MITF Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description microphthalmia-associated transcription factor|This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4286)
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Genes

335 genes differentially expressed following the MITF gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LBHD1 LBH domain containing 1 4.11217
TEX13B testis expressed 13B 4.11217
FGL2 fibrinogen-like 2 4.11217
CELA3A chymotrypsin-like elastase family, member 3A 4.11217
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 4.11217
GJA10 gap junction protein, alpha 10, 62kDa 4.11217
LMO1 LIM domain only 1 (rhombotin 1) 4.11217
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 4.11217
GFAP glial fibrillary acidic protein 4.11217
TRIM17 tripartite motif containing 17 4.11217
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 4.11217
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 4.11217
CD300E CD300e molecule 4.11217
TBX20 T-box 20 4.11217
OVGP1 oviductal glycoprotein 1, 120kDa 4.11217
FAM90A26 family with sequence similarity 90, member A26, pseudogene 4.11217
SOX1 SRY (sex determining region Y)-box 1 4.11217
SELPLG selectin P ligand 4.11217
MYO7B myosin VIIB 4.11217
SSX4B synovial sarcoma, X breakpoint 4B 4.11217
TUBB1 tubulin, beta 1 class VI 4.11217
REN renin 4.11217
BMP5 bone morphogenetic protein 5 4.11217
TSHZ1 teashirt zinc finger homeobox 1 4.11217
SP6 Sp6 transcription factor 4.11217
LOC105378220 macrophage receptor MARCO-like 4.11217
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 4.11217
KIAA1755 KIAA1755 4.11217
SMCO1 single-pass membrane protein with coiled-coil domains 1 4.11217
GPRASP1 G protein-coupled receptor associated sorting protein 1 4.11217
MPL MPL proto-oncogene, thrombopoietin receptor 4.11217
NPIPA3 nuclear pore complex interacting protein family, member A3 4.11217
SPDYE11 speedy/RINGO cell cycle regulator family member E11 4.11217
TRIM74 tripartite motif containing 74 4.11217
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 4.11217
AVPR2 arginine vasopressin receptor 2 4.11217
LMNTD1 lamin tail domain containing 1 4.11217
ADAMTSL5 ADAMTS-like 5 4.11217
OR13C9 olfactory receptor, family 13, subfamily C, member 9 4.11217
C9ORF152 chromosome 9 open reading frame 152 4.11217
EDDM3A epididymal protein 3A 4.11217
IRX1 iroquois homeobox 1 4.11217
PCDHA7 protocadherin alpha 7 4.11217
LOC124906892 uncharacterized LOC124906892 4.11217
TCIM transcriptional and immune response regulator 4.11217
ANGPTL8 angiopoietin like 8 4.11217
CES4A carboxylesterase 4A 4.11217
ROPN1L rhophilin associated tail protein 1-like 4.11217
OPRM1 opioid receptor, mu 1 4.11217
PNLIPRP2 pancreatic lipase-related protein 2 4.11217
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 4.11217
TMPRSS3 transmembrane protease, serine 3 4.11217
CCDC198 coiled-coil domain containing 198 4.11217
H2AC1 H2A clustered histone 1 4.11217
MAJIN membrane anchored junction protein 4.11217
LOC107986837 uncharacterized LOC107986837 4.11217
EPCIP exosomal polycystin 1 interacting protein 4.11217
TEX53 testis expressed 53 4.11217
LRRC8C-DT LRRC8C divergent transcript 4.11217
C8ORF90 chromosome 8 open reading frame 90 4.11217
H2BK1 H2B.K variant histone 1 4.11217
H3C13 H3 clustered histone 13 4.11217
PEAK3 PEAK family member 3 4.11217
TREX2 three prime repair exonuclease 2 4.11217
ASB9 ankyrin repeat and SOCS box containing 9 4.11217
S100G S100 calcium binding protein G 4.11217
SLAMF8 SLAM family member 8 4.11217
SIM2 single-minded family bHLH transcription factor 2 4.11217
CXCL11 chemokine (C-X-C motif) ligand 11 4.11217
MAGEB2 melanoma antigen family B2 4.11217
CLDN9 claudin 9 4.11217
VIT vitrin 4.11217
PRB4 proline-rich protein BstNI subfamily 4 4.11217
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 4.11217
NR0B1 nuclear receptor subfamily 0, group B, member 1 4.11217
C9 complement component 9 4.11217
GATA4 GATA binding protein 4 4.11217
GATA6 GATA binding protein 6 4.11217
PRDM6 PR domain containing 6 4.11217
MYO18B myosin XVIIIB 4.11217
ZAR1L zygote arrest 1-like 4.11217
