MERO41 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description Pleural Mesothelioma, Epithelioid Type cell line (Cancer Dependency Map)
External Link https://depmap.org/portal/cell_line/ACH-001557
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Genes

373 gene knockdowns changing fitness of MERO41 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 11.009
SH3PXD2B SH3 and PX domains 2B 8.18977
MREG melanoregulin 7.57708
FAM217A family with sequence similarity 217, member A 7.30538
KLHDC4 kelch domain containing 4 7.29918
THUMPD3 THUMP domain containing 3 6.78791
LRRK1 leucine-rich repeat kinase 1 6.31751
NBL1 neuroblastoma 1, DAN family BMP antagonist 6.31682
FAF1 Fas (TNFRSF6) associated factor 1 6.15154
C3ORF30 chromosome 3 open reading frame 30 6.14712
NRIP3 nuclear receptor interacting protein 3 6.05628
NUDCD2 NudC domain containing 2 6.05251
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 5.94955
CCDC102A coiled-coil domain containing 102A 5.84469
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 5.80794
SLC51A solute carrier family 51, alpha subunit 5.63951
WDR38 WD repeat domain 38 5.44319
MXD3 MAX dimerization protein 3 5.43859
COL4A4 collagen, type IV, alpha 4 5.42027
CORO7 coronin 7 5.40876
TMEM39B transmembrane protein 39B 5.3741
EME1 essential meiotic structure-specific endonuclease 1 5.35616
TMEM161A transmembrane protein 161A 5.33497
SAMD14 sterile alpha motif domain containing 14 5.29928
SHH sonic hedgehog 5.2886
TMEM170B transmembrane protein 170B 5.13211
MYO19 myosin XIX 5.10714
CCDC68 coiled-coil domain containing 68 5.09912
AGMAT agmatine ureohydrolase (agmatinase) 5.09457
ADA adenosine deaminase 5.06325
LPIN3 lipin 3 4.93669
MTARC1 mitochondrial amidoxime reducing component 1 4.90772
UBTD2 ubiquitin domain containing 2 4.9022
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 4.88355
ZBTB43 zinc finger and BTB domain containing 43 4.7465
OGG1 8-oxoguanine DNA glycosylase 4.68718
BPI bactericidal/permeability-increasing protein 4.67627
TAS1R2 taste receptor, type 1, member 2 4.67525
DUOXA1 dual oxidase maturation factor 1 4.65022
C6ORF47 chromosome 6 open reading frame 47 4.59837
TMEM169 transmembrane protein 169 4.56899
PARP14 poly (ADP-ribose) polymerase family, member 14 4.54367
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 4.49921
CPN2 carboxypeptidase N, polypeptide 2 4.47329
DAGLB diacylglycerol lipase, beta 4.45064
MYO5C myosin VC 4.41475
SYCP2L synaptonemal complex protein 2-like 4.41445
IRF6 interferon regulatory factor 6 4.39997
CDHR3 cadherin-related family member 3 4.35723
TNNI1 troponin I type 1 (skeletal, slow) 4.29741
TRAFD1 TRAF-type zinc finger domain containing 1 4.28305
NMUR1 neuromedin U receptor 1 4.26733
APOL3 apolipoprotein L, 3 4.26431
MDH1B malate dehydrogenase 1B, NAD (soluble) 4.23308
UBE2D2 ubiquitin-conjugating enzyme E2D 2 4.2004
DVL3 dishevelled segment polarity protein 3 4.19697
TSPAN17 tetraspanin 17 4.1924
ARMC9 armadillo repeat containing 9 4.1776
WISP3 WNT1 inducible signaling pathway protein 3 4.16536
KDM1B lysine (K)-specific demethylase 1B 4.08065
ELOVL2 ELOVL fatty acid elongase 2 4.06431
MYLK2 myosin light chain kinase 2 4.06211
HES6 hes family bHLH transcription factor 6 4.03133
ARX aristaless related homeobox 4.02444
FAM110D family with sequence similarity 110, member D 4.00018
ARL8A ADP-ribosylation factor-like 8A 3.92586
PDZK1IP1 PDZK1 interacting protein 1 3.916
PGAP2 post-GPI attachment to proteins 2 3.91489
ULK2 unc-51 like autophagy activating kinase 2 3.84906
PAQR4 progestin and adipoQ receptor family member IV 3.80856
MCFD2 multiple coagulation factor deficiency 2 3.78972
ART5 ADP-ribosyltransferase 5 3.7888
RBP5 retinol binding protein 5, cellular 3.77802
