MFN2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description mitofusin 2|This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9927)
External Link http://www.ncbi.nlm.nih.gov/gene/9927
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Genes

52 interacting proteins for MFN2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BAK1 BCL2-antagonist/killer 1
BUB3 BUB3 mitotic checkpoint protein
C1ORF116 chromosome 1 open reading frame 116
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CSNK1D casein kinase 1, delta
DCAF7 DDB1 and CUL4 associated factor 7
DGKA diacylglycerol kinase, alpha 80kDa
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DOCK9 dedicator of cytokinesis 9
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERBB2IP erbb2 interacting protein
HSPA1B heat shock 70kDa protein 1B
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ITGB4 integrin, beta 4
KLF5 Kruppel-like factor 5 (intestinal)
LEMD3 LEM domain containing 3
LRRK2 leucine-rich repeat kinase 2
MAPK9 mitogen-activated protein kinase 9
MARCH5 membrane-associated ring finger (C3HC4) 5
MAVS mitochondrial antiviral signaling protein
MFN1 mitofusin 1
MTCH1 mitochondrial carrier 1
OPA1 optic atrophy 1 (autosomal dominant)
PARK2 parkin RBR E3 ubiquitin protein ligase
PCID2 PCI domain containing 2
PSPC1 paraspeckle component 1
RIN1 Ras and Rab interactor 1
SACK1G scaffolding CK1 anchoring protein G
SIK3 SIK family kinase 3
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNW1 SNW domain containing 1
SQRDL sulfide quinone reductase-like (yeast)
TCHP trichoplein, keratin filament binding
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBC ubiquitin C
UBE2N ubiquitin-conjugating enzyme E2N
VCP valosin containing protein
WRNIP1 Werner helicase interacting protein 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
YY1 YY1 transcription factor
ZFYVE9 zinc finger, FYVE domain containing 9