MERO95 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description Pleural Mesothelioma, Epithelioid Type cell line (Cancer Dependency Map)
External Link https://depmap.org/portal/cell_line/ACH-001562
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Genes

321 gene knockdowns changing fitness of MERO95 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
LIFR leukemia inhibitory factor receptor alpha 10.5298
TRAPPC12 trafficking protein particle complex 12 8.68165
MSL3 male-specific lethal 3 homolog (Drosophila) 8.27939
PDLIM7 PDZ and LIM domain 7 (enigma) 8.02294
NCBP3 nuclear cap binding subunit 3 7.24996
IL6ST interleukin 6 signal transducer 7.2327
SLK STE20-like kinase 7.18524
RHOT2 ras homolog family member T2 6.91702
MAP3K4 mitogen-activated protein kinase kinase kinase 4 6.75261
PLTP phospholipid transfer protein 6.0201
MSN moesin 5.89282
NHEJ1 nonhomologous end-joining factor 1 5.84088
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 5.76135
IPO4 importin 4 5.71482
ADGRE3 adhesion G protein-coupled receptor E3 5.66866
OR2M3 olfactory receptor, family 2, subfamily M, member 3 5.62449
JAK1 Janus kinase 1 5.5641
IFNA17 interferon, alpha 17 5.52612
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) 5.51946
SEC23IP SEC23 interacting protein 5.41153
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 5.31967
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 5.25539
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 5.24439
WDR89 WD repeat domain 89 5.18345
LARP4B La ribonucleoprotein domain family, member 4B 5.15907
AP1M1 adaptor-related protein complex 1, mu 1 subunit 5.11885
XCL2 chemokine (C motif) ligand 2 5.06368
ZFHX4 zinc finger homeobox 4 4.9923
ASB16 ankyrin repeat and SOCS box containing 16 4.98981
RIOX2 ribosomal oxygenase 2 4.97656
MDC1 mediator of DNA-damage checkpoint 1 4.95861
NCOR2 nuclear receptor corepressor 2 4.85569
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 4.82974
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 4.74165
HDAC2 histone deacetylase 2 4.71112
TSLIG2 tRNA splicing ligase complex subunit 2 4.6759
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 4.65774
ZBTB20 zinc finger and BTB domain containing 20 4.55062
FBXL3 F-box and leucine-rich repeat protein 3 4.53404
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 4.51138
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 4.45461
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 4.45063
RIPOR1 RHO family interacting cell polarization regulator 1 4.44206
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 4.39757
SEPHS1 selenophosphate synthetase 1 4.37701
SAR1A secretion associated, Ras related GTPase 1A 4.37418
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 4.3149
SULF2 sulfatase 2 4.24363
FAM57B family with sequence similarity 57, member B 4.22812
GPATCH11 G patch domain containing 11 4.18512
ARMH3 armadillo like helical domain containing 3 4.16896
UBALD2 UBA-like domain containing 2 4.15796
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 4.11822
CORO1C coronin, actin binding protein, 1C 4.11391
CENPU centromere protein U 4.10291
MAPKBP1 mitogen-activated protein kinase binding protein 1 4.09036
MYRF myelin regulatory factor 4.08132
POFUT2 protein O-fucosyltransferase 2 4.0356
TSC22D1 TSC22 domain family, member 1 4.02077
CERT1 ceramide transporter 1 3.96913
LRRC49 leucine rich repeat containing 49 3.96747
TECPR1 tectonin beta-propeller repeat containing 1 3.96586
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 3.953
SACK1H scaffolding CK1 anchoring protein H 3.94976
GATA6 GATA binding protein 6 3.93036
SAMD14 sterile alpha motif domain containing 14 3.92517
ASB18 ankyrin repeat and SOCS box containing 18 3.92305
CPQ carboxypeptidase Q 3.92139
LAPTM4B lysosomal protein transmembrane 4 beta 3.87635
SNX17 sorting nexin 17 3.85846
KXD1 KxDL motif containing 1 3.84975
MKRN2 makorin ring finger protein 2 3.84207
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 3.81877
