MIA-PaCa-2 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description A immortal human cell line cell that has the characteristics: Human cell line derived from pancreatic cancer. TKG0227(Deposited from Tohoku Univ.) (Cell Line Ontology, CLO_0050101)
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Genes

261 genes with high or low expression in MIA-PaCa-2 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 3.60177
UBE2E3 ubiquitin-conjugating enzyme E2E 3 3.55399
RAB27B RAB27B, member RAS oncogene family 3.18034
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 3.02625
AGGF1 angiogenic factor with G patch and FHA domains 1 2.9948
ERMP1 endoplasmic reticulum metallopeptidase 1 2.91652
SOCS6 suppressor of cytokine signaling 6 2.90266
TUBB1 tubulin, beta 1 class VI 2.84131
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.81331
IL13RA1 interleukin 13 receptor, alpha 1 2.77943
C1RL complement component 1, r subcomponent-like 2.74255
LIPA lipase A, lysosomal acid, cholesterol esterase 2.45599
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.4388
DCAF6 DDB1 and CUL4 associated factor 6 2.39562
IL27RA interleukin 27 receptor, alpha 2.38476
MCHR1 melanin-concentrating hormone receptor 1 2.37255
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 2.3112
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.28416
STXBP3 syntaxin binding protein 3 2.20669
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.19904
ARHGAP12 Rho GTPase activating protein 12 2.19752
CASP8 caspase 8, apoptosis-related cysteine peptidase 2.19059
ARHGAP5 Rho GTPase activating protein 5 2.12474
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 2.10766
EPHA4 EPH receptor A4 2.10749
ZNF217 zinc finger protein 217 2.10389
ULK2 unc-51 like autophagy activating kinase 2 2.09822
CA11 carbonic anhydrase XI 2.08791
APIP APAF1 interacting protein 2.0216
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 2.01014
IL1R1 interleukin 1 receptor, type I 2.00697
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 1.97239
HSPA4 heat shock 70kDa protein 4 1.95592
MMRN2 multimerin 2 1.94916
XPO7 exportin 7 1.9474
CAPRIN2 caprin family member 2 1.93972
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 1.93692
EMCN endomucin 1.93009
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 1.9106
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 1.90541
RAP2B RAP2B, member of RAS oncogene family 1.89451
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.8784
PCYOX1 prenylcysteine oxidase 1 1.87202
SUMO1 small ubiquitin-like modifier 1 1.85321
PDHX pyruvate dehydrogenase complex, component X 1.84322
BFSP1 beaded filament structural protein 1, filensin 1.8432
ASMTL acetylserotonin O-methyltransferase-like 1.83712
EIF3M eukaryotic translation initiation factor 3, subunit M 1.83386
AP3B1 adaptor-related protein complex 3, beta 1 subunit 1.82838
YTHDC2 YTH domain containing 2 1.80719
GLMN glomulin, FKBP associated protein 1.80075
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 1.78284
C1GALT1C1 C1GALT1-specific chaperone 1 1.77751
PDE10A phosphodiesterase 10A 1.77056
MED7 mediator complex subunit 7 1.76697
SLK STE20-like kinase 1.7661
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 1.76294
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae) 1.75364
DPYD dihydropyrimidine dehydrogenase 1.75138
SH3TC2 SH3 domain and tetratricopeptide repeats 2 1.74946
TRIM23 tripartite motif containing 23 1.74712
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 1.73906
ANK1 ankyrin 1, erythrocytic 1.73046
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.72958
SHOX2 short stature homeobox 2 1.72611
ERCC1 excision repair cross-complementation group 1 1.72579
RP2 retinitis pigmentosa 2 (X-linked recessive) 1.72551
ACADSB acyl-CoA dehydrogenase, short/branched chain 1.71817
LTN1 listerin E3 ubiquitin protein ligase 1 1.71739
CETN3 centrin, EF-hand protein, 3 1.67169
SLC30A5 solute carrier family 30 (zinc transporter), member 5 1.65723
MRPL39 mitochondrial ribosomal protein L39 1.65701
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 1.65633
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 1.64922
PTCD2 pentatricopeptide repeat domain 2 1.64904
RGS4 regulator of G-protein signaling 4 1.60633
PODXL podocalyxin-like 1.60323
MAT2B methionine adenosyltransferase II, beta 1.59954
TTC30A tetratricopeptide repeat domain 30A 1.57848
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 1.57751
EML4 echinoderm microtubule associated protein like 4 1.57553
