MES-SA Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description disease: uterine sarcoma (Cell Line Ontology, CLO_0007677)
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Genes

299 genes with high or low expression in MES-SA relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
MYOT myotilin 3.60177
RARB retinoic acid receptor, beta 3.6
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 3.46835
USP9X ubiquitin specific peptidase 9, X-linked 3.32403
SMPX small muscle protein, X-linked 2.99455
KERA keratocan 2.9754
RAD51B RAD51 paralog B 2.92998
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.88412
MPDZ multiple PDZ domain protein 2.8781
SLIT2 slit homolog 2 (Drosophila) 2.78224
FOXN3 forkhead box N3 2.76639
PWP1 PWP1 homolog (S. cerevisiae) 2.76027
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.73878
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.66556
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 2.62435
TTC23 tetratricopeptide repeat domain 23 2.61613
RPUSD2 RNA pseudouridylate synthase domain containing 2 2.55785
GPD1L glycerol-3-phosphate dehydrogenase 1-like 2.48844
EPYC epiphycan 2.48742
METTL8 methyltransferase like 8 2.48504
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 2.41435
NFIB nuclear factor I/B 2.36381
MMRN2 multimerin 2 2.32542
UBXN4 UBX domain protein 4 2.32502
DCN decorin 2.31737
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.3122
DNAH9 dynein, axonemal, heavy chain 9 2.2994
FLRT3 fibronectin leucine rich transmembrane protein 3 2.28469
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 2.2808
SEC31A SEC31 homolog A (S. cerevisiae) 2.27292
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.25559
ZNF148 zinc finger protein 148 2.24745
SCAF11 SR-related CTD-associated factor 11 2.24555
LRRC8D leucine rich repeat containing 8 family, member D 2.24435
SLC39A8 solute carrier family 39 (zinc transporter), member 8 2.22935
CD248 CD248 molecule, endosialin 2.22812
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.22453
DPH5 diphthamide biosynthesis 5 2.22364
GLRB glycine receptor, beta 2.20281
BARD1 BRCA1 associated RING domain 1 2.17954
LPAR4 lysophosphatidic acid receptor 4 2.13607
NLGN1 neuroligin 1 2.13272
FXYD1 FXYD domain containing ion transport regulator 1 2.10951
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.10889
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.09904
PPP1R12A protein phosphatase 1, regulatory subunit 12A 2.09377
LOC284244 uncharacterized LOC284244 2.09155
DICER1 dicer 1, ribonuclease type III 2.09129
GSG1 germ cell associated 1 2.06633
TOM1L1 target of myb1 (chicken)-like 1 2.03739
DNM3 dynamin 3 2.02084
NXPE3 neurexophilin and PC-esterase domain family, member 3 2.01676
TUG1 taurine up-regulated 1 (non-protein coding) 2.01265
CCR1 chemokine (C-C motif) receptor 1 2.0071
EPRS glutamyl-prolyl-tRNA synthetase 1.96837
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 1.96705
NCK1 NCK adaptor protein 1 1.96512
HOXC8 homeobox C8 1.96261
EYA4 EYA transcriptional coactivator and phosphatase 4 1.96026
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 1.95943
EIF5B eukaryotic translation initiation factor 5B 1.95617
PLAGL1 pleiomorphic adenoma gene-like 1 1.95606
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 1.95544
GYG1 glycogenin 1 1.95284
NIPSNAP1 nipsnap homolog 1 (C. elegans) 1.95276
KPNB1 karyopherin (importin) beta 1 1.94969
SIKE1 suppressor of IKBKE 1 1.94749
ISYNA1 inositol-3-phosphate synthase 1 1.94456
PPBPP2 pro-platelet basic protein pseudogene 2 1.93635
MAP2K6 mitogen-activated protein kinase kinase 6 1.9327
FAM120A family with sequence similarity 120A 1.92265
ATXN2 ataxin 2 1.92221
FTO fat mass and obesity associated 1.91912
LIN28A lin-28 homolog A (C. elegans) 1.90425