HAL histidine ammonia-lyase 4.11217
TIMD4 T-cell immunoglobulin and mucin domain containing 4 4.11217
BLNK B-cell linker 4.11217
KLHL33 kelch-like family member 33 4.11217
CSF3R colony stimulating factor 3 receptor (granulocyte) 4.11217
HBE1 hemoglobin, epsilon 1 4.11217
MR1 major histocompatibility complex, class I-related 4.11217
OSR1 odd-skipped related transciption factor 1 4.11217
CNTF ciliary neurotrophic factor 4.11217
HHATL hedgehog acyltransferase-like 4.11217
CLRN3 clarin 3 4.11217
GCOM1 GRINL1A complex locus 1 4.11217
ADAM2 ADAM metallopeptidase domain 2 4.11217
CCL25 chemokine (C-C motif) ligand 25 4.11217
LRCOL1 leucine rich colipase-like 1 4.11217
AGR2 anterior gradient 2 4.11217
TOPAZ1 testis and ovary specific PAZ domain containing 1 4.11217
PDCD1 programmed cell death 1 4.11217
TCF21 transcription factor 21 4.11217
FOSB FBJ murine osteosarcoma viral oncogene homolog B 4.11217
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 4.11217
APOB apolipoprotein B 4.11217
RPA4 replication protein A4, 30kDa 4.11217
CALHM3 calcium homeostasis modulator 3 4.11217
IRGM immunity-related GTPase family, M 4.11217
DRD5 dopamine receptor D5 4.11217
MGP matrix Gla protein 4.11217
CLEC18A C-type lectin domain family 18, member A 4.11217
CXORF58 chromosome X open reading frame 58 4.11217
CNGB1 cyclic nucleotide gated channel beta 1 4.11217
GJC2 gap junction protein, gamma 2, 47kDa 4.11217
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 4.11217
BTG4 B-cell translocation gene 4 4.11217
OR52N1 olfactory receptor, family 52, subfamily N, member 1 4.11217
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 4.11217
GSC2 goosecoid homeobox 2 4.11217
TEX12 testis expressed 12 4.11217
SAMD9 sterile alpha motif domain containing 9 4.11217
UTS2B urotensin 2B 4.11217
PTPN20 protein tyrosine phosphatase, non-receptor type 20 4.11217
OCM oncomodulin 4.11217
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 4.11217
TF transferrin 4.11217
GPR68 G protein-coupled receptor 68 4.11217
ART1 ADP-ribosyltransferase 1 4.11217
NUTM2B NUT family member 2B 4.11217
TGM3 transglutaminase 3 4.11217
DCSTAMP dendrocyte expressed seven transmembrane protein 4.11217
SPNS3 spinster homolog 3 (Drosophila) 4.11217
MST1 macrophage stimulating 1 4.11217
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 4.11217
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 4.11217
GPR179 G protein-coupled receptor 179 4.11217
ZBED6 zinc finger, BED-type containing 6 4.11217
SLC51B solute carrier family 51, beta subunit 4.11217
APOL6 apolipoprotein L, 6 4.11217
ASCL1 achaete-scute family bHLH transcription factor 1 4.11217
TRAF3IP3 TRAF3 interacting protein 3 4.11217
IL37 interleukin 37 4.11217
PRRX1 paired related homeobox 1 4.11217
ANXA8 annexin A8 4.11217
TAS2R43 taste receptor, type 2, member 43 4.11217
PODNL1 podocan-like 1 4.0662
RAI2 retinoic acid induced 2 4.0662
QRFPR pyroglutamylated RFamide peptide receptor 3.4506
SYT16 synaptotagmin XVI 3.26328
PCP4L1 Purkinje cell protein 4 like 1 3.26328
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 3.17617
CRY2 cryptochrome circadian clock 2 3.1725
RIBC2 RIB43A domain with coiled-coils 2 3.14265
ZBBX zinc finger, B-box domain containing 3.14265
ENKUR enkurin, TRPC channel interacting protein 3.14265
CORO6 coronin 6 3.14265
SNAP91 synaptosomal-associated protein, 91kDa 3.14265
MRPL53 mitochondrial ribosomal protein L53 3.14265
BGN biglycan 3.14265
DRD3 dopamine receptor D3 3.14265
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 3.07285
NIBAN2 niban apoptosis regulator 2 3.0011
DENND4B DENN/MADD domain containing 4B 2.97547
ZNF436 zinc finger protein 436 2.97392
SLC16A11 solute carrier family 16, member 11 2.96355
AZI2 5-azacytidine induced 2 2.89399
EPN1 epsin 1 2.83285
P3H2 prolyl 3-hydroxylase 2 2.8234
FGF13 fibroblast growth factor 13 2.78395
METTL27 methyltransferase like 27 2.76077
GHR growth hormone receptor 2.70178
MEAF6 MYST/Esa1-associated factor 6 2.67914
ATG9A autophagy related 9A 2.67705
C3ORF70 chromosome 3 open reading frame 70 2.66639
ZBTB12 zinc finger and BTB domain containing 12 2.66639
