MK-1775 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/24856436
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Genes

199 proteins with high or low expression in MK-1775 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
POF1B premature ovarian failure, 1B 5.69
INPP5J inositol polyphosphate-5-phosphatase J 2.4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.53
OPTN optineurin 1.51
DHRS2 dehydrogenase/reductase (SDR family) member 2 1.47
TP53 tumor protein p53 1.4
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.99
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.91
PHLDA3 pleckstrin homology-like domain, family A, member 3 0.88
HIST1H1T histone cluster 1, H1t 0.87
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 0.86
VIM vimentin 0.85
ORC1 origin recognition complex, subunit 1 0.85
KANK3 KN motif and ankyrin repeat domains 3 0.84
F5 coagulation factor V (proaccelerin, labile factor) 0.83
TP53I3 tumor protein p53 inducible protein 3 0.79
FTL ferritin, light polypeptide 0.79
IGFBP6 insulin-like growth factor binding protein 6 0.75
CCDC158 coiled-coil domain containing 158 0.71
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.71
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.7
DDB2 damage-specific DNA binding protein 2, 48kDa 0.66
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.66
EPN3 epsin 3 0.66
FGFBP1 fibroblast growth factor binding protein 1 0.65
C1QTNF3 C1q and tumor necrosis factor related protein 3 0.65
RNF146 ring finger protein 146 0.64
HBA1 hemoglobin, alpha 1 0.64
SYTL1 synaptotagmin-like 1 0.63
BPGM 2,3-bisphosphoglycerate mutase 0.63
TDG thymine-DNA glycosylase 0.63
SULF2 sulfatase 2 0.63
ALK anaplastic lymphoma receptor tyrosine kinase 0.62
NIPSNAP3A nipsnap homolog 3A (C. elegans) 0.61
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.6
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.59
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.59
FDXR ferredoxin reductase 0.59
S100A5 S100 calcium binding protein A5 0.59
SGSH N-sulfoglucosamine sulfohydrolase 0.59
C4BPA complement component 4 binding protein, alpha 0.58
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.58
FAS Fas cell surface death receptor 0.58
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 0.58
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.58
NTAN1 N-terminal asparagine amidase 0.58
OMA1 OMA1 zinc metallopeptidase 0.56
PRG4 proteoglycan 4 0.56
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 0.55
LTBP3 latent transforming growth factor beta binding protein 3 0.55
CCN3 cellular communication network factor 3 0.55
MYH7 myosin, heavy chain 7, cardiac muscle, beta 0.55
H1-0 H1.0 linker histone 0.54
MID2 midline 2 0.53
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.53
GLRX glutaredoxin (thioltransferase) 0.53
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.52
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 0.52
RPL26 ribosomal protein L26 0.52
VTN vitronectin 0.51
TYMP thymidine phosphorylase 0.51
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.51
LRP1 low density lipoprotein receptor-related protein 1 0.5
SYN1 synapsin I 0.5
IQCB1 IQ motif containing B1 0.5
S100A2 S100 calcium binding protein A2 0.5
GM2A GM2 ganglioside activator 0.49
TSPYL2 TSPY-like 2 0.49
ATF3 activating transcription factor 3 0.49
S100A14 S100 calcium binding protein A14 0.49
LGALS3 lectin, galactoside-binding, soluble, 3 0.48
LGALSL lectin, galactoside-binding-like 0.48
CLTA clathrin, light chain A 0.48
CORO2B coronin, actin binding protein, 2B 0.48
SERAC1 serine active site containing 1 0.48
YDJC YdjC homolog (bacterial) 0.47
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.46
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 0.46
ARID5B AT rich interactive domain 5B (MRF1-like) 0.46
CCDC66 coiled-coil domain containing 66 0.46
IFI30 interferon, gamma-inducible protein 30 0.45
IRF3 interferon regulatory factor 3 0.45
TMEM248 transmembrane protein 248 0.45
XIRP1 xin actin binding repeat containing 1 0.45
DUSP14 dual specificity phosphatase 14 0.44
MDM1 Mdm1 nuclear protein homolog (mouse) 0.44
DXO decapping exoribonuclease 0.44
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.44
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.44
CES3 carboxylesterase 3 0.44
CCS copper chaperone for superoxide dismutase 0.44
FBXL20 F-box and leucine-rich repeat protein 20 0.44
ADIRF adipogenesis regulatory factor 0.43
APOE apolipoprotein E 0.43
RAB40C RAB40C, member RAS oncogene family 0.43
CSNK1G2 casein kinase 1, gamma 2 0.43
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.43
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.43
KSR2 kinase suppressor of ras 2 0.43
AKT1S1 AKT1 substrate 1 (proline-rich) 0.43

