MET Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description MET proto-oncogene, receptor tyrosine kinase|The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4233)
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Genes

331 genes differentially expressed following the MET gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MUC13 mucin 13, cell surface associated 2.99182
CLCF1 cardiotrophin-like cytokine factor 1 2.99182
PDF peptide deformylase (mitochondrial) 2.99182
CLDN23 claudin 23 2.99182
KLK15 kallikrein-related peptidase 15 2.99182
GRM6 glutamate receptor, metabotropic 6 2.99182
HSBP1L1 heat shock factor binding protein 1-like 1 2.99182
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.99182
IL32 interleukin 32 2.99182
NKPD1 NTPase, KAP family P-loop domain containing 1 2.99182
FAM86B2 family with sequence similarity 86, member B2 2.99182
SLC16A11 solute carrier family 16, member 11 2.99182
OOSP1 oocyte secreted protein 1, pseudogene 2.99182
SLC22A14 solute carrier family 22, member 14 2.99182
PDE11A phosphodiesterase 11A 2.99182
ADCY4 adenylate cyclase 4 2.99182
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.99182
DNAI1 dynein, axonemal, intermediate chain 1 2.99182
JHY junctional cadherin complex regulator 2.99182
TMEM176B transmembrane protein 176B 2.98701
PNMA5 paraneoplastic Ma antigen family member 5 2.98701
RSPO1 R-spondin 1 2.98701
GPR75 G protein-coupled receptor 75 2.98701
CELF3 CUGBP, Elav-like family member 3 2.98701
FGF21 fibroblast growth factor 21 2.98701
GLYAT glycine-N-acyltransferase 2.98701
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.98701
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.98701
PCDHB7 protocadherin beta 7 2.98701
PRICKLE4 prickle homolog 4 (Drosophila) 2.98701
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.98701
NAPSA napsin A aspartic peptidase 2.98701
CAMP cathelicidin antimicrobial peptide 2.98701
WDR87 WD repeat domain 87 2.98701
CLEC19A C-type lectin domain family 19, member A 2.98701
GPR22 G protein-coupled receptor 22 2.98701
POSTN periostin, osteoblast specific factor 2.98701
HAS1 hyaluronan synthase 1 2.98701
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.98701
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.98701
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.98701
C1ORF146 chromosome 1 open reading frame 146 2.98701
GMFG glia maturation factor, gamma 2.98701
TNS4 tensin 4 2.98701
GPR21 G protein-coupled receptor 21 2.98701
ASPA aspartoacylase 2.98701
ADTRP androgen-dependent TFPI-regulating protein 2.98701
PAX8 paired box 8 2.98701
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.98701
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 2.98701
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.98701
NFAM1 NFAT activating protein with ITAM motif 1 2.98701
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.98701
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.98701
FOXR1 forkhead box R1 2.98701
WSB2 WD repeat and SOCS box containing 2 2.98701
SPATA31G1 SPATA31 subfamily G member 1 2.98701
CXCL13 chemokine (C-X-C motif) ligand 13 2.98701
PLCZ1 phospholipase C, zeta 1 2.98701
C20ORF202 chromosome 20 open reading frame 202 2.98701
TBC1D3B TBC1 domain family, member 3B 2.98701
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.98701
TMPRSS6 transmembrane protease, serine 6 2.98701
LY6H lymphocyte antigen 6 complex, locus H 2.98701
FAM228A family with sequence similarity 228, member A 2.98701
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.98701
ALX4 ALX homeobox 4 2.98701
CD300LF CD300 molecule-like family member f 2.98701
HBG2 hemoglobin, gamma G 2.98701
CIMIP4 ciliary microtubule inner protein 4 2.98701
WASL-DT WASL divergent transcript 2.98701
C20ORF204 chromosome 20 open reading frame 204 2.98701
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.98701
SERTM2 serine rich and transmembrane domain containing 2 2.98701
CFAP157 cilia and flagella associated protein 157 2.98701
SMIM38 small integral membrane protein 38 2.98701