RGS17 regulator of G-protein signaling 17 2.66419
MITD1 MIT, microtubule interacting and transport, domain containing 1 2.64533
ENOSF1 enolase superfamily member 1 2.53763
COPS9 COP9 signalosome subunit 9 2.46169
CLASP1 cytoplasmic linker associated protein 1 2.46122
ZNF418 zinc finger protein 418 2.43935
NOL4L nucleolar protein 4-like 2.4065
KIDINS220 kinase D-interacting substrate, 220kDa 2.4065
TMTC4 transmembrane and tetratricopeptide repeat containing 4 2.40541
FBXO30 F-box protein 30 2.3902
CERT1 ceramide transporter 1 2.36463
DRC1 dynein regulatory complex subunit 1 2.35995
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 2.3592
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 2.35402
CAVIN3 caveolae associated protein 3 2.35188
MBTD1 mbt domain containing 1 2.35188
ZNF85 zinc finger protein 85 2.34404
FAM185A family with sequence similarity 185, member A 2.33477
COL4A4 collagen, type IV, alpha 4 2.26944
EIF3K eukaryotic translation initiation factor 3, subunit K 2.2537
SH2B3 SH2B adaptor protein 3 2.24531
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.24531
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 2.23608
NIP7 NIP7, nucleolar pre-rRNA processing protein 2.23608
RPF2 ribosome production factor 2 homolog (S. cerevisiae) 2.23608
RTN4IP1 reticulon 4 interacting protein 1 2.22278
CA8 carbonic anhydrase VIII 2.2185
ZNF793 zinc finger protein 793 2.17359
ANGPT1 angiopoietin 1 2.17311
MOB3B MOB kinase activator 3B 2.17311
PDIK1L PDLIM1 interacting kinase 1 like 2.17311
KPNA5 karyopherin alpha 5 (importin alpha 6) 2.16543
CA9 carbonic anhydrase IX 2.15022
FAM171B family with sequence similarity 171, member B 2.13215
CCDC141 coiled-coil domain containing 141 2.09969
H4C3 H4 clustered histone 3 2.09969
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 2.08515
PYM1 PYM homolog 1, exon junction complex associated factor 2.08439
CLMN calmin (calponin-like, transmembrane) 2.08423
NPIPA2 nuclear pore complex interacting protein family, member A2 2.06849
MTBP MDM2 binding protein 2.06457
SSC5D scavenger receptor cysteine rich family, 5 domains 2.05863
CECR2 cat eye syndrome chromosome region, candidate 2 2.04855
FN3KRP fructosamine 3 kinase related protein 2.00917
LONP2 lon peptidase 2, peroxisomal 2.00238
FASTKD3 FAST kinase domains 3 2.00058

decreased expression

Symbol Name Standardized Value
LMTK1 lemur tail kinase 1 -4.11217
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B -4.11217
C20ORF203 chromosome 20 open reading frame 203 -4.11217
BCHE butyrylcholinesterase -4.11217
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 -4.05606
SLC15A5 solute carrier family 15, member 5 -4.05606
DRICH1 aspartate-rich 1 -4.05606
EPPIN epididymal peptidase inhibitor -4.05606
ECM1 extracellular matrix protein 1 -4.05606
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -4.05606
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -4.05606
GPR22 G protein-coupled receptor 22 -4.05606
ADGB androglobin -4.05606
SPDYE2B speedy/RINGO cell cycle regulator family member E2B -4.05606
TP53TG5 TP53 target 5 -4.05606
GRM6 glutamate receptor, metabotropic 6 -4.05606
AKAP14 A kinase (PRKA) anchor protein 14 -4.05606
MEP1B meprin A, beta -4.05606
SYT15B synaptotagmin 15B -4.05606
TSKS testis-specific serine kinase substrate -4.05606
MUCL3 mucin like 3 -4.05606
HAO2 hydroxyacid oxidase 2 (long chain) -4.05606
ALX1 ALX homeobox 1 -4.05606
ASTL astacin-like metallo-endopeptidase (M12 family) -4.05606
LY6H lymphocyte antigen 6 complex, locus H -4.05606
FGFBP1 fibroblast growth factor binding protein 1 -4.05606
SAMD11 sterile alpha motif domain containing 11 -4.05606
LMOD2 leiomodin 2 (cardiac) -4.05606
TMIGD2 transmembrane and immunoglobulin domain containing 2 -4.05606
FPR2 formyl peptide receptor 2 -4.05606
TMEM52B transmembrane protein 52B -4.05606
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -3.96507
ERAP1 endoplasmic reticulum aminopeptidase 1 -3.6857
FIBCD1 fibrinogen C domain containing 1 -3.55383
SPDYE12 speedy/RINGO cell cycle regulator family member E12 -3.43438
