MG-132 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/462382
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Genes

200 proteins with high or low expression in MG-132 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ZFAND2A zinc finger, AN1-type domain 2A 6.53
OSGIN1 oxidative stress induced growth inhibitor 1 6.11
DDIT4 DNA-damage-inducible transcript 4 6.1
AZIN1 antizyme inhibitor 1 5.13
JUN jun proto-oncogene 5.12
PLK2 polo-like kinase 2 5.07
DEDD2 death effector domain containing 2 4.97
XBP1 X-box binding protein 1 4.87
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 4.61
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 4.6
HKDC1 hexokinase domain containing 1 4.34
F10 coagulation factor X 3.86
MIDN midnolin 3.74
NFE2L1 nuclear factor, erythroid 2-like 1 3.73
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 3.72
IER2 immediate early response 2 3.69
CLU clusterin 3.66
STC2 stanniocalcin 2 3.59
RND3 Rho family GTPase 3 3.58
SESN2 sestrin 2 3.5
IFRD1 interferon-related developmental regulator 1 3.5
CREB3L2 cAMP responsive element binding protein 3-like 2 3.45
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.45
DUSP5 dual specificity phosphatase 5 3.2
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit 3.19
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 3.18
ABHD2 abhydrolase domain containing 2 3.13
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 3.09
LAMB3 laminin, beta 3 3.09
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 3.08
AMOTL2 angiomotin like 2 3.08
MORC4 MORC family CW-type zinc finger 4 2.99
IP6K2 inositol hexakisphosphate kinase 2 2.98
ABHD4 abhydrolase domain containing 4 2.96
HMOX1 heme oxygenase 1 2.94
AEN apoptosis enhancing nuclease 2.94
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.94
AKIRIN2 akirin 2 2.93
MARCHF7 membrane associated ring-CH-type finger 7 2.93
CDC6 cell division cycle 6 2.92
PCGF1 polycomb group ring finger 1 2.9
C4BPA complement component 4 binding protein, alpha 2.89
NDFIP1 Nedd4 family interacting protein 1 2.83
LRRC58 leucine rich repeat containing 58 2.83
CDT1 chromatin licensing and DNA replication factor 1 2.81
DUSP6 dual specificity phosphatase 6 2.81
BAG3 BCL2-associated athanogene 3 2.8
SREBF1 sterol regulatory element binding transcription factor 1 2.76
MAGEA2 melanoma antigen family A2 2.73
CPA4 carboxypeptidase A4 2.71
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.68
CCNE2 cyclin E2 2.66
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.66
F5 coagulation factor V (proaccelerin, labile factor) 2.65
SNAI1 snail family zinc finger 1 2.62
OSGIN2 oxidative stress induced growth inhibitor family member 2 2.58
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.58
TRIB1 tribbles pseudokinase 1 2.57
KLHL21 kelch-like family member 21 2.55
OSER1 oxidative stress responsive serine-rich 1 2.5
KLF5 Kruppel-like factor 5 (intestinal) 2.5
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.46
CCND1 cyclin D1 2.45
TBX3 T-box 3 2.45
LAPTM4A lysosomal protein transmembrane 4 alpha 2.45
ZFAND5 zinc finger, AN1-type domain 5 2.44
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.43
MCL1 myeloid cell leukemia 1 2.42
TMEM59 transmembrane protein 59 2.41
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.41
GEM GTP binding protein overexpressed in skeletal muscle 2.4
BLZF1 basic leucine zipper nuclear factor 1 2.39
CCND3 cyclin D3 2.38
MAGEA12 melanoma antigen family A12 2.38
PER2 period circadian clock 2 2.36
CLK1 CDC-like kinase 1 2.34
PTOV1 prostate tumor overexpressed 1 2.33
HSPA1A heat shock 70kDa protein 1A 2.29
UPP1 uridine phosphorylase 1 2.28
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 2.24
MORF4L2 mortality factor 4 like 2 2.23
C16ORF72 chromosome 16 open reading frame 72 2.22
ODC1 ornithine decarboxylase 1 2.22
ZNF451 zinc finger protein 451 2.22
CPE carboxypeptidase E 2.2
ABHD3 abhydrolase domain containing 3 2.2
SYTL3 synaptotagmin-like 3 2.19
LAMC2 laminin, gamma 2 2.19
HRH1 histamine receptor H1 2.19
TUFT1 tuftelin 1 2.18
C5 complement component 5 2.17
ZNF430 zinc finger protein 430 2.16
ZMAT5 zinc finger, matrin-type 5 2.15
ETV5 ets variant 5 2.14
TUB tubby bipartite transcription factor 2.14
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2.14
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.13
TULP3 tubby like protein 3 2.11
ZNF3 zinc finger protein 3 2.09
TMBIM6 transmembrane BAX inhibitor motif containing 6 2.08