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 1.89855
RALBP1 ralA binding protein 1 1.89616
TNPO1 transportin 1 1.88705
NME4 NME/NM23 nucleoside diphosphate kinase 4 1.88664
CUTC cutC copper transporter 1.8793
KAT6B K(lysine) acetyltransferase 6B 1.87906
CCR10 chemokine (C-C motif) receptor 10 1.86596
MEIS2 Meis homeobox 2 1.86018
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.84804
SPATA20 spermatogenesis associated 20 1.84778
PDGFC platelet derived growth factor C 1.83578
RPA4 replication protein A4, 30kDa 1.83157
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 1.83034
TKT transketolase 1.82743
UBE3A ubiquitin protein ligase E3A 1.82113
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 1.81615
HYMAI hydatidiform mole associated and imprinted (non-protein coding) 1.81368
ZFP36L1 ZFP36 ring finger protein-like 1 1.81362
GREM2 gremlin 2, DAN family BMP antagonist 1.80971
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.78964
PTCD2 pentatricopeptide repeat domain 2 1.78761
PES1 pescadillo ribosomal biogenesis factor 1 1.78237
COX11 COX11 cytochrome c oxidase copper chaperone 1.78026
DIRAS2 DIRAS family, GTP-binding RAS-like 2 1.76915
SRP72 signal recognition particle 72kDa 1.76848
SPOP speckle-type POZ protein 1.76229
PTP4A2 protein tyrosine phosphatase type IVA, member 2 1.74723
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 1.7376
MTIF2 mitochondrial translational initiation factor 2 1.73636
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 1.73297
ARMCX3 armadillo repeat containing, X-linked 3 1.72746
PTPRR protein tyrosine phosphatase, receptor type, R 1.72594
UBE2K ubiquitin-conjugating enzyme E2K 1.72555
SNCG synuclein, gamma (breast cancer-specific protein 1) 1.7226
NR2F1 nuclear receptor subfamily 2, group F, member 1 1.7178
AK5 adenylate kinase 5 1.71746
RBM25 RNA binding motif protein 25 1.71337
CARD9 caspase recruitment domain family, member 9 1.70492
TRAP1 TNF receptor-associated protein 1 1.70334
SLITRK5 SLIT and NTRK-like family, member 5 1.70207
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 1.69662
FOXL2 forkhead box L2 1.69133
MED14 mediator complex subunit 14 1.68979
NOLC1 nucleolar and coiled-body phosphoprotein 1 1.68189
ZNF638 zinc finger protein 638 1.67821
EIF3A eukaryotic translation initiation factor 3, subunit A 1.67817
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 1.67543
PAK1IP1 PAK1 interacting protein 1 1.67365
MON2 MON2 homolog (S. cerevisiae) 1.67159
RAB11FIP2 RAB11 family interacting protein 2 (class I) 1.65832
MTDH metadherin 1.65177
REST RE1-silencing transcription factor 1.63963
IRS1 insulin receptor substrate 1 1.63745
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 1.63665
ASMTL acetylserotonin O-methyltransferase-like 1.63417
ATG12 autophagy related 12 1.62659
TRIM33 tripartite motif containing 33 1.62488
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 1.62395
MTPAP mitochondrial poly(A) polymerase 1.62026
YY1 YY1 transcription factor 1.61746
SETD5 SET domain containing 5 1.61481
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.61274
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) 1.6124
CAMK2D calcium/calmodulin-dependent protein kinase II delta 1.60274
GTPBP8 GTP-binding protein 8 (putative) 1.6027
PRR5 proline rich 5 (renal) 1.59962
DBP D site of albumin promoter (albumin D-box) binding protein 1.59559
RSAD1 radical S-adenosyl methionine domain containing 1 1.58934
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 1.58839
SSB Sjogren syndrome antigen B (autoantigen La) 1.58013
EP300 E1A binding protein p300 1.57502
NAAA N-acylethanolamine acid amidase 1.5749
APTX aprataxin 1.56965
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 1.55612
DNASE2B deoxyribonuclease II beta 1.54846
LYPLA1 lysophospholipase I 1.54579
