| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-3903 perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-3903_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.157642 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.11233 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.10881 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0780455 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0746393 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0745416 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0675813 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0675019 |
| ECT2 | epithelial cell transforming 2 | 0.0596172 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0578068 |
| SMAD3 | SMAD family member 3 | 0.0574521 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0558995 |
| SNX9 | sorting nexin 9 | 0.0542854 |
| TJP1 | tight junction protein 1 | 0.0512966 |
| SPAG9 | sperm associated antigen 9 | 0.0501912 |
| GOLGB1 | golgin B1 | 0.0501567 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0500076 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0495527 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0494234 |
| ASPH | aspartate beta-hydroxylase | 0.0492759 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0489707 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0468061 |
| SET | SET nuclear proto-oncogene | 0.0462801 |
| RPS2 | ribosomal protein S2 | 0.0456485 |
| WWC1 | WW and C2 domain containing 1 | 0.0450692 |
| YBX1 | Y box binding protein 1 | 0.0448372 |
| GOLGA4 | golgin A4 | 0.0444663 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.042715 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0425631 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0424545 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.041126 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0398935 |
| RPL3 | ribosomal protein L3 | 0.0398342 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0393722 |
| DIAPH1 | diaphanous-related formin 1 | 0.0392877 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0392755 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0384126 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0381032 |
| HELZ | helicase with zinc finger | 0.0375695 |
| RPS12 | ribosomal protein S12 | 0.0373952 |
| TPM3 | tropomyosin 3 | 0.0373886 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0371843 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0370991 |
| ZNF292 | zinc finger protein 292 | 0.0361442 |
| APP | amyloid beta (A4) precursor protein | 0.0353137 |
| RUNX1 | runt-related transcription factor 1 | 0.0350838 |
| SGMS2 | sphingomyelin synthase 2 | 0.0350603 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0347995 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0340856 |
| TXNRD1 | thioredoxin reductase 1 | 0.0340321 |
| PCBP2 | poly(rC) binding protein 2 | 0.0332747 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0329112 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0326334 |
| RYBP | RING1 and YY1 binding protein | 0.0324909 |
| CCNL1 | cyclin L1 | 0.0319992 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0318855 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0315524 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0313697 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0312721 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0312517 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0310633 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.030753 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0306777 |
| PKM | pyruvate kinase, muscle | 0.0305723 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0305343 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0302424 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0295795 |
| IRF1 | interferon regulatory factor 1 | 0.0291596 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0291513 |
| FAM120A | family with sequence similarity 120A | 0.0290081 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0284647 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0283428 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0283159 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0282746 |
| BRD2 | bromodomain containing 2 | 0.0279087 |
| RND3 | Rho family GTPase 3 | 0.0277191 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0276349 |
| SIK3 | SIK family kinase 3 | 0.0274648 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.027424 |
| CLTC | clathrin, heavy chain (Hc) | 0.0273817 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0269603 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0268178 |
| VMP1 | vacuole membrane protein 1 | 0.0266556 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0265751 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0264768 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0263707 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0263573 |
| RAB3IP | RAB3A interacting protein | 0.0261795 |
| CENPF | centromere protein F, 350/400kDa | 0.0261502 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0261292 |
| DSPP | dentin sialophosphoprotein | 0.0261042 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0260009 |
| RPL12 | ribosomal protein L12 | 0.0257957 |
| ANO6 | anoctamin 6 | 0.0256874 |
| RACK1 | receptor for activated C kinase 1 | 0.0256749 |
| FOSL1 | FOS-like antigen 1 | 0.0256669 |
| INTS6 | integrator complex subunit 6 | 0.0256481 |
| SQSTM1 | sequestosome 1 | 0.0255694 |
