| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-3903 perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-3903_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.184763 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.141397 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.13502 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.134824 |
| CDH13 | cadherin 13 | 0.107807 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0987175 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0926088 |
| MAP1B | microtubule-associated protein 1B | 0.0909343 |
| EGFR | epidermal growth factor receptor | 0.0892886 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0884862 |
| HDAC9 | histone deacetylase 9 | 0.0855519 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0854538 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0837593 |
| TPM3 | tropomyosin 3 | 0.0822895 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0802357 |
| CALR | calreticulin | 0.0791199 |
| CANX | calnexin | 0.0775902 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0772203 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0771438 |
| CENPF | centromere protein F, 350/400kDa | 0.0762833 |
| TPM4 | tropomyosin 4 | 0.0751588 |
| SQSTM1 | sequestosome 1 | 0.0738468 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0720741 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0676279 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0659213 |
| LDHA | lactate dehydrogenase A | 0.0649345 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0643237 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.063524 |
| PKM | pyruvate kinase, muscle | 0.0616973 |
| PODXL | podocalyxin-like | 0.0614399 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0601995 |
| EFNA5 | ephrin-A5 | 0.0601422 |
| MSN | moesin | 0.0600516 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0599568 |
| ASPH | aspartate beta-hydroxylase | 0.0592537 |
| NDRG1 | N-myc downstream regulated 1 | 0.0592012 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0569657 |
| VIM | vimentin | 0.0561463 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0532575 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0524449 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0521155 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0518256 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.051688 |
| RND3 | Rho family GTPase 3 | 0.0515737 |
| DSPP | dentin sialophosphoprotein | 0.0454882 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0447188 |
| COL5A1 | collagen, type V, alpha 1 | 0.0446091 |
| TAOK1 | TAO kinase 1 | 0.0442434 |
| COPA | coatomer protein complex, subunit alpha | 0.0440712 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0439626 |
| GOLGA4 | golgin A4 | 0.0436213 |
| GOLGB1 | golgin B1 | 0.0435612 |
| POTEF | POTE ankyrin domain family, member F | 0.0433344 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0433296 |
| NAV2 | neuron navigator 2 | 0.0432312 |
| CD44 | CD44 molecule (Indian blood group) | 0.0422527 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0421653 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0417027 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0415745 |
| ENO1 | enolase 1, (alpha) | 0.0414685 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0407404 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0404819 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0402391 |
| DST | dystonin | 0.0393853 |
| CLTC | clathrin, heavy chain (Hc) | 0.0390747 |
| FLNA | filamin A, alpha | 0.0384851 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.038297 |
| FNIP1 | folliculin interacting protein 1 | 0.0380604 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 0.0374886 |
| FSTL1 | follistatin-like 1 | 0.0371545 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0367003 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0364379 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0355784 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0351539 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.034975 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0349089 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0347551 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0344141 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0342667 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0341951 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0341303 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0339389 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0338279 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0336227 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0335872 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0335702 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0335105 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0331183 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.0330776 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0330588 |
| S100A10 | S100 calcium binding protein A10 | 0.032721 |
| SEPTIN7 | septin 7 | 0.0320777 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0315633 |
| PRKCE | protein kinase C, epsilon | 0.0310087 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0308889 |
| FOSL1 | FOS-like antigen 1 | 0.0306995 |
| SET | SET nuclear proto-oncogene | 0.0306066 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.0299256 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0297373 |
