| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/3630776 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in MERCK544 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KLHL23 | kelch-like family member 23 | 2.71 |
| POLQ | polymerase (DNA directed), theta | 1.53 |
| NAV2 | neuron navigator 2 | 1.18 |
| LANCL3 | LanC lantibiotic synthetase component C-like 3 (bacterial) | 0.69 |
| LRRK1 | leucine-rich repeat kinase 1 | 0.67 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.57 |
| ZSCAN32 | zinc finger and SCAN domain containing 32 | 0.55 |
| ZNF7 | zinc finger protein 7 | 0.52 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.52 |
| ZNF655 | zinc finger protein 655 | 0.51 |
| GPN2 | GPN-loop GTPase 2 | 0.51 |
| TMEM106C | transmembrane protein 106C | 0.5 |
| LGALSL | lectin, galactoside-binding-like | 0.5 |
| FAM89A | family with sequence similarity 89, member A | 0.5 |
| LYST | lysosomal trafficking regulator | 0.49 |
| AREL1 | apoptosis resistant E3 ubiquitin protein ligase 1 | 0.47 |
| KCTD6 | potassium channel tetramerization domain containing 6 | 0.47 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | 0.46 |
| PWWP2B | PWWP domain containing 2B | 0.46 |
| GPR161 | G protein-coupled receptor 161 | 0.44 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.44 |
| DPY19L2 | dpy-19-like 2 (C. elegans) | 0.43 |
| OSBPL1A | oxysterol binding protein-like 1A | 0.42 |
| C5ORF30 | chromosome 5 open reading frame 30 | 0.42 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | 0.42 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.41 |
| MASTL | microtubule associated serine/threonine kinase-like | 0.4 |
| FAM221A | family with sequence similarity 221, member A | 0.4 |
| MYH15 | myosin, heavy chain 15 | 0.39 |
| ATP8B2 | ATPase, aminophospholipid transporter, class I, type 8B, member 2 | 0.39 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.39 |
| E2F1 | E2F transcription factor 1 | 0.39 |
| ZNF652 | zinc finger protein 652 | 0.38 |
| ZNF367 | zinc finger protein 367 | 0.37 |
| PDE7A | phosphodiesterase 7A | 0.36 |
| MSX2 | msh homeobox 2 | 0.36 |
| TMEM64 | transmembrane protein 64 | 0.36 |
| IL17RB | interleukin 17 receptor B | 0.36 |
| PLEKHG4 | pleckstrin homology domain containing, family G (with RhoGef domain) member 4 | 0.35 |
| ZNF503 | zinc finger protein 503 | 0.35 |
| PTGES | prostaglandin E synthase | 0.35 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | 0.34 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.34 |
| TMPPE | transmembrane protein with metallophosphoesterase domain | 0.33 |
| CDC37 | cell division cycle 37 | 0.33 |
| MIIP | migration and invasion inhibitory protein | 0.33 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.33 |
| CES2 | carboxylesterase 2 | 0.33 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | 0.33 |
| R3HDM4 | R3H domain containing 4 | 0.32 |
| GJB3 | gap junction protein, beta 3, 31kDa | 0.32 |
| PCDHGA10 | protocadherin gamma subfamily A, 10 | 0.31 |
| PNKD | paroxysmal nonkinesigenic dyskinesia | 0.31 |
| FBXO44 | F-box protein 44 | 0.31 |
| MIEF1 | mitochondrial elongation factor 1 | 0.31 |
| GXYLT1 | glucoside xylosyltransferase 1 | 0.3 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.3 |
| GALNT13 | polypeptide N-acetylgalactosaminyltransferase 13 | 0.3 |
| MT-CO1 | cytochrome c oxidase subunit I | 0.29 |
| SPIDR | scaffolding protein involved in DNA repair | 0.29 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 0.29 |
| DNPEP | aspartyl aminopeptidase | 0.29 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.29 |
| CTDSP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 | 0.29 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.29 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.28 |
| TSPAN4 | tetraspanin 4 | 0.28 |
| MAML1 | mastermind-like 1 (Drosophila) | 0.28 |
| ZNF335 | zinc finger protein 335 | 0.28 |
| CSNK1G2 | casein kinase 1, gamma 2 | 0.28 |
| LRRC45 | leucine rich repeat containing 45 | 0.28 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.28 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.28 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.27 |
| AHI1 | Abelson helper integration site 1 | 0.27 |
| RPUSD1 | RNA pseudouridylate synthase domain containing 1 | 0.27 |
| DOCK10 | dedicator of cytokinesis 10 | 0.27 |
| HKDC1 | hexokinase domain containing 1 | 0.27 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.27 |
| COL7A1 | collagen, type VII, alpha 1 | 0.27 |
| FAM122A | family with sequence similarity 122A | 0.27 |
| ZKSCAN4 | zinc finger with KRAB and SCAN domains 4 | 0.27 |
| KLHL22 | kelch-like family member 22 | 0.27 |
| ZNF280B | zinc finger protein 280B | 0.26 |
| FAM104A | family with sequence similarity 104, member A | 0.26 |
| CCNA1 | cyclin A1 | 0.25 |
| PLD6 | phospholipase D family, member 6 | 0.25 |
| RNASEH2C | ribonuclease H2, subunit C | 0.25 |
| KIFC3 | kinesin family member C3 | 0.25 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.25 |
| BBS1 | Bardet-Biedl syndrome 1 | 0.25 |
| GNPTG | N-acetylglucosamine-1-phosphate transferase, gamma subunit | 0.25 |
| DCLRE1A | DNA cross-link repair 1A | 0.25 |
| NTAN1 | N-terminal asparagine amidase | 0.25 |
| SUPT7L | suppressor of Ty 7 (S. cerevisiae)-like | 0.25 |
| FAM136A | family with sequence similarity 136, member A | 0.25 |
| PRSS8 | protease, serine, 8 | 0.25 |
