| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/25019940 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in MK-3207 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| POF1B | premature ovarian failure, 1B | 0.87 |
| PIP | prolactin-induced protein | 0.61 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | 0.54 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.54 |
| ZNF12 | zinc finger protein 12 | 0.53 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.44 |
| MSH5 | mutS homolog 5 | 0.44 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.41 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.41 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | 0.4 |
| ZNF324 | zinc finger protein 324 | 0.39 |
| DOP1A | DOP1 leucine zipper like protein A | 0.39 |
| TMSB10 | thymosin beta 10 | 0.38 |
| ZNF584 | zinc finger protein 584 | 0.36 |
| CENPK | centromere protein K | 0.36 |
| SLC35A4 | solute carrier family 35, member A4 | 0.36 |
| PAH | phenylalanine hydroxylase | 0.35 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.34 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.34 |
| SELENOI | selenoprotein I | 0.34 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.33 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.33 |
| FGD1 | FYVE, RhoGEF and PH domain containing 1 | 0.33 |
| MGMT | O-6-methylguanine-DNA methyltransferase | 0.33 |
| S100A2 | S100 calcium binding protein A2 | 0.33 |
| RECK | reversion-inducing-cysteine-rich protein with kazal motifs | 0.33 |
| TDRD9 | tudor domain containing 9 | 0.33 |
| ZBTB46 | zinc finger and BTB domain containing 46 | 0.32 |
| NEU3 | sialidase 3 (membrane sialidase) | 0.32 |
| IQCG | IQ motif containing G | 0.32 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.32 |
| DONSON | downstream neighbor of SON | 0.31 |
| TRIM23 | tripartite motif containing 23 | 0.31 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.31 |
| MRPL50 | mitochondrial ribosomal protein L50 | 0.3 |
| LGALSL | lectin, galactoside-binding-like | 0.3 |
| CCDC150 | coiled-coil domain containing 150 | 0.29 |
| ACTL8 | actin-like 8 | 0.29 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.29 |
| TJP1 | tight junction protein 1 | 0.29 |
| ABRACL | ABRA C-terminal like | 0.29 |
| ZNF808 | zinc finger protein 808 | 0.29 |
| ZNF224 | zinc finger protein 224 | 0.29 |
| LYST | lysosomal trafficking regulator | 0.28 |
| RND3 | Rho family GTPase 3 | 0.28 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.28 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | 0.28 |
| HPS1 | Hermansky-Pudlak syndrome 1 | 0.28 |
| PMF1 | polyamine-modulated factor 1 | 0.28 |
| CDC26 | cell division cycle 26 | 0.28 |
| UBE2Q2 | ubiquitin-conjugating enzyme E2Q family member 2 | 0.28 |
| SPATA20 | spermatogenesis associated 20 | 0.28 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | 0.27 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | 0.27 |
| TMC6 | transmembrane channel-like 6 | 0.27 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.27 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.26 |
| NGFR | nerve growth factor receptor | 0.26 |
| RPLP1 | ribosomal protein, large, P1 | 0.26 |
| C11ORF49 | chromosome 11 open reading frame 49 | 0.26 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.26 |
| XTBD1 | XRN2 binding domain containing 1 | 0.25 |
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | 0.25 |
| PGLS | 6-phosphogluconolactonase | 0.25 |
| PLK2 | polo-like kinase 2 | 0.25 |
| COQ9 | coenzyme Q9 | 0.25 |
| TLE5 | TLE family member 5, transcriptional modulator | 0.24 |
| CALB2 | calbindin 2 | 0.24 |
| MAGEE1 | melanoma antigen family E1 | 0.24 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.24 |
| TXN2 | thioredoxin 2 | 0.24 |
| ITPRIPL1 | inositol 1,4,5-trisphosphate receptor interacting protein-like 1 | 0.24 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 | 0.24 |
| HAUS1 | HAUS augmin-like complex, subunit 1 | 0.24 |
| PIH1D1 | PIH1 domain containing 1 | 0.24 |
| CFAP36 | cilia and flagella associated protein 36 | 0.24 |
| CCDC158 | coiled-coil domain containing 158 | 0.24 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.24 |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | 0.24 |
| CRCP | CGRP receptor component | 0.23 |
| AXIN2 | axin 2 | 0.23 |
| RNF145 | ring finger protein 145 | 0.23 |
| ZNF226 | zinc finger protein 226 | 0.23 |
| PANK3 | pantothenate kinase 3 | 0.23 |
| GLMP | glycosylated lysosomal membrane protein | 0.23 |
| PACRGL | PARK2 co-regulated-like | 0.23 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.23 |
| RNF166 | ring finger protein 166 | 0.23 |
| COX5A | cytochrome c oxidase subunit Va | 0.23 |
| CCDC85B | coiled-coil domain containing 85B | 0.23 |
| FLII | flightless I homolog (Drosophila) | 0.23 |
| N4BP2 | NEDD4 binding protein 2 | 0.23 |
| UBE2F | ubiquitin-conjugating enzyme E2F (putative) | 0.23 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.23 |
| ALG3 | ALG3, alpha-1,3- mannosyltransferase | 0.23 |
| METTL25 | methyltransferase like 25 | 0.22 |
| LIPE | lipase, hormone-sensitive | 0.22 |
| HYPK | huntingtin interacting protein K | 0.22 |
| NAGA | N-acetylgalactosaminidase, alpha- | 0.22 |
