MK-3903_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-3903 perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-3903_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.158322
NAMPT nicotinamide phosphoribosyltransferase 0.108253
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.105905
PDIA4 protein disulfide isomerase family A, member 4 0.0981145
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0898581
ESYT2 extended synaptotagmin-like protein 2 0.0811665
FMNL2 formin-like 2 0.071371
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.065323
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.060995
IGFBP3 insulin-like growth factor binding protein 3 0.0594424
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0575907
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.05287
IFRD1 interferon-related developmental regulator 1 0.052216
IL1RAP interleukin 1 receptor accessory protein 0.0512722
LOC102724023 ES1 protein homolog, mitochondrial 0.0501829
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0495853
PTK2 protein tyrosine kinase 2 0.0495342
TAC4 tachykinin 4 (hemokinin) 0.0482472
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0482217
CANX calnexin 0.0477046
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0474471
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0466407
NUP58 nucleoporin 58 0.0463388
FNDC3B fibronectin type III domain containing 3B 0.0440049
CDC73 cell division cycle 73 0.0431289
COG5 component of oligomeric golgi complex 5 0.0427429
ASPH aspartate beta-hydroxylase 0.0423084
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0420125
NBAS neuroblastoma amplified sequence 0.0419121
COPA coatomer protein complex, subunit alpha 0.0396808
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.039487
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0391299
BHLHE40 basic helix-loop-helix family, member e40 0.0386559
FYN FYN proto-oncogene, Src family tyrosine kinase 0.037507
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0374844
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0373691
MACF1 microtubule-actin crosslinking factor 1 0.0366568
SEC24A SEC24 family member A 0.0363865
KMT2E lysine (K)-specific methyltransferase 2E 0.0356439
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0355334
UBE2H ubiquitin-conjugating enzyme E2H 0.0353343
TMEM178B transmembrane protein 178B 0.0353093
ZSWIM6 zinc finger, SWIM-type containing 6 0.0351485
GOLGA4 golgin A4 0.0349154
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0336122
ARFGEF3 ARFGEF family member 3 0.0334449
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0317224
AFDN afadin, adherens junction formation factor 0.0310813
ZFAND3 zinc finger, AN1-type domain 3 0.0308358
ANO6 anoctamin 6 0.0307977
LEF1 lymphoid enhancer-binding factor 1 0.0306874
ANXA2 annexin A2 0.0305616
NAV2 neuron navigator 2 0.0304338
SPAG9 sperm associated antigen 9 0.030132
MEF2A myocyte enhancer factor 2A 0.0298038
UBA6 ubiquitin-like modifier activating enzyme 6 0.0297876
SETBP1 SET binding protein 1 0.0293443
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0287676
RYBP RING1 and YY1 binding protein 0.0283553
TPD52 tumor protein D52 0.0280292
KDM5B lysine (K)-specific demethylase 5B 0.0278183
TPR translocated promoter region, nuclear basket protein 0.0275905
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0273745
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.027244
CALR calreticulin 0.0271506
PDIA3 protein disulfide isomerase family A, member 3 0.0270161
SNX14 sorting nexin 14 0.0267416
USP37 ubiquitin specific peptidase 37 0.0266784
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0264872
JMJD1C jumonji domain containing 1C 0.0262704
AKAP12 A kinase (PRKA) anchor protein 12 0.0260857
RLF rearranged L-myc fusion 0.0260564
FOS FBJ murine osteosarcoma viral oncogene homolog 0.026027
NDRG1 N-myc downstream regulated 1 0.0260265
PXMP2 peroxisomal membrane protein 2, 22kDa 0.0259567
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.025857
CENPF centromere protein F, 350/400kDa 0.0257915
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0257051
PRELID2 PRELI domain containing 2 0.0256958
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0256784
JUN jun proto-oncogene 0.0256612
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0255894
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0254967
FLNB filamin B, beta 0.0254166
GLS2 glutaminase 2 (liver, mitochondrial) 0.0253982
SBF2 SET binding factor 2 0.0251023
INTS6 integrator complex subunit 6 0.0249185
APLP2 amyloid beta (A4) precursor-like protein 2 0.0247421
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0247209
BIRC2 baculoviral IAP repeat containing 2 0.0243978
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0243594
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0242044
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0241407
HELZ helicase with zinc finger 0.0241024
IGF1R insulin-like growth factor 1 receptor 0.0240838
NHSL1 NHS-like 1 0.0240115