RBMS3 RNA binding motif, single stranded interacting protein 3 1.54425
ASXL2 additional sex combs like transcriptional regulator 2 1.53993
PTGDS prostaglandin D2 synthase 21kDa (brain) 1.53246
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 1.53114
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 1.52751
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 1.52536
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 1.51747
NEK1 NIMA-related kinase 1 1.51625
CNOT2 CCR4-NOT transcription complex, subunit 2 1.51556
LUC7L3 LUC7-like 3 (S. cerevisiae) 1.511
FGD1 FYVE, RhoGEF and PH domain containing 1 1.51093
CA11 carbonic anhydrase XI 1.50422
TROVE2 TROVE domain family, member 2 1.50067
HEMK1 HemK methyltransferase family member 1 1.49964
NCOA3 nuclear receptor coactivator 3 1.4988
MED1 mediator complex subunit 1 1.49622
MEOX1 mesenchyme homeobox 1 1.48217
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1.48062
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 1.47982
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 1.47744
TMEM121 transmembrane protein 121 1.47673
PIAS1 protein inhibitor of activated STAT, 1 1.47312
TCF4 transcription factor 4 1.46463
ZSCAN31 zinc finger and SCAN domain containing 31 1.4571
SH3BGR SH3 domain binding glutamate-rich protein 1.45666
PPAT phosphoribosyl pyrophosphate amidotransferase 1.45514
AHCYL1 adenosylhomocysteinase-like 1 1.45419
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 1.45097
HSPB2 heat shock 27kDa protein 2 1.45096
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 1.45089
PTGER4 prostaglandin E receptor 4 (subtype EP4) 1.45005
THUMPD1 THUMP domain containing 1 1.44961
RNMTL1 RNA methyltransferase like 1 1.44941
ADSL adenylosuccinate lyase 1.44
KRAS Kirsten rat sarcoma viral oncogene homolog 1.43969
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.43617
INO80B INO80 complex subunit B 1.42766
AVPR2 arginine vasopressin receptor 2 1.42551
TEK TEK tyrosine kinase, endothelial 1.4246
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 1.42287
TXNRD1 thioredoxin reductase 1 1.42129
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 1.41788

low expression

Symbol Name Standardized Value
SEC61G Sec61 gamma subunit -3.152
CYB5R4 cytochrome b5 reductase 4 -3.05875
DPYD dihydropyrimidine dehydrogenase -2.82049
PCDHGA3 protocadherin gamma subfamily A, 3 -2.58491
SAP30 Sin3A-associated protein, 30kDa -2.5451
PPIA peptidylprolyl isomerase A (cyclophilin A) -2.48709
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -2.46511
ACP2 acid phosphatase 2, lysosomal -2.45502
PIGA phosphatidylinositol glycan anchor biosynthesis, class A -2.44939
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 -2.38903
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.38541
HYI hydroxypyruvate isomerase (putative) -2.37083
MAPRE3 microtubule-associated protein, RP/EB family, member 3 -2.36455
MKKS McKusick-Kaufman syndrome -2.33117
H2AFV H2A histone family, member V -2.29878
NPR2 natriuretic peptide receptor 2 -2.28635
ITGA10 integrin, alpha 10 -2.2281
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.14756
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa -2.07688
ADARB1 adenosine deaminase, RNA-specific, B1 -2.06825
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 -2.05888
HDAC9 histone deacetylase 9 -2.04858
CDC40 cell division cycle 40 -2.04331
OASL 2'-5'-oligoadenylate synthetase-like -2.02984
GTDC1 glycosyltransferase-like domain containing 1 -2.01346
BMP2K BMP2 inducible kinase -1.99788
LMBRD1 LMBR1 domain containing 1 -1.95254
FAM3C family with sequence similarity 3, member C -1.93893
PAM peptidylglycine alpha-amidating monooxygenase -1.92123
SELT selenoprotein T -1.90078
CLCA1 chloride channel accessory 1 -1.90049
SSTR2 somatostatin receptor 2 -1.88369
