MITF Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description microphthalmia-associated transcription factor|This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4286)
External Link http://www.ncbi.nlm.nih.gov/gene/4286
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Genes

43 interacting proteins for MITF from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APP amyloid beta (A4) precursor protein
CDK2 cyclin-dependent kinase 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
EBP emopamil binding protein (sterol isomerase)
ELAVL1 ELAV like RNA binding protein 1
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HINT1 histidine triad nucleotide binding protein 1
HK3 hexokinase 3 (white cell)
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
JAK1 Janus kinase 1
LEF1 lymphoid enhancer-binding factor 1
LMO4 LIM domain only 4
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MARK3 MAP/microtubule affinity-regulating kinase 3
OTX2 orthodenticle homeobox 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX3 paired box 3
PAX6 paired box 6
PIAS1 protein inhibitor of activated STAT, 1
PIAS2 protein inhibitor of activated STAT, 2
PIAS3 protein inhibitor of activated STAT, 3
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
RB1 retinoblastoma 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SPI1 Spi-1 proto-oncogene
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
TFE3 transcription factor binding to IGHM enhancer 3
TFEB transcription factor EB
TFEC transcription factor EC
TTK TTK protein kinase
UBE2I ubiquitin-conjugating enzyme E2I
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta