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -0.00546718
FANCG Fanconi anemia, complementation group G -0.00536645
LAMP5 lysosomal-associated membrane protein family, member 5 -0.00536351
DCTN3 dynactin 3 (p22) -0.00532087
DCN decorin -0.00530533
TMSB15A thymosin beta 15a -0.00529099
XPO7 exportin 7 -0.00527867
BLNK B-cell linker -0.00527191
DCAF10 DDB1 and CUL4 associated factor 10 -0.005124
MPDZ multiple PDZ domain protein -0.00506887
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) -0.00504058
TM4SF4 transmembrane 4 L six family member 4 -0.00495603
MFAP2 microfibrillar-associated protein 2 -0.00484693
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -0.00482765
VCP valosin containing protein -0.00479951
STOML2 stomatin (EPB72)-like 2 -0.00478487
STK10 serine/threonine kinase 10 -0.00473951
SRGN serglycin -0.00468781
LUM lumican -0.00466386
LGALS1 lectin, galactoside-binding, soluble, 1 -0.00465041
PCOLCE procollagen C-endopeptidase enhancer -0.004625
PDGFD platelet derived growth factor D -0.00458577
KRT1 keratin 1, type II -0.00453028
CLTA clathrin, light chain A -0.00447801
STEAP1 six transmembrane epithelial antigen of the prostate 1 -0.00443315
GRHPR glyoxylate reductase/hydroxypyruvate reductase -0.00435024
NID2 nidogen 2 (osteonidogen) -0.00433993
GLDC glycine dehydrogenase (decarboxylating) -0.00433268
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) -0.0043223
ZBTB5 zinc finger and BTB domain containing 5 -0.00431769
DMTF1 cyclin D binding myb-like transcription factor 1 -0.00430454
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 -0.00428854
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.00428067
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -0.00422987
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.00420732
ISYNA1 inositol-3-phosphate synthase 1 -0.00419046
PTGDS prostaglandin D2 synthase 21kDa (brain) -0.00418052
COLEC12 collectin sub-family member 12 -0.00414718
MATN2 matrilin 2 -0.00414006
REEP1 receptor accessory protein 1 -0.00411847
COL3A1 collagen, type III, alpha 1 -0.0041138
ATP5IF1 ATP synthase inhibitory factor subunit 1 -0.00408069
BST2 bone marrow stromal cell antigen 2 -0.00406919
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -0.00406812
IL11RA interleukin 11 receptor, alpha -0.004037
PSIP1 PC4 and SFRS1 interacting protein 1 -0.00402344
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -0.00401116
AGR2 anterior gradient 2 -0.00399095
CCDC92 coiled-coil domain containing 92 -0.00397717
GSTA1 glutathione S-transferase alpha 1 -0.00397522
S100A8 S100 calcium binding protein A8 -0.00394044
BEX1 brain expressed, X-linked 1 -0.00393044
F13A1 coagulation factor XIII, A1 polypeptide -0.00392949
CDO1 cysteine dioxygenase type 1 -0.00389487
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 -0.00388035
SCRG1 stimulator of chondrogenesis 1 -0.00385025
POSTN periostin, osteoblast specific factor -0.00383967
PTTG1 pituitary tumor-transforming 1 -0.00383797
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A -0.00381286
IFITM1 interferon induced transmembrane protein 1 -0.0037834
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -0.00376991
CDKN3 cyclin-dependent kinase inhibitor 3 -0.0037418
C6ORF48 chromosome 6 open reading frame 48 -0.00373435
VTCN1 V-set domain containing T cell activation inhibitor 1 -0.00370539
MT1F metallothionein 1F -0.00369179
ANXA6 annexin A6 -0.00368659
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 -0.00364882
PLEK pleckstrin -0.00363913
FOCAD focadhesin -0.00363104
RAB40B RAB40B, member RAS oncogene family -0.00361783
PLS3 plastin 3 -0.00361656
EPS15 epidermal growth factor receptor pathway substrate 15 -0.0036144
PDIA4 protein disulfide isomerase family A, member 4 -0.00361302
PLXNC1 plexin C1 -0.00361099
ADGRL2 adhesion G protein-coupled receptor L2 -0.00359783
NPIPB3 nuclear pore complex interacting protein family, member B3 -0.00358185
SEPP1 selenoprotein P, plasma, 1 -0.0035783
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -0.0035768
PLAAT3 phospholipase A and acyltransferase 3 -0.00357399