PTH1R parathyroid hormone 1 receptor 2.98701
C3AR1 complement component 3a receptor 1 2.98701
PARVG parvin, gamma 2.98701
TMEM119 transmembrane protein 119 2.98701
VSX2 visual system homeobox 2 2.98701
CLDN2 claudin 2 2.98701
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.98701
GGT6 gamma-glutamyltransferase 6 2.98701
PRB4 proline-rich protein BstNI subfamily 4 2.98701
MTNR1B melatonin receptor 1B 2.98701
CPNE5 copine V 2.98701
TBX20 T-box 20 2.98701
ZNF99 zinc finger protein 99 2.98701
OLAH oleoyl-ACP hydrolase 2.98701
OR51B5 olfactory receptor, family 51, subfamily B, member 5 2.98701
CATSPER3 cation channel, sperm associated 3 2.98701
PNPLA1 patatin-like phospholipase domain containing 1 2.98701
LRRC71 leucine rich repeat containing 71 2.98701
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.98701
TSPO2 translocator protein 2 2.98701
FOXI2 forkhead box I2 2.98701
CREB3L3 cAMP responsive element binding protein 3-like 3 2.98701
RNF113B ring finger protein 113B 2.98701
OR2A14 olfactory receptor, family 2, subfamily A, member 14 2.98701
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.98701
GPR4 G protein-coupled receptor 4 2.98701
AMER3 APC membrane recruitment protein 3 2.98701
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.98701
NXNL1 nucleoredoxin-like 1 2.98701
ZNF541 zinc finger protein 541 2.98701
DQX1 DEAQ box RNA-dependent ATPase 1 2.98701
S100A14 S100 calcium binding protein A14 2.98701
CDHR2 cadherin-related family member 2 2.98701
SCML4 sex comb on midleg-like 4 (Drosophila) 2.98701
ERICH6B glutamate-rich 6B 2.98701
KRTAP5-11 keratin associated protein 5-11 2.98701
PALMD palmdelphin 2.98701
ALOX15B arachidonate 15-lipoxygenase, type B 2.98701
CLRN2 clarin 2 2.98701
PRR15L proline rich 15-like 2.98701
TMIGD2 transmembrane and immunoglobulin domain containing 2 2.98701
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 2.98701
ZMYND10 zinc finger, MYND-type containing 10 2.98701
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.98701
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.98701
CD248 CD248 molecule, endosialin 2.98701
MAB21L1 mab-21-like 1 (C. elegans) 2.98701
FIBIN fin bud initiation factor homolog (zebrafish) 2.98701
TG thyroglobulin 2.98701
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.98701
PENK proenkephalin 2.98701
SLC38A3 solute carrier family 38, member 3 2.98701
CLEC4A C-type lectin domain family 4, member A 2.98701
CD27 CD27 molecule 2.98701
C1ORF105 chromosome 1 open reading frame 105 2.98701
TM4SF19 transmembrane 4 L six family member 19 2.98701
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 2.98701
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.98701
CAGE1 cancer antigen 1 2.98701
GJC2 gap junction protein, gamma 2, 47kDa 2.98701
IL19 interleukin 19 2.98701
SLC22A24 solute carrier family 22, member 24 2.98701
STRC stereocilin 2.98701
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.98701
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.98701
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 2.98701
C10ORF105 chromosome 10 open reading frame 105 2.98701
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.98701
KCTD4 potassium channel tetramerization domain containing 4 2.98701
ANGPTL5 angiopoietin-like 5 2.98701
ADH6 alcohol dehydrogenase 6 (class V) 2.98701
MMP10 matrix metallopeptidase 10 2.98701
SHISA3 shisa family member 3 2.98701
TBATA thymus, brain and testes associated 2.98701
CLNK cytokine-dependent hematopoietic cell linker 2.98701
IL17F interleukin 17F 2.98701
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.98701
ADAT3 adenosine deaminase, tRNA-specific 3 2.98701
TREML1 triggering receptor expressed on myeloid cells-like 1 2.98701
IL17B interleukin 17B 2.98701
AOC1 amine oxidase, copper containing 1 2.98701
PGM5 phosphoglucomutase 5 2.98701
FRMPD1 FERM and PDZ domain containing 1 2.98701
TMEM221 transmembrane protein 221 2.98701
RBP4 retinol binding protein 4, plasma 2.98701
CIB3 calcium and integrin binding family member 3 2.98701
BOLA2 bolA family member 2 2.98701
