MK-3903_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-3903 perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-3903_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.117879
AKAP12 A kinase (PRKA) anchor protein 12 0.089925
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0854118
EFNA5 ephrin-A5 0.0780663
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0704238
EGFR epidermal growth factor receptor 0.0658579
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0576323
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0568236
ASPH aspartate beta-hydroxylase 0.0538458
ZSWIM6 zinc finger, SWIM-type containing 6 0.0523789
GRB10 growth factor receptor-bound protein 10 0.0476695
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0470763
ALCAM activated leukocyte cell adhesion molecule 0.0462591
FAM107B family with sequence similarity 107, member B 0.0460032
ARHGAP26 Rho GTPase activating protein 26 0.0432386
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0430974
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.042104
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0401518
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0390297
DSTN destrin (actin depolymerizing factor) 0.0387639
MYO10 myosin X 0.0386363
FMNL2 formin-like 2 0.0382046
NRG1 neuregulin 1 0.0378754
LDHA lactate dehydrogenase A 0.0375891
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0369376
IGFBP3 insulin-like growth factor binding protein 3 0.0346596
EXT1 exostosin glycosyltransferase 1 0.0341438
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0337084
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.033654
MAML3 mastermind-like 3 (Drosophila) 0.033604
CXCL5 chemokine (C-X-C motif) ligand 5 0.0327955
SLC35F3 solute carrier family 35, member F3 0.0325255
PTK2 protein tyrosine kinase 2 0.0322744
CXCL8 chemokine (C-X-C motif) ligand 8 0.0319224
GOLGB1 golgin B1 0.0318941
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0317109
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0315884
PKM pyruvate kinase, muscle 0.0314731
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0311184
GLS2 glutaminase 2 (liver, mitochondrial) 0.0297895
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0296426
THSD4 thrombospondin, type I, domain containing 4 0.0296333
EHBP1 EH domain binding protein 1 0.029589
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0286263
BIRC3 baculoviral IAP repeat containing 3 0.0279075
MACF1 microtubule-actin crosslinking factor 1 0.0277615
LOC102724023 ES1 protein homolog, mitochondrial 0.0277547
HMGA2 high mobility group AT-hook 2 0.0277396
NFE2L2 nuclear factor, erythroid 2-like 2 0.0277035
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.027344
CCDC88A coiled-coil domain containing 88A 0.027191
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0269651
PCBP2 poly(rC) binding protein 2 0.026596
TPM3 tropomyosin 3 0.026292
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0257641
FAM13A family with sequence similarity 13, member A 0.0253127
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0248786
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0246711
SPAG9 sperm associated antigen 9 0.0242904
TNIP1 TNFAIP3 interacting protein 1 0.024209
QKI QKI, KH domain containing, RNA binding 0.0240322
HIPK2 homeodomain interacting protein kinase 2 0.0238695
EREG epiregulin 0.0237231
TRIO trio Rho guanine nucleotide exchange factor 0.0235194
KTN1 kinectin 1 (kinesin receptor) 0.023497
UBA6 ubiquitin-like modifier activating enzyme 6 0.0233431
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0233307
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0233244
STC1 stanniocalcin 1 0.0232672
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0232465
COPA coatomer protein complex, subunit alpha 0.023109
USP34 ubiquitin specific peptidase 34 0.0230303
LMO7 LIM domain 7 0.0229637
MCTP1 multiple C2 domains, transmembrane 1 0.0229407
TXNRD1 thioredoxin reductase 1 0.0228017
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.022763
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0225181
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0224978
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0224344
NPAS2 neuronal PAS domain protein 2 0.0223817
USP3 ubiquitin specific peptidase 3 0.0223643
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0223279
CD44 CD44 molecule (Indian blood group) 0.022326
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0222203
WAC WW domain containing adaptor with coiled-coil 0.0220429
RAB10 RAB10, member RAS oncogene family 0.021968
DOCK5 dedicator of cytokinesis 5 0.0217776
SOD2 superoxide dismutase 2, mitochondrial 0.0212323
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0211566
GPATCH2L G patch domain containing 2-like 0.0211477
LIMCH1 LIM and calponin homology domains 1 0.0207203
CLTC clathrin, heavy chain (Hc) 0.0206117
MAP1B microtubule-associated protein 1B 0.0205357