low expression

Symbol Name Standardized Value
RRM2 ribonucleotide reductase M2 -1.32
E2F2 E2F transcription factor 2 -1.29
CCNE2 cyclin E2 -1.14
PCLAF PCNA clamp associated factor -1.13
EXO1 exonuclease 1 -1.07
ZIC5 Zic family member 5 -1.04
CCNA1 cyclin A1 -1.04
ASF1B anti-silencing function 1B histone chaperone -1.0
FCHO1 FCH domain only 1 -0.98
GJC1 gap junction protein, gamma 1, 45kDa -0.98
ATAD2 ATPase family, AAA domain containing 2 -0.98
CCNF cyclin F -0.96
CLSPN claspin -0.96
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 -0.95
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.93
FBXO5 F-box protein 5 -0.92
CCNA2 cyclin A2 -0.92
LZTS1 leucine zipper, putative tumor suppressor 1 -0.91
ATAD2B ATPase family, AAA domain containing 2B -0.9
TP73 tumor protein p73 -0.87
PIGX phosphatidylinositol glycan anchor biosynthesis, class X -0.86
RMI2 RecQ mediated genome instability 2 -0.86
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -0.84
E2F7 E2F transcription factor 7 -0.84
OSGIN2 oxidative stress induced growth inhibitor family member 2 -0.81
RNF115 ring finger protein 115 -0.78
RABEP2 rabaptin, RAB GTPase binding effector protein 2 -0.78
ZBTB43 zinc finger and BTB domain containing 43 -0.77
MCRIP2 MAPK regulated corepressor interacting protein 2 -0.77
OBSL1 obscurin-like 1 -0.77
RADX RPA1 related single stranded DNA binding protein, X-linked -0.73
MELK maternal embryonic leucine zipper kinase -0.73
CBX2 chromobox homolog 2 -0.72
LRR1 leucine rich repeat protein 1 -0.72
TATDN2 TatD DNase domain containing 2 -0.71
KATNBL1 katanin p80 subunit B-like 1 -0.71
ZNF407 zinc finger protein 407 -0.71
PRSS8 protease, serine, 8 -0.71
E2F8 E2F transcription factor 8 -0.7
E2F1 E2F transcription factor 1 -0.7
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase -0.69
NEIL3 nei endonuclease VIII-like 3 (E. coli) -0.69
CDCA5 cell division cycle associated 5 -0.69
CCDC150 coiled-coil domain containing 150 -0.69
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -0.68
RAD51AP1 RAD51 associated protein 1 -0.68
ANKLE1 ankyrin repeat and LEM domain containing 1 -0.68
DNA2 DNA replication helicase/nuclease 2 -0.67
GMNN geminin, DNA replication inhibitor -0.67
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -0.67
ZFP62 ZFP62 zinc finger protein -0.66
NRBP2 nuclear receptor binding protein 2 -0.65
CDC25B cell division cycle 25B -0.65
NMU neuromedin U -0.64
DIAPH3 diaphanous-related formin 3 -0.63
PHF13 PHD finger protein 13 -0.63
NIBAN1 niban apoptosis regulator 1 -0.62
ICK intestinal cell (MAK-like) kinase -0.62
ZFP36L1 ZFP36 ring finger protein-like 1 -0.61
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.61
WDR76 WD repeat domain 76 -0.61
RAD54B RAD54 homolog B (S. cerevisiae) -0.6
DUSP5 dual specificity phosphatase 5 -0.6
TIPE1 TNF alpha induced protein 8 like 1 -0.6
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -0.59
HELLS helicase, lymphoid-specific -0.59
RGPD8 RANBP2-like and GRIP domain containing 8 -0.59
PLK4 polo-like kinase 4 -0.59
KIF22 kinesin family member 22 -0.59
RNF111 ring finger protein 111 -0.58
LRP12 low density lipoprotein receptor-related protein 12 -0.58
USP37 ubiquitin specific peptidase 37 -0.58
C15ORF41 chromosome 15 open reading frame 41 -0.57
ANKRD20A4 ankyrin repeat domain 20 family, member A4 -0.57
USB1 U6 snRNA biogenesis 1 -0.57
RAD51 RAD51 recombinase -0.57
SNX8 sorting nexin 8 -0.56
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 -0.56
ALKBH5 AlkB family member 5, RNA demethylase -0.55
C19ORF25 chromosome 19 open reading frame 25 -0.55
SLC4A11 solute carrier family 4, sodium borate transporter, member 11 -0.55
DONSON downstream neighbor of SON -0.54
KLF16 Kruppel-like factor 16 -0.54
FOXM1 forkhead box M1 -0.54
NECTIN1 nectin cell adhesion molecule 1 -0.54
RNF166 ring finger protein 166 -0.53
ALMS1 Alstrom syndrome protein 1 -0.53
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 -0.52
FANCM Fanconi anemia, complementation group M -0.52
SKA1 spindle and kinetochore associated complex subunit 1 -0.51
SKA3 spindle and kinetochore associated complex subunit 3 -0.51
RGPD5 RANBP2-like and GRIP domain containing 5 -0.51
PRELID1 PRELI domain containing 1 -0.51
CA3 carbonic anhydrase III -0.51
KIF15 kinesin family member 15 -0.51
MKI67 marker of proliferation Ki-67 -0.51
FAM133B family with sequence similarity 133, member B -0.51
CENPU centromere protein U -0.5
CCNE1 cyclin E1 -0.5