MINK1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description misshapen-like kinase 1|This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 50488)
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Genes

329 genes differentially expressed following the MINK1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OR2A7 olfactory receptor, family 2, subfamily A, member 7 2.61536
CARD16 caspase recruitment domain family, member 16 2.61536
ZSCAN5B zinc finger and SCAN domain containing 5B 2.61536
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 2.61536
SLC46A3 solute carrier family 46, member 3 2.61536
OR51A7 olfactory receptor, family 51, subfamily A, member 7 2.61536
PLIN4 perilipin 4 2.61536
SLC16A11 solute carrier family 16, member 11 2.61536
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.61536
PRODH2 proline dehydrogenase (oxidase) 2 2.61536
HES3 hes family bHLH transcription factor 3 2.61536
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.61536
TRIAP1 TP53 regulated inhibitor of apoptosis 1 2.61536
LOC390937 Ets2 repressor factor-like 2.61536
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.61536
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.61536
ZNF589 zinc finger protein 589 2.61536
NDRG1 N-myc downstream regulated 1 2.61536
GJA5 gap junction protein, alpha 5, 40kDa 2.61536
ELF5 E74-like factor 5 (ets domain transcription factor) 2.61536
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.61536
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.61536
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.61536
SOX14 SRY (sex determining region Y)-box 14 2.61536
OSGIN1 oxidative stress induced growth inhibitor 1 2.61536
PCDH8 protocadherin 8 2.61536
RGPD4 RANBP2-like and GRIP domain containing 4 2.61536
PARP10 poly (ADP-ribose) polymerase family, member 10 2.61536
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.61536
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.61536
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 2.61536
HMX3 H6 family homeobox 3 2.61536
ACY3 aminoacylase 3 2.61536
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.61536
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.61536
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.61536
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.61536
TERT telomerase reverse transcriptase 2.61536
PCDHGB3 protocadherin gamma subfamily B, 3 2.61536
SGPP2 sphingosine-1-phosphate phosphatase 2 2.61536
SLC25A45 solute carrier family 25, member 45 2.61536
SH2D7 SH2 domain containing 7 2.61536
MTTP microsomal triglyceride transfer protein 2.61536
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.61536
SSMEM1 serine-rich single-pass membrane protein 1 2.61536
RFPL3 ret finger protein-like 3 2.61536
DEFB106B defensin, beta 106B 2.61536
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.61536
SCRG1 stimulator of chondrogenesis 1 2.61536
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.61536
TMOD4 tropomodulin 4 (muscle) 2.61536
C2ORF72 chromosome 2 open reading frame 72 2.61536
ACER1 alkaline ceramidase 1 2.61536
DNAAF1 dynein, axonemal, assembly factor 1 2.61536
PDF peptide deformylase (mitochondrial) 2.61536
SMLR1 small leucine-rich protein 1 2.61536
TREX2 three prime repair exonuclease 2 2.61536
TMEM40 transmembrane protein 40 2.61536
MYEOV myeloma overexpressed 2.61536
DOK7 docking protein 7 2.61536
SMIM40 small integral membrane protein 40 2.61536
JAML junction adhesion molecule like 2.61536
SLC67A1 solute carrier family 67 member 1 2.61536
AGA-DT AGA divergent transcript 2.61536
CIMAP1B ciliary microtubule associated protein 1B 2.61536
LINC02798 long intergenic non-protein coding RNA 2798 2.61536
INSYN1 inhibitory synaptic factor 1 2.61536
SPAAR small regulatory polypeptide of amino acid response 2.61536
GREP1 glycine rich extracellular protein 1 2.61536
H3-7 H3.7 histone (putative) 2.61536
LY6L lymphocyte antigen 6 family member L 2.61536
CFAP97D1 CFAP97 domain containing 1 2.61536
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.61536
C1QA complement component 1, q subcomponent, A chain 2.61536
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.61536