MAPK14 mitogen-activated protein kinase 14 3.81366
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.79772
INPP5K inositol polyphosphate-5-phosphatase K 3.77321
CDC14B cell division cycle 14B 3.73286
GNL1 guanine nucleotide binding protein-like 1 3.72411
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 3.71409
CENPO centromere protein O 3.71295
INHBB inhibin, beta B 3.67118
IFNL3 interferon, lambda 3 3.65375
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 3.64209
ALG6 ALG6, alpha-1,3-glucosyltransferase 3.62758
FBXL18 F-box and leucine-rich repeat protein 18 3.62463
MKRN3 makorin ring finger protein 3 3.54973
THAP12 THAP domain containing 12 3.53406
RCC2 regulator of chromosome condensation 2 3.51969
MEGF8 multiple EGF-like-domains 8 3.45723
RCCD1 RCC1 domain containing 1 3.45228
ADARB1 adenosine deaminase, RNA-specific, B1 3.45066
ZNF699 zinc finger protein 699 3.41664
ANKRD17 ankyrin repeat domain 17 3.39588
KPNA6 karyopherin alpha 6 (importin alpha 7) 3.36382
ASPRV1 aspartic peptidase, retroviral-like 1 3.35241
C8ORF33 chromosome 8 open reading frame 33 3.32965
ABHD17C abhydrolase domain containing 17C 3.32376
FRS2 fibroblast growth factor receptor substrate 2 3.31879
TXNDC9 thioredoxin domain containing 9 3.31503
ATRX alpha thalassemia/mental retardation syndrome X-linked 3.31403
TAGLN2 transgelin 2 3.31378
PUM3 pumilio RNA binding family member 3 3.29718
SPEM1 spermatid maturation 1 3.26636
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.26544
FGFR1OP2 FGFR1 oncogene partner 2 3.24363
LARP4 La ribonucleoprotein domain family, member 4 3.23246
FGFR1 fibroblast growth factor receptor 1 3.22075
RETREG3 reticulophagy regulator family member 3 3.21523
PPP4R1 protein phosphatase 4, regulatory subunit 1 3.20438
SURF4 surfeit 4 3.18859
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 3.18787
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 3.18668
CDV3 CDV3 homolog (mouse) 3.14981
CRK v-crk avian sarcoma virus CT10 oncogene homolog 3.13563
COMMD3 COMM domain containing 3 3.12194
ZFPM2 zinc finger protein, FOG family member 2 3.11317
OTX1 orthodenticle homeobox 1 3.11189
ERCC6L excision repair cross-complementation group 6-like 3.09534
LCE6A late cornified envelope 6A 3.09127
SECISBP2 SECIS binding protein 2 3.08839
MDM4 MDM4, p53 regulator 3.07125
MTFR2 mitochondrial fission regulator 2 3.06084
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 3.05367
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 3.02988
EXTL3 exostosin-like glycosyltransferase 3 3.01499
PKDCC protein kinase domain containing, cytoplasmic 3.00195
TUSC5 tumor suppressor candidate 5 3.0011
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 2.99639
SFXN3 sideroflexin 3 2.99376
ZNF511 zinc finger protein 511 2.99111
CSPG4 chondroitin sulfate proteoglycan 4 2.93511
OR6X1 olfactory receptor, family 6, subfamily X, member 1 2.93111
AMBRA1 autophagy/beclin-1 regulator 1 2.92676
ERLIN2 ER lipid raft associated 2 2.92387
B3GAT3 beta-1,3-glucuronyltransferase 3 2.9226
SPOP speckle-type POZ protein 2.90576
TRAPPC2L trafficking protein particle complex 2-like 2.89563
SRSF9 serine/arginine-rich splicing factor 9 2.89394
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 2.85472
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 2.84287
TMEM174 transmembrane protein 174 2.83739
UVRAG UV radiation resistance associated 2.83151
STEEP1 STING1 ER exit protein 1 2.81241
COMMD2 COMM domain containing 2 2.80511
ANKRD52 ankyrin repeat domain 52 2.79725
GOLGA8M golgin A8 family, member M 2.79686
IGSF8 immunoglobulin superfamily, member 8 2.79101
BTBD11 BTB (POZ) domain containing 11 2.78967
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 2.78522
DCSTAMP dendrocyte expressed seven transmembrane protein 2.7596
SSH2 slingshot protein phosphatase 2 2.75695
MRTFA myocardin related transcription factor A 2.75607
TEAD3 TEA domain family member 3 2.75512
RBIS ribosomal biogenesis factor 2.75428
ERV3-1 endogenous retrovirus group 3, member 1 2.74525
OR2M7 olfactory receptor, family 2, subfamily M, member 7 2.74377