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.98701
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 2.98701
PSCA prostate stem cell antigen 2.98701
TTLL2 tubulin tyrosine ligase-like family member 2 2.98701
IRX5 iroquois homeobox 5 2.98701
DLX4 distal-less homeobox 4 2.98701
RNF39 ring finger protein 39 2.98701
MAGED4 melanoma antigen family D4 2.98701
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 2.98701
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.94234
IFI35 interferon-induced protein 35 2.85674
C19ORF73 chromosome 19 open reading frame 73 2.85674
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 2.7304
TMEM276 transmembrane protein 276 2.71083
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.62833
ALAS1 5'-aminolevulinate synthase 1 2.61563
TRPM3 transient receptor potential cation channel, subfamily M, member 3 2.59334
ZNF623 zinc finger protein 623 2.57608
CABLES1 Cdk5 and Abl enzyme substrate 1 2.51897
SEPTIN9 septin 9 2.50745
RAP1GAP2 RAP1 GTPase activating protein 2 2.50745
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.48563
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.44433
CD96 CD96 molecule 2.44433
PEAK1 pseudopodium-enriched atypical kinase 1 2.44433
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 2.4054
NUDT16 nudix (nucleoside diphosphate linked moiety X)-type motif 16 2.3995
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.33992
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.33992
C19ORF38 chromosome 19 open reading frame 38 2.33992
MPPED1 metallophosphoesterase domain containing 1 2.30825
CHMP1A charged multivesicular body protein 1A 2.30441
SYT9 synaptotagmin IX 2.24594
KDM7A lysine (K)-specific demethylase 7A 2.23959
AKAP1 A kinase (PRKA) anchor protein 1 2.23108
ADA2 adenosine deaminase 2 2.20844
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.19735
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.17284
ZNF391 zinc finger protein 391 2.16382
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.13975
RFLNB refilin B 2.13975
BRSK1 BR serine/threonine kinase 1 2.13975
REV1 REV1, polymerase (DNA directed) 2.13254
PHLDB1 pleckstrin homology-like domain, family B, member 1 2.12429
PLCL2 phospholipase C-like 2 2.11156
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 2.11156
TMEM14A transmembrane protein 14A 2.09054
NOSTRIN nitric oxide synthase trafficking 2.09054
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 2.0867
SRSF6 serine/arginine-rich splicing factor 6 2.08196
FAHD1 fumarylacetoacetate hydrolase domain containing 1 2.07477
VAMP4 vesicle-associated membrane protein 4 2.07131
PMPCA peptidase (mitochondrial processing) alpha 2.03168
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 2.02775
KLC1 kinesin light chain 1 2.02578
CHGA chromogranin A 2.00669

decreased expression

Symbol Name Standardized Value
CLIC2 chloride intracellular channel 2 -2.99182
MBLAC2 metallo-beta-lactamase domain containing 2 -2.99182
THRSP thyroid hormone responsive -2.99182
RPS26 ribosomal protein S26 -2.99182
CORT cortistatin -2.99182
FCSK fucose kinase -2.99182
PADI4 peptidyl arginine deiminase, type IV -2.98701
SYTL4 synaptotagmin-like 4 -2.98701
RTBDN retbindin -2.98701
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.98701
REN renin -2.98701
SV2B synaptic vesicle glycoprotein 2B -2.98701
TUBA8 tubulin, alpha 8 -2.98701
ZBED6 zinc finger, BED-type containing 6 -2.98701
NELL1 NEL-like 1 (chicken) -2.98701
MOGAT1 monoacylglycerol O-acyltransferase 1 -2.98701
CAPS calcyphosine -2.98701
MASTL microtubule associated serine/threonine kinase-like -2.98701
WFDC13 WAP four-disulfide core domain 13 -2.98701
AZU1 azurocidin 1 -2.98701
CHL1 cell adhesion molecule L1-like -2.98701
OXSM 3-oxoacyl-ACP synthase, mitochondrial -2.98701
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 -2.98701
ERFE erythroferrone -2.98701
PLPPR4 phospholipid phosphatase related 4 -2.98701
GOLM1 golgi membrane protein 1 -2.98701
ZNF441 zinc finger protein 441 -2.98701
SYT10 synaptotagmin X -2.98701
SLC22A25 solute carrier family 22, member 25 -2.98701