RNF113B ring finger protein 113B 2.61536
OVOL3 ovo-like zinc finger 3 2.61536
SCRT2 scratch family zinc finger 2 2.61536
CATSPERD catsper channel auxiliary subunit delta 2.61536
C3ORF80 chromosome 3 open reading frame 80 2.61536
CCR6 chemokine (C-C motif) receptor 6 2.61536
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.61536
CLDN9 claudin 9 2.61536
CCDC13 coiled-coil domain containing 13 2.61536
RASAL3 RAS protein activator like 3 2.61536
EXOC3L1 exocyst complex component 3-like 1 2.61536
ZNF705A zinc finger protein 705A 2.61536
LAMA4 laminin, alpha 4 2.61536
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.61536
TUBA4B tubulin, alpha 4b 2.61536
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 2.61536
TOX2 TOX high mobility group box family member 2 2.61536
COX8C cytochrome c oxidase subunit VIIIC 2.61536
GPR83 G protein-coupled receptor 83 2.61536
SAMD11 sterile alpha motif domain containing 11 2.61536
CLEC17A C-type lectin domain family 17, member A 2.61536
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.61536
ACKR2 atypical chemokine receptor 2 2.61536
CNTF ciliary neurotrophic factor 2.61536
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.61536
CST1 cystatin SN 2.61536
EFCAB9 EF-hand calcium binding domain 9 2.61536
TNR tenascin R 2.61536
OR9A4 olfactory receptor, family 9, subfamily A, member 4 2.61536
CXCR5 chemokine (C-X-C motif) receptor 5 2.61536
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.61536
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.61536
HAMP hepcidin antimicrobial peptide 2.61536
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.61536
TMEM132D transmembrane protein 132D 2.61536
MAPK11 mitogen-activated protein kinase 11 2.61536
BATF2 basic leucine zipper transcription factor, ATF-like 2 2.61536
NTSR2 neurotensin receptor 2 2.61536
HSPB8 heat shock 22kDa protein 8 2.61536
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 2.61536
SMIM22 small integral membrane protein 22 2.61536
IL13RA2 interleukin 13 receptor, alpha 2 2.61536
IPP intracisternal A particle-promoted polypeptide 2.61536
EBF2 early B-cell factor 2 2.61536
PCDHGA4 protocadherin gamma subfamily A, 4 2.61536
IFITM5 interferon induced transmembrane protein 5 2.61536
HELQ helicase, POLQ-like 2.61536
HLA-G major histocompatibility complex, class I, G 2.61536
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.61536
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.61536
PCDHAC2 protocadherin alpha subfamily C, 2 2.61536
C22ORF31 chromosome 22 open reading frame 31 2.61536
TEX29 testis expressed 29 2.61536
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.61536
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.61536
FOXS1 forkhead box S1 2.61536
C1ORF105 chromosome 1 open reading frame 105 2.61536
SH2D1A SH2 domain containing 1A 2.61536
CLEC4A C-type lectin domain family 4, member A 2.61536
CDK20 cyclin-dependent kinase 20 2.61536
PATE4 prostate and testis expressed 4 2.61536
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.61536
SAMD5 sterile alpha motif domain containing 5 2.61536
TG thyroglobulin 2.61536
RBM24 RNA binding motif protein 24 2.61536
XIRP2 xin actin binding repeat containing 2 2.61536
ADGRD1 adhesion G protein-coupled receptor D1 2.61536
NCR3 natural cytotoxicity triggering receptor 3 2.61536
CRTAM cytotoxic and regulatory T cell molecule 2.61536
NOS2 nitric oxide synthase 2, inducible 2.61536
TMEM86A transmembrane protein 86A 2.61536
ITPKA inositol-trisphosphate 3-kinase A 2.61536
LAMP3 lysosomal-associated membrane protein 3 2.61536
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.61536
DSPP dentin sialophosphoprotein 2.61536
PITX3 paired-like homeodomain 3 2.61536
PTBP1 polypyrimidine tract binding protein 1 2.61536
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.61536
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.61536
CLEC2A C-type lectin domain family 2, member A 2.61536
MEIG1 meiosis/spermiogenesis associated 1 2.61536
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.61536
SDSL serine dehydratase-like 2.61536
GCSAML germinal center-associated, signaling and motility-like 2.61536