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2.70898
TLE5 TLE family member 5, transcriptional modulator 2.70236
OR2L5 olfactory receptor, family 2, subfamily L, member 5 2.69576
PAPOLA poly(A) polymerase alpha 2.6923
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 2.68254
CLIC4 chloride intracellular channel 4 2.67439
PUS3 pseudouridylate synthase 3 2.67291
CYB561D2 cytochrome b561 family, member D2 2.66065
MT1H metallothionein 1H 2.65869
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 2.65774
RBM18 RNA binding motif protein 18 2.655
FNDC8 fibronectin type III domain containing 8 2.65354
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11 2.6454
ZNF479 zinc finger protein 479 2.63902
BCAR1 breast cancer anti-estrogen resistance 1 2.63647
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.61317
FBXL14 F-box and leucine-rich repeat protein 14 2.61002
RHPN2 rhophilin, Rho GTPase binding protein 2 2.60498
MVB12B multivesicular body subunit 12B 2.60062
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 2.59354
SSX7 synovial sarcoma, X breakpoint 7 2.59336
TMEM223 transmembrane protein 223 2.59288
RASA4 RAS p21 protein activator 4 2.581
PDZK1 PDZ domain containing 1 2.57845
SRRD SRR1 domain containing 2.57706
USP42 ubiquitin specific peptidase 42 2.57592
BLCAP bladder cancer associated protein 2.57571
CSNK1D casein kinase 1, delta 2.56396
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.56351
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.56327
EXT2 exostosin glycosyltransferase 2 2.56082
KMT2A lysine (K)-specific methyltransferase 2A 2.55931
TAPT1 transmembrane anterior posterior transformation 1 2.55705
PER2 period circadian clock 2 2.55147
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.54852
RIPK3 receptor-interacting serine-threonine kinase 3 2.53105
NKAPD1 NKAP domain containing 1 2.52746
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 2.52326
CTRL chymotrypsin-like 2.50715
PPP4R3A protein phosphatase 4 regulatory subunit 3A 2.50256
GATAD2B GATA zinc finger domain containing 2B 2.49741
FOXK1 forkhead box K1 2.495
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 2.49292
IFNA21 interferon, alpha 21 2.49215
NSUN5 NOP2/Sun domain family, member 5 2.48829
AASDH aminoadipate-semialdehyde dehydrogenase 2.48728
LMNA lamin A/C 2.4772
RSU1 Ras suppressor protein 1 2.47314
BLVRA biliverdin reductase A 2.47067
MCTS1 malignant T cell amplified sequence 1 2.46688
ERCC8 excision repair cross-complementation group 8 2.46629
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 2.46556
NFU1 NFU1 iron-sulfur cluster scaffold 2.46052
ATXN7L3 ataxin 7-like 3 2.45818
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.45235
SLC39A9 solute carrier family 39, member 9 2.44983
DAXX death-domain associated protein 2.44787
CENPP centromere protein P 2.44473
GSG1L GSG1-like 2.44327
HMMR hyaluronan-mediated motility receptor (RHAMM) 2.44014
NRBP2 nuclear receptor binding protein 2 2.43881
PLAGL2 pleiomorphic adenoma gene-like 2 2.43556
OR4K15 olfactory receptor, family 4, subfamily K, member 15 2.43551
EPHA1 EPH receptor A1 2.43531
SREK1 splicing regulatory glutamine/lysine-rich protein 1 2.42794
ARNT aryl hydrocarbon receptor nuclear translocator 2.42289
FKBP8 FK506 binding protein 8, 38kDa 2.42277
PRIMA1 proline rich membrane anchor 1 2.41324
OVOL1 ovo-like zinc finger 1 2.40259
ZNF239 zinc finger protein 239 2.37634
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 2.36915
C19ORF25 chromosome 19 open reading frame 25 2.357
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.35699
N4BP2 NEDD4 binding protein 2 2.3558
ACR acrosin 2.35299
MPRIP myosin phosphatase Rho interacting protein 2.34812
MTX2 metaxin 2 2.34561
LAT2 linker for activation of T cells family, member 2 2.34095
NME6 NME/NM23 nucleoside diphosphate kinase 6 2.33507
MTRF1 mitochondrial translational release factor 1 2.33497
IQCJ IQ motif containing J 2.33286
MRPL40 mitochondrial ribosomal protein L40 2.32928
