| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-3903 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-3903_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.14197 |
| RRM2 | ribonucleotide reductase M2 | 0.046251 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0445384 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0400421 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0394143 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0329929 |
| ZNF638 | zinc finger protein 638 | 0.0320976 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0319791 |
| FTL | ferritin, light polypeptide | 0.0318514 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0313813 |
| INTS6 | integrator complex subunit 6 | 0.0300149 |
| ATP11A | ATPase, class VI, type 11A | 0.0298257 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0296213 |
| PCDH7 | protocadherin 7 | 0.0295028 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0290643 |
| VMP1 | vacuole membrane protein 1 | 0.0280091 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0279217 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0267887 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0262273 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0261378 |
| EPHA6 | EPH receptor A6 | 0.0261314 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0256271 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.025332 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0245796 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.024346 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0243391 |
| HDAC9 | histone deacetylase 9 | 0.0243293 |
| RPL3 | ribosomal protein L3 | 0.0240241 |
| RCC1 | regulator of chromosome condensation 1 | 0.0239659 |
| BRD2 | bromodomain containing 2 | 0.0238542 |
| ARRDC3 | arrestin domain containing 3 | 0.023591 |
| DENND5A | DENN/MADD domain containing 5A | 0.0234271 |
| DSCAM | Down syndrome cell adhesion molecule | 0.02291 |
| SETD5 | SET domain containing 5 | 0.022815 |
| WWOX | WW domain containing oxidoreductase | 0.0227199 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0226326 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0225279 |
| LRRC23 | leucine rich repeat containing 23 | 0.0223958 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0215217 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0211615 |
| RPS23 | ribosomal protein S23 | 0.0206139 |
| GPHN | gephyrin | 0.0205784 |
| PCDH9 | protocadherin 9 | 0.020187 |
| CPOX | coproporphyrinogen oxidase | 0.0198558 |
| TCP1 | t-complex 1 | 0.019528 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0193517 |
| EXOC6B | exocyst complex component 6B | 0.0191316 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0188172 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0187641 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0187621 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0187596 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0186556 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0186393 |
| SQSTM1 | sequestosome 1 | 0.0184777 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0183303 |
| EPHA5 | EPH receptor A5 | 0.0182654 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.018097 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0180908 |
| PTK2 | protein tyrosine kinase 2 | 0.0180609 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0179512 |
| GOLGB1 | golgin B1 | 0.0178928 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.0176693 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0175747 |
| RLF | rearranged L-myc fusion | 0.0175124 |
| ADIPOR2 | adiponectin receptor 2 | 0.0174753 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0173808 |
| FMNL2 | formin-like 2 | 0.0169408 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0169374 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0168523 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0168051 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.0167908 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.016474 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0164305 |
| RPL4 | ribosomal protein L4 | 0.0162482 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0162113 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.0161926 |
| ASPH | aspartate beta-hydroxylase | 0.0161651 |
| CCNL1 | cyclin L1 | 0.016163 |
| TRAPPC8 | trafficking protein particle complex 8 | 0.0161552 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.0160433 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0158974 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0158775 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0158304 |
| RPS12 | ribosomal protein S12 | 0.015794 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0154741 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0152768 |
| H1-5 | H1.5 linker histone, cluster member | 0.0152608 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0151682 |
| TFG | TRK-fused gene | 0.0150675 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0150161 |
| HMGA2 | high mobility group AT-hook 2 | 0.0149189 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0149107 |
| USP47 | ubiquitin specific peptidase 47 | 0.0148705 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0148361 |
| STXBP4 | syntaxin binding protein 4 | 0.0147922 |
| YTHDC1 | YTH domain containing 1 | 0.014749 |
| ST3GAL3 | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 | 0.0147321 |
| RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.0146926 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0146898 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0143753 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.35362 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.11934 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.111228 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.109782 |
| MYL12B | myosin, light chain 12B, regulatory | -0.105475 |
| ACTG1 | actin gamma 1 | -0.0877079 |
| TMSB10 | thymosin beta 10 | -0.0858968 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0850917 |
| NLGN1 | neuroligin 1 | -0.0798875 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0634721 |
| TMEM123 | transmembrane protein 123 | -0.0621347 |
| DST | dystonin | -0.06198 |
| YBX3 | Y box binding protein 3 | -0.0612804 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0592667 |
| ANXA1 | annexin A1 | -0.0579702 |
| RASAL2 | RAS protein activator like 2 | -0.0579432 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0554239 |
| AHNAK | AHNAK nucleoprotein | -0.0536342 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.053334 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0516259 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0514466 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0513553 |
| MAP1B | microtubule-associated protein 1B | -0.049334 |
| ANKRD28 | ankyrin repeat domain 28 | -0.049022 |
| KPNB1 | karyopherin (importin) beta 1 | -0.047691 |
| KLF6 | Kruppel-like factor 6 | -0.047224 |
| TPI1 | triosephosphate isomerase 1 | -0.047124 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0469201 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0466847 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.046671 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0462524 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0459291 |
| HMGA1 | high mobility group AT-hook 1 | -0.0457538 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0451567 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.044446 |
| CLDN1 | claudin 1 | -0.0440108 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0438722 |
| RPS6 | ribosomal protein S6 | -0.0433862 |
| ZNF804A | zinc finger protein 804A | -0.0429231 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0427552 |
| MMP12 | matrix metallopeptidase 12 | -0.0414155 |
| EHBP1 | EH domain binding protein 1 | -0.0409342 |
| BCHE | butyrylcholinesterase | -0.0385749 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0383335 |
| CBX3 | chromobox homolog 3 | -0.0383283 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0382857 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0377281 |
| PFN1 | profilin 1 | -0.0374795 |
| ENO1 | enolase 1, (alpha) | -0.0371015 |
| GNAS | GNAS complex locus | -0.0364398 |
| RPS21 | ribosomal protein S21 | -0.036378 |
| JMJD1C | jumonji domain containing 1C | -0.0356563 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0355851 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0355614 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0354409 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0348213 |
| CMIP | c-Maf inducing protein | -0.0348161 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0343799 |
| PDGFC | platelet derived growth factor C | -0.034309 |
| TUBA1B | tubulin, alpha 1b | -0.0339735 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0338485 |
| CENPF | centromere protein F, 350/400kDa | -0.0337633 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0335995 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0333569 |
| RPLP0 | ribosomal protein, large, P0 | -0.0332119 |
| XPO1 | exportin 1 | -0.0329421 |
| FBXO11 | F-box protein 11 | -0.0315349 |
| RPS24 | ribosomal protein S24 | -0.0313926 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0308294 |
| CAVIN1 | caveolae associated protein 1 | -0.0306444 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0305549 |
| CANX | calnexin | -0.0299702 |
| PTMA | prothymosin, alpha | -0.029852 |
| ZNF217 | zinc finger protein 217 | -0.029601 |
| DTNA | dystrobrevin, alpha | -0.0294394 |
| S100A6 | S100 calcium binding protein A6 | -0.0293939 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0293885 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0290122 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0287899 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0286966 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0284732 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0282499 |
| GCG | glucagon | -0.0280395 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.027231 |
| VCL | vinculin | -0.0271595 |
| S100A10 | S100 calcium binding protein A10 | -0.0268107 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | -0.0267252 |
| LDHA | lactate dehydrogenase A | -0.026591 |
| CUX1 | cut-like homeobox 1 | -0.0265659 |
| XPOT | exportin, tRNA | -0.0264872 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0261978 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0254978 |
| RPL26 | ribosomal protein L26 | -0.0253847 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0253608 |
| KHSRP | KH-type splicing regulatory protein | -0.0253051 |
| RPL11 | ribosomal protein L11 | -0.0252366 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0251911 |
| RPL23 | ribosomal protein L23 | -0.0251146 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0245789 |
| RACK1 | receptor for activated C kinase 1 | -0.0242476 |
