MIER1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mesoderm induction early response 1, transcriptional regulator|This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013] (NCBI Entrez Gene Database, 57708)
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Genes

352 genes differentially expressed following the MIER1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
POF1B premature ovarian failure, 1B 3.50388
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.50388
DND1 DND microRNA-mediated repression inhibitor 1 3.50388
ARSF arylsulfatase F 3.50388
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.50388
RIPPLY2 ripply transcriptional repressor 2 3.50388
CFAP45 cilia and flagella associated protein 45 3.50388
TMEM176A transmembrane protein 176A 3.50388
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 3.50388
C8ORF89 chromosome 8 open reading frame 89 3.50388
MAG myelin associated glycoprotein 3.50388
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 3.50388
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.50388
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 3.50388
ASGR2 asialoglycoprotein receptor 2 3.50388
PRAP1 proline-rich acidic protein 1 3.50388
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.50388
GARIN1A golgi associated RAB2 interactor 1A 3.50388
NMBR neuromedin B receptor 3.50388
ANGPTL5 angiopoietin-like 5 3.50388
LY6S-AS1 LY6S antisense RNA 1 3.50388
ANGPTL4 angiopoietin-like 4 3.50388
MISP3 MISP family member 3 3.50388
S100Z S100 calcium binding protein Z 3.50388
RAX retina and anterior neural fold homeobox 3.35569
VWA5B1 von Willebrand factor A domain containing 5B1 3.35569
MBD3L3 methyl-CpG binding domain protein 3-like 3 3.35569
LRRC55 leucine rich repeat containing 55 3.35569
IRX4 iroquois homeobox 4 3.35569
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 3.35569
SIGLECL1 SIGLEC family like 1 3.35569
NLRP5 NLR family, pyrin domain containing 5 3.35569
IL4 interleukin 4 3.35569
MGAM2 maltase-glucoamylase 2 (putative) 3.35569
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 3.35569
PCDHB7 protocadherin beta 7 3.35569
HORMAD1 HORMA domain containing 1 3.35569
VPREB3 pre-B lymphocyte 3 3.35569
APOA2 apolipoprotein A-II 3.35569
ERAP2 endoplasmic reticulum aminopeptidase 2 3.35569
AVP arginine vasopressin 3.35569
MISP mitotic spindle positioning 3.35569
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.35569
C1GALT1C1L C1GALT1-specific chaperone 1 like 3.35569
KIF2B kinesin family member 2B 3.35569
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.35569
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.35569
TRAT1 T cell receptor associated transmembrane adaptor 1 3.35569
DEFB106B defensin, beta 106B 3.35569
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.35569
PLXNB3 plexin B3 3.35569
PITX3 paired-like homeodomain 3 3.35569
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.35569
OLFM4 olfactomedin 4 3.35569
LRG1 leucine-rich alpha-2-glycoprotein 1 3.35569
PLCH2 phospholipase C, eta 2 3.35569
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.35569
IYD iodotyrosine deiodinase 3.35569
SPATA31H1 SPATA31 subfamily H member 1 3.35569
TRIM31 tripartite motif containing 31 3.35569
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 3.35569
SAG S-antigen; retina and pineal gland (arrestin) 3.35569
MYEOV myeloma overexpressed 3.35569
TYROBP TYRO protein tyrosine kinase binding protein 3.35569
ZNF705B zinc finger protein 705B 3.35569
CLEC6A C-type lectin domain family 6, member A 3.35569
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.35569
FMOD fibromodulin 3.35569
STX11 syntaxin 11 3.35569
FRG2C FSHD region gene 2 family, member C 3.35569
ZC3H11C zinc finger CCCH-type containing 11C 3.35569
DRC3 dynein regulatory complex subunit 3 3.35569
ZNF593OS ZNF593 opposite strand 3.35569
STING1 stimulator of interferon response cGAMP interactor 1 3.35569
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.35569
ALDOB aldolase B, fructose-bisphosphate 3.35569
LTB4R2 leukotriene B4 receptor 2 3.35569
SCEL sciellin 3.35569
ACE2 angiotensin I converting enzyme 2 3.35569
LRRC73 leucine rich repeat containing 73 3.35569
LRRC72 leucine rich repeat containing 72 3.35569
PRB1 proline-rich protein BstNI subfamily 1 3.35569
SRPX2 sushi-repeat containing protein, X-linked 2 3.35569
SIX1 SIX homeobox 1 3.35569
