| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/3651377 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in MK 886 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIM29 | tripartite motif containing 29 | 1.47 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 1.17 |
| THAP9 | THAP domain containing 9 | 1.02 |
| NIBAN1 | niban apoptosis regulator 1 | 0.98 |
| PRELID3B | PRELI domain containing 3B | 0.95 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.95 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.94 |
| MCL1 | myeloid cell leukemia 1 | 0.88 |
| TMC5 | transmembrane channel-like 5 | 0.82 |
| COL17A1 | collagen, type XVII, alpha 1 | 0.8 |
| NRP1 | neuropilin 1 | 0.78 |
| UPP1 | uridine phosphorylase 1 | 0.78 |
| ZNF354B | zinc finger protein 354B | 0.75 |
| TMEM231 | transmembrane protein 231 | 0.74 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 0.72 |
| ZBTB46 | zinc finger and BTB domain containing 46 | 0.71 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.7 |
| SMIM26 | small integral membrane protein 26 | 0.7 |
| BRSK2 | BR serine/threonine kinase 2 | 0.7 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.7 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.68 |
| NHSL1 | NHS-like 1 | 0.68 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.67 |
| APOE | apolipoprotein E | 0.65 |
| COL7A1 | collagen, type VII, alpha 1 | 0.61 |
| ADCK1 | aarF domain containing kinase 1 | 0.59 |
| SIAH2 | siah E3 ubiquitin protein ligase 2 | 0.59 |
| TRAF3IP2 | TRAF3 interacting protein 2 | 0.58 |
| SLFN5 | schlafen family member 5 | 0.58 |
| ICAM1 | intercellular adhesion molecule 1 | 0.58 |
| ABHD4 | abhydrolase domain containing 4 | 0.58 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.56 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | 0.56 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.56 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 0.55 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.55 |
| CCDC158 | coiled-coil domain containing 158 | 0.55 |
| ATF6B | activating transcription factor 6 beta | 0.55 |
| IFRD1 | interferon-related developmental regulator 1 | 0.55 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.53 |
| ABHD3 | abhydrolase domain containing 3 | 0.53 |
| R3HDM4 | R3H domain containing 4 | 0.52 |
| TMEM94 | transmembrane protein 94 | 0.52 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.52 |
| ANK2 | ankyrin 2, neuronal | 0.51 |
| TC2N | tandem C2 domains, nuclear | 0.51 |
| OGFOD2 | 2-oxoglutarate and iron-dependent oxygenase domain containing 2 | 0.51 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.51 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.51 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.5 |
| ARG2 | arginase 2 | 0.5 |
| TGOLN2 | trans-golgi network protein 2 | 0.5 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.5 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.49 |
| LYST | lysosomal trafficking regulator | 0.49 |
| VAV2 | vav 2 guanine nucleotide exchange factor | 0.49 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.49 |
| FHIT | fragile histidine triad | 0.49 |
| SYTL2 | synaptotagmin-like 2 | 0.49 |
| PRMT6 | protein arginine methyltransferase 6 | 0.48 |
| SLC38A1 | solute carrier family 38, member 1 | 0.48 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.48 |
| SETD6 | SET domain containing 6 | 0.48 |
| LRATD2 | LRAT domain containing 2 | 0.48 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.47 |
| LAMA3 | laminin, alpha 3 | 0.47 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | 0.46 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.46 |
| SLC38A2 | solute carrier family 38, member 2 | 0.46 |
| PSPH | phosphoserine phosphatase | 0.46 |
| HES1 | hes family bHLH transcription factor 1 | 0.46 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.46 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | 0.46 |
| EED | embryonic ectoderm development | 0.46 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | 0.45 |
| B4GALT4 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | 0.45 |
| SGMS2 | sphingomyelin synthase 2 | 0.45 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | 0.45 |
| LAMC2 | laminin, gamma 2 | 0.45 |
| PHGDH | phosphoglycerate dehydrogenase | 0.44 |
| CA8 | carbonic anhydrase VIII | 0.44 |
| CALHM2 | calcium homeostasis modulator 2 | 0.44 |
| PGPEP1 | pyroglutamyl-peptidase I | 0.44 |
| FBXO17 | F-box protein 17 | 0.44 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.44 |
| TMEM177 | transmembrane protein 177 | 0.43 |
| MAP1B | microtubule-associated protein 1B | 0.43 |
| CLSTN3 | calsyntenin 3 | 0.43 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.42 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.42 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.42 |
| MT1X | metallothionein 1X | 0.42 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.41 |
| ARHGAP23 | Rho GTPase activating protein 23 | 0.41 |
| HYAL2 | hyaluronoglucosaminidase 2 | 0.41 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.41 |
| PLK2 | polo-like kinase 2 | 0.41 |
| CCN2 | cellular communication network factor 2 | 0.4 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | 0.4 |
