| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-3903 perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-3903_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.120984 |
| LMO7 | LIM domain 7 | 0.119387 |
| MTSS1 | metastasis suppressor 1 | 0.107003 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.099783 |
| RASAL2 | RAS protein activator like 2 | 0.0790638 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0786068 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.072631 |
| ASPH | aspartate beta-hydroxylase | 0.071883 |
| INTS6 | integrator complex subunit 6 | 0.0697835 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0689588 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0687206 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0673095 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0667751 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0642595 |
| CD44 | CD44 molecule (Indian blood group) | 0.0629404 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0560518 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0550537 |
| NAV2 | neuron navigator 2 | 0.0547636 |
| HMGA2 | high mobility group AT-hook 2 | 0.0541092 |
| EFNA5 | ephrin-A5 | 0.0533222 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0517927 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0495459 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0482704 |
| SIK3 | SIK family kinase 3 | 0.0444951 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0441644 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0441278 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0428879 |
| JMJD1C | jumonji domain containing 1C | 0.0426581 |
| DST | dystonin | 0.0426525 |
| CDK6 | cyclin-dependent kinase 6 | 0.0423598 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0421144 |
| DOCK5 | dedicator of cytokinesis 5 | 0.041906 |
| RAD51B | RAD51 paralog B | 0.0409631 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0398693 |
| PTK2 | protein tyrosine kinase 2 | 0.0389444 |
| FNDC3B | fibronectin type III domain containing 3B | 0.038921 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0369823 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0369244 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0367597 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0366501 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0364821 |
| EXOC4 | exocyst complex component 4 | 0.0362854 |
| LAMC2 | laminin, gamma 2 | 0.0360967 |
| TPM3 | tropomyosin 3 | 0.0353053 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0350923 |
| DOK5 | docking protein 5 | 0.034903 |
| VMP1 | vacuole membrane protein 1 | 0.0346724 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0344763 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0344253 |
| GOLGB1 | golgin B1 | 0.0343658 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0343221 |
| SMAD3 | SMAD family member 3 | 0.0335753 |
| GRB10 | growth factor receptor-bound protein 10 | 0.03356 |
| MSN | moesin | 0.0333586 |
| FNIP1 | folliculin interacting protein 1 | 0.0331855 |
| DIAPH1 | diaphanous-related formin 1 | 0.0330221 |
| CSMD2 | CUB and Sushi multiple domains 2 | 0.0328704 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0328477 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0328093 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0321318 |
| RNF217 | ring finger protein 217 | 0.0320859 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0317855 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0316369 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0314128 |
| ANO6 | anoctamin 6 | 0.0313945 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0313676 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0313554 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0309013 |
| SVIL | supervillin | 0.0308387 |
| UTRN | utrophin | 0.0305521 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0300747 |
| FAM107B | family with sequence similarity 107, member B | 0.029744 |
| SULF2 | sulfatase 2 | 0.029494 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0290272 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0281793 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0277739 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0272623 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.026983 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0268068 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0267733 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0264273 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0261877 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0257998 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.02573 |
| USP34 | ubiquitin specific peptidase 34 | 0.025265 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0252644 |
| RND3 | Rho family GTPase 3 | 0.0251407 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0251103 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0250309 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0247808 |
| HDAC9 | histone deacetylase 9 | 0.0245287 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0244443 |
| ATXN1 | ataxin 1 | 0.0243251 |
| PCDH1 | protocadherin 1 | 0.0241632 |
| AMOTL1 | angiomotin like 1 | 0.0239184 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0236778 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0236448 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0236008 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0235087 |
| RAI14 | retinoic acid induced 14 | 0.0233193 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.183614 |
| CLU | clusterin | -0.121824 |
| FLNB | filamin B, beta | -0.101785 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0976519 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0898507 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0868551 |
| PTMA | prothymosin, alpha | -0.0868183 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0841198 |
| NDRG1 | N-myc downstream regulated 1 | -0.0804958 |
| KRT17 | keratin 17, type I | -0.0780707 |
| AHNAK | AHNAK nucleoprotein | -0.0767111 |
| TMSB10 | thymosin beta 10 | -0.0669497 |
| H1-0 | H1.0 linker histone | -0.0651698 |
| RBM39 | RNA binding motif protein 39 | -0.0647444 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0635406 |
| GNAS | GNAS complex locus | -0.0565026 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0534481 |
| LMNA | lamin A/C | -0.0526248 |
| RPS21 | ribosomal protein S21 | -0.0522502 |
| ANLN | anillin, actin binding protein | -0.0519597 |
| MEF2A | myocyte enhancer factor 2A | -0.0505364 |
| PGK1 | phosphoglycerate kinase 1 | -0.0503209 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.049921 |
| OGA | O-GlcNAcase | -0.0491548 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0469095 |
| TMSB4X | thymosin beta 4, X-linked | -0.0455729 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0451974 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.044563 |
| IGF2 | insulin-like growth factor 2 | -0.0440113 |
| EMP1 | epithelial membrane protein 1 | -0.0420912 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0404483 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.039374 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0391531 |
| CAVIN1 | caveolae associated protein 1 | -0.0387344 |
| PLAT | plasminogen activator, tissue | -0.0377284 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0377079 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0366098 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0339723 |
| YBX3 | Y box binding protein 3 | -0.0336516 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0331806 |
| SYPL1 | synaptophysin-like 1 | -0.0329722 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0325319 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0320465 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.0317667 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0317011 |
| MT1X | metallothionein 1X | -0.030964 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0309627 |
| LDHA | lactate dehydrogenase A | -0.0306572 |
| C4BPB | complement component 4 binding protein, beta | -0.030301 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0302529 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0300277 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0299526 |
| STC1 | stanniocalcin 1 | -0.0297781 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0297501 |
| ENO1 | enolase 1, (alpha) | -0.0295141 |
| BCL2L1 | BCL2-like 1 | -0.0291457 |
| IER3 | immediate early response 3 | -0.0288487 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0288224 |
| TAGLN2 | transgelin 2 | -0.0282276 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0279877 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0279274 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.027772 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.027612 |
| ITGA6 | integrin, alpha 6 | -0.0271593 |
| S100A10 | S100 calcium binding protein A10 | -0.0267694 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0267661 |
| KRT6A | keratin 6A, type II | -0.0266823 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.026623 |
| CUL4B | cullin 4B | -0.0266097 |
| RPS24 | ribosomal protein S24 | -0.0261606 |
| ANXA2 | annexin A2 | -0.0256367 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0252828 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0250951 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0248565 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0246679 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0246625 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.024544 |
| SEPTIN7 | septin 7 | -0.024493 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0243923 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0243275 |
| SLC45A4 | solute carrier family 45, member 4 | -0.024071 |
| CSNK1E | casein kinase 1, epsilon | -0.023955 |
| TMEM123 | transmembrane protein 123 | -0.0239436 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0238174 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | -0.0237259 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0234899 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0234598 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0232793 |
| KRT14 | keratin 14, type I | -0.0231263 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0228027 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0226707 |
| GATA6 | GATA binding protein 6 | -0.0222812 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0222547 |
| TKT | transketolase | -0.0222061 |
| CD99 | CD99 molecule | -0.0221252 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0221158 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.02204 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0218032 |
| S100A6 | S100 calcium binding protein A6 | -0.0217055 |
| RIOK3 | RIO kinase 3 | -0.0214365 |
