MK-3903_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-3903 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-3903_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.208102
AKAP12 A kinase (PRKA) anchor protein 12 0.187233
ERRFI1 ERBB receptor feedback inhibitor 1 0.141955
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.139455
TIMP1 TIMP metallopeptidase inhibitor 1 0.10969
SPTBN1 spectrin, beta, non-erythrocytic 1 0.10351
DSPP dentin sialophosphoprotein 0.0993365
ASPH aspartate beta-hydroxylase 0.0979009
SVIL supervillin 0.0962079
EHBP1 EH domain binding protein 1 0.0848986
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0731957
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0703844
FAM107B family with sequence similarity 107, member B 0.0690691
GMDS GDP-mannose 4,6-dehydratase 0.0647659
FRMD5 FERM domain containing 5 0.0637837
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.062244
MAML2 mastermind-like 2 (Drosophila) 0.0619266
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0603748
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0578151
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0571243
ELL2 elongation factor, RNA polymerase II, 2 0.0562733
SAMD4A sterile alpha motif domain containing 4A 0.0540152
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0535738
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.052819
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0516723
ENO1 enolase 1, (alpha) 0.050336
DLC1 DLC1 Rho GTPase activating protein 0.0448665
RUNX1 runt-related transcription factor 1 0.044065
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0438631
GRB10 growth factor receptor-bound protein 10 0.0420358
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0417787
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0410268
CCL20 chemokine (C-C motif) ligand 20 0.0401158
LMO7 LIM domain 7 0.0400363
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0386548
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0384879
ATXN1 ataxin 1 0.0375436
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0373452
SDC4 syndecan 4 0.0373353
MT2A metallothionein 2A 0.0357313
FOXP1 forkhead box P1 0.0353724
FAT1 FAT atypical cadherin 1 0.034609
EXT1 exostosin glycosyltransferase 1 0.0345604
DSTN destrin (actin depolymerizing factor) 0.0342318
SOS1 son of sevenless homolog 1 (Drosophila) 0.0340758
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0340571
DST dystonin 0.0339752
RRBP1 ribosome binding protein 1 0.0335235
ZBTB20 zinc finger and BTB domain containing 20 0.0327777
DTNA dystrobrevin, alpha 0.0322541
TRIO trio Rho guanine nucleotide exchange factor 0.0321936
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0321584
KYNU kynureninase 0.0312871
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0312321
KIAA1217 KIAA1217 0.0312095
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0312091
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0302276
CRY1 cryptochrome circadian clock 1 0.030198
TMSB10 thymosin beta 10 0.0293467
TM4SF1 transmembrane 4 L six family member 1 0.0289425
CEMIP2 cell migration inducing hyaluronidase 2 0.0289141
LRMDA leucine rich melanocyte differentiation associated 0.0284574
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0282533
PRRC2C proline-rich coiled-coil 2C 0.0282454
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0281659
PDGFB platelet-derived growth factor beta polypeptide 0.0278999
RTN4 reticulon 4 0.0278675
FMNL2 formin-like 2 0.0278458
ESYT2 extended synaptotagmin-like protein 2 0.0277276
AFDN afadin, adherens junction formation factor 0.0274807
IL1RAP interleukin 1 receptor accessory protein 0.0270122
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0269144
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0264827
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0263611
WWC2 WW and C2 domain containing 2 0.0261068
MBNL2 muscleblind-like splicing regulator 2 0.0260343
DOCK4 dedicator of cytokinesis 4 0.0256808
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.025339
JMJD1C jumonji domain containing 1C 0.0252865
TBC1D22A TBC1 domain family, member 22A 0.0249917
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0248844
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0247447
SRPK1 SRSF protein kinase 1 0.0246648
CCDC88A coiled-coil domain containing 88A 0.0243288
NSUN6 NOP2/Sun domain family, member 6 0.0242411
ARFGEF3 ARFGEF family member 3 0.0241258
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0238443
TOP1 topoisomerase (DNA) I 0.0235344
TMEM181 transmembrane protein 181 0.023534
NFE2L2 nuclear factor, erythroid 2-like 2 0.0235175
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0231718
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0230559
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0229546
NPAS2 neuronal PAS domain protein 2 0.0228044