NBAS neuroblastoma amplified sequence 0.0204101
RND3 Rho family GTPase 3 0.0202694
RAI14 retinoic acid induced 14 0.0202335
NF1 neurofibromin 1 0.020166
PRKCA protein kinase C, alpha 0.0201221
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.020058
PRRC2C proline-rich coiled-coil 2C 0.0198207

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.180861
TMSB10 thymosin beta 10 -0.143701
MT1X metallothionein 1X -0.100802
RPLP1 ribosomal protein, large, P1 -0.0837413
RPS19 ribosomal protein S19 -0.0647015
ACTG1 actin gamma 1 -0.0638657
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0581925
RPL35A ribosomal protein L35a -0.0461425
RPS16 ribosomal protein S16 -0.0457264
FTL ferritin, light polypeptide -0.045608
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0445929
TPT1 tumor protein, translationally-controlled 1 -0.0438274
EIF1 eukaryotic translation initiation factor 1 -0.0437306
RPL23 ribosomal protein L23 -0.0425476
RPLP2 ribosomal protein, large, P2 -0.037971
RPS29 ribosomal protein S29 -0.0357376
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0354245
RPS24 ribosomal protein S24 -0.0330255
RPL28 ribosomal protein L28 -0.0319784
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0315042
C15ORF48 chromosome 15 open reading frame 48 -0.0297073
RPL31 ribosomal protein L31 -0.0296797
RPL26 ribosomal protein L26 -0.0292692
RPS13 ribosomal protein S13 -0.0281705
RPL38 ribosomal protein L38 -0.0275768
OSMR oncostatin M receptor -0.0270159
S100A6 S100 calcium binding protein A6 -0.0259199
NPC1 Niemann-Pick disease, type C1 -0.0248415
RNF213 ring finger protein 213 -0.0246035
RPL12 ribosomal protein L12 -0.0245497
BASP1 brain abundant, membrane attached signal protein 1 -0.0245211
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0242171
RPL32 ribosomal protein L32 -0.0241897
ANGPTL4 angiopoietin-like 4 -0.0240487
RPL36A ribosomal protein L36a -0.0237376
RPL34 ribosomal protein L34 -0.0225682
RPS6 ribosomal protein S6 -0.022523
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0222622
RPS27A ribosomal protein S27a -0.0218823
KLF6 Kruppel-like factor 6 -0.0211392
RPL7A ribosomal protein L7a -0.0204401
RPS11 ribosomal protein S11 -0.0204295
RPL19 ribosomal protein L19 -0.0203201
DUSP5 dual specificity phosphatase 5 -0.020045
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.019868
RPS23 ribosomal protein S23 -0.01974
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0197125
IGFBP4 insulin-like growth factor binding protein 4 -0.0195293
VCL vinculin -0.0189971
IFI6 interferon, alpha-inducible protein 6 -0.0188016
RPL37A ribosomal protein L37a -0.0187314
TGM2 transglutaminase 2 -0.0184865
NCOA7 nuclear receptor coactivator 7 -0.0184611
RPL8 ribosomal protein L8 -0.0176456
NDRG1 N-myc downstream regulated 1 -0.0174167
ACTN4 actinin, alpha 4 -0.0168932
RPS21 ribosomal protein S21 -0.0168057
TM4SF1 transmembrane 4 L six family member 1 -0.0167737
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0167041
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0166085
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0164132
NRIP1 nuclear receptor interacting protein 1 -0.0163392
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0162347
BCL2L1 BCL2-like 1 -0.0161766
RPL36 ribosomal protein L36 -0.0156601
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.015555
CTSL cathepsin L -0.0147274
OGA O-GlcNAcase -0.0145579
EGR1 early growth response 1 -0.0144863
PTMA prothymosin, alpha -0.0144795
RPL13A ribosomal protein L13a -0.0143419
RPL30 ribosomal protein L30 -0.0143035
RPLP0 ribosomal protein, large, P0 -0.0140427
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0138934
WSB1 WD repeat and SOCS box containing 1 -0.013832
RPS5 ribosomal protein S5 -0.0137964
KPNB1 karyopherin (importin) beta 1 -0.0137038
RPS20 ribosomal protein S20 -0.0136438
ZNFX1 zinc finger, NFX1-type containing 1 -0.0135512
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0135355
BMERB1 bMERB domain containing 1 -0.0133406
RPL35 ribosomal protein L35 -0.0133059
IFIH1 interferon induced with helicase C domain 1 -0.013288
RIGI RNA sensor RIG-I -0.0131635
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0131233
KIFC3 kinesin family member C3 -0.0131134
AGFG1 ArfGAP with FG repeats 1 -0.0129093
ANXA4 annexin A4 -0.0127239
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0126646
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0126435
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0126016
H3-3B H3.3 histone B -0.0123065
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0122719
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0122379
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0120975
HLA-B major histocompatibility complex, class I, B -0.0120695
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -0.0117926
RPL37 ribosomal protein L37 -0.0116963
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0116
KDM3A lysine (K)-specific demethylase 3A -0.0115967