OR5P3 olfactory receptor, family 5, subfamily P, member 3 3.35569
CD6 CD6 molecule 3.35569
CARD16 caspase recruitment domain family, member 16 3.35569
CARD18 caspase recruitment domain family, member 18 3.35569
UCN urocortin 3.35569
FRMD7 FERM domain containing 7 3.35569
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 3.35569
MTNR1B melatonin receptor 1B 3.35569
FGFBP2 fibroblast growth factor binding protein 2 3.35569
FMR1NB fragile X mental retardation 1 neighbor 3.35569
OOSP1 oocyte secreted protein 1, pseudogene 3.35569
LRRC3C leucine rich repeat containing 3C 3.35569
SBSN suprabasin 3.35569
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.35569
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.35569
RAB11FIP3 RAB11 family interacting protein 3 (class II) 3.35569
WDR87 WD repeat domain 87 3.35569
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 3.35569
MUC13 mucin 13, cell surface associated 3.35569
VWA3A von Willebrand factor A domain containing 3A 3.35569
FBXO39 F-box protein 39 3.35569
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.35569
TIPE2 TNF alpha induced protein 8 like 2 3.35569
PLEKHS1 pleckstrin homology domain containing, family S member 1 3.35569
FBXO47 F-box protein 47 3.35569
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.35569
C8G complement component 8, gamma polypeptide 3.35569
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.35569
DMTN dematin actin binding protein 3.35569
EBF2 early B-cell factor 2 3.35569
IL17REL interleukin 17 receptor E-like 3.35569
EDN3 endothelin 3 3.35569
RGS11 regulator of G-protein signaling 11 3.35569
AQP8 aquaporin 8 3.35569
TCEA3 transcription elongation factor A (SII), 3 3.35569
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1 3.35569
CLDN34 claudin 34 3.35569
TMEM132E transmembrane protein 132E 3.35569
CLEC4D C-type lectin domain family 4, member D 3.35569
LRRC46 leucine rich repeat containing 46 3.35569
TRIM50 tripartite motif containing 50 3.35569
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 3.35569
NT5DC4 5'-nucleotidase domain containing 4 3.35569
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.35569
HMGB4 high mobility group box 4 3.35569
ORM2 orosomucoid 2 3.35569
RTN4RL1 reticulon 4 receptor-like 1 3.35569
GRAP2 GRB2-related adaptor protein 2 3.35569
EFCC1 EF-hand and coiled-coil domain containing 1 3.35569
TGM7 transglutaminase 7 3.35569
NKX6-1 NK6 homeobox 1 3.35569
IL27 interleukin 27 3.35569
PPP1R3A protein phosphatase 1, regulatory subunit 3A 3.35569
CLEC18A C-type lectin domain family 18, member A 3.35569
FKBP1C FK506 binding protein 1C 3.35569
ZNF831 zinc finger protein 831 3.35569
RNF224 ring finger protein 224 3.35569
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.35569
FGF10 fibroblast growth factor 10 3.35569
IBSP integrin-binding sialoprotein 3.35569
TP63 tumor protein p63 3.35569
CRHBP corticotropin releasing hormone binding protein 3.35569
OR8B3 olfactory receptor, family 8, subfamily B, member 3 3.35569
SCN3A sodium channel, voltage gated, type III alpha subunit 3.35569
SH2D1B SH2 domain containing 1B 3.35569
PXT1 peroxisomal, testis specific 1 3.35569
CYTH4 cytohesin 4 3.35569
MOG myelin oligodendrocyte glycoprotein 3.35569
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.35569
KRCC1 lysine-rich coiled-coil 1 3.33244
ESR1 estrogen receptor 1 3.27568
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 3.17118
FABP5 fatty acid binding protein 5 (psoriasis-associated) 3.12689
CNOT2 CCR4-NOT transcription complex, subunit 2 3.04048
SYMPK symplekin 2.9867
ACRBP acrosin binding protein 2.93536
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.88948
OR4D1 olfactory receptor, family 4, subfamily D, member 1 2.8638
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 2.76888
KLK10 kallikrein-related peptidase 10 2.72723
RPS9 ribosomal protein S9 2.6673
LRRC57 leucine rich repeat containing 57 2.65937
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.64809
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.60152
COA5 cytochrome c oxidase assembly factor 5 2.57557
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 2.55397
SNX15 sorting nexin 15 2.52543
ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 2.45699
ERF Ets2 repressor factor 2.45348
PCDHGA1 protocadherin gamma subfamily A, 1 2.39571
PCDHB5 protocadherin beta 5 2.37263
