| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-3903 perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-3903_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.197506 |
| INTS6 | integrator complex subunit 6 | 0.1244 |
| LCN2 | lipocalin 2 | 0.11414 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0870452 |
| SMAD3 | SMAD family member 3 | 0.0633845 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0619035 |
| PLSCR2 | phospholipid scramblase 2 | 0.0557537 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0545518 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0537452 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0523807 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0492967 |
| CANX | calnexin | 0.0491422 |
| GOLGB1 | golgin B1 | 0.0481458 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0425358 |
| ASPH | aspartate beta-hydroxylase | 0.042048 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0413256 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0401403 |
| KYNU | kynureninase | 0.0391229 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0390999 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0389048 |
| DST | dystonin | 0.0351688 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0345671 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0319266 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0304705 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0303533 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0302876 |
| FNIP2 | folliculin interacting protein 2 | 0.0294255 |
| EFNB2 | ephrin-B2 | 0.0292961 |
| TRIM2 | tripartite motif containing 2 | 0.0287187 |
| SIK3 | SIK family kinase 3 | 0.0277403 |
| IFNGR1 | interferon gamma receptor 1 | 0.0271041 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0270752 |
| RUNX1 | runt-related transcription factor 1 | 0.0269329 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0267568 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0265346 |
| WWOX | WW domain containing oxidoreductase | 0.0263145 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.026268 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0259715 |
| SDC4 | syndecan 4 | 0.0259179 |
| MEIS2 | Meis homeobox 2 | 0.0257661 |
| SLK | STE20-like kinase | 0.0256363 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0256162 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.025603 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0255171 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0241193 |
| VMP1 | vacuole membrane protein 1 | 0.0236881 |
| DUSP16 | dual specificity phosphatase 16 | 0.0236248 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0235166 |
| EREG | epiregulin | 0.0227352 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0220273 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0215484 |
| ATXN1 | ataxin 1 | 0.0214335 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0212024 |
| MYO1E | myosin IE | 0.0210507 |
| GK | glycerol kinase | 0.0209598 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0207228 |
| RACK1 | receptor for activated C kinase 1 | 0.0202379 |
| AHI1 | Abelson helper integration site 1 | 0.0199591 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0198678 |
| PDZD8 | PDZ domain containing 8 | 0.0197939 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0197073 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0196955 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0196361 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.019313 |
| HOMER1 | homer scaffolding protein 1 | 0.0190933 |
| PLPP3 | phospholipid phosphatase 3 | 0.0190653 |
| YAP1 | Yes-associated protein 1 | 0.019035 |
| IER3 | immediate early response 3 | 0.0190013 |
| RND3 | Rho family GTPase 3 | 0.0188848 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0187413 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | 0.0187222 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0183331 |
| FEM1C | fem-1 homolog c (C. elegans) | 0.0182619 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0179239 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.0179215 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0178409 |
| SUCLA2 | succinate-CoA ligase, ADP-forming, beta subunit | 0.0178298 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0177949 |
| RAD51B | RAD51 paralog B | 0.0174468 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0169198 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0169063 |
| FTL | ferritin, light polypeptide | 0.0167494 |
| TOP1 | topoisomerase (DNA) I | 0.016653 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.0166044 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0165751 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0165072 |
| MORF4L2 | mortality factor 4 like 2 | 0.0163014 |
| TMEM65 | transmembrane protein 65 | 0.0161383 |
| PHF3 | PHD finger protein 3 | 0.01611 |
| RPL7A | ribosomal protein L7a | 0.0159531 |
| SEPTIN9 | septin 9 | 0.0158091 |
| MCU | mitochondrial calcium uniporter | 0.0157202 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 0.0156874 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 | 0.0156463 |
| SET | SET nuclear proto-oncogene | 0.0155687 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0155303 |
| FHIT | fragile histidine triad | 0.0155227 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0154236 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0153854 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0153486 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.102449 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.090427 |
| ERBIN | erbb2 interacting protein | -0.0776693 |
| LYZ | lysozyme | -0.0753974 |
| HLA-B | major histocompatibility complex, class I, B | -0.0742544 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0736685 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0735409 |
| SPATA13 | spermatogenesis associated 13 | -0.0632395 |
| PTMA | prothymosin, alpha | -0.0617043 |
| RNF213 | ring finger protein 213 | -0.0612288 |
| RPS6 | ribosomal protein S6 | -0.0587802 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0585174 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.058416 |
| EGR1 | early growth response 1 | -0.0565032 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0563384 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | -0.0552 |
| NDRG1 | N-myc downstream regulated 1 | -0.0549117 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0530552 |
| MX1 | MX dynamin-like GTPase 1 | -0.0514213 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0500998 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0472731 |
| TMSB10 | thymosin beta 10 | -0.0470153 |
| NPSR1 | neuropeptide S receptor 1 | -0.0459313 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0458005 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0445258 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0437957 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0437014 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.042231 |
| H1-0 | H1.0 linker histone | -0.0408082 |
| ITGA6 | integrin, alpha 6 | -0.0405261 |
| PLSCR1 | phospholipid scramblase 1 | -0.0404551 |
| RBM39 | RNA binding motif protein 39 | -0.0401353 |
| TXNIP | thioredoxin interacting protein | -0.0400333 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0395376 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0389464 |
| PRKCA | protein kinase C, alpha | -0.0383565 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0381655 |
| MX2 | MX dynamin-like GTPase 2 | -0.0381598 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0373733 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | -0.0372261 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.036692 |
| TAOK3 | TAO kinase 3 | -0.0361246 |
| FMN1 | formin 1 | -0.035925 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0356561 |
| RIGI | RNA sensor RIG-I | -0.0355507 |
| CTSD | cathepsin D | -0.035526 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0352092 |
| AREG | amphiregulin | -0.0351436 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0350048 |
| BCL2L1 | BCL2-like 1 | -0.0349683 |
| KLF6 | Kruppel-like factor 6 | -0.0346101 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0345744 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.034416 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0342662 |
| PTGR1 | prostaglandin reductase 1 | -0.03393 |
| KLHL24 | kelch-like family member 24 | -0.033866 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0336544 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0333126 |
| FA2H | fatty acid 2-hydroxylase | -0.0332425 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0329546 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0322747 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0322391 |
| FBXO34 | F-box protein 34 | -0.0322053 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0319202 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0318211 |
| XAF1 | XIAP associated factor 1 | -0.031643 |
| HLA-C | major histocompatibility complex, class I, C | -0.0316346 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0315283 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0313843 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.031282 |
| DGKH | diacylglycerol kinase, eta | -0.0307007 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0303381 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0303022 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.030296 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0300888 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0296631 |
| RSF1 | remodeling and spacing factor 1 | -0.0294582 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0292252 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0292179 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.029067 |
| ZC3H13 | zinc finger CCCH-type containing 13 | -0.0290585 |
| RNF149 | ring finger protein 149 | -0.0278159 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0272159 |
| TOB1 | transducer of ERBB2, 1 | -0.0271913 |
| RPL35A | ribosomal protein L35a | -0.0271256 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0270475 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | -0.0269904 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0268768 |
| HLA-E | major histocompatibility complex, class I, E | -0.0268329 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | -0.0266857 |
| CCNL1 | cyclin L1 | -0.0266787 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0265928 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0262492 |
| GNAS | GNAS complex locus | -0.0262168 |
| APOL1 | apolipoprotein L, 1 | -0.0259734 |
| DNM2 | dynamin 2 | -0.0255823 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0254977 |
| TMSB4X | thymosin beta 4, X-linked | -0.0253988 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0251496 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0251043 |