PRND prion protein 2 (dublet) 3.76216
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 3.74313
PIEZO1 piezo-type mechanosensitive ion channel component 1 3.73411
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 3.64913
TRIM26 tripartite motif containing 26 3.64474
FAM193B family with sequence similarity 193, member B 3.64358
ARL10 ADP-ribosylation factor-like 10 3.60169
TRAF3IP3 TRAF3 interacting protein 3 3.59295
AGO4 argonaute RISC catalytic component 4 3.58863
NLRC4 NLR family, CARD domain containing 4 3.57084
ACYP2 acylphosphatase 2, muscle type 3.56624
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 3.558
PECR peroxisomal trans-2-enoyl-CoA reductase 3.55049
ZNF169 zinc finger protein 169 3.54077
RAB26 RAB26, member RAS oncogene family 3.53902
IFNLR1 interferon, lambda receptor 1 3.51108
NR1I2 nuclear receptor subfamily 1, group I, member 2 3.50959
ZNF839 zinc finger protein 839 3.50092
FAM163A family with sequence similarity 163, member A 3.48244
EIF2D eukaryotic translation initiation factor 2D 3.4785
DPPA5 developmental pluripotency associated 5 3.47425
CHMP1A charged multivesicular body protein 1A 3.46423
CCDC28B coiled-coil domain containing 28B 3.46239
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.45634
BICDL2 BICD family like cargo adaptor 2 3.45568
PQLC2 PQ loop repeat containing 2 3.43385
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 3.41949
ZSCAN10 zinc finger and SCAN domain containing 10 3.41684
SFTPA2 surfactant protein A2 3.38522
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 3.38126
PPP1R16A protein phosphatase 1, regulatory subunit 16A 3.38061
BID BH3 interacting domain death agonist 3.37267
PGBDF plakoglobin binding and degradation factor 3.35633
CAMK1 calcium/calmodulin-dependent protein kinase I 3.34166
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 3.33203
RHOT2 ras homolog family member T2 3.29552
TRH thyrotropin-releasing hormone 3.2907
MELTF melanotransferrin 3.28243
OXER1 oxoeicosanoid (OXE) receptor 1 3.27065
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 3.22258
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) 3.2205
TMEM14A transmembrane protein 14A 3.20798
AMDHD1 amidohydrolase domain containing 1 3.19423
TOP1MT topoisomerase (DNA) I, mitochondrial 3.17205
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 3.15438
TLR9 toll-like receptor 9 3.14496
MAVS mitochondrial antiviral signaling protein 3.14466
RAD54L RAD54-like (S. cerevisiae) 3.14462
PRKX protein kinase, X-linked 3.09296
DCDC2B doublecortin domain containing 2B 3.08736
PRADC1 protease-associated domain containing 1 3.08113
OR2T29 olfactory receptor, family 2, subfamily T, member 29 3.08066
C19ORF67 chromosome 19 open reading frame 67 3.07969
HOXD11 homeobox D11 3.06965
PDIA3 protein disulfide isomerase family A, member 3 3.06304
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.05453
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.0512
C6ORF15 chromosome 6 open reading frame 15 3.04947
DPPA2 developmental pluripotency associated 2 3.04228
IFITM2 interferon induced transmembrane protein 2 3.03345
HRH3 histamine receptor H3 3.02122
ALDOC aldolase C, fructose-bisphosphate 3.00673
GP5 glycoprotein V (platelet) 3.00398
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.99937
TNNT2 troponin T type 2 (cardiac) 2.99688
LRRC31 leucine rich repeat containing 31 2.98791
FAAH fatty acid amide hydrolase 2.97373
SLC35A5 solute carrier family 35, member A5 2.96007
ALPI alkaline phosphatase, intestinal 2.95466
FGFR1 fibroblast growth factor receptor 1 2.92398
CBX7 chromobox homolog 7 2.92006
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.91968
HCRTR1 hypocretin (orexin) receptor 1 2.91376
GALK1 galactokinase 1 2.89761
