| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-3903 perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the MK-3903_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.142334 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.136352 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.12767 |
| FTL | ferritin, light polypeptide | 0.113025 |
| TXNRD1 | thioredoxin reductase 1 | 0.108062 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.100513 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0909164 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0829908 |
| B2M | beta-2-microglobulin | 0.0768316 |
| DEK | DEK proto-oncogene | 0.0737862 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0703758 |
| SET | SET nuclear proto-oncogene | 0.0595261 |
| CENPF | centromere protein F, 350/400kDa | 0.0561214 |
| YBX1 | Y box binding protein 1 | 0.0550952 |
| TPM3 | tropomyosin 3 | 0.0548497 |
| LDHA | lactate dehydrogenase A | 0.0547117 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0533788 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0505627 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0463881 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0457569 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0451655 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0437514 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0417632 |
| TPX2 | TPX2, microtubule-associated | 0.0410486 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0399908 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0386142 |
| GOLGA4 | golgin A4 | 0.0385951 |
| CANX | calnexin | 0.0375373 |
| PKM | pyruvate kinase, muscle | 0.0373785 |
| MAP1B | microtubule-associated protein 1B | 0.0373524 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.037234 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0371361 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0364875 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0344761 |
| LIMA1 | LIM domain and actin binding 1 | 0.0341614 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0332869 |
| FOSL1 | FOS-like antigen 1 | 0.0331283 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0330029 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0323188 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.032215 |
| GOLGB1 | golgin B1 | 0.0315022 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0313073 |
| TPD52 | tumor protein D52 | 0.0311106 |
| ANXA1 | annexin A1 | 0.0309553 |
| CALR | calreticulin | 0.0303752 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0301087 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0296209 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0293953 |
| PLK2 | polo-like kinase 2 | 0.0291252 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0290389 |
| POTEF | POTE ankyrin domain family, member F | 0.0286994 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0282486 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0280116 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0279584 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0273317 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0273 |
| DIAPH3 | diaphanous-related formin 3 | 0.0272832 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0271776 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0269008 |
| MKI67 | marker of proliferation Ki-67 | 0.0268173 |
| KRT8 | keratin 8, type II | 0.0267183 |
| ENO1 | enolase 1, (alpha) | 0.0266994 |
| MSN | moesin | 0.0266664 |
| FAM120A | family with sequence similarity 120A | 0.0261747 |
| JUN | jun proto-oncogene | 0.0258061 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0250677 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.025015 |
| RPS6 | ribosomal protein S6 | 0.0239212 |
| CKAP5 | cytoskeleton associated protein 5 | 0.023787 |
| BBX | bobby sox homolog (Drosophila) | 0.0235751 |
| CD44 | CD44 molecule (Indian blood group) | 0.023379 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0232687 |
| SMC4 | structural maintenance of chromosomes 4 | 0.023184 |
| KRT7 | keratin 7, type II | 0.0231465 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0230809 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0230663 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0229391 |
| SMAD3 | SMAD family member 3 | 0.022815 |
| PAPOLA | poly(A) polymerase alpha | 0.0225298 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0224925 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0221964 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.022118 |
| HMGB2 | high mobility group box 2 | 0.0217942 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0217385 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0216373 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0211808 |
| KRT18 | keratin 18, type I | 0.0210103 |
| SON | SON DNA binding protein | 0.0208434 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0207355 |
| PFN1 | profilin 1 | 0.0207316 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0206801 |
| FAM107B | family with sequence similarity 107, member B | 0.0206755 |
| EZR | ezrin | 0.0205801 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0205514 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0204224 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.0203206 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0203093 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0202594 |
| ANO6 | anoctamin 6 | 0.0201822 |
| ZNF292 | zinc finger protein 292 | 0.0199987 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.270638 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.139207 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.119725 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0932406 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0451037 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0441301 |
| GLIS3 | GLIS family zinc finger 3 | -0.0440289 |
| RPL35A | ribosomal protein L35a | -0.0410491 |
| NDRG1 | N-myc downstream regulated 1 | -0.0382502 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0367236 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0365809 |
| HLA-B | major histocompatibility complex, class I, B | -0.0351317 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0349201 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0345017 |
| CAVIN1 | caveolae associated protein 1 | -0.0328644 |
| COL5A1 | collagen, type V, alpha 1 | -0.0323504 |
| INTS6 | integrator complex subunit 6 | -0.0311226 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0264312 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0252093 |
| WNT5B | wingless-type MMTV integration site family, member 5B | -0.0250227 |
| MT2A | metallothionein 2A | -0.0248643 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0244765 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0242494 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0238976 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0235356 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0233017 |
| HLA-C | major histocompatibility complex, class I, C | -0.0227676 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0224843 |
| MT1X | metallothionein 1X | -0.021614 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0214182 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0213769 |
| CAST | calpastatin | -0.0212378 |
| FRMD4A | FERM domain containing 4A | -0.0210627 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0206649 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0201866 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0201401 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0196427 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0194975 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0194561 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0190456 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.0190367 |
| OSMR | oncostatin M receptor | -0.0190314 |
| CTSD | cathepsin D | -0.0186879 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0185398 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0182075 |
| ZNF804A | zinc finger protein 804A | -0.0179969 |
| AHNAK | AHNAK nucleoprotein | -0.0179031 |
| VCL | vinculin | -0.0177484 |
| TNS3 | tensin 3 | -0.0177042 |
| PODXL | podocalyxin-like | -0.0176929 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0172096 |
| TMSB10 | thymosin beta 10 | -0.017167 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.01686 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0168427 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0164612 |
| RPS24 | ribosomal protein S24 | -0.016365 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.016356 |
| NABP1 | nucleic acid binding protein 1 | -0.0162992 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0162695 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0162264 |
| AEBP2 | AE binding protein 2 | -0.0160698 |
| GNAS | GNAS complex locus | -0.015611 |
| PRELID2 | PRELI domain containing 2 | -0.0155287 |
| MGLL | monoglyceride lipase | -0.0154238 |
| CSTF3 | cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa | -0.015345 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0153279 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0152972 |
| RPS29 | ribosomal protein S29 | -0.0151063 |
| RAI14 | retinoic acid induced 14 | -0.0150039 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0147638 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.014668 |
| E2F3 | E2F transcription factor 3 | -0.0146257 |
| RPL27A | ribosomal protein L27a | -0.0144412 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0142938 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0142 |
| FLNB | filamin B, beta | -0.0139817 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0137898 |
| SNX14 | sorting nexin 14 | -0.0135931 |
| TBCA | tubulin folding cofactor A | -0.0135031 |
| RAD51B | RAD51 paralog B | -0.0133445 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0133031 |
| POSTN | periostin, osteoblast specific factor | -0.0132703 |
| RSU1 | Ras suppressor protein 1 | -0.0129501 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0129374 |
| CTSL | cathepsin L | -0.0129042 |
| SLC22A3 | solute carrier family 22 (organic cation transporter), member 3 | -0.0128907 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.012879 |
| STK4 | serine/threonine kinase 4 | -0.0127861 |
| RPL38 | ribosomal protein L38 | -0.012767 |
| MROH1 | maestro heat-like repeat family member 1 | -0.0127092 |
| IGF1R | insulin-like growth factor 1 receptor | -0.012559 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0125274 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0123562 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0122967 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0122774 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0122649 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0122181 |
| LAMP1 | lysosomal-associated membrane protein 1 | -0.0121905 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0121443 |
| VIM | vimentin | -0.0121055 |