RERGL RERG/RAS-like 2.61536
OR56B1 olfactory receptor, family 56, subfamily B, member 1 2.61536
TAS2R46 taste receptor, type 2, member 46 2.61536
PANO1 proapoptotic nucleolar protein 1 2.61536
FGF7 fibroblast growth factor 7 2.61536
AOC3 amine oxidase, copper containing 3 2.61536
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.61536
ACRBP acrosin binding protein 2.61536
BTBD19 BTB (POZ) domain containing 19 2.61536
PODN podocan 2.61536
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.61536
MAGEA9B melanoma antigen family A9B 2.61536
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 2.61536
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.60836
DIPK1B divergent protein kinase domain 1B 2.5987
GARRE1 granule associated Rac and RHOG effector 1 2.55104
OCIAD1 OCIA domain containing 1 2.54291
TEX264 testis expressed 264 2.52402
MCOLN2 mucolipin 2 2.52204
LRRC2 leucine rich repeat containing 2 2.51028
SPRING1 SREBF pathway regulator in golgi 1 2.48911
FAM168B family with sequence similarity 168, member B 2.47904
PNMA6A paraneoplastic Ma antigen family member 6A 2.47251
CDKL5 cyclin-dependent kinase-like 5 2.4661
MIGA2 mitoguardin 2 2.44928
ENTHD1 ENTH domain containing 1 2.44928
CD86 CD86 molecule 2.44928
LRRTM2 leucine rich repeat transmembrane neuronal 2 2.44928
MRM2 mitochondrial rRNA methyltransferase 2 2.4456
PRORP protein only RNase P catalytic subunit 2.37816
SLCO2A1 solute carrier organic anion transporter family, member 2A1 2.37816
COBLL1 cordon-bleu WH2 repeat protein-like 1 2.374
PCF11 PCF11 cleavage and polyadenylation factor subunit 2.37358
PLCH1 phospholipase C, eta 1 2.37358
UFM1 ubiquitin-fold modifier 1 2.37358
KDM4B lysine (K)-specific demethylase 4B 2.36708
CEP44 centrosomal protein 44kDa 2.36455
TOR3A torsin family 3, member A 2.35039
PARP4 poly (ADP-ribose) polymerase family, member 4 2.32245
POU5F1B POU class 5 homeobox 1B 2.31039
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.2892
WDR45B WD repeat domain 45B 2.28748
TTLL9 tubulin tyrosine ligase-like family member 9 2.28748
MMD monocyte to macrophage differentiation-associated 2.28699
TOR1AIP2 torsin A interacting protein 2 2.28699
PWWP2B PWWP domain containing 2B 2.286
TCL1B T-cell leukemia/lymphoma 1B 2.26907
TNRC6C trinucleotide repeat containing 6C 2.24042
MEIS3 Meis homeobox 3 2.18954
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.18954
PTCH1 patched 1 2.18091
NTN1 netrin 1 2.18082
SNU13 small nuclear ribonucleoprotein 13 2.17776
GNAS GNAS complex locus 2.14973
CAND1 cullin-associated and neddylation-dissociated 1 2.14782
GPI glucose-6-phosphate isomerase 2.1071
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 2.09259
PSMC3IP PSMC3 interacting protein 2.0749
PPP1R7 protein phosphatase 1, regulatory subunit 7 2.0749
ITM2A integral membrane protein 2A 2.04695
SKIC8 SKI8 subunit of superkiller complex 2.04695
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 2.01597
ERCC6 excision repair cross-complementation group 6 2.0084
SEC24C SEC24 family member C 2.00128

decreased expression

Symbol Name Standardized Value
MYORG myogenesis regulating glycosidase (putative) -2.61536
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -2.61536
C1ORF146 chromosome 1 open reading frame 146 -2.61536
EHBP1L1 EH domain binding protein 1-like 1 -2.61536
DLX4 distal-less homeobox 4 -2.61536
RNF6 ring finger protein (C3H2C3 type) 6 -2.61536
GARIN2 golgi associated RAB2 interactor family member 2 -2.61536
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -2.61536
IKZF3 IKAROS family zinc finger 3 (Aiolos) -2.61536
LHX6 LIM homeobox 6 -2.61536
TMEM220 transmembrane protein 220 -2.61536
ZBBX zinc finger, B-box domain containing -2.61536
SCLT1 sodium channel and clathrin linker 1 -2.61536
KCNK15 potassium channel, two pore domain subfamily K, member 15 -2.61536
B3GNT7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 -2.61536
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 -2.61536
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -2.61536
NECAB2 N-terminal EF-hand calcium binding protein 2 -2.61536
OTOG otogelin -2.61536
ALX3 ALX homeobox 3 -2.61536
PNLIPRP2 pancreatic lipase-related protein 2 -2.61536