| LRRC58 | leucine rich repeat containing 58 | 0.25 |
| SLC43A3 | solute carrier family 43, member 3 | 0.25 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT4 | FAT atypical cadherin 4 | -1.31 |
| DPYSL2 | dihydropyrimidinase-like 2 | -1.02 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.96 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.76 |
| SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5 | -0.74 |
| SERF2 | small EDRK-rich factor 2 | -0.65 |
| KPNA5 | karyopherin alpha 5 (importin alpha 6) | -0.65 |
| PLXNA3 | plexin A3 | -0.64 |
| CCDC112 | coiled-coil domain containing 112 | -0.64 |
| ZNF566 | zinc finger protein 566 | -0.62 |
| PBLD | phenazine biosynthesis-like protein domain containing | -0.62 |
| FKBP14 | FK506 binding protein 14, 22 kDa | -0.62 |
| MT1X | metallothionein 1X | -0.56 |
| NBPF20 | neuroblastoma breakpoint family, member 20 | -0.54 |
| ENTPD2 | ectonucleoside triphosphate diphosphohydrolase 2 | -0.52 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | -0.46 |
| TCF19 | transcription factor 19 | -0.45 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.45 |
| ARSK | arylsulfatase family, member K | -0.44 |
| PRMT2IP | PRMT2 interacting protein | -0.44 |
| LMBR1 | limb development membrane protein 1 | -0.43 |
| ZNF689 | zinc finger protein 689 | -0.42 |
| ZNF672 | zinc finger protein 672 | -0.41 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | -0.4 |
| TRANK1 | tetratricopeptide repeat and ankyrin repeat containing 1 | -0.38 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.38 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | -0.37 |
| TBRG1 | transforming growth factor beta regulator 1 | -0.37 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.36 |
| MIPOL1 | mirror-image polydactyly 1 | -0.36 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.35 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.35 |
| ADSS1 | adenylosuccinate synthase 1 | -0.35 |
| HSBP1 | heat shock factor binding protein 1 | -0.35 |
| FITM2 | fat storage-inducing transmembrane protein 2 | -0.34 |
| PAH | phenylalanine hydroxylase | -0.33 |
| FTL | ferritin, light polypeptide | -0.32 |
| ZNF189 | zinc finger protein 189 | -0.32 |
| CDK11A | cyclin-dependent kinase 11A | -0.32 |
| LTBR | lymphotoxin beta receptor (TNFR superfamily, member 3) | -0.32 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.32 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | -0.32 |
| SLC25A39 | solute carrier family 25, member 39 | -0.31 |
| ATP13A2 | ATPase type 13A2 | -0.31 |
| BAIAP2 | BAI1-associated protein 2 | -0.3 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | -0.3 |
| CCDC158 | coiled-coil domain containing 158 | -0.3 |
| IER5L | immediate early response 5-like | -0.3 |
| CENPT | centromere protein T | -0.29 |
| ISL2 | ISL LIM homeobox 2 | -0.29 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.29 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.28 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.28 |
| ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 | -0.28 |
| PIP | prolactin-induced protein | -0.28 |
| LSM10 | LSM10, U7 small nuclear RNA associated | -0.28 |
| OGG1 | 8-oxoguanine DNA glycosylase | -0.28 |
| CLTCL1 | clathrin, heavy chain-like 1 | -0.28 |
| CDK10 | cyclin-dependent kinase 10 | -0.28 |
| EXPH5 | exophilin 5 | -0.27 |
| MT1E | metallothionein 1E | -0.27 |
| SP6 | Sp6 transcription factor | -0.27 |
| FAM189B | family with sequence similarity 189, member B | -0.27 |
| ANGPTL4 | angiopoietin-like 4 | -0.27 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | -0.26 |
| RNF41 | ring finger protein 41, E3 ubiquitin protein ligase | -0.26 |
| ATXN1L | ataxin 1-like | -0.26 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.26 |
| H1-4 | H1.4 linker histone, cluster member | -0.26 |
| RAB33B | RAB33B, member RAS oncogene family | -0.26 |
| MGA | MGA, MAX dimerization protein | -0.26 |
| POF1B | premature ovarian failure, 1B | -0.26 |
| NMRK1 | nicotinamide riboside kinase 1 | -0.26 |
| CCDC150 | coiled-coil domain containing 150 | -0.26 |
| MT1L | metallothionein 1L (gene/pseudogene) | -0.26 |
| PGK2 | phosphoglycerate kinase 2 | -0.26 |
| BRD8 | bromodomain containing 8 | -0.26 |
| KCTD17 | potassium channel tetramerization domain containing 17 | -0.26 |
| FKRP | fukutin related protein | -0.25 |
| PRMT6 | protein arginine methyltransferase 6 | -0.25 |
| GMIP | GEM interacting protein | -0.25 |
| ABHD17C | abhydrolase domain containing 17C | -0.24 |
| MB21D2 | Mab-21 domain containing 2 | -0.24 |
| TRIM32 | tripartite motif containing 32 | -0.24 |
| APOE | apolipoprotein E | -0.24 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.24 |
| ZNF408 | zinc finger protein 408 | -0.24 |
| IFT88 | intraflagellar transport 88 | -0.23 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | -0.23 |
| IRX4 | iroquois homeobox 4 | -0.23 |
| MED8 | mediator complex subunit 8 | -0.23 |
| SMAP1 | small ArfGAP 1 | -0.23 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | -0.23 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.23 |
| PLXND1 | plexin D1 | -0.23 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -0.23 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -0.23 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | -0.23 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | -0.23 |
