MG-132-1140 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the MG-132-1140 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
AEN apoptosis enhancing nuclease
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD11 ankyrin repeat domain 11
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BMP7 bone morphogenetic protein 7
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BTG2 BTG family, member 2
C9ORF91 chromosome 9 open reading frame 91
CALCOCO2 calcium binding and coiled-coil domain 2
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GCC1 GRIP and coiled-coil domain containing 1
GCLM glutamate-cysteine ligase, modifier subunit
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB10 growth factor receptor-bound protein 10
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
INSIG1 insulin induced gene 1
IP6K2 inositol hexakisphosphate kinase 2
IQCB1 IQ motif containing B1
JUN jun proto-oncogene
KIN Kin17 DNA and RNA binding protein
LDLR low density lipoprotein receptor
LMO4 LIM domain only 4
LPIN1 lipin 1
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MORC4 MORC family CW-type zinc finger 4
MSMO1 methylsterol monooxygenase 1
NFIL3 nuclear factor, interleukin 3 regulated
NKRF NFKB repressing factor
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS8 protease, serine, 8
PSPH phosphoserine phosphatase
S100P S100 calcium binding protein P
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH2B3 SH2B adaptor protein 3
SH3BGR SH3 domain binding glutamate-rich protein
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SMOX spermine oxidase
STK17A serine/threonine kinase 17a
TES testin LIM domain protein
TGDS TDP-glucose 4,6-dehydratase
TMEM97 transmembrane protein 97
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ABHD10 abhydrolase domain containing 10
ACKR3 atypical chemokine receptor 3
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
B3GNT1
BATF basic leucine zipper transcription factor, ATF-like
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C11ORF71 chromosome 11 open reading frame 71
C1GALT1C1 C1GALT1-specific chaperone 1
CD9 CD9 molecule
CDK5 cyclin-dependent kinase 5
CENPB centromere protein B, 80kDa
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
COA3 cytochrome c oxidase assembly factor 3
DEXI Dexi homolog (mouse)
DHRS1 dehydrogenase/reductase (SDR family) member 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DOLK dolichol kinase
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
EFNA1 ephrin-A1
EGR3 early growth response 3
ESRP2 epithelial splicing regulatory protein 2
FAM127A family with sequence similarity 127, member A
FJX1 four jointed box 1 (Drosophila)
FOXA1 forkhead box A1
FUCA1 fucosidase, alpha-L- 1, tissue
FZD2 frizzled class receptor 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GJA1 gap junction protein, alpha 1, 43kDa
GRHL2 grainyhead-like 2 (Drosophila)
GTF2H5 general transcription factor IIH, polypeptide 5
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXC6 homeobox C6
IER2 immediate early response 2
IGSF3 immunoglobulin superfamily, member 3
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
IRX5 iroquois homeobox 5
ISG15 ISG15 ubiquitin-like modifier
KLF10 Kruppel-like factor 10
LPCAT1 lysophosphatidylcholine acyltransferase 1
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYRM2 LYR motif containing 2
MEN1 multiple endocrine neoplasia I
MFSD5 major facilitator superfamily domain containing 5
MGP matrix Gla protein
MRPL17 mitochondrial ribosomal protein L17
MSL1 male-specific lethal 1 homolog (Drosophila)
MT2A metallothionein 2A
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME3 NME/NM23 nucleoside diphosphate kinase 3
NPY1R neuropeptide Y receptor Y1
NTHL1 nth endonuclease III-like 1 (E. coli)
OSR2 odd-skipped related transciption factor 2
PAGR1 PAXIP1 associated glutamate-rich protein 1
PAQR4 progestin and adipoQ receptor family member IV
PCP4 Purkinje cell protein 4
PCYOX1 prenylcysteine oxidase 1
PCYOX1L prenylcysteine oxidase 1 like
PEX11B peroxisomal biogenesis factor 11 beta
PMVK phosphomevalonate kinase
PRR15L proline rich 15-like
RBX1 ring-box 1, E3 ubiquitin protein ligase
RGS19 regulator of G-protein signaling 19
SCO2 SCO2 cytochrome c oxidase assembly protein
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC2A4RG SLC2A4 regulator
SPA17 sperm autoantigenic protein 17
SPANXC SPANX family, member C
SPATA2L spermatogenesis associated 2-like
SUOX sulfite oxidase
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TCEAL1 transcription elongation factor A (SII)-like 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
THAP11 THAP domain containing 11
TM7SF2 transmembrane 7 superfamily member 2
TMEM177 transmembrane protein 177
TMEM186 transmembrane protein 186
TMEM187 transmembrane protein 187
TMEM223 transmembrane protein 223
TPBG trophoblast glycoprotein
UBL4A ubiquitin-like 4A
VAMP8 vesicle-associated membrane protein 8
VANGL1 VANGL planar cell polarity protein 1
WDR6 WD repeat domain 6
ZC3H4 zinc finger CCCH-type containing 4