SLC46A3 solute carrier family 46, member 3 -0.00355184
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -0.00353708
BGN biglycan -0.0035344
DHRS1 dehydrogenase/reductase (SDR family) member 1 -0.00353203
CLU clusterin -0.00352351
HMGB3 high mobility group box 3 -0.00352298
DCXR dicarbonyl/L-xylulose reductase -0.00351901
IRF8 interferon regulatory factor 8 -0.0035156
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -0.00351526
CXCR4 chemokine (C-X-C motif) receptor 4 -0.00351495
TM7SF2 transmembrane 7 superfamily member 2 -0.00349748
TSPYL5 TSPY-like 5 -0.00349025
HDAC1 histone deacetylase 1 -0.00346691
LACTB2 lactamase, beta 2 -0.00343427
DDAH2 dimethylarginine dimethylaminohydrolase 2 -0.00342798
WLS wntless Wnt ligand secretion mediator -0.00341749
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 -0.00341484
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -0.00341326
NCAPD3 non-SMC condensin II complex, subunit D3 -0.00340712
S100B S100 calcium binding protein B -0.00340546
PSAT1 phosphoserine aminotransferase 1 -0.00340422
TPD52L1 tumor protein D52-like 1 -0.00339664
LEPR leptin receptor -0.00339227
NAV3 neuron navigator 3 -0.00338016
LPAR1 lysophosphatidic acid receptor 1 -0.00337462
DMAC2L distal membrane arm assembly component 2 like -0.00335834
PLAGL1 pleiomorphic adenoma gene-like 1 -0.00335804
KRT2 keratin 2, type II -0.00334401
CDCA4 cell division cycle associated 4 -0.00332565
C3ORF14 chromosome 3 open reading frame 14 -0.00332264
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -0.00329234
OPN3 opsin 3 -0.00328786
TAGLN2 transgelin 2 -0.00328404
WASHC4 WASH complex subunit 4 -0.00327304
GCH1 GTP cyclohydrolase 1 -0.00327028
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.00326026
NUSAP1 nucleolar and spindle associated protein 1 -0.00326008
CPM carboxypeptidase M -0.00325638
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -0.0032378
DYNLT1 dynein, light chain, Tctex-type 1 -0.00322593
SIGMAR1 sigma non-opioid intracellular receptor 1 -0.00322269
DLD dihydrolipoamide dehydrogenase -0.00322243
PHACTR2 phosphatase and actin regulator 2 -0.00322129
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.00319893
NCOA2 nuclear receptor coactivator 2 -0.00319864
USP18 ubiquitin specific peptidase 18 -0.00319496
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.00319443
TTC39A tetratricopeptide repeat domain 39A -0.00319427
NDRG1 N-myc downstream regulated 1 -0.00317354
VSNL1 visinin-like 1 -0.00316945
HMGN3 high mobility group nucleosomal binding domain 3 -0.00316682
ZIC1 Zic family member 1 -0.00315586
NARF nuclear prelamin A recognition factor -0.00313811
CSTA cystatin A (stefin A) -0.00313669
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) -0.00313665
IGSF3 immunoglobulin superfamily, member 3 -0.00313239
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -0.00312125
HAL histidine ammonia-lyase -0.00312115
CDH1 cadherin 1, type 1, E-cadherin (epithelial) -0.00311922
FAM3C family with sequence similarity 3, member C -0.00311897
PERP PERP, TP53 apoptosis effector -0.00311808
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.00311361
PCCB propionyl CoA carboxylase, beta polypeptide -0.00311308
FST follistatin -0.00311151
CSAD cysteine sulfinic acid decarboxylase -0.00310871
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -0.00310779
GALT galactose-1-phosphate uridylyltransferase -0.00310521
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -0.0031009
LRRC15 leucine rich repeat containing 15 -0.00309638
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -0.00309621
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 -0.00308904
LMNB2 lamin B2 -0.00308826
MEG3 maternally expressed 3 (non-protein coding) -0.00308563
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -0.00308049
ZFPM2 zinc finger protein, FOG family member 2 -0.00307433
C6 complement component 6 -0.00306557
PDGFRL platelet-derived growth factor receptor-like -0.00305503
IRF7 interferon regulatory factor 7 -0.00304528
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.00304276
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) -0.00303938
STK3 serine/threonine kinase 3 -0.00303553
PLSCR4 phospholipid scramblase 4 -0.00303479
RNH1 ribonuclease/angiogenin inhibitor 1 -0.00303433
FGL1 fibrinogen-like 1 -0.00302698
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -0.00302422
GAL galanin/GMAP prepropeptide -0.00302119
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) -0.00301896
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 -0.00300923
PDGFRB platelet-derived growth factor receptor, beta polypeptide -0.00300848
CYBA cytochrome b-245, alpha polypeptide -0.00299761
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.00299734
PLK1 polo-like kinase 1 -0.00299696
GPM6B glycoprotein M6B -0.00297558
TMEM255A transmembrane protein 255A -0.00297194
LTBP1 latent transforming growth factor beta binding protein 1 -0.00297075
LY86 lymphocyte antigen 86 -0.00296723
AADAC arylacetamide deacetylase -0.00295788
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.00295376
TMEM106C transmembrane protein 106C -0.00294931
FDPS farnesyl diphosphate synthase -0.00294803
SPA17 sperm autoantigenic protein 17 -0.00294083
MTMR9 myotubularin related protein 9 -0.00293987
CTSK cathepsin K -0.00293497
CALD1 caldesmon 1 -0.00293497
ZSCAN18 zinc finger and SCAN domain containing 18 -0.00293332
DSP desmoplakin -0.00293162
ACO1 aconitase 1, soluble -0.00293117
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -0.00292496
CEP170B centrosomal protein 170B -0.00292486
MT1E metallothionein 1E -0.00292094
KATNA1 katanin p60 (ATPase containing) subunit A 1 -0.00292055
POLR1E polymerase (RNA) I polypeptide E, 53kDa -0.00291989
LARS1 leucyl-tRNA synthetase 1 -0.00291915
OSR2 odd-skipped related transciption factor 2 -0.00291157
RXRA retinoid X receptor, alpha -0.00290659
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00290608
CDKN2A cyclin-dependent kinase inhibitor 2A -0.00290589
GLO1 glyoxalase I -0.00290221
LAPTM5 lysosomal protein transmembrane 5 -0.00289748
NECTIN3 nectin cell adhesion molecule 3 -0.00288573
GBP1 guanylate binding protein 1, interferon-inducible -0.00288435
CRIP2 cysteine-rich protein 2 -0.00287514
VCL vinculin -0.0028746
AHR aryl hydrocarbon receptor -0.00287373
RGS3 regulator of G-protein signaling 3 -0.00287359
DNALI1 dynein, axonemal, light intermediate chain 1 -0.00287304
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic -0.00287079
MAP7 microtubule-associated protein 7 -0.00286505
CDC20 cell division cycle 20 -0.00284555
PXDN peroxidasin -0.00284474
FGB fibrinogen beta chain -0.00284129
RNF38 ring finger protein 38 -0.00282614
CCDC28B coiled-coil domain containing 28B -0.00282198
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -0.00280949
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 -0.00280897
DDR2 discoidin domain receptor tyrosine kinase 2 -0.00280843
NOVA1 neuro-oncological ventral antigen 1 -0.00280353
NRCAM neuronal cell adhesion molecule -0.00280351
IFITM2 interferon induced transmembrane protein 2 -0.00278939
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.00277781
AKAP7 A kinase (PRKA) anchor protein 7 -0.00277427
DKK2 dickkopf WNT signaling pathway inhibitor 2 -0.00277327
NIT1 nitrilase 1 -0.00276703
GMPR guanosine monophosphate reductase -0.00276544
CREG1 cellular repressor of E1A-stimulated genes 1 -0.00276284
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.00275698
KIF15 kinesin family member 15 -0.00275398
UGDH UDP-glucose 6-dehydrogenase -0.00275071
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -0.00274899
SNX7 sorting nexin 7 -0.00274288
TBC1D31 TBC1 domain family, member 31 -0.00273946
ZNF226 zinc finger protein 226 -0.00273847
HGD homogentisate 1,2-dioxygenase -0.00273702
CYBC1 cytochrome b-245 chaperone 1 -0.00273403
DIO1 deiodinase, iodothyronine, type I -0.0027203
KLK5 kallikrein-related peptidase 5 -0.00271641
ZBED5 zinc finger, BED-type containing 5 -0.00271414
CENPF centromere protein F, 350/400kDa -0.00271382
AKT1 v-akt murine thymoma viral oncogene homolog 1 -0.00271168
CCL21 chemokine (C-C motif) ligand 21 -0.00270755