low expression

Symbol Name Standardized Value
SDC1 syndecan 1 -4.37
MT2A metallothionein 2A -3.84
DERPC DERPC proline and glycine rich nuclear protein -2.2
PROCR protein C receptor, endothelial -2.08
SF1 splicing factor 1 -2.05
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.02
COA5 cytochrome c oxidase assembly factor 5 -1.88
SDHAF3 succinate dehydrogenase complex assembly factor 3 -1.8
ERVMER34-1 endogenous retrovirus group MER34, member 1 -1.79
NOVA2 neuro-oncological ventral antigen 2 -1.79
MBP myelin basic protein -1.71
ACOX1 acyl-CoA oxidase 1, palmitoyl -1.63
CCDC170 coiled-coil domain containing 170 -1.58
ONECUT2 one cut homeobox 2 -1.54
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 -1.5
MTERF3 mitochondrial transcription termination factor 3 -1.45
NCBP2AS2 NCBP2 antisense 2 (head to head) -1.38
SPINT1 serine peptidase inhibitor, Kunitz type 1 -1.37
WWC2 WW and C2 domain containing 2 -1.36
RTN4R reticulon 4 receptor -1.35
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -1.29
MDK midkine (neurite growth-promoting factor 2) -1.28
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -1.27
TMEM106B transmembrane protein 106B -1.27
GLG1 golgi glycoprotein 1 -1.27
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -1.24
TACSTD2 tumor-associated calcium signal transducer 2 -1.23
B2M beta-2-microglobulin -1.22
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -1.21
NMU neuromedin U -1.21
ERICH5 glutamate-rich 5 -1.21
MSRB2 methionine sulfoxide reductase B2 -1.2
CHCHD2P9 coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 -1.16
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -1.15
DUSP22 dual specificity phosphatase 22 -1.15
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 -1.13
CRIP1 cysteine-rich protein 1 (intestinal) -1.12
PRORP protein only RNase P catalytic subunit -1.12
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B -1.12
BOK BCL2-related ovarian killer -1.11
AKAP11 A kinase (PRKA) anchor protein 11 -1.1
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 -1.09
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 -1.09
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -1.08
EPOP elongin BC and polycomb repressive complex 2 associated protein -1.08
BCKDK branched chain ketoacid dehydrogenase kinase -1.08
CACHD1 cache domain containing 1 -1.07
MANEA mannosidase, endo-alpha -1.06
FDX1 ferredoxin 1 -1.05
PROSER3 proline and serine rich 3 -1.05
NEO1 neogenin 1 -1.04
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -1.04
PUDP pseudouridine 5'-phosphatase -1.03
ABHD14B abhydrolase domain containing 14B -1.03
C6ORF47 chromosome 6 open reading frame 47 -1.03
GCAT glycine C-acetyltransferase -1.03
TMSB10 thymosin beta 10 -1.03
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino -1.03
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -1.02
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -1.01
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -1.01
OXA1L oxidase (cytochrome c) assembly 1-like -1.0
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -1.0
WIPF3 WAS/WASL interacting protein family, member 3 -0.99
ZBTB12 zinc finger and BTB domain containing 12 -0.99
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 -0.99
GLRX5 glutaredoxin 5 -0.99
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.99
RPUSD4 RNA pseudouridylate synthase domain containing 4 -0.99
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) -0.98
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -0.97
SP100 SP100 nuclear antigen -0.97
PTMA prothymosin, alpha -0.97
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -0.97
GOLM1 golgi membrane protein 1 -0.97
PNKD paroxysmal nonkinesigenic dyskinesia -0.97
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide -0.96
CEBPZOS CEBPZ opposite strand -0.96
CLDN7 claudin 7 -0.96
TET3 tet methylcytosine dioxygenase 3 -0.96
ISCA1 iron-sulfur cluster assembly 1 -0.96
PTCD2 pentatricopeptide repeat domain 2 -0.96
GPC1 glypican 1 -0.96
FAM3C family with sequence similarity 3, member C -0.95
H3C1 H3 clustered histone 1 -0.95
SDHAF4 succinate dehydrogenase complex assembly factor 4 -0.95
ATP5F1D ATP synthase F1 subunit delta -0.95
SMIM12 small integral membrane protein 12 -0.94
LRP11 low density lipoprotein receptor-related protein 11 -0.94
MCEE methylmalonyl CoA epimerase -0.94
RWDD1 RWD domain containing 1 -0.93
NECTIN3 nectin cell adhesion molecule 3 -0.93
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -0.93
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 -0.93
MAN1B1 mannosidase, alpha, class 1B, member 1 -0.92
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -0.92
ZADH2 zinc binding alcohol dehydrogenase domain containing 2 -0.92
ADAM19 ADAM metallopeptidase domain 19 -0.92
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.92
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.91