MI-773 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/52938482
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Genes

200 proteins with high or low expression in MI-773 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 4.82
TP53I3 tumor protein p53 inducible protein 3 4.05
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 3.57
TP53 tumor protein p53 3.35
GDF15 growth differentiation factor 15 3.19
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.52
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.37
FAS Fas cell surface death receptor 2.27
PRX periaxin 2.16
GGT2 gamma-glutamyltransferase 2 2.02
CCND1 cyclin D1 1.94
RINL Ras and Rab interactor-like 1.94
ZMAT3 zinc finger, matrin-type 3 1.92
LACC1 laccase (multicopper oxidoreductase) domain containing 1 1.88
FDXR ferredoxin reductase 1.8
LRP10 low density lipoprotein receptor-related protein 10 1.77
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 1.7
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 1.67
DGKA diacylglycerol kinase, alpha 80kDa 1.66
FHL2 four and a half LIM domains 2 1.66
PPARD peroxisome proliferator-activated receptor delta 1.62
EPS8L2 EPS8-like 2 1.58
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 1.57
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.5
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 1.49
CNTROB centrobin, centrosomal BRCA2 interacting protein 1.46
SESN2 sestrin 2 1.45
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 1.44
PARD6G par-6 family cell polarity regulator gamma 1.39
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 1.38
SLFN5 schlafen family member 5 1.38
MAPKBP1 mitogen-activated protein kinase binding protein 1 1.36
BAX BCL2-associated X protein 1.34
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 1.34
TTYH3 tweety family member 3 1.34
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.34
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 1.33
ABAT 4-aminobutyrate aminotransferase 1.33
TMEM63B transmembrane protein 63B 1.32
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 1.32
SYTL1 synaptotagmin-like 1 1.32
TIGAR TP53 induced glycolysis regulatory phosphatase 1.31
APOE apolipoprotein E 1.31
ITPKC inositol-trisphosphate 3-kinase C 1.29
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 1.29
RAD54L RAD54-like (S. cerevisiae) 1.29
BTBD3 BTB (POZ) domain containing 3 1.28
H1-0 H1.0 linker histone 1.24
CPPED1 calcineurin-like phosphoesterase domain containing 1 1.24
MKNK2 MAP kinase interacting serine/threonine kinase 2 1.23
BANF1 barrier to autointegration factor 1 1.23
ABHD4 abhydrolase domain containing 4 1.23
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.23
ANXA4 annexin A4 1.21
RHOD ras homolog family member D 1.21
TDG thymine-DNA glycosylase 1.21
DDB2 damage-specific DNA binding protein 2, 48kDa 1.18
EWSR1 EWS RNA-binding protein 1 1.18
PTPRE protein tyrosine phosphatase, receptor type, E 1.18
GSS glutathione synthetase 1.18
PGPEP1 pyroglutamyl-peptidase I 1.17
LAMB3 laminin, beta 3 1.16
F5 coagulation factor V (proaccelerin, labile factor) 1.16
POTEE POTE ankyrin domain family, member E 1.16
GBE1 glucan (1,4-alpha-), branching enzyme 1 1.15
BORCS7 BLOC-1 related complex subunit 7 1.14
VIM vimentin 1.14
PML promyelocytic leukemia 1.14
LAMC2 laminin, gamma 2 1.14
ATG4A autophagy related 4A, cysteine peptidase 1.13
UNC13C unc-13 homolog C (C. elegans) 1.13
FBF1 Fas (TNFRSF6) binding factor 1 1.12
KDM4B lysine (K)-specific demethylase 4B 1.12
FBXO22 F-box protein 22 1.12
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 1.12
MICALL1 MICAL-like 1 1.12
VTN vitronectin 1.12
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 1.1
ADGRG1 adhesion G protein-coupled receptor G1 1.09
CCN2 cellular communication network factor 2 1.09
IKBIP IKBKB interacting protein 1.08
PHLDB3 pleckstrin homology-like domain, family B, member 3 1.07
APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D 1.05
XPC xeroderma pigmentosum, complementation group C 1.05
ICAM5 intercellular adhesion molecule 5, telencephalin 1.05
YPEL5 yippee-like 5 (Drosophila) 1.05
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 1.04
UBTD2 ubiquitin domain containing 2 1.04
FIG4 FIG4 phosphoinositide 5-phosphatase 1.04
DES desmin 1.04
FTH1 ferritin, heavy polypeptide 1 1.04
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) 1.04
RNASE4 ribonuclease, RNase A family, 4 1.03
MVP major vault protein 1.03
EFNB1 ephrin-B1 1.01
MKRN1 makorin ring finger protein 1 1.0
HMOX1 heme oxygenase 1 0.99
ASS1 argininosuccinate synthase 1 0.98
FUCA1 fucosidase, alpha-L- 1, tissue 0.98
ATF3 activating transcription factor 3 0.98