CDC5L cell division cycle 5-like 2.35393
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 2.34609
ABLIM3 actin binding LIM protein family, member 3 2.341
CA7 carbonic anhydrase VII 2.341
IER3IP1 immediate early response 3 interacting protein 1 2.32484
IFI27 interferon, alpha-inducible protein 27 2.31695
TSPAN19 tetraspanin 19 2.29307
ACO2 aconitase 2, mitochondrial 2.29307
PADI1 peptidyl arginine deiminase, type I 2.29307
FABP3 fatty acid binding protein 3, muscle and heart 2.28888
PEX10 peroxisomal biogenesis factor 10 2.28135
DEUP1 deuterosome assembly protein 1 2.27508
GCOM1 GRINL1A complex locus 1 2.27508
MRPL3 mitochondrial ribosomal protein L3 2.27508
DMRT1 doublesex and mab-3 related transcription factor 1 2.27508
EXTL1 exostosin-like glycosyltransferase 1 2.27508
MYH15 myosin, heavy chain 15 2.27508
SCT secretin 2.27508
SAMD5 sterile alpha motif domain containing 5 2.27508
ADIRF adipogenesis regulatory factor 2.27508
C11ORF68 chromosome 11 open reading frame 68 2.27373
CHIT1 chitinase 1 (chitotriosidase) 2.26006
EVI5 ecotropic viral integration site 5 2.25796
AEBP2 AE binding protein 2 2.25054
GADD45G growth arrest and DNA-damage-inducible, gamma 2.23518
TRNP1 TMF1-regulated nuclear protein 1 2.23119
CLK4 CDC-like kinase 4 2.22862
RAN RAN, member RAS oncogene family 2.21779
MORF4L2 mortality factor 4 like 2 2.20899
OSER1 oxidative stress responsive serine-rich 1 2.20584
IER2 immediate early response 2 2.19934
CBARP CACN subunit beta associated regulatory protein 2.15622
RPS27 ribosomal protein S27 2.13511
BIRC5 baculoviral IAP repeat containing 5 2.13121
SWT1 SWT1 RNA endoribonuclease homolog (S. cerevisiae) 2.08031
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 2.08031
PARP16 poly (ADP-ribose) polymerase family, member 16 2.08031
EPB41L3 erythrocyte membrane protein band 4.1-like 3 2.0699
GRHL2 grainyhead-like 2 (Drosophila) 2.06506
FBXO34 F-box protein 34 2.06217
AZI2 5-azacytidine induced 2 2.06217
GABARAP GABA(A) receptor-associated protein 2.06217
TRIM11 tripartite motif containing 11 2.06217
EXTL3 exostosin-like glycosyltransferase 3 2.05867
RBM7 RNA binding motif protein 7 2.04966
LIN37 lin-37 DREAM MuvB core complex component 2.04966
ZSWIM7 zinc finger, SWIM-type containing 7 2.04385
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.04348
PARVA parvin, alpha 2.03208
MRPS7 mitochondrial ribosomal protein S7 2.01866
ATF6B activating transcription factor 6 beta 2.00641
OMA1 OMA1 zinc metallopeptidase 2.00326
SLC35H1 solute carrier family 35 member H1 2.00316
TSPYL5 TSPY-like 5 2.00157
DPH1 diphthamide biosynthesis 1 2.00133

decreased expression

Symbol Name Standardized Value
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -3.50388
PLET1 placenta expressed transcript 1 -3.50388
LOC124903233 uncharacterized LOC124903233 -3.50388
PCDHB14 protocadherin beta 14 -3.50388
IAPP islet amyloid polypeptide -3.50388
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -3.50388
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 -3.50388
TSPAN16 tetraspanin 16 -3.50388
PNMA6F PNMA family member 6F -3.35569
ADGRG1 adhesion G protein-coupled receptor G1 -3.35569
TMEM179 transmembrane protein 179 -3.35569
AQP3 aquaporin 3 (Gill blood group) -3.35569
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -3.35569
COL9A2 collagen, type IX, alpha 2 -3.35569
USP26 ubiquitin specific peptidase 26 -3.35569
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -3.35569
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 -3.35569
VMAC vimentin-type intermediate filament associated coiled-coil protein -3.35569
DEFB134 defensin, beta 134 -3.35569
ALOX15B arachidonate 15-lipoxygenase, type B -3.35569
LMOD2 leiomodin 2 (cardiac) -3.35569
TAFA3 TAFA chemokine like family member 3 -3.35569
GPRC6A G protein-coupled receptor, class C, group 6, member A -3.35569
CA1 carbonic anhydrase I -3.35569
TMOD4 tropomodulin 4 (muscle) -3.35569
VAV1 vav 1 guanine nucleotide exchange factor -3.35569
NWD1 NACHT and WD repeat domain containing 1 -3.35569
NPIPA7 nuclear pore complex interacting protein family, member A7 -3.35569
GADL1 glutamate decarboxylase-like 1 -3.35569
CD200R1 CD200 receptor 1 -3.35569
LMOD3 leiomodin 3 (fetal) -3.35569
LRRK2 leucine-rich repeat kinase 2 -3.35569
SLC35G5 solute carrier family 35, member G5 -3.35569
OCM oncomodulin -3.35569
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 -3.33123