| UBXN7 | UBX domain protein 7 | 0.0296821 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FBN1 | fibrillin 1 | -0.173911 |
| COL1A2 | collagen, type I, alpha 2 | -0.0945219 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0771561 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0740222 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.070129 |
| MT2A | metallothionein 2A | -0.0688944 |
| LOX | lysyl oxidase | -0.0685997 |
| THBS2 | thrombospondin 2 | -0.0667024 |
| HLA-B | major histocompatibility complex, class I, B | -0.066247 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0620752 |
| TMSB10 | thymosin beta 10 | -0.0577009 |
| OGA | O-GlcNAcase | -0.054601 |
| COL3A1 | collagen, type III, alpha 1 | -0.0541695 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0509398 |
| MEIS2 | Meis homeobox 2 | -0.0468962 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0444656 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0429661 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0422745 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0411536 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.040699 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0400742 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0386309 |
| MT1X | metallothionein 1X | -0.0383377 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0382607 |
| FRMD5 | FERM domain containing 5 | -0.0359227 |
| WTAP | Wilms tumor 1 associated protein | -0.0343526 |
| IER3 | immediate early response 3 | -0.0326896 |
| LOXL2 | lysyl oxidase-like 2 | -0.0325359 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0323678 |
| COL5A2 | collagen, type V, alpha 2 | -0.0322514 |
| CAVIN1 | caveolae associated protein 1 | -0.0311134 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0299374 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0286206 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0285726 |
| GNAS | GNAS complex locus | -0.0284159 |
| TMOD1 | tropomodulin 1 | -0.0283982 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0282787 |
| HLA-E | major histocompatibility complex, class I, E | -0.0279727 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0278703 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0274675 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0272261 |
| HLA-C | major histocompatibility complex, class I, C | -0.0269229 |
| PRSS23 | protease, serine, 23 | -0.0267843 |
| KIFAP3 | kinesin-associated protein 3 | -0.025059 |
| SUCNR1 | succinate receptor 1 | -0.0245446 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0244454 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.0240639 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0240518 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0240314 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0235595 |
| TRIM56 | tripartite motif containing 56 | -0.0230392 |
| RNF213 | ring finger protein 213 | -0.0228289 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0227725 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0223738 |
| GPC6 | glypican 6 | -0.0223277 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0222465 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0221734 |
| PLAT | plasminogen activator, tissue | -0.0219352 |
| MX2 | MX dynamin-like GTPase 2 | -0.0216836 |
| NPR2 | natriuretic peptide receptor 2 | -0.0215087 |
| PXDN | peroxidasin | -0.0214461 |
| CTSB | cathepsin B | -0.0211886 |
| TCF25 | transcription factor 25 (basic helix-loop-helix) | -0.0204129 |
| AHNAK | AHNAK nucleoprotein | -0.0201171 |
| FNBP1 | formin binding protein 1 | -0.0198675 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0197375 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0196311 |
| PRKD1 | protein kinase D1 | -0.0195652 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0188602 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0188485 |
| LRRC49 | leucine rich repeat containing 49 | -0.018449 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0183054 |
| SEC11A | SEC11 homolog A (S. cerevisiae) | -0.0182914 |
| ACTN4 | actinin, alpha 4 | -0.0181524 |
| RBM25 | RNA binding motif protein 25 | -0.0181204 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.017899 |
| AUTS2 | autism susceptibility candidate 2 | -0.0177848 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0177059 |
| SBF2 | SET binding factor 2 | -0.0175997 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -0.0175881 |
| ZNF217 | zinc finger protein 217 | -0.0175 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0172406 |
| PRRX1 | paired related homeobox 1 | -0.0172135 |
| GASK1B | golgi associated kinase 1B | -0.0172052 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0171866 |
| JAZF1 | JAZF zinc finger 1 | -0.017154 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0170915 |
| TXNIP | thioredoxin interacting protein | -0.0170881 |
| TMEM123 | transmembrane protein 123 | -0.0169931 |
| TMEM263 | transmembrane protein 263 | -0.0168022 |
| KLF6 | Kruppel-like factor 6 | -0.0166645 |
| MKX | mohawk homeobox | -0.0164792 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0164771 |
| MTSS1 | metastasis suppressor 1 | -0.0164521 |
| ARF1 | ADP-ribosylation factor 1 | -0.0164076 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0162194 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0160198 |
| CD47 | CD47 molecule | -0.0158619 |
| DENND5A | DENN/MADD domain containing 5A | -0.0157702 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0156112 |