AACS acetoacetyl-CoA synthetase 2.89366
IFITM1 interferon induced transmembrane protein 1 2.87533
OR5AU1 olfactory receptor, family 5, subfamily AU, member 1 2.87253
RAB37 RAB37, member RAS oncogene family 2.84709
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.83492
NID1 nidogen 1 2.82346
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 2.82079
IL3 interleukin 3 2.81955
WRNIP1 Werner helicase interacting protein 1 2.81404
FAM183A family with sequence similarity 183, member A 2.81294
ANGEL2 angel homolog 2 (Drosophila) 2.81203
SOAT2 sterol O-acyltransferase 2 2.79591
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.79373
SLC39A4 solute carrier family 39 (zinc transporter), member 4 2.79107
PACC1 proton activated chloride channel 1 2.78881
XCL1 chemokine (C motif) ligand 1 2.78864
HEATR5B HEAT repeat containing 5B 2.77686
PIMREG PICALM interacting mitotic regulator 2.77373
OSER1 oxidative stress responsive serine-rich 1 2.77145
ZFYVE19 zinc finger, FYVE domain containing 19 2.76704
PDK2 pyruvate dehydrogenase kinase, isozyme 2 2.76629
TRAPPC9 trafficking protein particle complex 9 2.76607
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2 2.75921
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.7477
ZBTB34 zinc finger and BTB domain containing 34 2.74492
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 2.74227
DND1 DND microRNA-mediated repression inhibitor 1 2.7401
CDK10 cyclin-dependent kinase 10 2.73263
AMZ1 archaelysin family metallopeptidase 1 2.72418
CATSPER2 cation channel, sperm associated 2 2.72302
FBXL3 F-box and leucine-rich repeat protein 3 2.71904
ESPN espin 2.71885
DHRS13 dehydrogenase/reductase (SDR family) member 13 2.70052
NOXO1 NADPH oxidase organizer 1 2.69533
TM6SF2 transmembrane 6 superfamily member 2 2.69032
TBC1D16 TBC1 domain family, member 16 2.68013
RTKN rhotekin 2.67985
UBXN10 UBX domain protein 10 2.67665
PIGX phosphatidylinositol glycan anchor biosynthesis, class X 2.67033
LIN7C lin-7 homolog C (C. elegans) 2.66715
SEPTIN5 septin 5 2.65433
ASB16 ankyrin repeat and SOCS box containing 16 2.64548
HRH4 histamine receptor H4 2.64071
PPIB peptidylprolyl isomerase B (cyclophilin B) 2.6387
PRLH prolactin releasing hormone 2.63703
ZNF674 zinc finger protein 674 2.63297
CD164L2 CD164 sialomucin-like 2 2.63216
OR2Y1 olfactory receptor, family 2, subfamily Y, member 1 2.63195
UBALD1 UBA-like domain containing 1 2.62789
NENF neudesin neurotrophic factor 2.61207
DPYSL4 dihydropyrimidinase-like 4 2.60873
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 2.58844
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2.58284
PDLIM7 PDZ and LIM domain 7 (enigma) 2.576
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae) 2.57234
EPN3 epsin 3 2.56613
HCK HCK proto-oncogene, Src family tyrosine kinase 2.56032
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 2.55903
BAZ2A bromodomain adjacent to zinc finger domain, 2A 2.54597
CDHR5 cadherin-related family member 5 2.53778
CCDC158 coiled-coil domain containing 158 2.53777
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 2.5363
TEKT2 tektin 2 (testicular) 2.53438
GATA5 GATA binding protein 5 2.53093
CCL28 chemokine (C-C motif) ligand 28 2.53042
LRRC15 leucine rich repeat containing 15 2.5302
ANKRD11 ankyrin repeat domain 11 2.5255
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.51334
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 2.51227
WWC1 WW and C2 domain containing 1 2.50996
PIGS phosphatidylinositol glycan anchor biosynthesis, class S 2.50565
C2ORF57 chromosome 2 open reading frame 57 2.50306
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.49806
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.4948