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -1.87679
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -1.87662
EBP emopamil binding protein (sterol isomerase) -1.84901
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -1.84778
ZNF232 zinc finger protein 232 -1.83976
MTRF1L mitochondrial translational release factor 1-like -1.83394
NRL neural retina leucine zipper -1.83363
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding) -1.82966
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 -1.82037
FAM63B family with sequence similarity 63, member B -1.80381
ZNF302 zinc finger protein 302 -1.79744
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -1.79095
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -1.77174
OSGEP O-sialoglycoprotein endopeptidase -1.77027
RPA3 replication protein A3, 14kDa -1.75993
FLI1 Fli-1 proto-oncogene, ETS transcription factor -1.75819
CDKL3 cyclin-dependent kinase-like 3 -1.74294
HSF2BP heat shock transcription factor 2 binding protein -1.74011
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) -1.72848
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -1.7121
FRZB frizzled-related protein -1.70311
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -1.70024
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -1.68539
CPQ carboxypeptidase Q -1.67686
LAMB4 laminin, beta 4 -1.6707
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -1.66686
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 -1.65914
TBX5 T-box 5 -1.65752
POLM polymerase (DNA directed), mu -1.65092
NELL2 NEL-like 2 (chicken) -1.64634
CLEC16A C-type lectin domain family 16, member A -1.64226
AVL9 AVL9 homolog (S. cerevisiase) -1.63715
ZNF287 zinc finger protein 287 -1.63494
PTS 6-pyruvoyltetrahydropterin synthase -1.63064
SNX13 sorting nexin 13 -1.62654
ACYP2 acylphosphatase 2, muscle type -1.615
CEP162 centrosomal protein 162kDa -1.61469
KPNA5 karyopherin alpha 5 (importin alpha 6) -1.59666
INSR insulin receptor -1.58568
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -1.5804
COX17 COX17 cytochrome c oxidase copper chaperone -1.57911
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -1.57742
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -1.56228
RHOBTB1 Rho-related BTB domain containing 1 -1.55934
CASP5 caspase 5, apoptosis-related cysteine peptidase -1.5557
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 -1.5556
RASAL2 RAS protein activator like 2 -1.54889
PAX8 paired box 8 -1.5467
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -1.54377
TMX4 thioredoxin-related transmembrane protein 4 -1.54152
SCARA3 scavenger receptor class A, member 3 -1.53317
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -1.52953
RGS16 regulator of G-protein signaling 16 -1.52112
SZT2 seizure threshold 2 homolog (mouse) -1.52043
AHI1 Abelson helper integration site 1 -1.5129
NBEA neurobeachin -1.5119
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -1.51077
REG1B regenerating islet-derived 1 beta -1.50717
MRPS17 mitochondrial ribosomal protein S17 -1.50184
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.50167
MTMR7 myotubularin related protein 7 -1.49865
STAG1 stromal antigen 1 -1.49706
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -1.48844
SOX30 SRY (sex determining region Y)-box 30 -1.48514
PTK2B protein tyrosine kinase 2 beta -1.47468
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -1.47044
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 -1.46407
IGFLR1 IGF-like family receptor 1 -1.4522
NPY5R neuropeptide Y receptor Y5 -1.43692
HAO2 hydroxyacid oxidase 2 (long chain) -1.43248
CD226 CD226 molecule -1.4316
C1QTNF1 C1q and tumor necrosis factor related protein 1 -1.42709
MED23 mediator complex subunit 23 -1.42266
ZSCAN12 zinc finger and SCAN domain containing 12 -1.41961
CTRL chymotrypsin-like -1.41665