MFN2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mitofusin 2|This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9927)
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Genes

333 genes differentially expressed following the MFN2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DKK1 dickkopf WNT signaling pathway inhibitor 1 3.29917
PRPH2 peripherin 2 (retinal degeneration, slow) 3.29917
LTB4R leukotriene B4 receptor 3.29917
DUSP9 dual specificity phosphatase 9 3.29917
GADL1 glutamate decarboxylase-like 1 3.29917
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.29917
KCTD4 potassium channel tetramerization domain containing 4 3.29917
LRRTM2 leucine rich repeat transmembrane neuronal 2 3.29917
FLI1 Fli-1 proto-oncogene, ETS transcription factor 3.29917
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 3.29917
PRR4 proline rich 4 (lacrimal) 3.29917
NWD1 NACHT and WD repeat domain containing 1 3.29917
BCAS1 breast carcinoma amplified sequence 1 3.29917
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 3.29917
UMOD uromodulin 3.29917
KCTD11 potassium channel tetramerization domain containing 11 3.29917
CA10 carbonic anhydrase X 3.29917
CLDN16 claudin 16 3.29917
TMEM184A transmembrane protein 184A 3.29917
SHISA8 shisa family member 8 3.29917
FGF16 fibroblast growth factor 16 3.29917
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.29917
ADCY2 adenylate cyclase 2 (brain) 3.29917
IRX1 iroquois homeobox 1 3.29917
LIPH lipase, member H 3.29553
INHBB inhibin, beta B 3.29553
SKOR2 SKI family transcriptional corepressor 2 3.29553
MYBPHL myosin binding protein H-like 3.29553
BTN3A3 butyrophilin, subfamily 3, member A3 3.29553
FGF20 fibroblast growth factor 20 3.29553
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 3.29553
TEX36 testis expressed 36 3.29553
SCN2A sodium channel, voltage gated, type II alpha subunit 3.29553
TM4SF20 transmembrane 4 L six family member 20 3.29553
RUNDC3A RUN domain containing 3A 3.29553
ACTG2 actin, gamma 2, smooth muscle, enteric 3.29553
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 3.29553
AKAP14 A kinase (PRKA) anchor protein 14 3.29553
PDYN prodynorphin 3.29553
SOX14 SRY (sex determining region Y)-box 14 3.29553
DDR2 discoidin domain receptor tyrosine kinase 2 3.29553
TPPP tubulin polymerization promoting protein 3.29553
PODNL1 podocan-like 1 3.29553
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.29553
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 3.29553
GPATCH3 G patch domain containing 3 3.29553
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.29553
GPR183 G protein-coupled receptor 183 3.29553
MOGAT3 monoacylglycerol O-acyltransferase 3 3.29553
RGPD4 RANBP2-like and GRIP domain containing 4 3.29553
FSCN3 fascin actin-bundling protein 3, testicular 3.29553
CA1 carbonic anhydrase I 3.29553
UQCRHL ubiquinol-cytochrome c reductase hinge protein-like 3.29553
FETUB fetuin B 3.29553
XCL1 chemokine (C motif) ligand 1 3.29553
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 3.29553
TUBB1 tubulin, beta 1 class VI 3.29553
ARHGAP30 Rho GTPase activating protein 30 3.29553
C12ORF42 chromosome 12 open reading frame 42 3.29553
CATSPERT catsper channel auxiliary subunit tau 3.29553
MYORG myogenesis regulating glycosidase (putative) 3.29553
MGAM maltase-glucoamylase 3.29553
SPI1 Spi-1 proto-oncogene 3.29553
FIMP1 fertilization-influencing membrane protein 1 3.29553
FMO1 flavin containing monooxygenase 1 3.29553
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 3.29553
NEURL3 neuralized E3 ubiquitin protein ligase 3 3.29553
BDKRB1 bradykinin receptor B1 3.29553
GC group-specific component (vitamin D binding protein) 3.29553
PARVG parvin, gamma 3.29553
SMIM40 small integral membrane protein 40 3.29553
PLAAT4 phospholipase A and acyltransferase 4 3.29553
TMEM278 transmembrane protein 278 3.29553
TEX53 testis expressed 53 3.29553
LY6L lymphocyte antigen 6 family member L 3.29553
IHO1 interactor of HORMAD1 1 3.29553
STPG3 sperm-tail PG-rich repeat containing 3 3.29553
NFILZ NFIL3 like basic leucine zipper 3.29553
