| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-3903 perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-3903_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | 0.224812 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.159738 |
| VMP1 | vacuole membrane protein 1 | 0.107763 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0985517 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0972636 |
| TLE4 | transducin-like enhancer of split 4 | 0.0933042 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.090263 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0844066 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0789733 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0647251 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0621054 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0613296 |
| MCL1 | myeloid cell leukemia 1 | 0.0571107 |
| EGR1 | early growth response 1 | 0.056729 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0560078 |
| INTS6 | integrator complex subunit 6 | 0.0549717 |
| VIM | vimentin | 0.0515207 |
| LSAMP | limbic system-associated membrane protein | 0.0513976 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0497134 |
| FMN1 | formin 1 | 0.0494191 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0465671 |
| PRKCA | protein kinase C, alpha | 0.0459917 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0453972 |
| PDE10A | phosphodiesterase 10A | 0.0442648 |
| CANX | calnexin | 0.043909 |
| RPL4 | ribosomal protein L4 | 0.043071 |
| RAD51B | RAD51 paralog B | 0.042801 |
| HOMER1 | homer scaffolding protein 1 | 0.0414738 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0414467 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0412613 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0406199 |
| RIGI | RNA sensor RIG-I | 0.0405949 |
| MYO1E | myosin IE | 0.0403564 |
| RPL19 | ribosomal protein L19 | 0.0399047 |
| ASPH | aspartate beta-hydroxylase | 0.0396834 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0394911 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0385808 |
| FLT1 | fms-related tyrosine kinase 1 | 0.0374481 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0373717 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0370852 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0364072 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0363196 |
| ACTG1 | actin gamma 1 | 0.0360938 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0360785 |
| DST | dystonin | 0.0355282 |
| RPS23 | ribosomal protein S23 | 0.0350548 |
| STK38L | serine/threonine kinase 38 like | 0.0338413 |
| GLCCI1 | glucocorticoid induced 1 | 0.0338025 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0336498 |
| PGK1 | phosphoglycerate kinase 1 | 0.0332158 |
| AEBP2 | AE binding protein 2 | 0.0323993 |
| SVIL | supervillin | 0.0320357 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0318829 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0314541 |
| LIMA1 | LIM domain and actin binding 1 | 0.0314358 |
| DNM3 | dynamin 3 | 0.0311021 |
| HDX | highly divergent homeobox | 0.0309749 |
| FERMT2 | fermitin family member 2 | 0.0308672 |
| B2M | beta-2-microglobulin | 0.0307821 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0306811 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0306608 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0304073 |
| RPS27 | ribosomal protein S27 | 0.0300797 |
| BPTF | bromodomain PHD finger transcription factor | 0.0300267 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0290895 |
| PDLIM5 | PDZ and LIM domain 5 | 0.029007 |
| ATXN1 | ataxin 1 | 0.0284221 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0282929 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0281328 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0280614 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0279849 |
| FAM107B | family with sequence similarity 107, member B | 0.027913 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0275142 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0274763 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | 0.0274342 |
| ACTN1 | actinin, alpha 1 | 0.0273942 |
| CXXC5 | CXXC finger protein 5 | 0.0271812 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 0.0267695 |
| SMAD3 | SMAD family member 3 | 0.0267586 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0266792 |
| STC1 | stanniocalcin 1 | 0.0266493 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0266484 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0265261 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | 0.026501 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0259787 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0259491 |
| CENPF | centromere protein F, 350/400kDa | 0.0259061 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0256889 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0256445 |
| RPL13A | ribosomal protein L13a | 0.025518 |
| DIAPH2 | diaphanous-related formin 2 | 0.0254268 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.025414 |
| ANGPTL4 | angiopoietin-like 4 | 0.0251967 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0248844 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0248803 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0248096 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0246558 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0244262 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0242664 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | 0.0241407 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.222433 |