RETREG3 reticulophagy regulator family member 3 2.48864
UPK3A uroplakin 3A 2.48797
THBS2 thrombospondin 2 2.48712
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.48546
RAX2 retina and anterior neural fold homeobox 2 2.48452
FABP6 fatty acid binding protein 6, ileal 2.48384
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.47947
FAM167B family with sequence similarity 167, member B 2.47722
GM2A GM2 ganglioside activator 2.47504
APTX aprataxin 2.47253
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 2.47213
ARSL arylsulfatase L 2.47084
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 2.46075
RNF25 ring finger protein 25 2.45914
SLC52A3 solute carrier family 52 (riboflavin transporter), member 3 2.4585
ZFP69 ZFP69 zinc finger protein 2.45437
BFSP1 beaded filament structural protein 1, filensin 2.44943
CTRC chymotrypsin C (caldecrin) 2.4481
EBF4 early B-cell factor 4 2.44587
TTYH3 tweety family member 3 2.44384
C1ORF111 chromosome 1 open reading frame 111 2.44322
XYLT2 xylosyltransferase II 2.43653
ZCCHC2 zinc finger, CCHC domain containing 2 2.43497
ABR active BCR-related 2.42666
ENOPH1 enolase-phosphatase 1 2.41934
MUL1 mitochondrial E3 ubiquitin protein ligase 1 2.41816
OSCP1 organic solute carrier partner 1 2.41622
CLCN2 chloride channel, voltage-sensitive 2 2.40577
MYCBPAP MYCBP associated protein 2.40288
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) 2.40087
ELF2 E74-like factor 2 (ets domain transcription factor) 2.39924
CRYGD crystallin, gamma D 2.39414
LMNA lamin A/C 2.38401
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2.37889
HELLS helicase, lymphoid-specific 2.36897
ZNF428 zinc finger protein 428 2.36799
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 2.36446
STARD9 StAR-related lipid transfer (START) domain containing 9 2.36443
PLTP phospholipid transfer protein 2.35563
KIF21B kinesin family member 21B 2.34884
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.34743
LACC1 laccase (multicopper oxidoreductase) domain containing 1 2.34605
SPATA2L spermatogenesis associated 2-like 2.34478
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.34166
NOL4L nucleolar protein 4-like 2.33864
HRH2 histamine receptor H2 2.33407
LY6D lymphocyte antigen 6 complex, locus D 2.33203
KCNIP3 Kv channel interacting protein 3, calsenilin 2.32978
ARF5 ADP-ribosylation factor 5 2.31593
GC group-specific component (vitamin D binding protein) 2.31224
OCM2 oncomodulin 2 2.30862
CCDC105 coiled-coil domain containing 105 2.30656
WDR86 WD repeat domain 86 2.30605
SCUBE2 signal peptide, CUB domain, EGF-like 2 2.30195
TMEM53 transmembrane protein 53 2.29935
CFAP57 cilia and flagella associated protein 57 2.29799
GTF2IRD1 GTF2I repeat domain containing 1 2.28817
GPR160 G protein-coupled receptor 160 2.28243
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.27842
PRELP proline/arginine-rich end leucine-rich repeat protein 2.27482
GOLGA3 golgin A3 2.25918
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 2.25733
CAPN7 calpain 7 2.25656
SHCBP1 SHC SH2-domain binding protein 1 2.25359
SLURP2 secreted LY6/PLAUR domain containing 2 2.2472
ODAD1 outer dynein arm docking complex subunit 1 2.24612
HYAL3 hyaluronoglucosaminidase 3 2.24563
C19ORF12 chromosome 19 open reading frame 12 2.24291
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 2.23993
C16ORF71 chromosome 16 open reading frame 71 2.23707
FAM46B family with sequence similarity 46, member B 2.23306
ADRM1 adhesion regulating molecule 1 2.23091
FAM131C family with sequence similarity 131, member C 2.22812
SIRPG signal-regulatory protein gamma 2.22807
ACOX2 acyl-CoA oxidase 2, branched chain 2.22736
CYBA cytochrome b-245, alpha polypeptide 2.22576
MYL5 myosin, light chain 5, regulatory 2.22385