ATF6 activating transcription factor 6 0.0239625
EMP1 epithelial membrane protein 1 0.0236126
KMT2C lysine (K)-specific methyltransferase 2C 0.0235591
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0234467

decreased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 -0.119944
VGF VGF nerve growth factor inducible -0.0970832
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0911042
DCT dopachrome tautomerase -0.088503
IGFBP5 insulin-like growth factor binding protein 5 -0.0877803
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0856411
NAV3 neuron navigator 3 -0.0762725
TMSB10 thymosin beta 10 -0.0626476
GPC6 glypican 6 -0.0588751
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0564455
POTEF POTE ankyrin domain family, member F -0.0558186
PDE10A phosphodiesterase 10A -0.0507199
ACTG1 actin gamma 1 -0.0484716
MACROD2 MACRO domain containing 2 -0.0480029
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0461105
S100A6 S100 calcium binding protein A6 -0.0460831
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0437863
TRIM2 tripartite motif containing 2 -0.0427799
VIM vimentin -0.0427018
PTCHD4 patched domain containing 4 -0.0426434
PRKD1 protein kinase D1 -0.0399261
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.039552
FRMD4A FERM domain containing 4A -0.0372949
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0355392
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0352006
FHIT fragile histidine triad -0.0347212
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0331888
AHCYL2 adenosylhomocysteinase-like 2 -0.0312464
HLA-B major histocompatibility complex, class I, B -0.0311998
PTPRD protein tyrosine phosphatase, receptor type, D -0.0310723
CD44 CD44 molecule (Indian blood group) -0.0304224
NPC1 Niemann-Pick disease, type C1 -0.0302617
CTTNBP2 cortactin binding protein 2 -0.0300779
FBXL7 F-box and leucine-rich repeat protein 7 -0.0300466
FMN1 formin 1 -0.0292923
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0285823
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0281719
S100A9 S100 calcium binding protein A9 -0.0280619
NEGR1 neuronal growth regulator 1 -0.0278798
TAGLN2 transgelin 2 -0.027818
CALD1 caldesmon 1 -0.0271013
CTSD cathepsin D -0.0266859
GRID1 glutamate receptor, ionotropic, delta 1 -0.0265213
OXR1 oxidation resistance 1 -0.026456
SCFD2 sec1 family domain containing 2 -0.0258795
PPP2R2B protein phosphatase 2, regulatory subunit B, beta -0.0255878
SOX5 SRY (sex determining region Y)-box 5 -0.0251733
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -0.0251327
ZEB2 zinc finger E-box binding homeobox 2 -0.0233949
GNAS GNAS complex locus -0.0233875
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0232565
RPL35A ribosomal protein L35a -0.0231626
AHR aryl hydrocarbon receptor -0.0231289
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0221269
ADGRG1 adhesion G protein-coupled receptor G1 -0.021591
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0209113
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.02091
RPL37A ribosomal protein L37a -0.0203881
EHBP1 EH domain binding protein 1 -0.0203267
GHR growth hormone receptor -0.0203079
TNNC1 troponin C type 1 (slow) -0.0200595
DMD dystrophin -0.0199988
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0188478
PCDH7 protocadherin 7 -0.018651
MT1X metallothionein 1X -0.018624
TPI1 triosephosphate isomerase 1 -0.0186085
NRP2 neuropilin 2 -0.0185886
PI15 peptidase inhibitor 15 -0.0184706
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0184148
PTMS parathymosin -0.0183091
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0181994
PDE4B phosphodiesterase 4B, cAMP-specific -0.0178885
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0173039
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0172877
CYB5R3 cytochrome b5 reductase 3 -0.0171428
MEF2C myocyte enhancer factor 2C -0.0171043
RPS19 ribosomal protein S19 -0.016993
FTL ferritin, light polypeptide -0.0168909
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.016811
SFTPA2 surfactant protein A2 -0.0167676
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0167425
SESN3 sestrin 3 -0.0167201
COL19A1 collagen, type XIX, alpha 1 -0.016511
HLA-A major histocompatibility complex, class I, A -0.0164473
RPL34 ribosomal protein L34 -0.0162764
ENO2 enolase 2 (gamma, neuronal) -0.0162565
SOX6 SRY (sex determining region Y)-box 6 -0.0162387
NRG1 neuregulin 1 -0.0160832
HIPK2 homeodomain interacting protein kinase 2 -0.0160334
PFN1 profilin 1 -0.0159593
COL1A2 collagen, type I, alpha 2 -0.0156819
HMCN1 hemicentin 1 -0.0156746
SRSF11 serine/arginine-rich splicing factor 11 -0.0154524
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0154266
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0151793
MITF microphthalmia-associated transcription factor -0.0151573
MFSD12 major facilitator superfamily domain containing 12 -0.0151391
ARHGAP24 Rho GTPase activating protein 24 -0.0150565
SEM1 SEM1 26S proteasome subunit -0.015022
HMGA1 high mobility group AT-hook 1 -0.014909