| IGF2 | insulin-like growth factor 2 | -0.132422 |
| NRG1 | neuregulin 1 | -0.121269 |
| LPIN1 | lipin 1 | -0.0997599 |
| SYT1 | synaptotagmin I | -0.0700995 |
| COL1A1 | collagen, type I, alpha 1 | -0.0685642 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0616543 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0575223 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0523306 |
| NEK7 | NIMA-related kinase 7 | -0.0506456 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0506397 |
| HIP1 | huntingtin interacting protein 1 | -0.0473448 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0462976 |
| MSI2 | musashi RNA-binding protein 2 | -0.0459729 |
| FOXK2 | forkhead box K2 | -0.0449955 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0436941 |
| CEP95 | centrosomal protein 95kDa | -0.0435708 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0430655 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0391034 |
| RBM25 | RNA binding motif protein 25 | -0.0385755 |
| HELZ | helicase with zinc finger | -0.0381627 |
| AOPEP | aminopeptidase O (putative) | -0.0379955 |
| RPS2 | ribosomal protein S2 | -0.0369934 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0367048 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0364472 |
| MAP1B | microtubule-associated protein 1B | -0.0363862 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0362501 |
| COL3A1 | collagen, type III, alpha 1 | -0.0358378 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0351633 |
| H3-3B | H3.3 histone B | -0.0349646 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0346539 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.034622 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0344541 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0343468 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0337955 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0337244 |
| MBTD1 | mbt domain containing 1 | -0.0336526 |
| OGA | O-GlcNAcase | -0.0332533 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0322862 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0322605 |
| HMGB2 | high mobility group box 2 | -0.031566 |
| PLAT | plasminogen activator, tissue | -0.0314389 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0310836 |
| GRB2 | growth factor receptor-bound protein 2 | -0.0307867 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0307735 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0307439 |
| CCNY | cyclin Y | -0.0306723 |
| CRH | corticotropin releasing hormone | -0.030583 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.029961 |
| PHIP | pleckstrin homology domain interacting protein | -0.029693 |
| XPO1 | exportin 1 | -0.0296113 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0292857 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0291881 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0291243 |
| NKTR | natural killer cell triggering receptor | -0.0290654 |
| PHF3 | PHD finger protein 3 | -0.0289621 |
| CDC27 | cell division cycle 27 | -0.0285857 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.028257 |
| PCM1 | pericentriolar material 1 | -0.0279183 |
| ZNF207 | zinc finger protein 207 | -0.0278517 |
| RPL38 | ribosomal protein L38 | -0.0273402 |
| NCOR1 | nuclear receptor corepressor 1 | -0.027254 |
| FOXO3 | forkhead box O3 | -0.0272135 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | -0.0271564 |
| TRIB2 | tribbles pseudokinase 2 | -0.0264397 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0263042 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | -0.026159 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0260288 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0259137 |
| CASC3 | cancer susceptibility candidate 3 | -0.0257637 |
| HAND2 | heart and neural crest derivatives expressed 2 | -0.0256359 |
| QKI | QKI, KH domain containing, RNA binding | -0.0255601 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0254962 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0250545 |
| AUTS2 | autism susceptibility candidate 2 | -0.0246995 |
| WDR45B | WD repeat domain 45B | -0.0246665 |
| PRTG | protogenin | -0.0246064 |
| TLK2 | tousled-like kinase 2 | -0.0246032 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0245955 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0245351 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0244241 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.024364 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0243038 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0240667 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0240245 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0239824 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0239671 |
| CCND1 | cyclin D1 | -0.0239122 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0238938 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0234982 |
| GNAS | GNAS complex locus | -0.0234848 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0232653 |
| PLPP1 | phospholipid phosphatase 1 | -0.0231224 |
| NBR1 | neighbor of BRCA1 gene 1 | -0.0228368 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | -0.0228274 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0227716 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0227687 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0223836 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | -0.0223739 |
| MYH10 | myosin, heavy chain 10, non-muscle | -0.0221881 |