ARL5B ADP-ribosylation factor-like 5B 0.0226623
CUL3 cullin 3 0.0224216
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0220129
USP34 ubiquitin specific peptidase 34 0.0219582
DUSP6 dual specificity phosphatase 6 0.0218013
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0217558

decreased expression

Symbol Name Standardized Value
C3 complement component 3 -0.0816018
CTSB cathepsin B -0.0761583
APOA2 apolipoprotein A-II -0.0706887
RPL37A ribosomal protein L37a -0.0531351
TPT1 tumor protein, translationally-controlled 1 -0.0449718
RPS12 ribosomal protein S12 -0.0434689
RPS6 ribosomal protein S6 -0.0417889
VCL vinculin -0.0407475
RPL23 ribosomal protein L23 -0.0396146
RPL9 ribosomal protein L9 -0.0393276
AHSG alpha-2-HS-glycoprotein -0.0382887
IGF2 insulin-like growth factor 2 -0.037788
RPLP1 ribosomal protein, large, P1 -0.0337367
RPS29 ribosomal protein S29 -0.0291939
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.028691
FST follistatin -0.0282842
ITGAV integrin, alpha V -0.0280594
ECE1 endothelin converting enzyme 1 -0.0273168
RPL26 ribosomal protein L26 -0.0267265
RPS3 ribosomal protein S3 -0.0264274
RPL31 ribosomal protein L31 -0.0260772
RPL35A ribosomal protein L35a -0.0259713
RPL13A ribosomal protein L13a -0.0251605
RPS8 ribosomal protein S8 -0.0242634
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0241005
HNMT histamine N-methyltransferase -0.0233713
NOL4L nucleolar protein 4-like -0.0232239
FTL ferritin, light polypeptide -0.0231217
APOB apolipoprotein B -0.023036
PLIN2 perilipin 2 -0.0230253
GPC6 glypican 6 -0.0228207
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0224283
RPS23 ribosomal protein S23 -0.0224148
APOC1 apolipoprotein C-I -0.0223994
RPS25 ribosomal protein S25 -0.0222754
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0221209
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0213012
AOPEP aminopeptidase O (putative) -0.0212752
RPL36 ribosomal protein L36 -0.0212199
TNS3 tensin 3 -0.0210568
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0209887
IGFBP1 insulin-like growth factor binding protein 1 -0.0207331
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0206976
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0204874
RPL7A ribosomal protein L7a -0.0203548
CP ceruloplasmin (ferroxidase) -0.0194046
RPS27A ribosomal protein S27a -0.0193084
SELENOP selenoprotein P -0.0190747
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.018899
FOXN3 forkhead box N3 -0.0188327
HMGA1 high mobility group AT-hook 1 -0.0185034
APOE apolipoprotein E -0.0183433
RPL37 ribosomal protein L37 -0.0182318
RPS14 ribosomal protein S14 -0.0182187
MED13L mediator complex subunit 13-like -0.0181693
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0179126
RAN RAN, member RAS oncogene family -0.0169844
TNRC6B trinucleotide repeat containing 6B -0.0168698
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0168584
LCOR ligand dependent nuclear receptor corepressor -0.0167918
COL27A1 collagen, type XXVII, alpha 1 -0.0165992
RPL34 ribosomal protein L34 -0.0163873
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0162986
AKAP9 A kinase (PRKA) anchor protein 9 -0.0160749
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0159189
RPL38 ribosomal protein L38 -0.0159163
RPS16 ribosomal protein S16 -0.0158836
RPLP2 ribosomal protein, large, P2 -0.0158603
RPS13 ribosomal protein S13 -0.0154236
RPS10 ribosomal protein S10 -0.0153723
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0151663
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -0.0151262
RPL15 ribosomal protein L15 -0.0148661
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0148512
RPS21 ribosomal protein S21 -0.0144808
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0140778
NDRG1 N-myc downstream regulated 1 -0.0140541
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0139423
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.0136284
TMC7 transmembrane channel-like 7 -0.0136095
TTC28 tetratricopeptide repeat domain 28 -0.0134803
RPLP0 ribosomal protein, large, P0 -0.0134339
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0133495
GNAS GNAS complex locus -0.0133213
PTPRK protein tyrosine phosphatase, receptor type, K -0.0132383
RPL11 ribosomal protein L11 -0.0132305
SQSTM1 sequestosome 1 -0.0131295
CHD9 chromodomain helicase DNA binding protein 9 -0.0130621
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0130585
RPS20 ribosomal protein S20 -0.0130003
UBE2B ubiquitin-conjugating enzyme E2B -0.0128608
EFNA1 ephrin-A1 -0.0128328
CPT1A carnitine palmitoyltransferase 1A (liver) -0.0127219
CCAR1 cell division cycle and apoptosis regulator 1 -0.0125907
RACK1 receptor for activated C kinase 1 -0.0125173
B2M beta-2-microglobulin -0.0125021
ATP9A ATPase, class II, type 9A -0.0124275
MRTFA myocardin related transcription factor A -0.0122927
RPS17 ribosomal protein S17 -0.0122449
RPS11 ribosomal protein S11 -0.0121735