low expression

Symbol Name Standardized Value
BIRC5 baculoviral IAP repeat containing 5 -7.36
NEIL3 nei endonuclease VIII-like 3 (E. coli) -6.58
RAD51AP1 RAD51 associated protein 1 -4.17
FBXO5 F-box protein 5 -3.78
ZWINT ZW10 interacting kinetochore protein -3.69
CCNA2 cyclin A2 -3.3
RGS3 regulator of G-protein signaling 3 -3.24
TK1 thymidine kinase 1, soluble -3.2
PCLAF PCNA clamp associated factor -3.12
CLSPN claspin -3.11
CCNB1 cyclin B1 -3.03
PRR11 proline rich 11 -3.02
SURF2 surfeit 2 -2.95
ANLN anillin, actin binding protein -2.95
PIMREG PICALM interacting mitotic regulator -2.92
KIF22 kinesin family member 22 -2.79
CDCA8 cell division cycle associated 8 -2.73
C5ORF34 chromosome 5 open reading frame 34 -2.73
PLK1 polo-like kinase 1 -2.72
MCM10 minichromosome maintenance complex component 10 -2.68
CDCA5 cell division cycle associated 5 -2.66
TPX2 TPX2, microtubule-associated -2.63
KIF20A kinesin family member 20A -2.63
AURKB aurora kinase B -2.62
TACC3 transforming, acidic coiled-coil containing protein 3 -2.59
TOP2A topoisomerase (DNA) II alpha 170kDa -2.59
NUSAP1 nucleolar and spindle associated protein 1 -2.58
RRM2 ribonucleotide reductase M2 -2.58
CDC25B cell division cycle 25B -2.53
NET1 neuroepithelial cell transforming 1 -2.49
KIF18A kinesin family member 18A -2.44
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.4
UBE2S ubiquitin-conjugating enzyme E2S -2.39
CDC20 cell division cycle 20 -2.37
DNAH5 dynein, axonemal, heavy chain 5 -2.37
CENPF centromere protein F, 350/400kDa -2.37
CKS2 CDC28 protein kinase regulatory subunit 2 -2.36
PRC1 protein regulator of cytokinesis 1 -2.35
CDC7 cell division cycle 7 -2.35
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.34
CDCA2 cell division cycle associated 2 -2.3
EXO1 exonuclease 1 -2.27
KIF2C kinesin family member 2C -2.27
STIL SCL/TAL1 interrupting locus -2.23
INCENP inner centromere protein antigens 135/155kDa -2.2
NDC80 NDC80 kinetochore complex component -2.2
KIFC1 kinesin family member C1 -2.19
CCNB2 cyclin B2 -2.18
KNL1 kinetochore scaffold 1 -2.18
SGO2 shugoshin 2 -2.17
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -2.16
WEE1 WEE1 G2 checkpoint kinase -2.14
MASTL microtubule associated serine/threonine kinase-like -2.13
HELLS helicase, lymphoid-specific -2.12
USP37 ubiquitin specific peptidase 37 -2.11
UBE2T ubiquitin-conjugating enzyme E2T -2.11
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.1
ECT2 epithelial cell transforming 2 -2.1
CEP55 centrosomal protein 55kDa -2.09
TIPIN TIMELESS interacting protein -2.07
KMT5A lysine methyltransferase 5A -2.04
ORC6 origin recognition complex, subunit 6 -2.01
RACGAP1 Rac GTPase activating protein 1 -1.95
KIF11 kinesin family member 11 -1.95
UBE2C ubiquitin-conjugating enzyme E2C -1.94
SPDL1 spindle apparatus coiled-coil protein 1 -1.94
SKA3 spindle and kinetochore associated complex subunit 3 -1.94
CHEK1 checkpoint kinase 1 -1.93
MELK maternal embryonic leucine zipper kinase -1.92
KIF23 kinesin family member 23 -1.92
MCM8 minichromosome maintenance complex component 8 -1.91
NUF2 NUF2, NDC80 kinetochore complex component -1.89
MIS18BP1 MIS18 binding protein 1 -1.88
PHF19 PHD finger protein 19 -1.83
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -1.82
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -1.82
GREB1 growth regulation by estrogen in breast cancer 1 -1.82
CKAP2 cytoskeleton associated protein 2 -1.82
SACK1D scaffolding CK1 anchoring protein D -1.81
SKA1 spindle and kinetochore associated complex subunit 1 -1.81
WDR76 WD repeat domain 76 -1.8
DEPDC1 DEP domain containing 1 -1.8
ARHGAP11A Rho GTPase activating protein 11A -1.8
SLBP stem-loop binding protein -1.8
H3C1 H3 clustered histone 1 -1.78
DONSON downstream neighbor of SON -1.76
SHCBP1 SHC SH2-domain binding protein 1 -1.75
CHAF1A chromatin assembly factor 1, subunit A (p150) -1.75
DEPDC1B DEP domain containing 1B -1.72
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -1.72
RAD54B RAD54 homolog B (S. cerevisiae) -1.71
CCNE2 cyclin E2 -1.71
UHRF1 ubiquitin-like with PHD and ring finger domains 1 -1.7
KNSTRN kinetochore-localized astrin/SPAG5 binding protein -1.7
DOCK3 dedicator of cytokinesis 3 -1.69
CENPQ centromere protein Q -1.67
ESAM endothelial cell adhesion molecule -1.67
PEG10 paternally expressed 10 -1.67
KIF20B kinesin family member 20B -1.66
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -1.66