SCO2 SCO2 cytochrome c oxidase assembly protein 2.3275
NQO1 NAD(P)H dehydrogenase, quinone 1 2.32539
UBALD1 UBA-like domain containing 1 2.31782
NAF1 nuclear assembly factor 1 ribonucleoprotein 2.27426
SPATC1 spermatogenesis and centriole associated 1 2.27337
C3ORF38 chromosome 3 open reading frame 38 2.27288
LAGE3 L antigen family, member 3 2.26972
CCDC40 coiled-coil domain containing 40 2.26646
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.26479
ZNFX1 zinc finger, NFX1-type containing 1 2.26028
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.26006
GANAB glucosidase, alpha; neutral AB 2.25996
TLK1 tousled-like kinase 1 2.25383
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 2.25035
CRTAC1 cartilage acidic protein 1 2.23928
ZMYM3 zinc finger, MYM-type 3 2.23503
JUN jun proto-oncogene 2.23147
MSL1 male-specific lethal 1 homolog (Drosophila) 2.2287
GOLGA6D golgin A6 family, member D 2.22828
MTCH2 mitochondrial carrier 2 2.22295
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 2.21958
ARPC5L actin related protein 2/3 complex, subunit 5-like 2.21539
AQP12B aquaporin 12B 2.21495
TCTN1 tectonic family member 1 2.20751
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.2041
FRG2B FSHD region gene 2 family, member B 2.20371
QPRT quinolinate phosphoribosyltransferase 2.20105
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.19994
ZNF514 zinc finger protein 514 2.19879
C1QL4 complement component 1, q subcomponent-like 4 2.19732
TSLIG3B tRNA splicing ligase complex subunit 3B 2.19458
AKAP1 A kinase (PRKA) anchor protein 1 2.19344
SCRT1 scratch family zinc finger 1 2.19343
INTS13 integrator complex subunit 13 2.18707
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.18173
ZRANB1 zinc finger, RAN-binding domain containing 1 2.18171
OR51V1 olfactory receptor, family 51, subfamily V, member 1 2.17547
ACACA acetyl-CoA carboxylase alpha 2.17476
CST2 cystatin SA 2.17315
PDGFA platelet-derived growth factor alpha polypeptide 2.17284
FAM183A family with sequence similarity 183, member A 2.16319
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.15979
CDH26 cadherin 26 2.15896
WRAP53 WD repeat containing, antisense to TP53 2.15269
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 2.14853
RPS6KL1 ribosomal protein S6 kinase-like 1 2.14483
CIP2A cellular inhibitor of PP2A 2.14383
ZBTB34 zinc finger and BTB domain containing 34 2.13654
RGMA repulsive guidance molecule family member a 2.13271
ELMO2 engulfment and cell motility 2 2.13087
SGMS1 sphingomyelin synthase 1 2.12722
GSC2 goosecoid homeobox 2 2.12406
SLIRP SRA stem-loop interacting RNA binding protein 2.1228
ADAT2 adenosine deaminase, tRNA-specific 2 2.11516
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.11219
TTC24 tetratricopeptide repeat domain 24 2.10902
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 2.10843
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.09909
CFAP97 cilia and flagella associated protein 97 2.09717
GON4L gon-4-like (C. elegans) 2.08649
USP1 ubiquitin specific peptidase 1 2.07835
MIB1 mindbomb E3 ubiquitin protein ligase 1 2.07556
SFXN2 sideroflexin 2 2.0729
LAPTM5 lysosomal protein transmembrane 5 2.06452
RNF11 ring finger protein 11 2.06161
TEX29 testis expressed 29 2.0597
TEDC1 tubulin epsilon and delta complex 1 2.05249
STRN striatin, calmodulin binding protein 2.05238
SAMD4A sterile alpha motif domain containing 4A 2.0503
NXNL1 nucleoredoxin-like 1 2.04983
FGF10 fibroblast growth factor 10 2.04184
TBX6 T-box 6 2.03957
SREBF1 sterol regulatory element binding transcription factor 1 2.03567
ZC3H7A zinc finger CCCH-type containing 7A 2.03237
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 2.03234
VCL vinculin 2.02259
BRPF1 bromodomain and PHD finger containing, 1 2.0224
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 2.02181
IPO5 importin 5 2.01182
TMCO6 transmembrane and coiled-coil domains 6 2.00931
TTC5 tetratricopeptide repeat domain 5 2.00568
ADAMTSL5 ADAMTS-like 5 2.00485
HDLBP high density lipoprotein binding protein 2.00409