MK-3903_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-3903 perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-3903_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLIT2 slit homolog 2 (Drosophila) 0.227327
ERBB4 erb-b2 receptor tyrosine kinase 4 0.146527
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.132582
TENM3 teneurin transmembrane protein 3 0.123731
ZNF608 zinc finger protein 608 0.110749
COL5A2 collagen, type V, alpha 2 0.102959
NEBL nebulette 0.0897022
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0763403
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0762947
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0688386
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0672012
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0637342
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0627805
USP9X ubiquitin specific peptidase 9, X-linked 0.0623967
VMP1 vacuole membrane protein 1 0.0606959
DST dystonin 0.0583037
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0568432
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0567275
ARHGAP32 Rho GTPase activating protein 32 0.0564166
EEF2 eukaryotic translation elongation factor 2 0.0540657
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0513594
KTN1 kinectin 1 (kinesin receptor) 0.0505472
SOX5 SRY (sex determining region Y)-box 5 0.0493897
JMJD1C jumonji domain containing 1C 0.0486866
MLIP muscular LMNA-interacting protein 0.0484164
KMT2C lysine (K)-specific methyltransferase 2C 0.0483724
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0482155
ZSWIM6 zinc finger, SWIM-type containing 6 0.0474798
CELF2 CUGBP, Elav-like family member 2 0.0470312
CENPF centromere protein F, 350/400kDa 0.0456449
NFIA nuclear factor I/A 0.0453747
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0430706
EXT1 exostosin glycosyltransferase 1 0.0429357
SIK3 SIK family kinase 3 0.0423785
SRRM2 serine/arginine repetitive matrix 2 0.0419666
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0417814
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0413684
HSPA8 heat shock 70kDa protein 8 0.041088
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0410747
ZNF638 zinc finger protein 638 0.0410208
USP34 ubiquitin specific peptidase 34 0.0404403
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0397438
ATP11A ATPase, class VI, type 11A 0.0395779
NBEAL1 neurobeachin-like 1 0.0394683
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0390944
MKI67 marker of proliferation Ki-67 0.0390195
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.038787
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0387768
MED13 mediator complex subunit 13 0.0386894
TOX thymocyte selection-associated high mobility group box 0.0385899
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0382096
CDH18 cadherin 18, type 2 0.0381302
JUN jun proto-oncogene 0.0381208
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0381009
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0378645
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0378479
SMYD3 SET and MYND domain containing 3 0.0378035
WLS wntless Wnt ligand secretion mediator 0.0377233
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0372854
TRIO trio Rho guanine nucleotide exchange factor 0.0370007
BNC2 basonuclin 2 0.036764
VCL vinculin 0.0366809
SFPQ splicing factor proline/glutamine-rich 0.0363692
ENO1 enolase 1, (alpha) 0.0359906
CLTC clathrin, heavy chain (Hc) 0.0357631
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0353086
DENND1A DENN/MADD domain containing 1A 0.0349196
SPDYA speedy/RINGO cell cycle regulator family member A 0.034559
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0344703
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0344311
PCM1 pericentriolar material 1 0.0344202
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0341867
PHF21A PHD finger protein 21A 0.0334677
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0332641
TAS2R14 taste receptor, type 2, member 14 0.0329875
MACF1 microtubule-actin crosslinking factor 1 0.0329106
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0327401
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0326109
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0325782
PAPOLA poly(A) polymerase alpha 0.0325451
HOMER1 homer scaffolding protein 1 0.0325238
WNK1 WNK lysine deficient protein kinase 1 0.0320344
DSCAM Down syndrome cell adhesion molecule 0.0319471
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0317084
FMNL2 formin-like 2 0.0309737
SON SON DNA binding protein 0.0309524
VEGFC vascular endothelial growth factor C 0.030909
PRRC2C proline-rich coiled-coil 2C 0.0305868
TBC1D5 TBC1 domain family, member 5 0.0304835
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0296434
SET SET nuclear proto-oncogene 0.0296268
RCC1 regulator of chromosome condensation 1 0.0295889
AGO3 argonaute RISC catalytic component 3 0.029545
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0294454
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0293162