DVL3 dishevelled segment polarity protein 3 -3.37708
ADD3 adducin 3 (gamma) -3.24939
AK5 adenylate kinase 5 -3.17084
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 -3.14265
SRRM3 serine/arginine repetitive matrix 3 -3.11256
RC3H1 ring finger and CCCH-type domains 1 -2.95624
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.89399
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 -2.89399
LBP lipopolysaccharide binding protein -2.89399
ADAM33 ADAM metallopeptidase domain 33 -2.89399
C6ORF163 chromosome 6 open reading frame 163 -2.89399
GREM2 gremlin 2, DAN family BMP antagonist -2.89399
LOC107985101 uncharacterized LOC107985101 -2.89399
ARC activity-regulated cytoskeleton-associated protein -2.87746
TMPRSS5 transmembrane protease, serine 5 -2.87746
PLD3 phospholipase D family, member 3 -2.84646
MRPS27 mitochondrial ribosomal protein S27 -2.83722
ZNF548 zinc finger protein 548 -2.83011
POMT2 protein-O-mannosyltransferase 2 -2.76077
GPS1 G protein pathway suppressor 1 -2.72304
TNPO3 transportin 3 -2.68579
KNSTRN kinetochore-localized astrin/SPAG5 binding protein -2.68062
GCLC glutamate-cysteine ligase, catalytic subunit -2.65016
RAD51C RAD51 paralog C -2.57667
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 -2.57189
NUP62CL nucleoporin 62kDa C-terminal like -2.53225
CSTB cystatin B (stefin B) -2.5314
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.5314
LPL lipoprotein lipase -2.44775
SLC9B1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 -2.42714
CCAR1 cell division cycle and apoptosis regulator 1 -2.42412
ZNF232 zinc finger protein 232 -2.42306
BAG4 BCL2-associated athanogene 4 -2.39825
LDB3 LIM domain binding 3 -2.35103
TULP2 tubby like protein 2 -2.35103
EGR1 early growth response 1 -2.35103
ACTL6B actin-like 6B -2.35103
FAIM Fas apoptotic inhibitory molecule -2.3271
NR1D1 nuclear receptor subfamily 1, group D, member 1 -2.31104
NPIPB2 nuclear pore complex interacting protein family member B2 -2.31104
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -2.30538
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.28411
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -2.26185
ARHGAP9 Rho GTPase activating protein 9 -2.2537
HPD 4-hydroxyphenylpyruvate dioxygenase -2.2537
ACSS1 acyl-CoA synthetase short-chain family member 1 -2.2537
PKD1L1 polycystic kidney disease 1 like 1 -2.2537
PABPC1L poly(A) binding protein, cytoplasmic 1-like -2.24531
EFTUD2 elongation factor Tu GTP binding domain containing 2 -2.24496
CNGB3 cyclic nucleotide gated channel beta 3 -2.23608
IL23A interleukin 23, alpha subunit p19 -2.23608
LRRC3 leucine rich repeat containing 3 -2.23608
ANKAR ankyrin and armadillo repeat containing -2.23237
HOMER1 homer scaffolding protein 1 -2.22144
CENPVL3 centromere protein V like 3 -2.21719
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 -2.18087
WDFY1 WD repeat and FYVE domain containing 1 -2.16612
BEST2 bestrophin 2 -2.15221
CD1D CD1d molecule -2.15221
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.15022
S100A13 S100 calcium binding protein A13 -2.14956
HOMER2 homer scaffolding protein 2 -2.14191
TMEM267 transmembrane protein 267 -2.09772
SP8 Sp8 transcription factor -2.09684
METTL5 methyltransferase like 5 -2.09593
SMAP2 small ArfGAP2 -2.09593
GRIK4 glutamate receptor, ionotropic, kainate 4 -2.08809
FHL2 four and a half LIM domains 2 -2.08809
TFCP2 transcription factor CP2 -2.06457
RARB retinoic acid receptor, beta -2.06387
CPEB4 cytoplasmic polyadenylation element binding protein 4 -2.05039
SH2D4A SH2 domain containing 4A -2.04855
FGF8 fibroblast growth factor 8 (androgen-induced) -2.04855
THAP1 THAP domain containing, apoptosis associated protein 1 -2.04132
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -2.01751
OPN1SW opsin 1 (cone pigments), short-wave-sensitive -2.0157
TCEAL4 transcription elongation factor A (SII)-like 4 -2.01374
EDF1 endothelial differentiation-related factor 1 -2.00917
ZC3H15 zinc finger CCCH-type containing 15 -2.00448
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -2.00137
MRPL28 mitochondrial ribosomal protein L28 -2.00137