ALKAL1 ALK and LTK ligand 1 3.29553
AJM1 apical junction component 1 homolog 3.29553
ANKRD40CL ANKRD40 C-terminal like 3.29553
G6PC1 glucose-6-phosphatase catalytic subunit 1 3.29553
LRRC71 leucine rich repeat containing 71 3.29553
ARHGAP15 Rho GTPase activating protein 15 3.29553
GJD2 gap junction protein, delta 2, 36kDa 3.29553
ATP13A5 ATPase type 13A5 3.29553
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 3.29553
HBA2 hemoglobin, alpha 2 3.29553
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 3.29553
TSSK4 testis-specific serine kinase 4 3.29553
ZNF582 zinc finger protein 582 3.29553
FER1L6 fer-1-like family member 6 3.29553
FOXL1 forkhead box L1 3.29553
GPR75 G protein-coupled receptor 75 3.29553
SIX1 SIX homeobox 1 3.29553
PCDHA8 protocadherin alpha 8 3.29553
PCDHA9 protocadherin alpha 9 3.29553
SPDYE17 speedy/RINGO cell cycle regulator family member E17 3.29553
SCN7A sodium channel, voltage gated, type VII alpha subunit 3.29553
RUNX3 runt-related transcription factor 3 3.29553
ADGRG1 adhesion G protein-coupled receptor G1 3.29553
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.29553
CXCL14 chemokine (C-X-C motif) ligand 14 3.29553
TMEM233 transmembrane protein 233 3.29553
TMEM235 transmembrane protein 235 3.29553
TSGA10IP testis specific, 10 interacting protein 3.29553
LOC122394732 uncharacterized LOC122394732 3.29553
UPK3B uroplakin 3B 3.29553
SEZ6L seizure related 6 homolog (mouse)-like 3.29553
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.29553
TSLP thymic stromal lymphopoietin 3.29553
CDHR4 cadherin-related family member 4 3.29553
TPSG1 tryptase gamma 1 3.29553
KLF4 Kruppel-like factor 4 (gut) 3.29553
WFDC2 WAP four-disulfide core domain 2 3.29553
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 3.29553
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.29553
MRLN myoregulin 3.29553
IGFBP7 insulin-like growth factor binding protein 7 3.29553
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.29553
CASS4 Cas scaffolding protein family member 4 3.29553
ALAS2 5'-aminolevulinate synthase 2 3.29553
FBXO39 F-box protein 39 3.29553
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.29553
PCDHGB4 protocadherin gamma subfamily B, 4 3.29553
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.29553
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.29553
TRIM58 tripartite motif containing 58 3.29553
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.29553
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.29553
SIGLEC15 sialic acid binding Ig-like lectin 15 3.29553
SLC38A8 solute carrier family 38, member 8 3.29553
TCAP titin-cap 3.29553
MYADML2 myeloid-associated differentiation marker-like 2 3.29553
RIN1 Ras and Rab interactor 1 3.29553
SYT5 synaptotagmin V 3.29553
EVI2A ecotropic viral integration site 2A 3.29553
RASL11A RAS-like, family 11, member A 3.29553
LY96 lymphocyte antigen 96 3.29553
IL1B interleukin 1, beta 3.29553
SLC22A24 solute carrier family 22, member 24 3.29553
FBXO47 F-box protein 47 3.29553
ZFP92 ZFP92 zinc finger protein 3.29553
FBXL22 F-box and leucine-rich repeat protein 22 3.29553
IGF2 insulin-like growth factor 2 3.29553
UTS2R urotensin 2 receptor 3.29553
PRR35 proline rich 35 3.29553
IL12A interleukin 12A 3.29553
UPP2 uridine phosphorylase 2 3.29553
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.29553
CD86 CD86 molecule 3.29553
DISP2 dispatched homolog 2 (Drosophila) 3.29553
BIN2 bridging integrator 2 3.29553
ACAN aggrecan 3.29553
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.29553
ZNF319 zinc finger protein 319 3.29553
IL33 interleukin 33 3.29553
C17ORF78 chromosome 17 open reading frame 78 3.29553
TNMD tenomodulin 3.29553
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.29553
NLRP6 NLR family, pyrin domain containing 6 3.29553
MRGPRX3 MAS-related GPR, member X3 3.29553
CYGB cytoglobin 3.29553
LEP leptin 3.29553
NOS2 nitric oxide synthase 2, inducible 3.29553
SLITRK1 SLIT and NTRK-like family, member 1 3.29553
ADGRF5 adhesion G protein-coupled receptor F5 3.29553