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0290991
SRRM1 serine/arginine repetitive matrix 1 0.0290682
SRSF4 serine/arginine-rich splicing factor 4 0.0289943
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0286273
TBL1X transducin (beta)-like 1X-linked 0.0284264

decreased expression

Symbol Name Standardized Value
NPAS3 neuronal PAS domain protein 3 -0.0756462
RAD51B RAD51 paralog B -0.0691347
RPL35A ribosomal protein L35a -0.0404068
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0381774
IFI6 interferon, alpha-inducible protein 6 -0.0365899
RPLP1 ribosomal protein, large, P1 -0.0325064
RPL38 ribosomal protein L38 -0.0297286
RPS6 ribosomal protein S6 -0.0291472
HMGB1 high mobility group box 1 -0.0286808
TMSB10 thymosin beta 10 -0.0286134
WDR45B WD repeat domain 45B -0.0278527
RPL23 ribosomal protein L23 -0.0274592
PTMA prothymosin, alpha -0.0271815
RPS3 ribosomal protein S3 -0.026379
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0263181
SLF1 SMC5-SMC6 complex localization factor 1 -0.0254064
MYL12B myosin, light chain 12B, regulatory -0.0247873
RPL34 ribosomal protein L34 -0.0242136
RPL26 ribosomal protein L26 -0.0235184
RPS29 ribosomal protein S29 -0.0235116
SOX4 SRY (sex determining region Y)-box 4 -0.0219207
KDM3A lysine (K)-specific demethylase 3A -0.0216726
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0216492
TPT1 tumor protein, translationally-controlled 1 -0.0214912
RPS28 ribosomal protein S28 -0.0206709
S100A9 S100 calcium binding protein A9 -0.0205116
RPS27A ribosomal protein S27a -0.0203305
RPLP2 ribosomal protein, large, P2 -0.0200345
RPL28 ribosomal protein L28 -0.0187375
CADM2 cell adhesion molecule 2 -0.0187112
RPS13 ribosomal protein S13 -0.0185784
RPS24 ribosomal protein S24 -0.018086
RPS8 ribosomal protein S8 -0.0179724
VDAC1 voltage-dependent anion channel 1 -0.0179438
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0178445
RAB6A RAB6A, member RAS oncogene family -0.0174104
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0169893
MT2A metallothionein 2A -0.0164341
RPS21 ribosomal protein S21 -0.0164055
RPL30 ribosomal protein L30 -0.016063
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0160347
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0158519
VIM vimentin -0.0156084
RPS11 ribosomal protein S11 -0.0153425
HLA-B major histocompatibility complex, class I, B -0.0150737
RPL31 ribosomal protein L31 -0.01498
SOX2 SRY (sex determining region Y)-box 2 -0.0149502
RPS19 ribosomal protein S19 -0.0148333
GRID2 glutamate receptor, ionotropic, delta 2 -0.0147553
NAP1L1 nucleosome assembly protein 1-like 1 -0.0147509
ZFP64 ZFP64 zinc finger protein -0.0145534
RPL37A ribosomal protein L37a -0.0144751
PFN1 profilin 1 -0.0143299
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0143215
RPS25 ribosomal protein S25 -0.0141364
ANAPC5 anaphase promoting complex subunit 5 -0.013805
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0136736
PTPRF protein tyrosine phosphatase, receptor type, F -0.0132514
CAVIN1 caveolae associated protein 1 -0.0131454
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0131454
RPS4X ribosomal protein S4, X-linked -0.0129938
PCDH11X protocadherin 11 X-linked -0.0129693
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0129674
FAM222B family with sequence similarity 222, member B -0.0127469
ACTG1 actin gamma 1 -0.0127013
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0124457
RFLNA refilin A -0.0122864
RPL35 ribosomal protein L35 -0.012217
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0121775
FOXK2 forkhead box K2 -0.0121184
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0119447
RPLP0 ribosomal protein, large, P0 -0.0119381
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0119312
IMMT inner membrane protein, mitochondrial -0.0119234
ZMYND8 zinc finger, MYND-type containing 8 -0.0118759
RPS23 ribosomal protein S23 -0.0118009
RPL27A ribosomal protein L27a -0.0117734
FKBP10 FK506 binding protein 10, 65 kDa -0.0117649
RPS27 ribosomal protein S27 -0.0117471
EGR1 early growth response 1 -0.0117213
CDC73 cell division cycle 73 -0.011444
ATP5F1E ATP synthase F1 subunit epsilon -0.0114363
ENOSF1 enolase superfamily member 1 -0.011417
INSR insulin receptor -0.0113023
FTL ferritin, light polypeptide -0.0112915
SINHCAF SIN3-HDAC complex associated factor -0.011269
FAM162A family with sequence similarity 162, member A -0.0112399
TUBB tubulin, beta class I -0.01121
WSB1 WD repeat and SOCS box containing 1 -0.0111835
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0111819
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0111527
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -0.0111479
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0111233
RPL12 ribosomal protein L12 -0.0110915
MIDN midnolin -0.0110328
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0108399
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0108295
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.010817
S100A10 S100 calcium binding protein A10 -0.0108092
RPS20 ribosomal protein S20 -0.0107294