ITPRID1 ITPR interacting domain containing 1 -3.1784
ZNF740 zinc finger protein 740 -3.14646
MTMR3 myotubularin related protein 3 -3.10126
YLPM1 YLP motif containing 1 -3.10126
MYC v-myc avian myelocytomatosis viral oncogene homolog -3.02243
ZNF112 zinc finger protein 112 -2.92486
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.90202
PAIP2 poly(A) binding protein interacting protein 2 -2.89417
TSLIG3A tRNA splicing ligase complex subunit 3A -2.8638
TRPM6 transient receptor potential cation channel, subfamily M, member 6 -2.85127
RPRM reprimo, TP53 dependent G2 arrest mediator candidate -2.75101
FAM76A family with sequence similarity 76, member A -2.72076
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.71855
PQBP1 polyglutamine binding protein 1 -2.70753
DHCR7 7-dehydrocholesterol reductase -2.69109
CUL1 cullin 1 -2.61603
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -2.53712
KLHL42 kelch-like family member 42 -2.53473
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.52543
FERMT2 fermitin family member 2 -2.51833
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -2.49178
CELF2 CUGBP, Elav-like family member 2 -2.48373
PLA2G10 phospholipase A2, group X -2.46667
KRT222 keratin 222, type II -2.45348
TTC29 tetratricopeptide repeat domain 29 -2.45348
SNX3 sorting nexin 3 -2.43617
FNDC11 fibronectin type III domain containing 11 -2.41599
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma -2.41599
FBXL7 F-box and leucine-rich repeat protein 7 -2.37263
CASR calcium-sensing receptor -2.36338
TBX6 T-box 6 -2.36338
IQCJ IQ motif containing J -2.36338
SH2D7 SH2 domain containing 7 -2.36338
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -2.3559
CTNNBIP1 catenin, beta interacting protein 1 -2.32552
FAM78A family with sequence similarity 78, member A -2.32348
MCTS1 malignant T cell amplified sequence 1 -2.31254
TIGD7 tigger transposable element derived 7 -2.29816
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -2.294
TFR2 transferrin receptor 2 -2.29307
ADNP2 ADNP homeobox 2 -2.29115
MIER1 mesoderm induction early response 1, transcriptional regulator -2.28632
ZNF549 zinc finger protein 549 -2.27508
H4C2 H4 clustered histone 2 -2.27508
ZNF84 zinc finger protein 84 -2.27508
TBK1 TANK-binding kinase 1 -2.27508
H2BC21 H2B clustered histone 21 -2.26632
CFAP54 cilia and flagella associated 54 -2.26006
PLCG1 phospholipase C, gamma 1 -2.26006
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 -2.26006
FBLN7 fibulin 7 -2.26006
PIWIL4 piwi-like RNA-mediated gene silencing 4 -2.26006
SCP2 sterol carrier protein 2 -2.22498
TSGA10IP testis specific, 10 interacting protein -2.21779
C18ORF54 chromosome 18 open reading frame 54 -2.20984
RALBP1 ralA binding protein 1 -2.20314
CHMP5 charged multivesicular body protein 5 -2.19898
CCDC169 coiled-coil domain containing 169 -2.1889
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -2.17798
NET1 neuroepithelial cell transforming 1 -2.17043
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -2.14849
SYNJ2 synaptojanin 2 -2.12652
DBT dihydrolipoamide branched chain transacylase E2 -2.12339
NYNRIN NYN domain and retroviral integrase containing -2.10334
GPR137C G protein-coupled receptor 137C -2.08935
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 -2.08031
DNHD1 dynein heavy chain domain 1 -2.07425
UFL1 UFM1-specific ligase 1 -2.0699
IGFLR1 IGF-like family receptor 1 -2.0699
SRRM3 serine/arginine repetitive matrix 3 -2.0699
PDS5A PDS5 cohesin associated factor A -2.06506
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -2.06217
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -2.06217
LHFPL6 LHFPL tetraspan subfamily member 6 -2.06217
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -2.06217
KPNA5 karyopherin alpha 5 (importin alpha 6) -2.04385
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) -2.04385
SETD2 SET domain containing 2 -2.04385
GPR107 G protein-coupled receptor 107 -2.04385
WBP11 WW domain binding protein 11 -2.04232
UBAP2 ubiquitin associated protein 2 -2.03123
STAR steroidogenic acute regulatory protein -2.01713
MCMDC2 minichromosome maintenance domain containing 2 -2.01713
ZNF280C zinc finger protein 280C -2.01582
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.00641
ITPRIPL1 inositol 1,4,5-trisphosphate receptor interacting protein-like 1 -2.00641
TSC1 tuberous sclerosis 1 -2.00063