| ATP11B | ATPase, class VI, type 11B | 0.0255308 |
| TUSC3 | tumor suppressor candidate 3 | 0.0249837 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.136156 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.090381 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0794618 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.07901 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0776161 |
| AHNAK | AHNAK nucleoprotein | -0.0742673 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0731757 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0685618 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0652966 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.0641463 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0577703 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.054984 |
| MT2A | metallothionein 2A | -0.0542375 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0483275 |
| CCND1 | cyclin D1 | -0.0471366 |
| LDHA | lactate dehydrogenase A | -0.0468274 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0460282 |
| PTMA | prothymosin, alpha | -0.0416372 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0407918 |
| HMGA1 | high mobility group AT-hook 1 | -0.0403524 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0401648 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0395165 |
| PCED1B | PC-esterase domain containing 1B | -0.0388354 |
| VCAN | versican | -0.038765 |
| POU5F1 | POU class 5 homeobox 1 | -0.0378947 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0361297 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0358899 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0352992 |
| RAD51B | RAD51 paralog B | -0.0351784 |
| NDUFAF2 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 | -0.0341135 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0339297 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0337814 |
| KRT7 | keratin 7, type II | -0.0329391 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0328146 |
| ZFHX3 | zinc finger homeobox 3 | -0.0320074 |
| KAZN | kazrin, periplakin interacting protein | -0.0319551 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0319123 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.031738 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.030499 |
| ATG7 | autophagy related 7 | -0.0301489 |
| RPL35A | ribosomal protein L35a | -0.0296498 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0295716 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0292404 |
| MGLL | monoglyceride lipase | -0.0289142 |
| ZNF609 | zinc finger protein 609 | -0.02818 |
| PAX8 | paired box 8 | -0.0281707 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0278991 |
| THOC2 | THO complex 2 | -0.0275415 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0275288 |
| OXR1 | oxidation resistance 1 | -0.0275269 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | -0.0272649 |
| KRT19 | keratin 19, type I | -0.0269827 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0268012 |
| MT1X | metallothionein 1X | -0.0267972 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0261947 |
| HMGA2 | high mobility group AT-hook 2 | -0.0260597 |
| GLIS3 | GLIS family zinc finger 3 | -0.0259965 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0258316 |
| S100A6 | S100 calcium binding protein A6 | -0.0256843 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0256687 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.0254689 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0250428 |
| RNF213 | ring finger protein 213 | -0.0247924 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0247022 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0246058 |
| EGFR | epidermal growth factor receptor | -0.0245973 |
| ENO1 | enolase 1, (alpha) | -0.0245475 |
| ACTG1 | actin gamma 1 | -0.0245296 |
| TPM4 | tropomyosin 4 | -0.0244935 |
| RNASET2 | ribonuclease T2 | -0.0244273 |
| CLDN1 | claudin 1 | -0.0241199 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0239519 |
| SSH2 | slingshot protein phosphatase 2 | -0.0237847 |
| TCF12 | transcription factor 12 | -0.0237633 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0237152 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0235188 |
| TNS3 | tensin 3 | -0.0235158 |
| FOXP1 | forkhead box P1 | -0.0234002 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0232601 |
| NDRG1 | N-myc downstream regulated 1 | -0.0231712 |
| TMSB4X | thymosin beta 4, X-linked | -0.0230537 |
| DAPK1 | death-associated protein kinase 1 | -0.022991 |
| ANXA3 | annexin A3 | -0.0229909 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0228927 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0227856 |
| H1-0 | H1.0 linker histone | -0.022733 |
| EXOC4 | exocyst complex component 4 | -0.0226853 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | -0.0226415 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0225985 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0225094 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0223858 |
| S100A4 | S100 calcium binding protein A4 | -0.0222602 |
| CDK12 | cyclin-dependent kinase 12 | -0.0221748 |
| DNM3 | dynamin 3 | -0.0221622 |
| MKI67 | marker of proliferation Ki-67 | -0.0220422 |
| APOL1 | apolipoprotein L, 1 | -0.0220279 |
| ENOSF1 | enolase superfamily member 1 | -0.0219313 |
| GNAS | GNAS complex locus | -0.0217578 |
| PRR11 | proline rich 11 | -0.0212442 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0211871 |
