| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-3903 perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-3903_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.166834 |
| FTL | ferritin, light polypeptide | 0.118389 |
| VIM | vimentin | 0.105081 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.100877 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.100557 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0979098 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.093314 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0845967 |
| TMSB10 | thymosin beta 10 | 0.0802487 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0705693 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0689639 |
| FRMD4A | FERM domain containing 4A | 0.0652509 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.061524 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0601727 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0576816 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0565184 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0551195 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0519297 |
| CREB5 | cAMP responsive element binding protein 5 | 0.051735 |
| CRY1 | cryptochrome circadian clock 1 | 0.05006 |
| RND3 | Rho family GTPase 3 | 0.0499538 |
| GOLGB1 | golgin B1 | 0.0487852 |
| RPL23 | ribosomal protein L23 | 0.0470665 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0466004 |
| EGFR | epidermal growth factor receptor | 0.0462839 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0459981 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0459942 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0445556 |
| SP100 | SP100 nuclear antigen | 0.0444924 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.04407 |
| MLF1 | myeloid leukemia factor 1 | 0.0437324 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0433226 |
| RPS19 | ribosomal protein S19 | 0.0431193 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0423016 |
| COG5 | component of oligomeric golgi complex 5 | 0.0419416 |
| ATF3 | activating transcription factor 3 | 0.040786 |
| GPC6 | glypican 6 | 0.0407419 |
| EFNA5 | ephrin-A5 | 0.0402529 |
| RPS4X | ribosomal protein S4, X-linked | 0.0402457 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0401644 |
| CANX | calnexin | 0.0397237 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0391233 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0389136 |
| GPC5 | glypican 5 | 0.0373131 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.0366116 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0363876 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0363756 |
| HDAC9 | histone deacetylase 9 | 0.0362816 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0359484 |
| SUCO | SUN domain containing ossification factor | 0.0358561 |
| ANXA2 | annexin A2 | 0.0357514 |
| INTS6 | integrator complex subunit 6 | 0.0354283 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0347772 |
| SEC24D | SEC24 family member D | 0.0347169 |
| RPL35A | ribosomal protein L35a | 0.0346354 |
| CTBP2 | C-terminal binding protein 2 | 0.0342888 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0334501 |
| ATF6 | activating transcription factor 6 | 0.0331931 |
| CADM1 | cell adhesion molecule 1 | 0.0324523 |
| RPS8 | ribosomal protein S8 | 0.0321666 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 0.0320505 |
| HLA-A | major histocompatibility complex, class I, A | 0.0319081 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0317937 |
| RPL34 | ribosomal protein L34 | 0.0317734 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0316025 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.0314092 |
| MT2A | metallothionein 2A | 0.0310251 |
| FMNL2 | formin-like 2 | 0.0310211 |
| VMP1 | vacuole membrane protein 1 | 0.0306146 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0305454 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0303077 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0300425 |
| MYADM | myeloid-associated differentiation marker | 0.0300363 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0295568 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0295377 |
| MCL1 | myeloid cell leukemia 1 | 0.0292368 |
| SEC24A | SEC24 family member A | 0.0291461 |
| SIK3 | SIK family kinase 3 | 0.0288447 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0288447 |
| EGR1 | early growth response 1 | 0.0287048 |
| RPL12 | ribosomal protein L12 | 0.0286114 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0283197 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | 0.0281822 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0281797 |
| HBP1 | HMG-box transcription factor 1 | 0.0274393 |
| RLF | rearranged L-myc fusion | 0.0272928 |
| HLA-B | major histocompatibility complex, class I, B | 0.0271366 |
| CALR | calreticulin | 0.0271028 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0270335 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0269988 |
| B2M | beta-2-microglobulin | 0.0269663 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0268056 |
| RPL35 | ribosomal protein L35 | 0.026777 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0267649 |
| RPLP1 | ribosomal protein, large, P1 | 0.0267542 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0266016 |
| FNIP1 | folliculin interacting protein 1 | 0.0264135 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0263801 |
| MSR1 | macrophage scavenger receptor 1 | 0.0262863 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0259534 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.15481 |