EPX eosinophil peroxidase 3.29553
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 3.29553
PRR15L proline rich 15-like 3.29553
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.29553
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 3.23044
LAMA3 laminin, alpha 3 3.14504
HLA-DRA major histocompatibility complex, class II, DR alpha 3.14504
CNN2 calponin 2 3.13095
RARG retinoic acid receptor, gamma 3.06358
KIF19 kinesin family member 19 3.00424
GPA33 glycoprotein A33 (transmembrane) 3.00424
ELL2 elongation factor, RNA polymerase II, 2 2.98866
PPCDC phosphopantothenoylcysteine decarboxylase 2.90111
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 2.76209
FAHD2B fumarylacetoacetate hydrolase domain containing 2B 2.76209
CADM1 cell adhesion molecule 1 2.75614
TMPRSS5 transmembrane protease, serine 5 2.71032
BAIAP3 BAI1-associated protein 3 2.71032
PDE11A phosphodiesterase 11A 2.71032
PLAC8 placenta-specific 8 2.71032
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.71032
UNK unkempt family zinc finger 2.68586
DUSP8 dual specificity phosphatase 8 2.68586
NAGA N-acetylgalactosaminidase, alpha- 2.65305
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.54551
SOS1 son of sevenless homolog 1 (Drosophila) 2.51874
COL21A1 collagen, type XXI, alpha 1 2.41853
MT1X metallothionein 1X 2.41215
SLC71A1 solute carrier family 71 member 1 2.38574
CNOT1 CCR4-NOT transcription complex, subunit 1 2.38428
CLDN4 claudin 4 2.38428
SH2D3A SH2 domain containing 3A 2.38284
DENND4A DENN/MADD domain containing 4A 2.37774
NCOA7 nuclear receptor coactivator 7 2.36008
RBSN rabenosyn, RAB effector 2.30975
CDX4 caudal type homeobox 4 2.309
RRAGA Ras-related GTP binding A 2.26651
RNF217 ring finger protein 217 2.2616
CD47 CD47 molecule 2.25898
TMEM38B transmembrane protein 38B 2.24495
RTEL1 regulator of telomere elongation helicase 1 2.24109
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 2.24076
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 2.23407
WDR89 WD repeat domain 89 2.23366
RSRC2 arginine/serine-rich coiled-coil 2 2.22921
TICRR TOPBP1-interacting checkpoint and replication regulator 2.22087
GLYATL1 glycine-N-acyltransferase-like 1 2.22087
AP3D1 adaptor-related protein complex 3, delta 1 subunit 2.21633
SYNE1 spectrin repeat containing, nuclear envelope 1 2.20836
FAM193A family with sequence similarity 193, member A 2.20836
PLEKHO2 pleckstrin homology domain containing, family O member 2 2.16617
OSBP oxysterol binding protein 2.16394
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 2.16394
EYA1 EYA transcriptional coactivator and phosphatase 1 2.16317
TAGLN transgelin 2.1494
FKBP11 FK506 binding protein 11, 19 kDa 2.14487
MT1G metallothionein 1G 2.10379
ANAPC5 anaphase promoting complex subunit 5 2.10043
GALNT17 polypeptide N-acetylgalactosaminyltransferase 17 2.09453
ZNF468 zinc finger protein 468 2.09453
AKNA AT-hook transcription factor 2.08027
PCNX1 pecanex 1 2.07882
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 2.04564
TRMT6 tRNA methyltransferase 6 2.04203
CLDN12 claudin 12 2.00669

decreased expression

Symbol Name Standardized Value
ULK3 unc-51 like kinase 3 -3.29917
CCDC106 coiled-coil domain containing 106 -3.29917
CCDC22 coiled-coil domain containing 22 -3.29553
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 -3.29553
COMMD5 COMM domain containing 5 -3.29553
ZNF263 zinc finger protein 263 -3.29553
PLCB2 phospholipase C, beta 2 -3.27957
THSD7A thrombospondin, type I, domain containing 7A -3.2526
AFF4 AF4/FMR2 family, member 4 -3.14504
LRTM1 leucine-rich repeats and transmembrane domains 1 -2.95916
ZNF285 zinc finger protein 285 -2.95916
ELL3 elongation factor RNA polymerase II-like 3 -2.95916
GRM2 glutamate receptor, metabotropic 2 -2.95916
CLEC2L C-type lectin domain family 2, member L -2.95916
SLC7A14 solute carrier family 7, member 14 -2.95916
ALG10 ALG10, alpha-1,2-glucosyltransferase -2.95916
PPP1R3D protein phosphatase 1, regulatory subunit 3D -2.95916
TIMP4 TIMP metallopeptidase inhibitor 4 -2.95916
MKX mohawk homeobox -2.95916
QRFPR pyroglutamylated RFamide peptide receptor -2.95916
BTBD6 BTB (POZ) domain containing 6 -2.95916
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -2.95916
SCART1 scavenger receptor protein family member -2.95916
SLC49A3 solute carrier family 49 member 3 -2.95916
CIDEB cell death-inducing DFFA-like effector b -2.95916
FAM178B family with sequence similarity 178, member B -2.95916
ZFP28 ZFP28 zinc finger protein -2.95916
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -2.95916
CRTC2 CREB regulated transcription coactivator 2 -2.95916
HYAL1 hyaluronoglucosaminidase 1 -2.95916
ZXDB zinc finger, X-linked, duplicated B -2.95916
GAB3 GRB2-associated binding protein 3 -2.95916
SCT secretin -2.95916
COMMD3 COMM domain containing 3 -2.95916
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -2.95916
C3ORF18 chromosome 3 open reading frame 18 -2.95916
PDCL2 phosducin-like 2 -2.95916
DUSP28 dual specificity phosphatase 28 -2.95916
SSUH2 ssu-2 homolog (C. elegans) -2.95916
PCDHAC1 protocadherin alpha subfamily C, 1 -2.95916
CPN1 carboxypeptidase N, polypeptide 1 -2.95916
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -2.8599
PRPF19 pre-mRNA processing factor 19 -2.84842
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.83243
FAM20A family with sequence similarity 20, member A -2.78154
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.72367
H2BC21 H2B clustered histone 21 -2.68586
CMYA5 cardiomyopathy associated 5 -2.68586
IL10RB interleukin 10 receptor, beta -2.68586
TCP11L2 t-complex 11, testis-specific-like 2 -2.68586
KIFAP3 kinesin-associated protein 3 -2.68586
MATN3 matrilin 3 -2.68586
ZNF77 zinc finger protein 77 -2.68586
MALRD1 MAM and LDL receptor class A domain containing 1 -2.68234
TBC1D25 TBC1 domain family, member 25 -2.67492
MFSD2B major facilitator superfamily domain containing 2B -2.60941
PPT2 palmitoyl-protein thioesterase 2 -2.60941
PIGL phosphatidylinositol glycan anchor biosynthesis, class L -2.58917
COX18 COX18 cytochrome c oxidase assembly factor -2.55373
C1ORF94 chromosome 1 open reading frame 94 -2.42843
GFRA2 GDNF family receptor alpha 2 -2.42843
ANKMY1 ankyrin repeat and MYND domain containing 1 -2.42843
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -2.42385
ZNF630 zinc finger protein 630 -2.4143
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.41215
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.40699
WDR73 WD repeat domain 73 -2.38428
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -2.37903
CHID1 chitinase domain containing 1 -2.37588
DSCC1 DNA replication and sister chromatid cohesion 1 -2.36386
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 -2.35638
SLC22A17 solute carrier family 22, member 17 -2.35638
PSPC1 paraspeckle component 1 -2.34747
IFT20 intraflagellar transport 20 -2.33288
LCTL lactase-like -2.32351
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone -2.3156
PGRMC1 progesterone receptor membrane component 1 -2.31154
GLIPR2 GLI pathogenesis-related 2 -2.27485
JPH1 junctophilin 1 -2.24109
AKIRIN1 akirin 1 -2.24076
PANK1 pantothenate kinase 1 -2.22112
DHRS3 dehydrogenase/reductase (SDR family) member 3 -2.20836
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -2.20836
CDK2 cyclin-dependent kinase 2 -2.20836
SRI sorcin -2.20745
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 -2.16838
NOL4L nucleolar protein 4-like -2.15148
CDH7 cadherin 7, type 2 -2.14487
HAP1 huntingtin-associated protein 1 -2.14487
CHMP6 charged multivesicular body protein 6 -2.14487
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase -2.14091
SPRED2 sprouty-related, EVH1 domain containing 2 -2.11545
CDH3 cadherin 3, type 1, P-cadherin (placental) -2.08927
BANP BTG3 associated nuclear protein -2.04203
ZSWIM3 zinc finger, SWIM-type containing 3 -2.041
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -2.03719
DCPS decapping enzyme, scavenger -2.02297
ZNF385B zinc finger protein 385B -2.02003
RPL21 ribosomal protein L21 -2.01214
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa -2.01139
METTL8 methyltransferase like 8 -2.00093