MK-3903_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-3903 perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-3903_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.128608
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.114043
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0909446
FAM13A family with sequence similarity 13, member A 0.0705083
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.067497
STC1 stanniocalcin 1 0.0635175
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0602556
ZSWIM6 zinc finger, SWIM-type containing 6 0.048479
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0464735
B2M beta-2-microglobulin 0.0454841
TPM3 tropomyosin 3 0.0449323
HILPDA hypoxia inducible lipid droplet-associated 0.0442969
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0442561
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0430979
APLP2 amyloid beta (A4) precursor-like protein 2 0.0418364
LOC102724023 ES1 protein homolog, mitochondrial 0.0401415
CXCL8 chemokine (C-X-C motif) ligand 8 0.0383384
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.038216
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0375025
PDIA3 protein disulfide isomerase family A, member 3 0.0373291
HELZ helicase with zinc finger 0.0372974
KTN1 kinectin 1 (kinesin receptor) 0.0367776
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.035817
DTNA dystrobrevin, alpha 0.0355851
PDIA6 protein disulfide isomerase family A, member 6 0.0317461
RUNX1 runt-related transcription factor 1 0.031635
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0315255
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0312077
UBA6 ubiquitin-like modifier activating enzyme 6 0.0304774
FAM219A family with sequence similarity 219, member A 0.0302352
YBX1 Y box binding protein 1 0.030151
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0300682
VEGFA vascular endothelial growth factor A 0.030024
FOSL1 FOS-like antigen 1 0.0300135
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0296795
BACE2 beta-site APP-cleaving enzyme 2 0.029173
ZNF395 zinc finger protein 395 0.0289251
BRD2 bromodomain containing 2 0.0281654
SDK1 sidekick cell adhesion molecule 1 0.0281609
HYOU1 hypoxia up-regulated 1 0.0275418
FAM107B family with sequence similarity 107, member B 0.0270184
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0266887
RPL3 ribosomal protein L3 0.0264875
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0263904
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0263617
CLU clusterin 0.0260621
PTMA prothymosin, alpha 0.0258466
FNIP1 folliculin interacting protein 1 0.0257378
ADM adrenomedullin 0.025594
PKM pyruvate kinase, muscle 0.0252305
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0251449
TIMP3 TIMP metallopeptidase inhibitor 3 0.0248184
INTS6 integrator complex subunit 6 0.0247385
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0246313
CALR calreticulin 0.0245115
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0240856
EEF1G eukaryotic translation elongation factor 1 gamma 0.0240212
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.023878
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0236229
ASPH aspartate beta-hydroxylase 0.0231731
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0228988
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0227501
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0227261
GLS2 glutaminase 2 (liver, mitochondrial) 0.0225249
MYO1B myosin IB 0.0219505
KCTD16 potassium channel tetramerization domain containing 16 0.0217522
TNIP1 TNFAIP3 interacting protein 1 0.0215015
MEF2A myocyte enhancer factor 2A 0.0207687
PGM3 phosphoglucomutase 3 0.0206602
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.0206456
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0206228
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0205364
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 0.0202608
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0200268
HMGN2 high mobility group nucleosomal binding domain 2 0.0198983
DEPP1 DEPP autophagy regulator 1 0.0197806
INSIG2 insulin induced gene 2 0.0196417
RPS12 ribosomal protein S12 0.0196362
TMF1 TATA element modulatory factor 1 0.019573
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0195402
SUCO SUN domain containing ossification factor 0.0194496
RYBP RING1 and YY1 binding protein 0.0193284
DIPK2A divergent protein kinase domain 2A 0.0192805
RPS17 ribosomal protein S17 0.0192418
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0191154
GPHN gephyrin 0.0190611
TPI1 triosephosphate isomerase 1 0.0189933
SON SON DNA binding protein 0.0189212
MCL1 myeloid cell leukemia 1 0.0186771
NCAPG2 non-SMC condensin II complex, subunit G2 0.0186221
EEF2 eukaryotic translation elongation factor 2 0.0185039
NFE2L1 nuclear factor, erythroid 2-like 1 0.0184264
RIOK3 RIO kinase 3 0.0180738
RPL7 ribosomal protein L7 0.0180125
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0179795