FBXW2 F-box and WD repeat domain containing 2 2.22144
VASN vasorin 2.22004
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.21673
FAM8A1 family with sequence similarity 8, member A1 2.2163
ODR4 odr-4 GPCR localization factor homolog 2.21429
EPHB6 EPH receptor B6 2.2141
ASXL1 additional sex combs like transcriptional regulator 1 2.2134
SCARB1 scavenger receptor class B, member 1 2.21245
SDC1 syndecan 1 2.20966
TRIP4 thyroid hormone receptor interactor 4 2.20913
GPALPP1 GPALPP motifs containing 1 2.20719
NFE2L2 nuclear factor, erythroid 2-like 2 2.20125
IRF9 interferon regulatory factor 9 2.20033
SCD5 stearoyl-CoA desaturase 5 2.19973
ZCWPW2 zinc finger, CW type with PWWP domain 2 2.19555
LRRC37A3 leucine rich repeat containing 37, member A3 2.19299
SETD5 SET domain containing 5 2.19146
IQCC IQ motif containing C 2.18506
TRIM28 tripartite motif containing 28 2.18255
LAD1 ladinin 1 2.181
ARL4A ADP-ribosylation factor-like 4A 2.17994
ASIC4 acid sensing (proton gated) ion channel family member 4 2.1756
SSC4D scavenger receptor cysteine rich family, 4 domains 2.17363
PEF1 penta-EF-hand domain containing 1 2.1681
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.16778
ZNFX1 zinc finger, NFX1-type containing 1 2.16242
C5ORF28 chromosome 5 open reading frame 28 2.16018
C1QB complement component 1, q subcomponent, B chain 2.15829
ZFP69B ZFP69 zinc finger protein B 2.15802
GALM galactose mutarotase (aldose 1-epimerase) 2.15637
CLEC3B C-type lectin domain family 3, member B 2.15257
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 2.14774
EPS8L2 EPS8-like 2 2.14652
FAM76A family with sequence similarity 76, member A 2.14406
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 2.1428
ACAD11 acyl-CoA dehydrogenase family, member 11 2.14074
PNCK pregnancy up-regulated nonubiquitous CaM kinase 2.13888
KDF1 keratinocyte differentiation factor 1 2.13201
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.12755
ACBD6 acyl-CoA binding domain containing 6 2.12384
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2.11783
PANK3 pantothenate kinase 3 2.11763
LURAP1 leucine rich adaptor protein 1 2.11313
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 2.10761
UNC119 unc-119 homolog (C. elegans) 2.10579
PAMR1 peptidase domain containing associated with muscle regeneration 1 2.10531
GPR84 G protein-coupled receptor 84 2.10352
TRAP1 TNF receptor-associated protein 1 2.10323
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.10297
MMRN2 multimerin 2 2.09493
RSAD1 radical S-adenosyl methionine domain containing 1 2.08864
TLCD1 TLC domain containing 1 2.08391
TCEA3 transcription elongation factor A (SII), 3 2.08065
PHYH phytanoyl-CoA 2-hydroxylase 2.07977
F12 coagulation factor XII (Hageman factor) 2.0788
ZNF623 zinc finger protein 623 2.05714
GAS8 growth arrest-specific 8 2.05144
ADGRE5 adhesion G protein-coupled receptor E5 2.05004
ASB13 ankyrin repeat and SOCS box containing 13 2.04924
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 2.04653
PRR35 proline rich 35 2.04427
MNMIP1 manchette microtubule inner protein 1 2.04417
FBXL16 F-box and leucine-rich repeat protein 16 2.04194
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 2.04064
VMAC vimentin-type intermediate filament associated coiled-coil protein 2.03093
EMILIN2 elastin microfibril interfacer 2 2.03061
IL17RA interleukin 17 receptor A 2.03026
IL17RE interleukin 17 receptor E 2.01665
HEATR9 HEAT repeat containing 9 2.01565
MZF1 myeloid zinc finger 1 2.0134
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.01256
GPR37L1 G protein-coupled receptor 37 like 1 2.01104
IZUMO4 IZUMO family member 4 2.00897
CSNK1D casein kinase 1, delta 2.00761
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase 2.00058