C9ORF43 chromosome 9 open reading frame 43 -2.61536
LPIN3 lipin 3 -2.61536
OPLAH 5-oxoprolinase (ATP-hydrolysing) -2.61536
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 -2.61536
FOXI3 forkhead box I3 -2.61536
PRR19 proline rich 19 -2.61536
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -2.61536
LTBP3 latent transforming growth factor beta binding protein 3 -2.61536
CFAP99 cilia and flagella associated protein 99 -2.61536
PCDHB12 protocadherin beta 12 -2.61536
CES3 carboxylesterase 3 -2.61536
PDGFB platelet-derived growth factor beta polypeptide -2.61536
FGF18 fibroblast growth factor 18 -2.61536
PRKACA protein kinase, cAMP-dependent, catalytic, alpha -2.61536
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) -2.61536
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) -2.61536
KLK4 kallikrein-related peptidase 4 -2.61536
MYLK4 myosin light chain kinase family, member 4 -2.61536
CER1 cerberus 1, DAN family BMP antagonist -2.61536
KANK4 KN motif and ankyrin repeat domains 4 -2.61536
ABHD1 abhydrolase domain containing 1 -2.61536
CCDC78 coiled-coil domain containing 78 -2.61536
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -2.61536
UPK1A uroplakin 1A -2.61536
SEZ6L seizure related 6 homolog (mouse)-like -2.61536
PRSS51 protease, serine, 51 -2.61536
PDE1A phosphodiesterase 1A, calmodulin-dependent -2.60831
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 -2.60831
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 -2.58034
RASA1 RAS p21 protein activator (GTPase activating protein) 1 -2.57121
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.54621
ZNF311 zinc finger protein 311 -2.52013
FRMD5 FERM domain containing 5 -2.45176
CLVS1 clavesin 1 -2.44928
GGT1 gamma-glutamyltransferase 1 -2.44928
SNTA1 syntrophin, alpha 1 -2.44928
B9D2 B9 protein domain 2 -2.44928
TDRD7 tudor domain containing 7 -2.4325
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) -2.42828
KCTD11 potassium channel tetramerization domain containing 11 -2.41376
PCDHA9 protocadherin alpha 9 -2.41332
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -2.40354
UBIAD1 UbiA prenyltransferase domain containing 1 -2.39376
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -2.37816
AKNA AT-hook transcription factor -2.311
FEM1B fem-1 homolog b (C. elegans) -2.311
BMPR1A bone morphogenetic protein receptor, type IA -2.30166
SYS1 Sys1 golgi trafficking protein -2.29823
IPO4 importin 4 -2.286
IL4R interleukin 4 receptor -2.22547
GRIPAP1 GRIP1 associated protein 1 -2.21344
SMAP2 small ArfGAP2 -2.20474
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -2.19843
PPP1R42 protein phosphatase 1, regulatory subunit 42 -2.19837
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -2.19837
RAB18 RAB18, member RAS oncogene family -2.19837
CERK ceramide kinase -2.19667
PCNX2 pecanex 2 -2.18954
ZBTB40 zinc finger and BTB domain containing 40 -2.18796
CCL2 chemokine (C-C motif) ligand 2 -2.18796
HPS3 Hermansky-Pudlak syndrome 3 -2.17693
FUCA2 fucosidase, alpha-L- 2, plasma -2.17395
PTGES2 prostaglandin E synthase 2 -2.17395
GPBP1 GC-rich promoter binding protein 1 -2.17259
TDRKH tudor and KH domain containing -2.16316
HTRA2 HtrA serine peptidase 2 -2.14359
DNMBP dynamin binding protein -2.13687
INIP INTS3 and NABP interacting protein -2.13616
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -2.12889
CASKIN1 CASK interacting protein 1 -2.1226
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 -2.12046
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.1071
KLK1 kallikrein 1 -2.09173
IPMK inositol polyphosphate multikinase -2.07289
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.04695
TRPC4 transient receptor potential cation channel, subfamily C, member 4 -2.04695
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.04457
KRTCAP2 keratinocyte associated protein 2 -2.03435
DCTN4 dynactin 4 (p62) -2.03392
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -2.03209
LRRC34 leucine rich repeat containing 34 -2.01597
PCDH9 protocadherin 9 -2.01572
TM2D1 TM2 domain containing 1 -2.01536
BAIAP2 BAI1-associated protein 2 -2.01201
AEBP2 AE binding protein 2 -2.00519