| POTEF | POTE ankyrin domain family, member F | -0.091113 |
| ASPH | aspartate beta-hydroxylase | -0.0749687 |
| NRP2 | neuropilin 2 | -0.0669099 |
| RPS2 | ribosomal protein S2 | -0.0667094 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0642691 |
| SMAD3 | SMAD family member 3 | -0.0606467 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.056639 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0512989 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0500498 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0486219 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0479221 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0471274 |
| CENPF | centromere protein F, 350/400kDa | -0.047031 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0469051 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.0463707 |
| RAI14 | retinoic acid induced 14 | -0.0459087 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.044179 |
| XPO1 | exportin 1 | -0.0424629 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0419746 |
| ANLN | anillin, actin binding protein | -0.0410719 |
| TNS3 | tensin 3 | -0.0408634 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0404655 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0397963 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0388462 |
| SP3 | Sp3 transcription factor | -0.0379768 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.036839 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0368034 |
| GNA12 | guanine nucleotide binding protein (G protein) alpha 12 | -0.036604 |
| LOXL2 | lysyl oxidase-like 2 | -0.0361437 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.0360981 |
| CP | ceruloplasmin (ferroxidase) | -0.0340134 |
| RBM39 | RNA binding motif protein 39 | -0.0338572 |
| RTN4 | reticulon 4 | -0.033492 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0334599 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0325765 |
| MSN | moesin | -0.0323078 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0322687 |
| HPCAL1 | hippocalcin-like 1 | -0.0321257 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0319768 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0316786 |
| UBQLN1 | ubiquilin 1 | -0.0314959 |
| NRP1 | neuropilin 1 | -0.030281 |
| VCAN | versican | -0.0299851 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0298916 |
| MKI67 | marker of proliferation Ki-67 | -0.0296714 |
| GLIS3 | GLIS family zinc finger 3 | -0.0296391 |
| APOL1 | apolipoprotein L, 1 | -0.029507 |
| SET | SET nuclear proto-oncogene | -0.0287465 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0284147 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0283239 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0280394 |
| QKI | QKI, KH domain containing, RNA binding | -0.0279427 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0277137 |
| TPM1 | tropomyosin 1 (alpha) | -0.0276986 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0273619 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0273354 |
| RNF216 | ring finger protein 216 | -0.0269672 |
| COL4A2 | collagen, type IV, alpha 2 | -0.026916 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0267667 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.026709 |
| SLTM | SAFB-like, transcription modulator | -0.026669 |
| TGFB2 | transforming growth factor, beta 2 | -0.0266138 |
| DAPK1 | death-associated protein kinase 1 | -0.0265853 |
| STK17A | serine/threonine kinase 17a | -0.0265023 |
| WDR43 | WD repeat domain 43 | -0.0263444 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | -0.0261109 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | -0.0259338 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0250299 |
| FAM20C | family with sequence similarity 20, member C | -0.0250005 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | -0.0249878 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0249613 |
| CAPRIN1 | cell cycle associated protein 1 | -0.0249122 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.024873 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0246777 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0244937 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0243865 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.024329 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | -0.0242696 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -0.0240505 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0239564 |
| TPX2 | TPX2, microtubule-associated | -0.0239446 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0239282 |
| RRBP1 | ribosome binding protein 1 | -0.0239104 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0237211 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.0236909 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0236341 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0235804 |
| RRM2 | ribonucleotide reductase M2 | -0.0235246 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0235048 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0234938 |
| ACTN4 | actinin, alpha 4 | -0.0233482 |
| AOPEP | aminopeptidase O (putative) | -0.0231603 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -0.0230702 |
| ITGAV | integrin, alpha V | -0.0230064 |
| SLFN5 | schlafen family member 5 | -0.0229869 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0229186 |
| PTGR1 | prostaglandin reductase 1 | -0.0228709 |
| MRTFA | myocardin related transcription factor A | -0.0228161 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.022747 |