PRELID2 PRELI domain containing 2 0.0179054
NGLY1 N-glycanase 1 0.0178688
HOMER1 homer scaffolding protein 1 0.0175281
DIAPH3 diaphanous-related formin 3 0.0175087
USP37 ubiquitin specific peptidase 37 0.0173781

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.260015
FN1 fibronectin 1 -0.158713
TMSB10 thymosin beta 10 -0.120782
NALF1 NALCN channel auxiliary factor 1 -0.11005
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.102066
AHNAK AHNAK nucleoprotein -0.0911333
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0867639
TPM4 tropomyosin 4 -0.0835013
LOX lysyl oxidase -0.0809807
EXT1 exostosin glycosyltransferase 1 -0.0803507
VIM vimentin -0.0794581
OSMR oncostatin M receptor -0.0713262
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0662457
RTN4 reticulon 4 -0.0650528
SBF2 SET binding factor 2 -0.0627621
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0620943
GARS1 glycyl-tRNA synthetase 1 -0.0614144
KYNU kynureninase -0.0596804
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0584258
TNS3 tensin 3 -0.0582651
TNNC1 troponin C type 1 (slow) -0.0566228
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0546656
ACTN4 actinin, alpha 4 -0.0516789
ANKRD28 ankyrin repeat domain 28 -0.0516715
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0512623
FAM20C family with sequence similarity 20, member C -0.0507598
DST dystonin -0.0486473
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0485438
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0466363
WWTR1 WW domain containing transcription regulator 1 -0.0460439
WSB1 WD repeat and SOCS box containing 1 -0.0456842
ZFAND3 zinc finger, AN1-type domain 3 -0.0455072
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0445137
PRSS23 protease, serine, 23 -0.0439953
COL5A1 collagen, type V, alpha 1 -0.0438696
GRB10 growth factor receptor-bound protein 10 -0.0438653
IGF2 insulin-like growth factor 2 -0.0432824
MAP1B microtubule-associated protein 1B -0.0426922
MT1X metallothionein 1X -0.042067
JMJD1C jumonji domain containing 1C -0.0413582
MT2A metallothionein 2A -0.0397402
SCFD2 sec1 family domain containing 2 -0.039621
NPC1 Niemann-Pick disease, type C1 -0.0394613
LMAN1 lectin, mannose-binding, 1 -0.0389991
SH3KBP1 SH3-domain kinase binding protein 1 -0.0383378
MACF1 microtubule-actin crosslinking factor 1 -0.0380641
PHF14 PHD finger protein 14 -0.0380184
HLA-B major histocompatibility complex, class I, B -0.037853
GPR173 G protein-coupled receptor 173 -0.0376703
LPP LIM domain containing preferred translocation partner in lipoma -0.037666
VCL vinculin -0.0375232
TRIO trio Rho guanine nucleotide exchange factor -0.0367314
ATM ATM serine/threonine kinase -0.036729
GNAS GNAS complex locus -0.0366275
MCTP2 multiple C2 domains, transmembrane 2 -0.0365194
INHBA inhibin, beta A -0.0364071
RNF216 ring finger protein 216 -0.0361063
BBS9 Bardet-Biedl syndrome 9 -0.0359687
TPT1 tumor protein, translationally-controlled 1 -0.0354618
KPNB1 karyopherin (importin) beta 1 -0.0353166
LYPD6B LY6/PLAUR domain containing 6B -0.0351049
AOPEP aminopeptidase O (putative) -0.0345826
ANKRD11 ankyrin repeat domain 11 -0.0345073
ACTN1 actinin, alpha 1 -0.0340604
SPAG9 sperm associated antigen 9 -0.0339477
ANTXR2 anthrax toxin receptor 2 -0.0336531
FNDC3B fibronectin type III domain containing 3B -0.0328726
CAVIN1 caveolae associated protein 1 -0.0326728
ATP13A3 ATPase type 13A3 -0.0323641
PDLIM5 PDZ and LIM domain 5 -0.0320759
S100A6 S100 calcium binding protein A6 -0.0320698
GLIS3 GLIS family zinc finger 3 -0.0319025
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0312193
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0310523
PCNX4 pecanex 4 -0.0305595
MAP4 microtubule-associated protein 4 -0.0304464
RNF213 ring finger protein 213 -0.0303973
GOLGA3 golgin A3 -0.0303356
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0302916
NABP1 nucleic acid binding protein 1 -0.0301855
ATXN1 ataxin 1 -0.030052
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0298413
NAMPT nicotinamide phosphoribosyltransferase -0.0294098
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0293558
BMERB1 bMERB domain containing 1 -0.0292608
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0289463
NIPBL Nipped-B homolog (Drosophila) -0.0288944
ANKRD17 ankyrin repeat domain 17 -0.0287029
UBE2K ubiquitin-conjugating enzyme E2K -0.0286122
ARHGAP24 Rho GTPase activating protein 24 -0.0283661
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0283351
CLINT1 clathrin interactor 1 -0.0282364
USP34 ubiquitin specific peptidase 34 -0.0279598
NF1 neurofibromin 1 -0.0279435
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0279163
LRRC49 leucine rich repeat containing 49 -0.027876
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0278591
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0277618
CDK14 cyclin-dependent kinase 14 -0.0277596
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.027747