MYT1L myelin transcription factor 1-like -2.98701
LMX1B LIM homeobox transcription factor 1, beta -2.98701
JSRP1 junctional sarcoplasmic reticulum protein 1 -2.98701
CXXC1 CXXC finger protein 1 -2.98701
OLFML1 olfactomedin-like 1 -2.98701
ZNF804B zinc finger protein 804B -2.98701
PLAGL1 pleiomorphic adenoma gene-like 1 -2.98701
ANKRD42-DT ANKRD42 divergent transcript -2.98701
EID3 EP300 interacting inhibitor of differentiation 3 -2.91961
LRRC45 leucine rich repeat containing 45 -2.91871
TMEM68 transmembrane protein 68 -2.87721
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae) -2.8313
RENBP renin binding protein -2.78567
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.73712
EIF3K eukaryotic translation initiation factor 3, subunit K -2.72505
GLRB glycine receptor, beta -2.66108
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -2.65006
LLGL1 lethal giant larvae homolog 1 (Drosophila) -2.58825
FAM20C family with sequence similarity 20, member C -2.5833
COQ4 coenzyme Q4 -2.5833
ANO10 anoctamin 10 -2.57608
HPS3 Hermansky-Pudlak syndrome 3 -2.57608
EID2 EP300 interacting inhibitor of differentiation 2 -2.57033
MED17 mediator complex subunit 17 -2.51382
RPL28 ribosomal protein L28 -2.50224
MCOLN3 mucolipin 3 -2.49786
CD46 CD46 molecule, complement regulatory protein -2.49018
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -2.48563
KCNIP4 Kv channel interacting protein 4 -2.44405
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.41395
GGCT gamma-glutamylcyclotransferase -2.3995
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.39603
RAB7A RAB7A, member RAS oncogene family -2.38828
GPR135 G protein-coupled receptor 135 -2.34674
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.34064
CDC16 cell division cycle 16 -2.31288
DOCK7 dedicator of cytokinesis 7 -2.30729
KANK4 KN motif and ankyrin repeat domains 4 -2.2959
RB1CC1 RB1-inducible coiled-coil 1 -2.2959
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.26667
TPM2 tropomyosin 2 (beta) -2.25098
MRPS18C mitochondrial ribosomal protein S18C -2.23108
NMT2 N-myristoyltransferase 2 -2.21792
CNKSR2 connector enhancer of kinase suppressor of Ras 2 -2.19735
RABAC1 Rab acceptor 1 (prenylated) -2.18888
ZBED3 zinc finger, BED-type containing 3 -2.18888
PSEN1 presenilin 1 -2.1868
SET SET nuclear proto-oncogene -2.18054
ACO2 aconitase 2, mitochondrial -2.16536
HDGF hepatoma-derived growth factor -2.16238
LACTB lactamase, beta -2.16137
WDR13 WD repeat domain 13 -2.15983
TM2D1 TM2 domain containing 1 -2.15332
MYO10 myosin X -2.14742
TGFBR3L transforming growth factor, beta receptor III-like -2.13254
PRDX2 peroxiredoxin 2 -2.12742
RNF38 ring finger protein 38 -2.12742
FBXO34 F-box protein 34 -2.12429
CAPN7 calpain 7 -2.11517
MRPL35 mitochondrial ribosomal protein L35 -2.11156
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -2.11156
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.09896
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 -2.09896
GPR141 G protein-coupled receptor 141 -2.09712
PLXNA1 plexin A1 -2.09325
C5ORF15 chromosome 5 open reading frame 15 -2.09175
EFNB3 ephrin-B3 -2.09054
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -2.09054
IER3 immediate early response 3 -2.08929
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 -2.07684
SRGAP2B SLIT-ROBO Rho GTPase activating protein 2B -2.07477
SETD7 SET domain containing (lysine methyltransferase) 7 -2.06264
FAM161A family with sequence similarity 161, member A -2.06264
GHRL ghrelin/obestatin prepropeptide -2.05627
TIMM29 translocase of inner mitochondrial membrane 29 -2.04557
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 -2.04225
NR1H2 nuclear receptor subfamily 1, group H, member 2 -2.04199
CRYZL2P-SEC16B CRYZL2P-SEC16B readthrough -2.03392
NGF nerve growth factor (beta polypeptide) -2.03392
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 -2.03392
ERN2 endoplasmic reticulum to nucleus signaling 2 -2.03392
ZNF543 zinc finger protein 543 -2.03168
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 -2.02529