| CEP295 | centrosomal protein 295kDa | 0.22 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ALPK3 | alpha-kinase 3 | -3.39 |
| COL6A6 | collagen, type VI, alpha 6 | -2.06 |
| ADCY10 | adenylate cyclase 10 (soluble) | -1.8 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -1.78 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | -1.24 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -1.12 |
| EVA1C | eva-1 homolog C (C. elegans) | -1.09 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | -0.79 |
| SP110 | SP110 nuclear body protein | -0.75 |
| FER1L5 | fer-1-like family member 5 | -0.74 |
| MAP2 | microtubule-associated protein 2 | -0.65 |
| ENO1 | enolase 1, (alpha) | -0.62 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | -0.61 |
| AFG1L | AFG1 like ATPase | -0.6 |
| MYH8 | myosin, heavy chain 8, skeletal muscle, perinatal | -0.59 |
| SLC49A4 | solute carrier family 49 member 4 | -0.59 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.56 |
| AFAP1L1 | actin filament associated protein 1-like 1 | -0.54 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | -0.54 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.53 |
| COL7A1 | collagen, type VII, alpha 1 | -0.53 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.53 |
| PLIN2 | perilipin 2 | -0.52 |
| ZNF91 | zinc finger protein 91 | -0.51 |
| NCOA4 | nuclear receptor coactivator 4 | -0.48 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | -0.48 |
| CEP112 | centrosomal protein 112kDa | -0.46 |
| SCN11A | sodium channel, voltage gated, type XI alpha subunit | -0.46 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -0.44 |
| GJC1 | gap junction protein, gamma 1, 45kDa | -0.41 |
| TRIM62 | tripartite motif containing 62 | -0.39 |
| TLL2 | tolloid-like 2 | -0.39 |
| DYNC2LI1 | dynein, cytoplasmic 2, light intermediate chain 1 | -0.38 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.37 |
| LYRM2 | LYR motif containing 2 | -0.36 |
| ZNF480 | zinc finger protein 480 | -0.36 |
| MISP3 | MISP family member 3 | -0.36 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.35 |
| NDUFA11 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa | -0.34 |
| RTN1 | reticulon 1 | -0.34 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 | -0.33 |
| PWWP2B | PWWP domain containing 2B | -0.33 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | -0.32 |
| UBXN2B | UBX domain protein 2B | -0.32 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.32 |
| CFD | complement factor D (adipsin) | -0.32 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.31 |
| ZBTB4 | zinc finger and BTB domain containing 4 | -0.31 |
| RABIF | RAB interacting factor | -0.3 |
| MFSD8 | major facilitator superfamily domain containing 8 | -0.3 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.29 |
| BCL7B | B-cell CLL/lymphoma 7B | -0.29 |
| AGA | aspartylglucosaminidase | -0.29 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | -0.29 |
| MYO15B | myosin XVB | -0.29 |
| CHRNA5 | cholinergic receptor, nicotinic, alpha 5 (neuronal) | -0.29 |
| GGT7 | gamma-glutamyltransferase 7 | -0.28 |
| NLRC3 | NLR family, CARD domain containing 3 | -0.28 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.28 |
| CALHM2 | calcium homeostasis modulator 2 | -0.28 |
| CALD1 | caldesmon 1 | -0.28 |
| BBS10 | Bardet-Biedl syndrome 10 | -0.27 |
| SGMS1 | sphingomyelin synthase 1 | -0.27 |
| IFNGR1 | interferon gamma receptor 1 | -0.27 |
| TBC1D32 | TBC1 domain family, member 32 | -0.27 |
| NAV2 | neuron navigator 2 | -0.27 |
| FRMPD1 | FERM and PDZ domain containing 1 | -0.27 |
| UFC1 | ubiquitin-fold modifier conjugating enzyme 1 | -0.27 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | -0.27 |
| FANCF | Fanconi anemia, complementation group F | -0.26 |
| FXN | frataxin | -0.26 |
| PRX | periaxin | -0.26 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | -0.26 |
| JOSD1 | Josephin domain containing 1 | -0.26 |
| KIF27 | kinesin family member 27 | -0.26 |
| CCDC112 | coiled-coil domain containing 112 | -0.25 |
| TM7SF3 | transmembrane 7 superfamily member 3 | -0.25 |
| FMNL1 | formin-like 1 | -0.25 |
| CALU | calumenin | -0.25 |
| TPM4 | tropomyosin 4 | -0.25 |
| FANCL | Fanconi anemia, complementation group L | -0.24 |
| PLEKHA8 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 | -0.24 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | -0.24 |
| ZBTB6 | zinc finger and BTB domain containing 6 | -0.24 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | -0.24 |
| ZNF101 | zinc finger protein 101 | -0.24 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | -0.24 |
| NAA80 | N-alpha-acetyltransferase 80, NatH catalytic subunit | -0.23 |
| PLEK | pleckstrin | -0.23 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | -0.23 |
| SLC4A11 | solute carrier family 4, sodium borate transporter, member 11 | -0.23 |
| ACOT8 | acyl-CoA thioesterase 8 | -0.23 |
| ZNF107 | zinc finger protein 107 | -0.23 |
| NABP2 | nucleic acid binding protein 2 | -0.23 |
| RNF223 | ring finger protein 223 | -0.23 |
| ZNF672 | zinc finger protein 672 | -0.23 |
| C6ORF47 | chromosome 6 open reading frame 47 | -0.22 |
| ACAP3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 | -0.22 |
| DNAJC22 | DnaJ (Hsp40) homolog, subfamily C, member 22 | -0.22 |
| KLC1 | kinesin light chain 1 | -0.22 |