| B4GALNT1 | beta-1,4-N-acetyl-galactosaminyl transferase 1 | 0.4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF483 | zinc finger protein 483 | -1.24 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | -1.23 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -1.18 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -1.02 |
| RNF220 | ring finger protein 220 | -0.96 |
| ANGPTL4 | angiopoietin-like 4 | -0.95 |
| MTRF1 | mitochondrial translational release factor 1 | -0.81 |
| ARSK | arylsulfatase family, member K | -0.75 |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) | -0.75 |
| RHBDD2 | rhomboid domain containing 2 | -0.74 |
| MLF1 | myeloid leukemia factor 1 | -0.73 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | -0.72 |
| TSPAN4 | tetraspanin 4 | -0.71 |
| LOXL2 | lysyl oxidase-like 2 | -0.71 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | -0.7 |
| GLG1 | golgi glycoprotein 1 | -0.69 |
| SLC25A29 | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 | -0.68 |
| PSEN2 | presenilin 2 | -0.64 |
| ENDOG | endonuclease G | -0.64 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.63 |
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | -0.61 |
| DES | desmin | -0.61 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.61 |
| NPW | neuropeptide W | -0.61 |
| PEG10 | paternally expressed 10 | -0.6 |
| S100A5 | S100 calcium binding protein A5 | -0.58 |
| MYBPC1 | myosin binding protein C, slow type | -0.58 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | -0.58 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.57 |
| PRF1 | perforin 1 (pore forming protein) | -0.54 |
| AMN1 | antagonist of mitotic exit network 1 homolog (S. cerevisiae) | -0.54 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.53 |
| TMEM126B | transmembrane protein 126B | -0.53 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | -0.52 |
| TTPAL | tocopherol (alpha) transfer protein-like | -0.52 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | -0.52 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.52 |
| MNT | MAX network transcriptional repressor | -0.51 |
| MTSS2 | MTSS I-BAR domain containing 2 | -0.51 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.51 |
| ZNF320 | zinc finger protein 320 | -0.5 |
| TMEM184C | transmembrane protein 184C | -0.5 |
| ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | -0.49 |
| NADK | NAD kinase | -0.49 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | -0.49 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.48 |
| RIBC2 | RIB43A domain with coiled-coils 2 | -0.48 |
| PDE7A | phosphodiesterase 7A | -0.48 |
| H1-4 | H1.4 linker histone, cluster member | -0.48 |
| PTPMT1 | protein tyrosine phosphatase, mitochondrial 1 | -0.48 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -0.47 |
| PAQR7 | progestin and adipoQ receptor family member VII | -0.47 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | -0.47 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | -0.47 |
| RCAN1 | regulator of calcineurin 1 | -0.46 |
| FCHO1 | FCH domain only 1 | -0.45 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.45 |
| COA7 | cytochrome c oxidase assembly factor 7 (putative) | -0.44 |
| FKTN | fukutin | -0.44 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.44 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | -0.44 |
| KLHL21 | kelch-like family member 21 | -0.44 |
| ACTR3B | ARP3 actin-related protein 3 homolog B (yeast) | -0.43 |
| SOAT1 | sterol O-acyltransferase 1 | -0.43 |
| GCAT | glycine C-acetyltransferase | -0.43 |
| OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2 | -0.43 |
| MIPOL1 | mirror-image polydactyly 1 | -0.43 |
| TXNDC16 | thioredoxin domain containing 16 | -0.42 |
| DOCK11 | dedicator of cytokinesis 11 | -0.42 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.42 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | -0.42 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | -0.42 |
| ZNF532 | zinc finger protein 532 | -0.41 |
| UBOX5 | U-box domain containing 5 | -0.41 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | -0.41 |
| PHF19 | PHD finger protein 19 | -0.41 |
| SHANK3 | SH3 and multiple ankyrin repeat domains 3 | -0.41 |
| LYPD3 | LY6/PLAUR domain containing 3 | -0.41 |
| NDUFA12 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 | -0.4 |
| IREB2 | iron-responsive element binding protein 2 | -0.4 |
| RNF26 | ring finger protein 26 | -0.4 |
| IFT22 | intraflagellar transport 22 | -0.4 |
| ADCK5 | aarF domain containing kinase 5 | -0.4 |
| NDUFB9 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa | -0.4 |
| LRP4 | low density lipoprotein receptor-related protein 4 | -0.4 |
| NDUFA7 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa | -0.4 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.4 |
| BSN | bassoon presynaptic cytomatrix protein | -0.39 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.39 |
| SDF4 | stromal cell derived factor 4 | -0.39 |
| PRR3 | proline rich 3 | -0.39 |
| NUDT7 | nudix (nucleoside diphosphate linked moiety X)-type motif 7 | -0.39 |
| NDUFB7 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | -0.39 |
| TSPAN14 | tetraspanin 14 | -0.39 |
| MRPS18C | mitochondrial ribosomal protein S18C | -0.38 |
| H3C1 | H3 clustered histone 1 | -0.38 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.38 |
| LINS1 | lines homolog 1 | -0.38 |
| NDUFB4 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa | -0.38 |
| APOL2 | apolipoprotein L, 2 | -0.38 |