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 1.5708
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.5706
PRND prion protein 2 (dublet) 1.5684
TSPYL1 TSPY-like 1 1.5616
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa 1.55771
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 1.55336
SS18 synovial sarcoma translocation, chromosome 18 1.55104
TMCO6 transmembrane and coiled-coil domains 6 1.54857
CSNK1G3 casein kinase 1, gamma 3 1.54065
ADGRG6 adhesion G protein-coupled receptor G6 1.5353
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 1.53506
ACAT1 acetyl-CoA acetyltransferase 1 1.5318
MED23 mediator complex subunit 23 1.53143
FZD8 frizzled class receptor 8 1.52036
CCDC68 coiled-coil domain containing 68 1.51449
NANOG Nanog homeobox 1.51024
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 1.5085
AUH AU RNA binding protein/enoyl-CoA hydratase 1.50355
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 1.49859
TRIP10 thyroid hormone receptor interactor 10 1.49794
ADI1 acireductone dioxygenase 1 1.491
GML glycosylphosphatidylinositol anchored molecule like 1.48451
BCL2L13 BCL2-like 13 (apoptosis facilitator) 1.48375
MPPE1 metallophosphoesterase 1 1.48089
NME5 NME/NM23 family member 5 1.47496
IRS1 insulin receptor substrate 1 1.46997
HDAC9 histone deacetylase 9 1.46655
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 1.4653
GPALPP1 GPALPP motifs containing 1 1.46496
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 1.46457
B9D1 B9 protein domain 1 1.46092
TBCA tubulin folding cofactor A 1.46074
SDHAF3 succinate dehydrogenase complex assembly factor 3 1.45892
NR2F1 nuclear receptor subfamily 2, group F, member 1 1.44831
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.44562
PTPN12 protein tyrosine phosphatase, non-receptor type 12 1.44532
SGK1 serum/glucocorticoid regulated kinase 1 1.44506
TTC33 tetratricopeptide repeat domain 33 1.44483
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 1.43883
WAPAL wings apart-like homolog (Drosophila) 1.43851
RGS5 regulator of G-protein signaling 5 1.43748
SNX7 sorting nexin 7 1.42326
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 1.42233
XPO1 exportin 1 1.41686

low expression

Symbol Name Standardized Value
MFSD1 major facilitator superfamily domain containing 1 -3.53725
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -2.91132
SMAD7 SMAD family member 7 -2.88296
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -2.71598
MBD2 methyl-CpG binding domain protein 2 -2.66205
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.6301
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 -2.62839
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -2.62234
ARID5B AT rich interactive domain 5B (MRF1-like) -2.52533
CARS cysteinyl-tRNA synthetase -2.42714
MUS81 MUS81 structure-specific endonuclease subunit -2.35588
CIDEC cell death-inducing DFFA-like effector c -2.26648
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.26123
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -2.19752
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -2.11631
KIAA1024 KIAA1024 -2.08787
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -2.04356
KDM6A lysine (K)-specific demethylase 6A -2.02541
KLF5 Kruppel-like factor 5 (intestinal) -2.0107
LMO4 LIM domain only 4 -2.00776
BTG1 B-cell translocation gene 1, anti-proliferative -2.00466
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -1.97488
DERL1 derlin 1 -1.97353
ATF4 activating transcription factor 4 -1.95629
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A -1.9553
AGO3 argonaute RISC catalytic component 3 -1.94069
STIM1 stromal interaction molecule 1 -1.93274
ALCAM activated leukocyte cell adhesion molecule -1.92351
BMI1 BMI1 proto-oncogene, polycomb ring finger -1.92206
GAP43 growth associated protein 43 -1.91618
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -1.90185
MAST4 microtubule associated serine/threonine kinase family member 4 -1.89763
SGCE sarcoglycan, epsilon -1.89564
LAMP3 lysosomal-associated membrane protein 3 -1.89106
TSSC4 tumor suppressing subtransferable candidate 4 -1.87165
DAPK2 death-associated protein kinase 2 -1.86053
MARS methionyl-tRNA synthetase -1.84863
ARMCX1 armadillo repeat containing, X-linked 1 -1.83728
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1 -1.81782
PPCDC phosphopantothenoylcysteine decarboxylase -1.81405
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 -1.81256
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -1.81001
AP1B1 adaptor-related protein complex 1, beta 1 subunit -1.80396
KLHL9 kelch-like family member 9 -1.79062
RNF114 ring finger protein 114 -1.78961
KAT5 K(lysine) acetyltransferase 5 -1.78485
MED18 mediator complex subunit 18 -1.77404
CNN3 calponin 3, acidic -1.77145
PLAC1 placenta-specific 1 -1.77105
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -1.76339
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -1.76196
UBN1 ubinuclein 1 -1.75978
PLXNB1 plexin B1 -1.7584
AXIN1 axin 1 -1.75606
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta -1.75099
ABHD2 abhydrolase domain containing 2 -1.74776
KLF7 Kruppel-like factor 7 (ubiquitous) -1.74084
POU6F1 POU class 6 homeobox 1 -1.72843
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -1.72663
SF3B2 splicing factor 3b, subunit 2, 145kDa -1.72626
SH3BGRL SH3 domain binding glutamate-rich protein like -1.72293
CPNE1 copine I -1.71732
FKBP6 FK506 binding protein 6, 36kDa -1.70473
CD209 CD209 molecule -1.70261
BANF1 barrier to autointegration factor 1 -1.70199
LDHB lactate dehydrogenase B -1.69402
TTC9 tetratricopeptide repeat domain 9 -1.68435
JOSD1 Josephin domain containing 1 -1.66607
EPS8L1 EPS8-like 1 -1.6658
TAOK3 TAO kinase 3 -1.66077
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -1.6604
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -1.6575
GPC4 glypican 4 -1.65259
RNF122 ring finger protein 122 -1.64887
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) -1.64143
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -1.63602
GTPBP8 GTP-binding protein 8 (putative) -1.63194
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -1.6248
LAT2 linker for activation of T cells family, member 2 -1.62261
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -1.59594
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) -1.59513
AREG amphiregulin -1.59421
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -1.59192
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 -1.58975
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase -1.58088
ZNF711 zinc finger protein 711 -1.57721
HCFC1 host cell factor C1 -1.57533
STARD13 StAR-related lipid transfer (START) domain containing 13 -1.57282
PMEL premelanosome protein -1.56655
MAP1B microtubule-associated protein 1B -1.56496
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 -1.56387
SLIT2 slit homolog 2 (Drosophila) -1.56168
TSPAN2 tetraspanin 2 -1.56006
PDPK1 3-phosphoinositide dependent protein kinase 1 -1.5592
KLHL11 kelch-like family member 11 -1.55608
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -1.54328
MID1IP1 MID1 interacting protein 1 -1.53993
CHD3 chromodomain helicase DNA binding protein 3 -1.53756
PARP8 poly (ADP-ribose) polymerase family, member 8 -1.53298
CH25H cholesterol 25-hydroxylase -1.53146
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) -1.52938
MTUS1 microtubule associated tumor suppressor 1 -1.52646
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -1.5242
OXR1 oxidation resistance 1 -1.51974
PLEKHA5 pleckstrin homology domain containing, family A member 5 -1.51943
GRB14 growth factor receptor-bound protein 14 -1.51936
TESPA1 thymocyte expressed, positive selection associated 1 -1.51837
CD160 CD160 molecule -1.51672
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -1.50554
AQP3 aquaporin 3 (Gill blood group) -1.50154
CISH cytokine inducible SH2-containing protein -1.49638
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -1.48349
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 -1.48308
AIM1 absent in melanoma 1 -1.47781
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -1.46949
GCA grancalcin, EF-hand calcium binding protein -1.46631
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -1.45671
ZNF706 zinc finger protein 706 -1.45296
HOXA5 homeobox A5 -1.45293
KIAA0894 KIAA0894 protein -1.44764
DUSP4 dual specificity phosphatase 4 -1.44718
MTAP methylthioadenosine phosphorylase -1.44474
TMEM57 transmembrane protein 57 -1.44215
EVL Enah/Vasp-like -1.44091
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -1.44078
AMOT angiomotin -1.43832
TOLLIP toll interacting protein -1.43829
AGBL2 ATP/GTP binding protein-like 2 -1.43821
DPYSL4 dihydropyrimidinase-like 4 -1.43807
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -1.43082
SPARCL1 SPARC-like 1 (hevin) -1.42497
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -1.42433
ZNF408 zinc finger protein 408 -1.42066
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -1.42054
MEF2D myocyte enhancer factor 2D -1.4205
RAD9A RAD9 homolog A (S. pombe) -1.41695